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1. 发明申请

WO2004071067A3 DATA COMMUNICATION IN A LABORATORY ENVIRONMENT 审中-公开
标题翻译：实验室环境中的数据通信
公开(公告)号：WO2004071067A3
公开(公告)日：2005-01-27
申请号：PCT/US2004002617
申请日：2004-01-30
申请人： DISCOVERY PARTNERS INTERNAT , AFFLECK RHETT L , LEVIN ROBERT K , HANSEN ERIC , LILLIG JOHN E , NEEPER ROBERT K
发明人： AFFLECK RHETT L , LEVIN ROBERT K , HANSEN ERIC , LILLIG JOHN E , NEEPER ROBERT K
IPC分类号： A47B88/48 , B01L9/00 , C30B7/00 , C30B29/58 , G01N1/40 , G01N15/14 , G01N21/25 , G01N35/00 , G01N35/02 , G01N35/04 , G02B21/00 , G05B11/01 , G01N23/00
CPC分类号： C30B29/58 , B01L9/523 , C30B7/00 , G01N15/1475 , G01N21/253 , G01N35/0099 , G01N35/028 , G01N2001/4027 , G01N2015/1493 , G01N2035/00356 , G01N2035/00455 , G01N2035/00881 , G01N2035/042 , G01N2035/0425 , G01N2035/0463 , G02B21/0016
摘要： A system (100) for controlling the operation a one or more crystallography laboratories (110) according to Figure 1 comprises a user interface (150) coupled to an input device (120). The laboratories each house test samples and include imaging devices and automated machinery configured to retrieve specific samples for imaging. A controller is configured to receive scheduling information from the user interface indicating one or more samples to be imaged and one or more times to image the samples, wherein the controller communicates the scheduling information to each laboratory housing at least one of the test samples to be imagined. The laboratory devices may communicate asynchronously via a server configured to receive messages, determine process(es) to be executed based on the type of the received message, the source of the message, and/or the destination of the message. A transmit message may then be generated, through execution of the process(es), and transmitted to the determined destination device when available.
摘要翻译：根据图1的用于控制一个或多个晶体学实验室（110）的操作的系统（100）包括耦合到输入设备（120）的用户界面（150）。实验室各自测试样品，并包括成像设备和配置为检索特定样品进行成像的自动机械。控制器被配置为从用户界面接收指示要成像的一个或多个样本的调度信息，并且一次或多次以对图像进行成像，其中控制器将调度信息传送到每个实验室，将至少一个测试样本传送到可想而知的。实验室设备可以经由被配置为接收消息的服务器异步地进行通信，基于接收到的消息的类型，消息的源和/或消息的目的地来确定要执行的处理。然后可以通过执行该过程生成发送消息，并且如果可用，则发送到确定的目的地设备。

2. 发明申请

WO2004069984A2 AUTOMATED IMAGING SYSTEM AND METHOD 审中-公开
标题翻译：自动成像系统及方法
公开(公告)号：WO2004069984A2
公开(公告)日：2004-08-19
申请号：PCT/US2004003239
申请日：2004-01-30
申请人： DISCOVERY PARTNERS INTERNAT , AFFLECK RHETT L , LEVIN ROBERT K , LILLIG JOHN E , NEEPER ROBERT K
发明人： AFFLECK RHETT L , LEVIN ROBERT K , LILLIG JOHN E , NEEPER ROBERT K
IPC分类号： A47B88/48 , B01L9/00 , C30B7/00 , C30B29/58 , G01N1/40 , G01N15/14 , G01N21/25 , G01N35/00 , G01N35/02 , G01N35/04 , G02B21/00 , C12M
CPC分类号： C30B29/58 , B01L9/523 , C30B7/00 , G01N15/1475 , G01N21/253 , G01N35/0099 , G01N35/028 , G01N2001/4027 , G01N2015/1493 , G01N2035/00356 , G01N2035/00455 , G01N2035/00881 , G01N2035/042 , G01N2035/0425 , G01N2035/0463 , G02B21/0016
摘要： An imaging system for automation of sample monitoring includes an image capture device that cooperates with a lens assembly for imaging the samples. A translator positions the lens assembly and/or a sample plate mount for acquisition of the images. Some embodiments of the system include a light source configured to provide low temperature, flash illumination of a sample plate.
摘要翻译：用于样品监测的自动化的成像系统包括与用于成像样品的透镜组件配合的图像捕获装置。翻转器定位透镜组件和/或样品板安装件以获取图像。系统的一些实施例包括被配置为提供样品板的低温闪光照明的光源。

3. 发明申请

WO2008112660A1 DEVICE AND METHOD FOR REMOVING A PEELABLE SEAL 审中-公开
标题翻译：用于去除可剥离密封件的装置和方法
公开(公告)号：WO2008112660A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/056450
申请日：2008-03-10
申请人： NEXUS BIOSYSTEMS, INC. , NEEPER, Robert, K. , AFFLECK, Rhett, L. , HOWARD, Roger
发明人： NEEPER, Robert, K. , AFFLECK, Rhett, L. , HOWARD, Roger
IPC分类号： G01N37/00
CPC分类号： B01L9/00 , B01L99/00 , B29C63/0013 , B32B38/10 , B32B43/006 , B67B7/00 , Y10T156/1168 , Y10T156/1174 , Y10T156/19 , Y10T156/195 , Y10T156/1956 , Y10T156/1978 , Y10T156/1989
摘要： A container or array of containers that is are sealed with a peelable seal is transported via a conveyor along a processing path toward a desealing station at which an adhesive surface having a width substantially the same as or greater than the width of the seal is pressed against the upper surface of the peelable seal. A collection rod applies a downward pressure on the adhesive surface, pressing it against the seal and keeping the container or container array in position on the conveyor as the plate moves with the conveyor. As the leading edge of the seal passes the collection rod, the adhesive surface is rolled upward, away from the plane of the seal, pulling up on the leading edge of the seal to separate it from the container or container array while the container or container array is held down by the roller. The removed seal is then discarded.
摘要翻译：用可剥离密封件密封的容器或容器阵列通过输送机沿着处理路径被输送到一个吸引站，在该站处，具有基本上等于或大于密封件的宽度的宽度的粘合剂表面被压紧可剥离密封件的上表面。收集杆在粘合剂表面上施加向下的压力，当压板随着输送机移动时，将其压靠在密封件上并将容器或容器阵列保持在输送机上的适当位置。当密封件的前缘通过收集杆时，粘合剂表面向上滚动，远离密封件的平面，在密封件的前缘上拉起，以将其与容器或容器阵列分开，同时容器或容器阵列被滚筒压住。然后将去除的密封件丢弃。

4. 发明申请

WO2007087546A3 AUTOMATED SYSTEM FOR STORING, RETREIVING AND MANAGING SAMPLES 审中-公开
标题翻译：用于存储，恢复和管理样品的自动化系统
公开(公告)号：WO2007087546A3
公开(公告)日：2008-07-24
申请号：PCT/US2007060936
申请日：2007-01-23
申请人： NEXUS BIOSYSTEMS INC , NEEPER ROBERT K , AFFLECK RHETT L , LILLIG JOHN E
发明人： NEEPER ROBERT K , AFFLECK RHETT L , LILLIG JOHN E
IPC分类号： B01L9/00 , B01L3/00
CPC分类号： G01N35/0099 , G01N35/00732 , G01N2035/00752 , Y10T436/11 , Y10T436/113332 , Y10T436/114165
摘要： An automated storage system for storing large quantities of samples in trays includes a storage compartment, a tray shuttle compartment abutting the storage compartment on one side and a plurality of independent modules on the other side. The modules perform processing of samples that are retrieved from the storage compartment by a tray shuttle, including extraction of selected samples from retrieved source trays and transfer of the selected samples into a separate, destination tray that can be further processed or removed from the system for use. The independent operation of the modules permits handling and processing to be performed simultaneously by different modules while the tray shuttle accesses additional samples within the storage compartment. In one embodiment, a vertical carousel is used to vertically align a desired tray with the tray shuttle, while the tray shuttle operates within a horizontal plane.
摘要翻译：用于将大量样品储存在托盘中的自动存储系统包括：储存室，在一侧邻接储藏室的托盘穿梭隔室和另一侧上的多个独立模块。模块执行通过托盘穿梭从储存室取出的样品的处理，包括从检索的源托盘提取所选样品并将所选样品转移到单独的目的地托盘中，所述目的托盘可以进一步处理或从系统中移除使用。模块的独立操作允许不同模块同时执行处理和处理，而托盘穿梭器访问存储隔间内的附加样品。在一个实施例中，垂直转盘用于将期望的托盘垂直地对准托盘梭，而托盘梭在水平面内运行。

5. 发明申请

WO2004070653A3 IMAGE ANALYSIS SYSTEM AND METHOD 审中-公开
标题翻译：图像分析系统与方法
公开(公告)号：WO2004070653A3
公开(公告)日：2005-01-06
申请号：PCT/US2004002633
申请日：2004-01-30
申请人： DISCOVERY PARTNERS INTERNAT , AFFLECK RHETT L , LEVIN ROBERT K , LILLIG JOHN E , NEEPER ROBERT K , EWING WILLIAM R , DESIENO DUANE , HANSEN ERIC , BODNAR MIKE
发明人： AFFLECK RHETT L , LEVIN ROBERT K , LILLIG JOHN E , NEEPER ROBERT K , EWING WILLIAM R , DESIENO DUANE , HANSEN ERIC , BODNAR MIKE
IPC分类号： A47B88/48 , B01L9/00 , C30B7/00 , C30B29/58 , G01N1/40 , G01N15/14 , G01N21/25 , G01N35/00 , G01N35/02 , G01N35/04 , G02B21/00 , G06K9/00 , A61B5/00
CPC分类号： C30B29/58 , B01L9/523 , C30B7/00 , G01N15/1475 , G01N21/253 , G01N35/0099 , G01N35/028 , G01N2001/4027 , G01N2015/1493 , G01N2035/00356 , G01N2035/00455 , G01N2035/00881 , G01N2035/042 , G01N2035/0425 , G01N2035/0463 , G02B21/0016
摘要： An image analysis system (200) and related methods for automation of the monitoring of samples to determine crystal growth. Samples are imaged from time to time using a set of imaging parameters. The resulting images are evaluated to determine the contents of the samples. If the evaluation of the image indicates the presence of crystals, the sample may be re-imaged using a different set of imaging parameters, and the resulting image analyzed to determine its contents. The sample may also be evaluated by generating multiple images of a sample using various sets of imaging parameters, identifying pixels that depict regions of interest in a plurality of images, merging the pixels from each region of interest into a composite image and analyzing the composite image. An image of a sample can also be evaluated by classifying the pixels of the image based on the contents of the sample that they depict, color-coding the pixels using the classifications, and displaying the colored image for analysis.
摘要翻译：一种图像分析系统（200）及相关方法，用于监测样品的自动化，以确定晶体生长。使用一组成像参数不时地对样本进行成像。评估所得图像以确定样品的内容。如果图像的评估表明晶体的存在，则可以使用不同的成像参数集来重新成像样品，并且分析所得到的图像以确定其内容。也可以通过使用各种成像参数集合生成样本的多个图像来评估样本，识别在多个图像中描绘感兴趣区域的像素，将来自每个感兴趣区域的像素合并到合成图像中并分析合成图像。样本的图像也可以通过基于它们描绘的样本的内容，使用分类对像素进行颜色编码，并显示彩色图像进行分析来对图像的像素进行分类来评估。

6. 发明申请

WO2004069409A3 AUTOMATED SAMPLE ANALYSIS SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2004069409A3
公开(公告)日：2004-08-19
申请号：PCT/US2004/002717
申请日：2004-01-30
申请人： DISCOVERY PARTNERS INTERNATIONAL , AFFLECK, Rhett, L. , BODNAR, Mike , LEVING, Robert, Kenjiro , LILLIG, John, E. , NEEPER, Robert, K.
发明人： AFFLECK, Rhett, L. , BODNAR, Mike , LEVING, Robert, Kenjiro , LILLIG, John, E. , NEEPER, Robert, K.
IPC分类号： G01N21/03
摘要： An automated biological sample analysis system and method for use in incubating and analyzing multiple samples for protein crystallization. A temperature controlled cabinet houses sample storage, sample transport, and sample imaging systems. The operation of the system is automated and can be controlled by software, which can be reconfigured remotely. An array of storage shelves includes multiple shelf columns arranged around a core. Multiple banks of removable shelves arranged as magazines are accessed through a door on the cabinet. Each shelf stores a multi-well plate and different sizes can be stored in different shelves. The core houses a sample transport system that includes a multi-axis robot that rotates about a vertical axis to access the shelves in the shelf array. The transport system retrieves and replaces the multi-well plates in the shelves and can move plates from the shelves to an imaging system where each sample can be automatically imaged.

7. 发明申请

WO2007087546A2 AUTOMATED SYSTEM FOR STORING, RETREIVING AND MANAGING SAMPLES 审中-公开
标题翻译：用于存储，恢复和管理样品的自动化系统
公开(公告)号：WO2007087546A2
公开(公告)日：2007-08-02
申请号：PCT/US2007060936
申请日：2007-01-23
申请人： NEXUS BIOSYSTEMS INC , NEEPER ROBERT K , AFFLECK RHETT L , LILLIG JOHN E
发明人： NEEPER ROBERT K , AFFLECK RHETT L , LILLIG JOHN E
IPC分类号： B01L9/00
CPC分类号： G01N35/0099 , G01N35/00732 , G01N2035/00752 , Y10T436/11 , Y10T436/113332 , Y10T436/114165
摘要： An automated storage system for storing large quantities of samples in trays includes a storage compartment, a tray shuttle compartment abutting the storage compartment on one side and a plurality of independent modules on the other side. The modules perform processing of samples that are retrieved from the storage compartment by a tray shuttle, including extraction of selected samples from retrieved source trays and transfer of the selected samples into a separate, destination tray that can be further processed or removed from the system for use. The independent operation of the modules permits handling and processing to be performed simultaneously by different modules while the tray shuttle accesses additional samples within the storage compartment. In one embodiment, a vertical carousel is used to vertically align a desired tray with the tray shuttle, while the tray shuttle operates within a horizontal plane.
摘要翻译：用于将大量样品储存在托盘中的自动存储系统包括：储存室，在一侧邻接储藏室的托盘穿梭隔室和另一侧上的多个独立模块。模块执行通过托盘穿梭从储存室取出的样品的处理，包括从检索的源托盘提取所选样品并将所选样品转移到单独的目的地托盘中，所述目的托盘可以进一步处理或从系统中移除使用。模块的独立操作允许不同模块同时执行处理和处理，而托盘穿梭器访问存储隔间内的附加样品。在一个实施例中，垂直转盘用于将期望的托盘垂直地对准托盘梭，而托盘梭在水平面内运行。

8. 发明申请

WO2004092903A3 SPOT FINDING ALGORITHM USING IMAGE RECOGNITION SOFTWARE 审中-公开
标题翻译：使用图像识别软件的点搜索算法
公开(公告)号：WO2004092903A3
公开(公告)日：2005-09-15
申请号：PCT/US2004011282
申请日：2004-04-08
申请人： DISCOVERY PARTNERS INTERNAT , EWING WILLIAM R , DESIENO DUANE , AFFLECK RHETT L
发明人： EWING WILLIAM R , DESIENO DUANE , AFFLECK RHETT L
IPC分类号： G01N31/00 , G06F20060101 , G06K9/00 , G06T7/00
CPC分类号： G06T7/75 , G06T2207/30004
摘要： A plurality of samples are tested for their ability to enhance or inhibit a biological process in a multiplexed diffusive assay. The assay is imaged after the biological process has produced spots in a medium that indicate the tested enhancing or inhibiting ability of the samples. The image containing the resulting spots are evaluated to determine which samples caused the spots to form. The location of spots are identified by user selection or through a gradient triangulation technique that determines spot locations by analyzing the slope of pixel intensities in numerous subimages. The spots may also be analyzed by parametrically modeling the spots and comparing the spot characteristics in the image to a spot function, to determine the location of hit spots in the image. The hit spot locations, corresponding to the location of tested samples in the assay that enhanced or inhibited the biological process, are output to facilitate further analysis of the test samples.
摘要翻译：测试多个样品在多重扩散测定中增强或抑制生物过程的能力。在生物学过程在培养基中产生指示样品的增强或抑制能力的斑点之后，测定成像。评估含有所得斑点的图像，以确定哪些样品导致斑点形成。斑点的位置通过用户选择或通过梯度三角测量技术来识别，其通过分析许多子图像中像素强度的斜率来确定点位置。也可以通过对斑点进行参数建模和将图像中的斑点特征与斑点函数进行比较来分析斑点，以确定图像中命中点的位置。输出对应于增强或抑制生物过程的测定中测试样品的位置的命中点位置，以便于进一步分析测试样品。

9. 发明申请

WO2004071067A2 DATA COMMUNICATION IN A LABORATORY ENVIRONMENT 审中-公开
标题翻译：实验室环境中的数据通信
公开(公告)号：WO2004071067A2
公开(公告)日：2004-08-19
申请号：PCT/US2004/002617
申请日：2004-01-30
申请人： DISCOVERY PARTNERS INTERNATIONAL , AFFLECK, Rhett, L. , LEVIN, Robert, K. , HANSEN, Eric , LILLIG, John, E. , NEEPER, Robert, K.
发明人： AFFLECK, Rhett, L. , LEVIN, Robert, K. , HANSEN, Eric , LILLIG, John, E. , NEEPER, Robert, K.
IPC分类号： H04N
CPC分类号： C30B29/58 , B01L9/523 , C30B7/00 , G01N15/1475 , G01N21/253 , G01N35/0099 , G01N35/028 , G01N2001/4027 , G01N2015/1493 , G01N2035/00356 , G01N2035/00455 , G01N2035/00881 , G01N2035/042 , G01N2035/0425 , G01N2035/0463 , G02B21/0016
摘要： A system for controlling the operation a one or more crystallography laboratory comprises a user interface coupled to an input device. The laboratories each house test samples and include imaging devices and automated machinery configured to retrieve specific samples for imaging. A controller is configured to receive scheduling information from the user interface indicating one or more samples to be imaged and one or more times to image the samples, wherein the controller communicates the scheduling information to each laboratory housing at least one of the test samples to be imaged. The laboratory devices may communicate asynchronously via a server configured to receive messages, determine process(es) to be executed based on the type of the received message, the source of the message, and/or the destination of the message. A transmit message may then be generated, through execution of the process(es), and transmitted to the determined destination device when available.
摘要翻译：用于控制一个或多个晶体学实验室的操作的系统包括耦合到输入设备的用户界面。实验室各自测试样品，并包括成像设备和配置为检索特定样品进行成像的自动机械。控制器被配置为从用户界面接收指示要成像的一个或多个样本的调度信息，并且一次或多次以对图像进行成像，其中控制器将调度信息传送到每个实验室，将至少一个测试样本传送到成像。实验室设备可以经由被配置为接收消息的服务器异步地进行通信，基于接收到的消息的类型，消息的源和/或消息的目的地来确定要执行的处理。然后可以通过执行该过程生成发送消息，并且如果可用，则发送到确定的目的地设备。

10. 发明申请

WO2004069984A3 AUTOMATED IMAGING SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2004069984A3
公开(公告)日：2004-08-19
申请号：PCT/US2004/003239
申请日：2004-01-30
申请人： DISCOVERY PARTNERS INTERNATIONAL , AFFLECK, Rhett, L. , LEVIN, Robert, K. , LILLIG, John, E. , NEEPER, Robert, K.
发明人： AFFLECK, Rhett, L. , LEVIN, Robert, K. , LILLIG, John, E. , NEEPER, Robert, K.
IPC分类号： G01N21/84
摘要： An imaging system (200) for automation of sample monitoring includes an image capture device (214) that cooperates with a lens assembly (230) for imaging the samples on a sample plate (212) on a sample plate mount (210) the lens assembly (230) and another translator positions the sample plate (210) for acquisition of the images. Some embodiments of the system include a light source (216) configured to provide low temperature, flash illumination of a sample plate.

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