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1. 发明申请

WO2007053853A3 SYSTEM AND METHOD FOR SIMULTANEOUS CAPPING/DE-CAPPING OF STORAGE CONTAINERS IN AN ARRAY 审中-公开
标题翻译：用于在阵列中同时存储/解封存储容器的系统和方法
公开(公告)号：WO2007053853A3
公开(公告)日：2007-11-29
申请号：PCT/US2006060457
申请日：2006-11-01
申请人： NEXUS BIOSYSTEMS INC , NEEPER ROBERT K , BRIDWELL JOHN
发明人： NEEPER ROBERT K , BRIDWELL JOHN
IPC分类号： B65B7/28
CPC分类号： B65B7/2821 , B65B7/2835 , B67B7/02 , G01N35/028 , G01N2035/0405
摘要： The system for removing or replacing caps for vials in a fixed array includes a removable cartridge with a plurality of sets of gripper plates corresponding to the number of columns in the array. Each plate has a plurality of gripper arms corresponding to the number of rows in the array. The gripper arms have hooked ends which are oriented in opposite directions in each set of plates. Relative positioning of the gripper arms is varied by one or more rotating cams, which cause the gripper arms on one plate of each set to move relative to the gripper arms of the other plate(s) of the set, varying the combined width and/or relative angle of the gripper arms to manipulate a cap inserted into the end of each vial. The plurality of plate sets and gripper arms allow all vials in the array to be capped or de-capped simultaneously.
摘要翻译：用于移除或替换固定阵列中的小瓶盖的系统包括具有对应于阵列中的列数的多组夹持板的可移除盒。每个板具有对应于阵列中的行数的多个夹臂。夹臂具有在每组板中以相反方向取向的钩状端部。夹爪臂的相对定位通过一个或多个旋转凸轮来改变，这导致每组中的一个板上的夹臂相对于该组中的其它板的夹臂移动，改变组合的宽度和/ 或夹持器臂的相对角度来操纵插入每个小瓶的端部中的帽。多个板组和夹持臂允许阵列中的所有小瓶同时被封盖或去封盖。

2. 发明申请

WO2007087546A2 AUTOMATED SYSTEM FOR STORING, RETREIVING AND MANAGING SAMPLES 审中-公开
标题翻译：用于存储，恢复和管理样品的自动化系统
公开(公告)号：WO2007087546A2
公开(公告)日：2007-08-02
申请号：PCT/US2007060936
申请日：2007-01-23
申请人： NEXUS BIOSYSTEMS INC , NEEPER ROBERT K , AFFLECK RHETT L , LILLIG JOHN E
发明人： NEEPER ROBERT K , AFFLECK RHETT L , LILLIG JOHN E
IPC分类号： B01L9/00
CPC分类号： G01N35/0099 , G01N35/00732 , G01N2035/00752 , Y10T436/11 , Y10T436/113332 , Y10T436/114165
摘要： An automated storage system for storing large quantities of samples in trays includes a storage compartment, a tray shuttle compartment abutting the storage compartment on one side and a plurality of independent modules on the other side. The modules perform processing of samples that are retrieved from the storage compartment by a tray shuttle, including extraction of selected samples from retrieved source trays and transfer of the selected samples into a separate, destination tray that can be further processed or removed from the system for use. The independent operation of the modules permits handling and processing to be performed simultaneously by different modules while the tray shuttle accesses additional samples within the storage compartment. In one embodiment, a vertical carousel is used to vertically align a desired tray with the tray shuttle, while the tray shuttle operates within a horizontal plane.
摘要翻译：用于将大量样品储存在托盘中的自动存储系统包括：储存室，在一侧邻接储藏室的托盘穿梭隔室和另一侧上的多个独立模块。模块执行通过托盘穿梭从储存室取出的样品的处理，包括从检索的源托盘提取所选样品并将所选样品转移到单独的目的地托盘中，所述目的托盘可以进一步处理或从系统中移除使用。模块的独立操作允许不同模块同时执行处理和处理，而托盘穿梭器访问存储隔间内的附加样品。在一个实施例中，垂直转盘用于将期望的托盘垂直地对准托盘梭，而托盘梭在水平面内运行。

3. 发明申请

WO2011153279A2 AUTOMATED STORAGE SYSTEM FOR HIGH DENSITY STORAGE 审中-公开
标题翻译：自动存储系统用于高密度存储
公开(公告)号：WO2011153279A2
公开(公告)日：2011-12-08
申请号：PCT/US2011038815
申请日：2011-06-01
申请人： NEXUS BIOSYSTEMS INC , NEEPER ROBERT K
发明人： NEEPER ROBERT K
IPC分类号： G01N35/00 , G01N1/00
CPC分类号： G01N35/0099
摘要： Within a storage compartment, closely spaced rows of adjacent stacks are supported on a plurality of parallel sliding rails. A pair of coordinated robots is positioned with one robot on one side of the stacks to push the stacks within a selected row toward the other robot. The pushing robot on one side of the row starts off with a starting stack supported in its support arms. The pushing robot pushes the starting stack into one end of the selected row, causing the row to shift toward the waiting receiving robot, which receives the stack at the opposite end of the row from the starting stack. A series of pushes between the two robots moves a stack containing a desired sample into alignment with access port in the storage compartment.
摘要翻译：在储藏室内，紧密排列的相邻堆叠的行被支撑在多个平行的滑轨上。一对协调的机器人被定位成一个机器人位于堆叠的一侧，以将堆栈在选定的行内推向另一个机器人。在行的一侧的推动机器人从其支撑臂中支撑起始堆栈开始。推动机器人将启动堆栈推动到所选行的一端，导致该行朝向等待的接收机器人移动，该接收机器人在起始堆栈的相对端处接收堆栈。两个机器人之间的一系列推动将含有所需样品的堆叠移动到与储存室中的进入口对准。

4. 发明申请

WO2011050112A3 GRIPPER APPARATUS AND METHOD FOR CONTAINERS OF DIFFERENT SIZES 审中-公开
标题翻译：用于不同尺寸容器的抓取装置和方法
公开(公告)号：WO2011050112A3
公开(公告)日：2011-09-29
申请号：PCT/US2010053446
申请日：2010-10-20
申请人： NEXUS BIOSYSTEMS INC , NEEPER ROBERT K
发明人： NEEPER ROBERT K
IPC分类号： B25J15/00 , B25J19/00 , F16H1/28
CPC分类号： B25J15/0028 , B25J9/102 , B25J15/10 , B66C1/44 , Y10S294/902 , Y10S294/907 , Y10S901/38
摘要： A gripper apparatus for removing and replacing objects such as containers or vials in an array of containers has a gripper head which extends downward from a support arm, a planetary gear assembly mounted in the gripper head including at least three planet gears, and at least one gripping pin extending downward from each planet gear and projecting beyond a lower end of the gripper head. A drive motor drives the planetary gear assembly to rotate the planet gears in opposite directions, moving the pins inward and outward along predetermined paths to grip and carry an object and release the object when in a desired location.
摘要翻译：用于移除和替换诸如容器阵列中的容器或小瓶的物体的抓取装置具有从支撑臂向下延伸的抓取头，安装在抓取头中的行星齿轮组件，该行星齿轮组件包括至少三个行星齿轮，并且至少一个夹持销从每个行星齿轮向下延伸并突出超过夹头的下端。驱动电机驱动行星齿轮组件以沿相反方向旋转行星齿轮，沿着预定路径向内和向外移动销以抓握并承载物体，并在处于期望位置时释放物体。

5. 发明申请

WO2007087546A3 AUTOMATED SYSTEM FOR STORING, RETREIVING AND MANAGING SAMPLES 审中-公开
标题翻译：用于存储，恢复和管理样品的自动化系统
公开(公告)号：WO2007087546A3
公开(公告)日：2008-07-24
申请号：PCT/US2007060936
申请日：2007-01-23
申请人： NEXUS BIOSYSTEMS INC , NEEPER ROBERT K , AFFLECK RHETT L , LILLIG JOHN E
发明人： NEEPER ROBERT K , AFFLECK RHETT L , LILLIG JOHN E
IPC分类号： B01L9/00 , B01L3/00
CPC分类号： G01N35/0099 , G01N35/00732 , G01N2035/00752 , Y10T436/11 , Y10T436/113332 , Y10T436/114165
摘要： An automated storage system for storing large quantities of samples in trays includes a storage compartment, a tray shuttle compartment abutting the storage compartment on one side and a plurality of independent modules on the other side. The modules perform processing of samples that are retrieved from the storage compartment by a tray shuttle, including extraction of selected samples from retrieved source trays and transfer of the selected samples into a separate, destination tray that can be further processed or removed from the system for use. The independent operation of the modules permits handling and processing to be performed simultaneously by different modules while the tray shuttle accesses additional samples within the storage compartment. In one embodiment, a vertical carousel is used to vertically align a desired tray with the tray shuttle, while the tray shuttle operates within a horizontal plane.
摘要翻译：用于将大量样品储存在托盘中的自动存储系统包括：储存室，在一侧邻接储藏室的托盘穿梭隔室和另一侧上的多个独立模块。模块执行通过托盘穿梭从储存室取出的样品的处理，包括从检索的源托盘提取所选样品并将所选样品转移到单独的目的地托盘中，所述目的托盘可以进一步处理或从系统中移除使用。模块的独立操作允许不同模块同时执行处理和处理，而托盘穿梭器访问存储隔间内的附加样品。在一个实施例中，垂直转盘用于将期望的托盘垂直地对准托盘梭，而托盘梭在水平面内运行。

6. 发明申请

WO2004071067A3 DATA COMMUNICATION IN A LABORATORY ENVIRONMENT 审中-公开
标题翻译：实验室环境中的数据通信
公开(公告)号：WO2004071067A3
公开(公告)日：2005-01-27
申请号：PCT/US2004002617
申请日：2004-01-30
申请人： DISCOVERY PARTNERS INTERNAT , AFFLECK RHETT L , LEVIN ROBERT K , HANSEN ERIC , LILLIG JOHN E , NEEPER ROBERT K
发明人： AFFLECK RHETT L , LEVIN ROBERT K , HANSEN ERIC , LILLIG JOHN E , NEEPER ROBERT K
IPC分类号： A47B88/48 , B01L9/00 , C30B7/00 , C30B29/58 , G01N1/40 , G01N15/14 , G01N21/25 , G01N35/00 , G01N35/02 , G01N35/04 , G02B21/00 , G05B11/01 , G01N23/00
CPC分类号： C30B29/58 , B01L9/523 , C30B7/00 , G01N15/1475 , G01N21/253 , G01N35/0099 , G01N35/028 , G01N2001/4027 , G01N2015/1493 , G01N2035/00356 , G01N2035/00455 , G01N2035/00881 , G01N2035/042 , G01N2035/0425 , G01N2035/0463 , G02B21/0016
摘要： A system (100) for controlling the operation a one or more crystallography laboratories (110) according to Figure 1 comprises a user interface (150) coupled to an input device (120). The laboratories each house test samples and include imaging devices and automated machinery configured to retrieve specific samples for imaging. A controller is configured to receive scheduling information from the user interface indicating one or more samples to be imaged and one or more times to image the samples, wherein the controller communicates the scheduling information to each laboratory housing at least one of the test samples to be imagined. The laboratory devices may communicate asynchronously via a server configured to receive messages, determine process(es) to be executed based on the type of the received message, the source of the message, and/or the destination of the message. A transmit message may then be generated, through execution of the process(es), and transmitted to the determined destination device when available.
摘要翻译：根据图1的用于控制一个或多个晶体学实验室（110）的操作的系统（100）包括耦合到输入设备（120）的用户界面（150）。实验室各自测试样品，并包括成像设备和配置为检索特定样品进行成像的自动机械。控制器被配置为从用户界面接收指示要成像的一个或多个样本的调度信息，并且一次或多次以对图像进行成像，其中控制器将调度信息传送到每个实验室，将至少一个测试样本传送到可想而知的。实验室设备可以经由被配置为接收消息的服务器异步地进行通信，基于接收到的消息的类型，消息的源和/或消息的目的地来确定要执行的处理。然后可以通过执行该过程生成发送消息，并且如果可用，则发送到确定的目的地设备。

7. 发明申请

WO2013013246A1 METHOD AND DEVICE FOR COMPENSATION FOR DIMENSIONAL VARIATIONS IN LOW TEMPERATURE SAMPLE GROUP HOLDERS 审中-公开
标题翻译：用于补偿低温样品组容器中尺寸变化的方法和装置
公开(公告)号：WO2013013246A1
公开(公告)日：2013-01-24
申请号：PCT/US2012047883
申请日：2012-07-23
申请人： BROOKS AUTOMATION INC , NEEPER ROBERT K
发明人： NEEPER ROBERT K
IPC分类号： G01N35/00
CPC分类号： G01N35/0099 , G01N35/04 , G01N2035/00435
摘要： In accordance with one or more aspects of the disclosed embodiment an apparatus is provided. The apparatus includes a pick head configured to transfer sample containers to and from a sample group holder, at least one sensor connected to the pick head and configured to detect at least one predetermined feature of the sample group holder, and a controller configured to receive a detection signal from the at least one sensor corresponding to detection of the at least one predetermined feature, determine a change in a predetermined characteristic of the sample group holder based on a detected position of the at least one predetermined feature, and determine a location of one or more samples in the sample group holder to allow for the transfer of the one or more sample containers to and from the sample group holder based on the edge detection signal.
摘要翻译：根据所公开的实施例的一个或多个方面，提供了一种装置。所述设备包括拾取头，所述拾取头被配置为将样本容器传送到样品组保持器和从样品组保持器传送至少一个传感器，所述至少一个传感器连接到拾取头并被配置为检测样品组保持器的至少一个预定特征;以及控制器，基于检测到的至少一个预定特征的位置，确定来自所述至少一个传感器的对应于所述至少一个预定特征的检测的检测信号，确定所述样本组保持器的预定特性的变化，并确定一个或更多样品，以允许基于边缘检测信号将一个或多个样品容器传送到样品组保持器和从样品组保持器传送到样品组保持器。

8. 发明申请

WO2004069984A2 AUTOMATED IMAGING SYSTEM AND METHOD 审中-公开
标题翻译：自动成像系统及方法
公开(公告)号：WO2004069984A2
公开(公告)日：2004-08-19
申请号：PCT/US2004003239
申请日：2004-01-30
申请人： DISCOVERY PARTNERS INTERNAT , AFFLECK RHETT L , LEVIN ROBERT K , LILLIG JOHN E , NEEPER ROBERT K
发明人： AFFLECK RHETT L , LEVIN ROBERT K , LILLIG JOHN E , NEEPER ROBERT K
IPC分类号： A47B88/48 , B01L9/00 , C30B7/00 , C30B29/58 , G01N1/40 , G01N15/14 , G01N21/25 , G01N35/00 , G01N35/02 , G01N35/04 , G02B21/00 , C12M
CPC分类号： C30B29/58 , B01L9/523 , C30B7/00 , G01N15/1475 , G01N21/253 , G01N35/0099 , G01N35/028 , G01N2001/4027 , G01N2015/1493 , G01N2035/00356 , G01N2035/00455 , G01N2035/00881 , G01N2035/042 , G01N2035/0425 , G01N2035/0463 , G02B21/0016
摘要： An imaging system for automation of sample monitoring includes an image capture device that cooperates with a lens assembly for imaging the samples. A translator positions the lens assembly and/or a sample plate mount for acquisition of the images. Some embodiments of the system include a light source configured to provide low temperature, flash illumination of a sample plate.
摘要翻译：用于样品监测的自动化的成像系统包括与用于成像样品的透镜组件配合的图像捕获装置。翻转器定位透镜组件和/或样品板安装件以获取图像。系统的一些实施例包括被配置为提供样品板的低温闪光照明的光源。

9. 发明申请

WO2004070653A3 IMAGE ANALYSIS SYSTEM AND METHOD 审中-公开
标题翻译：图像分析系统与方法
公开(公告)号：WO2004070653A3
公开(公告)日：2005-01-06
申请号：PCT/US2004002633
申请日：2004-01-30
申请人： DISCOVERY PARTNERS INTERNAT , AFFLECK RHETT L , LEVIN ROBERT K , LILLIG JOHN E , NEEPER ROBERT K , EWING WILLIAM R , DESIENO DUANE , HANSEN ERIC , BODNAR MIKE
发明人： AFFLECK RHETT L , LEVIN ROBERT K , LILLIG JOHN E , NEEPER ROBERT K , EWING WILLIAM R , DESIENO DUANE , HANSEN ERIC , BODNAR MIKE
IPC分类号： A47B88/48 , B01L9/00 , C30B7/00 , C30B29/58 , G01N1/40 , G01N15/14 , G01N21/25 , G01N35/00 , G01N35/02 , G01N35/04 , G02B21/00 , G06K9/00 , A61B5/00
CPC分类号： C30B29/58 , B01L9/523 , C30B7/00 , G01N15/1475 , G01N21/253 , G01N35/0099 , G01N35/028 , G01N2001/4027 , G01N2015/1493 , G01N2035/00356 , G01N2035/00455 , G01N2035/00881 , G01N2035/042 , G01N2035/0425 , G01N2035/0463 , G02B21/0016
摘要： An image analysis system (200) and related methods for automation of the monitoring of samples to determine crystal growth. Samples are imaged from time to time using a set of imaging parameters. The resulting images are evaluated to determine the contents of the samples. If the evaluation of the image indicates the presence of crystals, the sample may be re-imaged using a different set of imaging parameters, and the resulting image analyzed to determine its contents. The sample may also be evaluated by generating multiple images of a sample using various sets of imaging parameters, identifying pixels that depict regions of interest in a plurality of images, merging the pixels from each region of interest into a composite image and analyzing the composite image. An image of a sample can also be evaluated by classifying the pixels of the image based on the contents of the sample that they depict, color-coding the pixels using the classifications, and displaying the colored image for analysis.
摘要翻译：一种图像分析系统（200）及相关方法，用于监测样品的自动化，以确定晶体生长。使用一组成像参数不时地对样本进行成像。评估所得图像以确定样品的内容。如果图像的评估表明晶体的存在，则可以使用不同的成像参数集来重新成像样品，并且分析所得到的图像以确定其内容。也可以通过使用各种成像参数集合生成样本的多个图像来评估样本，识别在多个图像中描绘感兴趣区域的像素，将来自每个感兴趣区域的像素合并到合成图像中并分析合成图像。样本的图像也可以通过基于它们描绘的样本的内容，使用分类对像素进行颜色编码，并显示彩色图像进行分析来对图像的像素进行分类来评估。

10. 发明申请

WO2004069409A2 AUTOMATED SAMPLE ANALYSIS SYSTEM AND METHOD 审中-公开
标题翻译：自动样本分析系统和方法
公开(公告)号：WO2004069409A2
公开(公告)日：2004-08-19
申请号：PCT/US2004002717
申请日：2004-01-30
申请人： DISCOVERY PARTNERS INTERNAT , AFFLECK RHETT L , BODNAR MIKE , LEVING ROBERT KENJIRO , LILLIG JOHN E , NEEPER ROBERT K
发明人： AFFLECK RHETT L , BODNAR MIKE , LEVING ROBERT KENJIRO , LILLIG JOHN E , NEEPER ROBERT K
IPC分类号： A47B88/48 , B01L9/00 , C30B7/00 , C30B29/58 , G01N1/40 , G01N15/14 , G01N21/25 , G01N35/00 , G01N35/02 , G01N35/04 , G02B21/00 , B01L
CPC分类号： C30B29/58 , B01L9/523 , C30B7/00 , G01N15/1475 , G01N21/253 , G01N35/0099 , G01N35/028 , G01N2001/4027 , G01N2015/1493 , G01N2035/00356 , G01N2035/00455 , G01N2035/00881 , G01N2035/042 , G01N2035/0425 , G01N2035/0463 , G02B21/0016
摘要： An automated biological sample analysis system and method for use in incubating and analyzing multiple samples for protein crystallization. A temperature controlled cabinet houses sample storage, sample transport, and sample imaging systems. The operation of the system is automated and can be controlled by software, which can be reconfigured remotely. An array of storage shelves includes multiple shelf columns arranged around a core. Multiple banks of removable shelves arranged as magazines are accessed through a door on the cabinet. Each shelf stores a multi-well plate and different sizes can be stored in different shelves. The core houses a sample transport system that includes a multi-axis robot that rotates about a vertical axis to access the shelves in the shelf array. The transport system retrieves and replaces the multi-well plates in the shelves and can move plates from the shelves to an imaging system where each sample can be automatically imaged.
摘要翻译：一种用于孵化和分析多个样品进行蛋白质结晶的自动化生物样品分析系统和方法。温度控制柜包含样品储存，样品运输和样品成像系统。系统的操作是自动化的，可以通过软件进行控制，可以远程重新配置。一组存储架包括围绕一个核心布置的多个搁架列。可以通过柜子上的门访问多个排列成杂志的可移动货架。每个货架存储多孔板，不同的尺寸可以存放在不同的货架上。核心包含一个样品输送系统，其中包括一个绕垂直轴旋转的多轴机器人，以便进入架子阵列中的货架。运输系统检索和取代货架中的多孔板，并可将板从货架移动到成像系统，每个样品可自动成像。

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