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1. 发明申请

WO0068263A2 STEREOSELECTIVE ANTIFIBRILLOGENIC PEPTIDES AND PEPTIDOMIMETICS THEREOF 审中-公开
标题翻译：立体选择性抗菌肽及其衍生物
公开(公告)号：WO0068263A2
公开(公告)日：2000-11-16
申请号：PCT/CA0000515
申请日：2000-05-04
申请人： NEUROCHEM INC , CHALIFOUR ROBERT , GERVAIS FRANCINE , GUPTA AJAY
发明人： CHALIFOUR ROBERT , GERVAIS FRANCINE , GUPTA AJAY
IPC分类号： C12N5/06 , A61K38/00 , A61K49/00 , A61P19/02 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/06 , A61P35/00 , C07K5/093 , C07K5/11 , C07K5/117 , C07K7/06 , C07K14/47 , A61K38/17 , A61K51/00 , C12N5/00 , G01N33/68
CPC分类号： C07K14/4711 , A61K38/00
摘要： The present invention relates to antifibrillogenic agents for inhibiting amyloidosis and/or for cytoprotection for the treatment of amyloidosis disorders. These agents include peptides, isomers thereof and peptidomimetic compounds thereof. These agents comprise a peptide having a sequence identified from the glycosaminoglycan (GAG) binding region and the prot-prot interaction region of the amyloid protein. The peptide has at least one [D] amino acid isomer substitution. The invention also relates to the peptide bound to a label for in vivo imaging of amyloid deposits.
摘要翻译：本发明涉及用于抑制淀粉样变性和/或细胞保护用于治疗淀粉样变性病症的抗纤维蛋白原化剂。这些试剂包括肽，其异构体和拟肽化合物。这些试剂包含具有从糖胺聚糖（GAG）结合区和淀粉样蛋白的prot-prot相互作用区确定的序列的肽。该肽具有至少一个[D]氨基酸异构体取代。本发明还涉及与淀粉样蛋白沉积物的体内成像的标记结合的肽。

2. 发明申请

WO0103680A3 COMPOUNDS FOR INHIBITING DISEASES AND PREPARING CELLS FOR TRANSPLANTATION 审中-公开
标题翻译：用于抑制疾病和制备细胞进行移植的化合物
公开(公告)号：WO0103680A3
公开(公告)日：2002-07-11
申请号：PCT/GB0002623
申请日：2000-07-07
申请人： ISIS INNOVATION , NEUROCHEM INC , UNIV KINGSTON , CLARK ANNE , FRASER PAUL , VERCHERE BRUCE , GUPTA AJAY , MIGNEAULT DAVID , SZAREK WALTER , WEAVER DONALD
发明人： CLARK ANNE , FRASER PAUL , VERCHERE BRUCE , GUPTA AJAY , MIGNEAULT DAVID , SZAREK WALTER , WEAVER DONALD
IPC分类号： A61K31/00 , A61K31/185 , A61K31/194 , A61K31/44 , A61K31/47 , A61K31/472 , A61P3/00 , A61P25/00 , C07K14/47 , A61K31/145 , A61K31/445 , A61K31/451 , A61K31/662
CPC分类号： A61K31/662 , A61K31/00 , A61K31/185 , A61K31/194 , A61K31/44 , A61K31/47 , A61K31/472 , C07K14/4711
摘要： Methods and compositions are provided for inhibiting, preventing and treating amyloid depositions, e.g. in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. Accordingly, the compositions and method of the invention are useful for inhibiting diabetes. The invention also provides a process for the preparation of cells suitable for transplantation into a mammal, which cells are capable of forming fibrils, said process comprising contacting the cells with an inhibitor of fibril formation. In particular the process prepares cells for use in a method of treating diabetes. Also provided are a culture medium comprising the inhibitor more particularly selected from the group consisting of 3-(3-hydroxy-1-propy)amino-1-propanesulfonic acid; DL-2-amino-5-phosphovaleric acid; 4-Phenyl-1-(3'-sulfopropyl)-1,2,3,6-tetrahydropyridine, cyclohexylsulfamic acid, O-phospho-L-serine, hexafluoroglutaric acid, 8-methoxyquinoline-5-sulfonic acid, 3-amino-2hydroxy-1-propanesulfonic acid, and 3-dimethylamino-1-propanesulfonic acid and 1,2,3,4-tetrahydroisoquinoleine.
摘要翻译：提供了用于抑制，预防和治疗淀粉样蛋白沉积的方法和组合物，例如。在胰岛中，淀粉样蛋白沉积物是胰岛淀粉样蛋白多肽（IAPP）相关的淀粉样蛋白沉积或沉积物。因此，本发明的组合物和方法可用于抑制糖尿病。本发明还提供了一种制备适于移植到哺乳动物中的细胞的方法，所述细胞能够形成原纤维，所述方法包括使细胞与原纤维形成抑制剂接触。特别地，该方法准备细胞用于治疗糖尿病的方法。还提供了包含更特别选自3-（3-羟基-1-丙基）氨基-1-丙磺酸的抑制剂的培养基; DL-2-氨基-5-磷酸戊酸; 4-苯基-1-（3'-磺基丙基）-1,2,3,6-四氢吡啶，环己基氨基磺酸，O-磷酸-L-丝氨酸，六氟戊二酸，8-甲氧基喹啉-5-磺酸，3-氨基 - 2-羟基-1-丙磺酸和3-二甲基氨基-1-丙磺酸和1,2,3,4-四氢异喹啉。

3. 发明申请

WO2012104864A1 ADIABATIC REGENERATION OF SULFUR CAPTURING ADSORBENTS 审中-公开
标题翻译：硫吸附吸附剂的绝热再生
公开(公告)号：WO2012104864A1
公开(公告)日：2012-08-09
申请号：PCT/IN2011000854
申请日：2011-12-14
申请人： RELIANCE IND LID , DAS ASIT , GUPTA AJAY , VAJA BHARAT KUMAR , TULSI GOVIND , BISHT HARENDER , SINHA JEYAVEL , JAGUTSE SHUBHANGI , MANDAL SUKUMAR
发明人： DAS ASIT , GUPTA AJAY , VAJA BHARAT KUMAR , TULSI GOVIND , BISHT HARENDER , SINHA JEYAVEL , JAGUTSE SHUBHANGI , MANDAL SUKUMAR
IPC分类号： C10G25/12 , B01J20/34
CPC分类号： B01J20/3466 , B01J20/3433 , B01J20/3458 , C10G25/12 , C10G2300/202 , C10G2300/807
摘要： The present invention provides a process for regeneration of the sulfur capturing spent adsorbents after sulfur capturing using a hydrolyzing agent under adiabatic conditions. In accordance with the process of the present invention hydrolyzing agent is introduced to the spent adsorbent in a controlled manner such that the exothermic heat generated within the adsorbent bed does not rise above the predetermined temperature limit.
摘要翻译：本发明提供了一种在绝热条件下使用水解剂俘获硫后再生硫捕获用过的吸附剂的方法。根据本发明的方法，水解剂以受控的方式引入失效的吸附剂，使得吸附剂床内产生的放热不会超过预定的温度极限。

4. 发明申请

WO2010140160A3 SYSTEM AND METHOD FOR REPRESENTING USER INTERACTION WITH A WEB SERVICE 审中-公开
标题翻译：用于表示用户与WEB服务交互的系统和方法
公开(公告)号：WO2010140160A3
公开(公告)日：2011-04-28
申请号：PCT/IN2009000327
申请日：2009-06-05
申请人： HEWLETT PACKARD DEVELOPMENT CO , MANJUNATH GEETHA , GUPTA AJAY
发明人： MANJUNATH GEETHA , GUPTA AJAY
IPC分类号： G06F17/27 , G06F9/45 , G06F15/16
CPC分类号： G06F9/4443 , G06F11/34 , H04L29/08675 , H04L43/04 , H04L67/22 , H04N21/44222
摘要： Disclosed is a system and method for representing user interaction with a web service. The method comprises the steps of acquiring a representation of the actions of a user performing a task with the web service (120); analysing the acquired actions (125) to determine semantics (130) and at least one variable describing the user actions (140); and representing the semantics and the at least one variable in at least one script file (170), the at least one script file supporting performance of user interaction with the web service based on the semantics and a value provided for the variable.
摘要翻译：公开了一种用于表示用户与web服务的交互的系统和方法。所述方法包括以下步骤：获取所述web服务（120）执行任务的用户的动作的表示; 分析获取的动作（125）以确定语义（130）和描述用户动作（140）的至少一个变量; 并且在至少一个脚本文件（170）中表示所述语义和所述至少一个变量，所述至少一个脚本文件基于所述语义和为所述变量提供的值来支持与所述web服务的用户交互的性能。

5. 发明申请

WO2007145819A3 CUSTOMER RELATIONSHIP MANAGEMENT SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2007145819A3
公开(公告)日：2008-12-18
申请号：PCT/US2007012704
申请日：2007-05-29
申请人： SUGARCRM INC , BAROUDI SADEK , SMITH ROGER , TAYLOR JACOB , ROBERTS JOHN , ORAM CLINTON , GUPTA AJAY , ITANI MAJED
发明人： BAROUDI SADEK , SMITH ROGER , TAYLOR JACOB , ROBERTS JOHN , ORAM CLINTON , GUPTA AJAY , ITANI MAJED
IPC分类号： G06F3/00 , G06F3/048 , G06Q10/00
CPC分类号： G06Q10/10
摘要： A software-based customer relationship management system and method.

6. 发明申请

WO2007075877A2 PARENTERAL NUTRITION COMPOSITION CONTAINING IRON 审中-公开
标题翻译：含铁的肠胃营养组合物
公开(公告)号：WO2007075877A2
公开(公告)日：2007-07-05
申请号：PCT/US2006048772
申请日：2006-12-22
申请人： GUPTA AJAY
发明人： GUPTA AJAY
IPC分类号： A61K33/42 , A61K31/70
CPC分类号： A61K33/42 , A23L33/10 , A23L33/115 , A23L33/16 , A23L33/175 , A23L33/30 , A23V2002/00 , A61K9/0029 , A61K31/195 , A61K31/70 , A61K33/26 , A61K45/06 , A61K2300/00 , A23V2200/08 , A23V2250/06 , A23V2250/51 , A23V2250/60 , A23V2250/18 , A23V2250/1592
摘要： Bioavailable iron-containing parenteral nutrition compositions are provided that are physico-chemically stable. Iron is present in the form of soluble ferric pyrophosphate. Methods of preparation and use of the compositions are provide, as well as kits.
摘要翻译：提供生物可利用的含铁肠胃外营养组合物，其物理化学稳定。铁以可溶性焦磷酸铁的形式存在。提供了组合物的制备和使用方法，以及试剂盒。

7. 发明申请

WO2010111599A3 COMPOSITIONS AND METHODS FOR TREATMENT OF RENAL DISEASE 审中-公开
标题翻译：用于治疗肾病的组合物和方法
公开(公告)号：WO2010111599A3
公开(公告)日：2011-07-28
申请号：PCT/US2010028841
申请日：2010-03-26
申请人： GUPTA AJAY
发明人： GUPTA AJAY
IPC分类号： A61K31/404 , A61K31/407 , A61K35/16 , A61K35/22 , A61P13/00 , A61P13/02 , A61P13/12
CPC分类号： A61K31/404 , A61K31/585 , A61K45/06
摘要： The invention relates to methods, compositions, and kits for the treatment of proteinuria and/or hypertension (e.g., proteinuria and/or hypertension arising from primary renal disease (e.g., focal segmental glomerulosclerosis, glomerular disease) or secondary to other conditions (e.g., diabetes, diabetic nephropathy, liver disease). Specifically, the invention relates to methods involving combination therapy wherein an indoline (e.g., indapamide) is administered in combination with an anti-aldosterone agent (e.g., spironolactone and/or epleronone).
摘要翻译：本发明涉及用于治疗蛋白尿和/或高血压的方法，组合物和试剂盒（例如，由原发性肾脏疾病（例如局灶性节段性肾小球硬化症，肾小球疾病）或其他病症继发的蛋白尿和/或高血压（例如，具体而言，本发明涉及涉及联合治疗的方法，其中二氢吲哚（例如，吲达帕胺）与抗醛固酮药物（例如，安体舒通内酯和/或戊倍酮）组合施用。

8. 发明申请

WO2007064374A9 CUSTOMER RELATIONSHIP MANAGEMENT SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2007064374A9
公开(公告)日：2007-08-23
申请号：PCT/US2006031749
申请日：2006-08-14
申请人： SUGARCRM INC , TAYLOR JACOB , ROBERTS JOHN , ORAM CLINTON , COOTES RON , DRIESCH ANDY , GUPTA AJAY , HSU ANDREW , HYUNH LAM , ITANI MAJED , OSTROW JULIAN , PARSONS JOEY , RANGEL ROBERT , SCHWARZMANN BOB , BEDEROV LILLIYA
发明人： TAYLOR JACOB , ROBERTS JOHN , ORAM CLINTON , COOTES RON , DRIESCH ANDY , GUPTA AJAY , HSU ANDREW , HYUNH LAM , ITANI MAJED , OSTROW JULIAN , PARSONS JOEY , RANGEL ROBERT , SCHWARZMANN BOB , BEDEROV LILLIYA
IPC分类号： A61F2/42 , A61F2/28 , G06Q10/00
CPC分类号： G06F8/65 , G06F8/71 , G06F17/30312 , G06Q10/06 , G06Q10/10 , G06Q30/02
摘要： A software-based customer relationship management system and method.

9. 发明申请

WO2007075389A2 CUSTOMER RELATIONSHIP MANAGEMENT SYSTEM AND METHOD 审中-公开
标题翻译：客户关系管理系统和方法
公开(公告)号：WO2007075389A2
公开(公告)日：2007-07-05
申请号：PCT/US2006047863
申请日：2006-12-15
申请人： SUGARCRM INC , TAYLOR JACOB , ROBERTS JOHN , ITANI MAJED , GUPTA AJAY , PARSONS JOSEPH , NOJIMA CHRIS , GREEN JASON , SMITH ROGER , PAN WAYNE , OSTROW JULIAN , DREISCH ANDREW , RANGEL ROBERT
发明人： TAYLOR JACOB , ROBERTS JOHN , ITANI MAJED , GUPTA AJAY , PARSONS JOSEPH , NOJIMA CHRIS , GREEN JASON , SMITH ROGER , PAN WAYNE , OSTROW JULIAN , DREISCH ANDREW , RANGEL ROBERT
IPC分类号： G06Q10/00
CPC分类号： G06Q30/02
摘要： A software-based customer relationship management system and method.
摘要翻译：基于软件的客户关系管理系统和方法。

10. 发明申请

WO2012142428A8 DEMAND-BASED MULTIMEDIA BROADCAST MULTICAST SERVICE MANAGEMENT 审中-公开
标题翻译：基于需求的多媒体广播多媒体服务管理
公开(公告)号：WO2012142428A8
公开(公告)日：2013-09-06
申请号：PCT/US2012033550
申请日：2012-04-13
申请人： QUALCOMM INC , GUPTA AJAY , BAO GANG , CHERIAN GEORGE , WANG JUN
发明人： GUPTA AJAY , BAO GANG , CHERIAN GEORGE , WANG JUN
IPC分类号： H04W4/06
CPC分类号： H04W72/005 , H04W4/06 , H04W28/08 , H04W64/00
摘要： A method or system for managing demand-based multicast services in a wireless communications system (WCS) capable of both unicast and multicast signaling may include providing content requested by a mobile entity in an area of the WCS via a unicast session, determining that a concurrent demand level for the content exceeds a defined threshold for the area of the WCS, and initiating a multicast session for the content in the area of the WCS, in response to determining the concurrent demand level has exceeded the threshold. The method or system may include more detailed operations or aspects for measuring the concurrent demand level, transitioning signaling between unicast and multicast modes, communicating between network components, or related functions.
摘要翻译：一种用于在能够同时进行单播和多播信令的无线通信系统（WCS）中管理基于需求的多播服务的方法或系统可以包括经由单播会话在WCS的区域中提供由移动实体请求的内容，确定并发响应于确定并发需求级别已经超过阈值，内容的需求级别超过WCS区域的定义的阈值，并且针对WCS的区域中的内容发起多播会话。该方法或系统可以包括用于测量并发需求级别，在单播和多播模式之间转换信令，网络组件之间的通信或相关功能的更详细的操作或方面。

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