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1. 发明申请

WO2012071566A3 SYSTEMS AND METHODS FOR AUTOMATED VOXELATION OF REGIONS OF INTEREST FOR MAGNETIC RESONANCE SPECTROSCOPY 审中-公开
标题翻译：用于磁共振光谱自动振荡区域的系统和方法
公开(公告)号：WO2012071566A3
公开(公告)日：2012-10-11
申请号：PCT/US2011062137
申请日：2011-11-23
申请人： NOCIMED LLC , CLAUDE JOHN P , PEACOCK JAMES C , KANE PAUL H
发明人： CLAUDE JOHN P , PEACOCK JAMES C , KANE PAUL H
IPC分类号： A61B5/055
CPC分类号： G06K9/34 , A61B5/055 , G01R33/485 , G01R33/543 , G06T7/11 , G06T7/75 , G06T2207/10088 , G06T2207/30012
摘要： A system and method for automating an appropriate voxel prescription in a uniquely definable region of interest (ROI) in a tissue of a patient is provided, such as for purpose of conducting magnetic resonance spectroscopy (MRS) in the ROI. The dimensions and coordinates of a single three dimensional rectilinear volume (voxel) within a single region of interest (ROI) are automatically identified. This is done, in some embodiments by: (1) applying statistically identified ROI search areas within a field of view (FOV); (2) image processing an MRI image to smooth the background and enhance a particular structure useful to define the ROI; (3) identifying a population of pixels that define the particular structure; (4) performing a statistical analysis of the pixel population to fit a 2D model such as an ellipsoid to the population and subsequently fit a rectilinear shape within the model; (5) repetiting elements (1) through (4) using multiple images that encompass the 3D ROI to create a 3D rectilinear shape; (6) a repetition of elements (1) through (5) for multiple ROIs with a common FOV. A manual interface may also be provided, allowing for override to replace by manual prescription, assistance to identify structures (e.g. clicking on disc levels), or modifying the automated voxel (e.g. modify location, shape, or one or more dimensions).
摘要翻译：提供了一种用于在患者组织中的唯一可定义的感兴趣区域（ROI）中自动化适当体素处方的系统和方法，例如用于在ROI中进行磁共振波谱（MRS）的目的。自动识别单个感兴趣区域（ROI）内单个三维直线体积（体素）的尺寸和坐标。这在一些实施例中通过以下方式完成：（1）在视场（FOV）内应用统计识别的ROI搜索区域; （2）图像处理MRI图像以平滑背景并增强用于定义ROI的特定结构; （3）识别定义特定结构的像素群; （4）对像素群体进行统计分析，以将诸如椭圆体的2D模型拟合到群体中，并随后在模型内拟合直线形状; （5）使用包含3D ROI的多个图像重复元件（1）至（4）以产生3D直线形状; （6）用于具有共同FOV的多个ROI的元件（1）至（5）的重复。还可以提供手动界面，允许通过手动处方来替代，以识别结构（例如，点击盘级别）或修改自动体素（例如修改位置，形状或一个或多个维度）。

2. 发明申请

WO2011143468A3 LOW PROFILE ELECTRODE ASSEMBLY 审中-公开
公开(公告)号：WO2011143468A3
公开(公告)日：2011-11-17
申请号：PCT/US2011/036310
申请日：2011-05-12
申请人： SHIFAMED HOLDINGS, LLC , SALAHIEH, Amr , LEPAK, Jonah , LEUNG, Emma , BRANDT, Brian, D. , CLAUDE, John, P.
发明人： SALAHIEH, Amr , LEPAK, Jonah , LEUNG, Emma , BRANDT, Brian, D. , CLAUDE, John, P.
IPC分类号： A61B18/18 , A61B18/14 , A61M29/02 , A61M25/01
摘要： A tissue electrode assembly includes a membrane configured to form an expandable, conformable body that is deployable in a patient. The assembly further includes a flexible circuit positioned on a surface of the membrane and comprising at least one base substrate layer, at least one insulating layer and at least one planar conducting layer. An electrically-conductive electrode covers at least a portion of the flexible circuit and a portion of the surface of the membrane not covered by the flexible circuit, wherein the electrically-conductive electrode is foldable upon itself with the membrane to a delivery conformation having a diameter suitable for minimally-invasive delivery of the assembly to the patient.

3. 发明申请

WO2011047197A2 MR SPECTROSCOPY SYSTEM AND METHOD FOR DIAGNOSING PAINFUL AND NON-PAINFUL INTERVERTEBRAL DISCS 审中-公开
标题翻译： MR光谱系统和用于诊断疼痛和非疼痛椎间盘的方法
公开(公告)号：WO2011047197A2
公开(公告)日：2011-04-21
申请号：PCT/US2010/052737
申请日：2010-10-14
申请人： NOCIMED, LLC , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , PEACOCK, James, C. , CLAUDE, John, P. , KANE, Paul, H. , LOTZ, Jeffrey, C.
发明人： PEACOCK, James, C. , CLAUDE, John, P. , KANE, Paul, H. , LOTZ, Jeffrey, C.
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/407 , A61B5/4514 , A61B5/4824 , A61B5/7203 , G01R33/34069 , G01R33/3415 , G01R33/4616 , G01R33/485 , G01R33/565 , G01R33/56527 , G06F19/00
摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs. A diagnostic display provides a scaled, color coded legend and indication of results for each disc analyzed as an overlay onto a mid-sagittal T2 -weighted MRI image of the lumbar spine for the patient being diagnosed. Clinical application of the embodiments provides a non-invasive, objective, pain-free, reliable approach for diagnosing painful vs. non-painful discs by simply extending and enhancing the utility of otherwise standard MRI exams of the lumbar spine.
摘要翻译：为慢性严重腰背痛患者（DDD-MRS）中的疼痛和非疼痛椎间盘诊断提供MR光谱学（MRS）系统和方法。 DDD-MRS脉冲序列在椎间盘核内产生并获取DDD-MRS光谱，用于稍后的信号处理和诊断分析。接口DDD-MRS信号处理器接收所获取的DDD-MRS谱的输出信号，并被配置为通过选择性地进行最佳信道选择，相位和频率校正和帧编辑的自动化系统来优化信噪比（SNR）适用于特定的收购系列。诊断处理器基于加权因子集合来计算盘片的诊断值，所述加权因子集合使用MRS数据，所述MRS数据从与已经与疼痛与非疼痛盘片相关的多种化学物质相关联的区域获取并处理MRS光谱中提取。诊断显示器提供缩放的颜色编码的图例和每个椎间盘的结果指示，作为覆盖到被诊断患者的腰椎的中间矢状T2加权MRI图像上的覆盖物。这些实施例的临床应用通过简单地扩展和增强对腰椎的其他标准MRI检查的实用性提供了非侵入性，客观，无痛，可靠的诊断疼痛与非疼痛椎间盘的方法。

4. 发明申请

WO2010056771A1 LOW PROFILE ELECTRODE ASSEMBLY 审中-公开
标题翻译：低剖面电极组件
公开(公告)号：WO2010056771A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/064069
申请日：2009-11-11
申请人： SHIFAMED LLC , SALAHIEH, Amr , LEPAK, Jonah , LEUNG, Emma , BRANDT, Brian , CLAUDE, John, P.
发明人： SALAHIEH, Amr , LEPAK, Jonah , LEUNG, Emma , BRANDT, Brian , CLAUDE, John, P.
IPC分类号： A61B18/14 , A61B5/042 , A61N1/05 , A61B18/00
CPC分类号： A61N1/05 , A61B5/01 , A61B5/0422 , A61B5/6846 , A61B18/1206 , A61B18/1492 , A61B2017/003 , A61B2017/00867 , A61B2017/22038 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00083 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00232 , A61B2018/00267 , A61B2018/00285 , A61B2018/00291 , A61B2018/00357 , A61B2018/00375 , A61B2018/00613 , A61B2018/00642 , A61B2018/00702 , A61B2018/00744 , A61B2018/00791 , A61B2018/00797 , A61B2018/00839 , A61B2018/00898 , A61B2018/124 , A61B2018/1465 , A61B2090/3966 , A61B2562/125 , C08L2201/12
摘要： A tissue electrode assembly includes a membrane configured to form an expandable, conformable body that is deployable in a patient. The assembly further includes a flexible circuit positioned on a surface of the membrane and comprising at least one base substrate layer, at least one insulating layer and at least one planar conducting layer. An electrically-conductive electrode covers at least a portion of the flexible circuit and a portion of the surface of the membrane not covered by the flexible circuit, wherein the electrically-conductive electrode is foldable upon itself with the membrane to a delivery conformation having a diameter suitable for minimally-invasive delivery of the assembly to the patient.
摘要翻译：组织电极组件包括被配置成形成可展开在患者体内的可扩张的适形身体的膜。组件还包括位于膜的表面上的柔性电路，并且包括至少一个基底衬底层，至少一个绝缘层和至少一个平面导电层。导电电极覆盖柔性电路的至少一部分，并且膜的表面的一部分未被柔性电路覆盖，其中导电电极可以自身与膜折叠成具有直径的输送构型适合于将组件的微创传送给患者。

5. 发明申请

WO2011047197A8 MR SPECTROSCOPY SYSTEM AND METHOD FOR DIAGNOSING PAINFUL AND NON-PAINFUL INTERVERTEBRAL DISCS 审中-公开
标题翻译： MR光谱系统及其诊断方法，用于诊断阴性和非阴性椎间盘
公开(公告)号：WO2011047197A8
公开(公告)日：2011-11-10
申请号：PCT/US2010052737
申请日：2010-10-14
申请人： NOCIMED LLC , UNIV CALIFORNIA , PEACOCK JAMES C III , CLAUDE JOHN P , KANE PAUL H , LOTZ JEFFREY C
发明人： PEACOCK JAMES C III , CLAUDE JOHN P , KANE PAUL H , LOTZ JEFFREY C
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/407 , A61B5/4514 , A61B5/4824 , A61B5/7203 , G01R33/34069 , G01R33/3415 , G01R33/4616 , G01R33/485 , G01R33/565 , G01R33/56527
摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs. A diagnostic display provides a scaled, color coded legend and indication of results for each disc analyzed as an overlay onto a mid-sagittal T2 -weighted MRI image of the lumbar spine for the patient being diagnosed. Clinical application of the embodiments provides a non-invasive, objective, pain-free, reliable approach for diagnosing painful vs. non-painful discs by simply extending and enhancing the utility of otherwise standard MRI exams of the lumbar spine.
摘要翻译：提供MR光谱（MRS）系统和方法用于诊断慢性，严重腰痛患者（DDD-MRS）中的疼痛和非疼痛的椎间盘。 DDD-MRS脉冲序列产生并获得椎间盘核内的DDD-MRS光谱，用于后续信号处理和诊断分析。接口DDD-MRS信号处理器接收所获得的DDD-MRS光谱的输出信号，并配置为通过选择性地进行最佳信道选择，相位和频率校正以及帧编辑的自动化系统来优化信噪比（SNR）适用于给定的采集系列。诊断处理器基于加权因子集合来计算盘的诊断值，该加权因子集合使用从与获得和处理的MRS光谱中提取的MRS数据沿着与多个化学物质相关联的区域，所述化学物质与疼痛与非痛苦盘相关。诊断显示提供缩放的颜色编码的图例和针对被诊断为患者的腰椎的中矢状T2加权MRI图像分析的每个椎间盘的结果的指示。实施例的临床应用提供了通过简单地扩展和增强腰椎否则的标准MRI检查的实用性来诊断疼痛与非痛性椎间盘的非侵入性，客观，无痛，可靠的方法。

6. 发明申请

WO2012071566A2 SYSTEMS AND METHODS FOR AUTOMATED VOXELATION OF REGIONS OF INTEREST FOR MAGNETIC RESONANCE SPECTROSCOPY 审中-公开
标题翻译：用于磁共振光谱的感兴趣区域的自动体积化的系统和方法
公开(公告)号：WO2012071566A2
公开(公告)日：2012-05-31
申请号：PCT/US2011/062137
申请日：2011-11-23
申请人： NOCIMED, LLC , CLAUDE, John, P. , PEACOCK, James, C. , KANE, Paul, H.
发明人： CLAUDE, John, P. , PEACOCK, James, C. , KANE, Paul, H.
IPC分类号： A61B5/055
CPC分类号： G06K9/34 , A61B5/055 , G01R33/485 , G01R33/543 , G06T7/11 , G06T7/75 , G06T2207/10088 , G06T2207/30012
摘要： A system and method for automating an appropriate voxel prescription in a uniquely definable region of interest (ROI) in a tissue of a patient is provided, such as for purpose of conducting magnetic resonance spectroscopy (MRS) in the ROI. The dimensions and coordinates of a single three dimensional rectilinear volume (voxel) within a single region of interest (ROI) are automatically identified. This is done, in some embodiments by: (1) applying statistically identified ROI search areas within a field of view (FOV); (2) image processing an MRI image to smooth the background and enhance a particular structure useful to define the ROI; (3) identifying a population of pixels that define the particular structure; (4) performing a statistical analysis of the pixel population to fit a 2D model such as an ellipsoid to the population and subsequently fit a rectilinear shape within the model; (5) repetiting elements (1) through (4) using multiple images that encompass the 3D ROI to create a 3D rectilinear shape; (6) a repetition of elements (1) through (5) for multiple ROIs with a common FOV. A manual interface may also be provided, allowing for override to replace by manual prescription, assistance to identify structures (e.g. clicking on disc levels), or modifying the automated voxel (e.g. modify location, shape, or one or more dimensions).
摘要翻译：提供了用于在患者组织中的唯一可定义的感兴趣区域（ROI）中自动化适当的体素处方的系统和方法，例如用于在患者的组织中进行磁共振波谱（MRS） ROI。自动识别单个感兴趣区域（ROI）内的单个三维直线体积（体素）的尺寸和坐标。这在一些实施例中通过以下来完成：（1）在视场（FOV）内应用统计上识别的ROI搜索区域; （2）对MRI图像进行图像处理以平滑背景并增强用于定义ROI的特定结构; （3）识别定义特定结构的像素群; （4）对像素群体进行统计分析，以将2D模型（例如椭球体）拟合至群体，并随后在模型内拟合直线形状; （5）使用包含3D ROI的多个图像重复元素（1）至（4）以创建3D直线形状; （6）对于具有共同FOV的多个ROI重复元素（1）至（5）。手动界面也可以被提供，允许替代手动处方，帮助识别结构（例如，点击光盘水平），或修改自动体素（例如修改位置，形状或一个或多个维度）。 p>

7. 发明申请

WO2011143468A2 LOW PROFILE ELECTRODE ASSEMBLY 审中-公开
标题翻译：低剖面电极组件
公开(公告)号：WO2011143468A2
公开(公告)日：2011-11-17
申请号：PCT/US2011036310
申请日：2011-05-12
申请人： SHIFAMED LLC , SALAHIEH AMR , LEPAK JONAH , LEUNG EMMA , BRANDT BRIAN D , CLAUDE JOHN P
发明人： SALAHIEH AMR , LEPAK JONAH , LEUNG EMMA , BRANDT BRIAN D , CLAUDE JOHN P
IPC分类号： A61B18/18 , A61B18/14 , A61M25/01 , A61M29/02
CPC分类号： A61B1/05 , A61B1/06 , A61B5/01 , A61B5/0422 , A61B5/6853 , A61B5/6855 , A61B5/6858 , A61B18/1206 , A61B18/1492 , A61B18/1815 , A61B2017/003 , A61B2017/00867 , A61B2017/22038 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00083 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00232 , A61B2018/00238 , A61B2018/00267 , A61B2018/00285 , A61B2018/00291 , A61B2018/00357 , A61B2018/00375 , A61B2018/00613 , A61B2018/00642 , A61B2018/00702 , A61B2018/00744 , A61B2018/00791 , A61B2018/00797 , A61B2018/00839 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/124 , A61B2018/1465 , A61B2090/065 , A61B2090/3966 , A61B2217/007 , A61B2562/125 , A61B2562/164 , A61M25/0108 , A61M25/0133 , A61M25/0147 , A61M25/04 , A61M25/10 , A61M25/1011 , A61M2025/0681 , A61N1/05 , A61N5/02 , C08L2201/12
摘要： A tissue electrode assembly includes a membrane configured to form an expandable, conformable body that is deployable in a patient. The assembly further includes a flexible circuit positioned on a surface of the membrane and comprising at least one base substrate layer, at least one insulating layer and at least one planar conducting layer. An electrically-conductive electrode covers at least a portion of the flexible circuit and a portion of the surface of the membrane not covered by the flexible circuit, wherein the electrically-conductive electrode is foldable upon itself with the membrane to a delivery conformation having a diameter suitable for minimally-invasive delivery of the assembly to the patient.
摘要翻译：组织电极组件包括被配置成形成可部署在患者体内的可扩张的适形身体的膜。组件还包括位于膜的表面上并包括至少一个基底层，至少一个绝缘层和至少一个平面导电层的柔性电路。导电电极覆盖柔性电路的至少一部分，并且膜的表面的一部分未被柔性电路覆盖，其中导电电极可以自身与膜折叠成具有直径的输送构型适合于将组件的微创输送递送给患者。

8. 发明申请

WO2011047197A3 MR SPECTROSCOPY SYSTEM AND METHOD FOR DIAGNOSING PAINFUL AND NON-PAINFUL INTERVERTEBRAL DISCS 审中-公开
标题翻译： MR光谱系统和用于诊断疼痛和非疼痛椎间盘的方法
公开(公告)号：WO2011047197A3
公开(公告)日：2011-09-22
申请号：PCT/US2010052737
申请日：2010-10-14
申请人： NOCIMED LLC , UNIV CALIFORNIA , PEACOCK JAMES C , CLAUDE JOHN P , KANE PAUL H , LOTZ JEFFREY C
发明人： PEACOCK JAMES C , CLAUDE JOHN P , KANE PAUL H , LOTZ JEFFREY C
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/407 , A61B5/4514 , A61B5/4824 , A61B5/7203 , G01R33/34069 , G01R33/3415 , G01R33/4616 , G01R33/485 , G01R33/565 , G01R33/56527
摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs. A diagnostic display provides a scaled, color coded legend and indication of results for each disc analyzed as an overlay onto a mid-sagittal T2 -weighted MRI image of the lumbar spine for the patient being diagnosed. Clinical application of the embodiments provides a non-invasive, objective, pain-free, reliable approach for diagnosing painful vs. non-painful discs by simply extending and enhancing the utility of otherwise standard MRI exams of the lumbar spine.
摘要翻译：磁共振波谱仪（MRS）系统和方法可用于诊断慢性严重腰痛患者（DDD-MRS）中的疼痛和非疼痛椎间盘。 DDD-MRS脉冲序列在椎间盘核内产生并获取DDD-MRS光谱，用于稍后的信号处理和诊断分析。接口DDD-MRS信号处理器接收所获取的DDD-MRS谱的输出信号，并被配置为通过选择性地进行最佳信道选择，相位和频率校正和帧编辑的自动化系统来优化信噪比（SNR）适用于特定的收购系列。诊断处理器基于加权因子集合来计算盘片的诊断值，所述加权因子集合使用MRS数据，所述MRS数据从与已经与疼痛与非疼痛盘片相关的多种化学物质相关联的区域获取并处理MRS光谱中提取。诊断显示器提供缩放的颜色编码的图例和每个椎间盘的结果指示，作为覆盖到被诊断患者的腰椎的中间矢状T2加权MRI图像上的覆盖物。实施例的临床应用通过简单地扩展和增强对腰椎的其他标准MRI检查的实用性提供了非侵入性，客观，无痛，可靠的方法来诊断疼痛与非疼痛椎间盘。

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