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1. 发明申请

WO2011156912A3 A CONTAINER, A CLOSURE FOR A CONTAINER, AND A BASE FOR A CONTAINER 审中-公开
标题翻译：集装箱，集装箱的封闭物和集装箱的基座
公开(公告)号：WO2011156912A3
公开(公告)日：2012-02-09
申请号：PCT/CA2011000716
申请日：2011-06-17
申请人： PATHOGEN DETECTION SYSTEMS INC , UNIV KINGSTON , BROWN R STEPHEN , MARCOTTE ERIC , WILTON DOUG , GALLANT PETER , ROBINSON DAVID , STOKES LES , HOLDCROFT PETER , MILES MATTHEW , WILKINSON SIMON , UNDERWOOD LEE
发明人： BROWN R STEPHEN , MARCOTTE ERIC , WILTON DOUG , GALLANT PETER , ROBINSON DAVID , STOKES LES , HOLDCROFT PETER , MILES MATTHEW , WILKINSON SIMON , UNDERWOOD LEE
IPC分类号： B65D55/00 , B01L3/14 , B65D43/16 , B65D43/22 , B65D50/00 , B65D55/02 , C12M1/24 , C12M1/42 , C12Q1/00 , G01N1/00 , G01N21/03 , G01N33/50 , G01N37/00
CPC分类号： B65D55/02 , B01L3/508 , B01L2200/141 , B01L2300/043 , B01L2300/0654 , B65B5/08 , B65B7/28 , B65D3/14 , B65D43/22 , B65D55/024
摘要： A container, comprising: a body; and, a closure; wherein the closure has a lid hinged to a ring mounted on the body, the lid moveable from an open position to a closed position; wherein the lid has a tab hinged thereto for: inserting into and engaging a slot formed in the ring as the lid is moved to the closed position from the open position to thereby lock the lid in the closed position; or, receiving and engaging a pin head of a pin mounted on the ring in a hole formed in the tab to thereby hold the lid in the closed position, the pin configured to detach from the ring when the tab and lid are returned to the opened position.
摘要翻译：一种容器，包括：身体; 和关闭; 其中所述封闭件具有铰接到安装在所述主体上的环的盖，所述盖可以从打开位置移动到关闭位置; 其中所述盖具有铰接到其上的突片，用于当所述盖从所述打开位置移动到所述关闭位置时插入并接合形成在所述环中的槽，从而将所述盖锁定在所述关闭位置。或者，将安装在所述环上的销的销头接收并接合在形成在所述突片中的孔中，从而将所述盖保持在所述关闭位置，所述销被构造成当所述突片和盖子返回到打开状态时与所述环分离位置。

2. 发明申请

WO2007118329A8 METHODS AND AGENTS FOR TREATING TUBERCULOSIS 审中-公开
标题翻译：治疗结核病的方法和药剂
公开(公告)号：WO2007118329A8
公开(公告)日：2009-07-16
申请号：PCT/CA2007000648
申请日：2007-04-17
申请人： UNIV BRITISH COLUMBIA , UNIV KINGSTON , ELTIS LINDSAY D , SNIECKUS VICTOR A
发明人： ELTIS LINDSAY D , SNIECKUS VICTOR A
IPC分类号： C07C49/747 , A61K31/05 , A61K31/055 , A61K31/06 , A61K31/122 , A61K31/19 , A61K31/192 , A61K31/5685 , A61P31/04 , A61P31/06 , C07C39/24 , C07C39/367 , C07C59/90 , C07C205/26 , G01N33/50
CPC分类号： C07C205/26 , A61K31/05 , A61K31/055 , A61K31/06 , A61K31/122 , A61K31/19 , A61K31/192 , A61K31/5685 , C07C39/245 , C07C39/367 , C07C49/747 , C07C59/90 , G01N33/56922 , G01N2500/02
摘要： The present invention relates to the treatment of tuberculosis (mycobacterial infections) by the use of KshAB complex inhibitors, or a KstD molecule, or a HsaAB complex, or a HsaC molecule, or a HsaD molecule. The application also includes a method for identifying an inhibitor or modulator of the previously mentioned molecules and complexes.
摘要翻译：本发明涉及通过使用KshAB复合抑制剂或KstD分子或HsaAB复合物或HsaC分子或HsaD分子治疗结核病（分枝杆菌感染）。该应用还包括鉴定前述分子和复合物的抑制剂或调节剂的方法。

3. 发明申请

WO2004111084A3 PEPTIDES ENHANCING CEH ACTIVITY OR INHIBITING ACAT ACTIVITY, PHARMACEUTICAL COMPOSITIONS COMPRISING THESE PEPTIDES AND THEIR USE IN THE TREATMENT OF ATHEROSCLEROSIS 审中-公开
标题翻译：肽增强CEH活性或抑制ACAT活性，包含这些肽的药物组合物及其在治疗ATHEROSCLEROSIS中的用途
公开(公告)号：WO2004111084A3
公开(公告)日：2005-07-14
申请号：PCT/CA2004000846
申请日：2004-06-11
申请人： UNIV KINGSTON , KISILEVSKY ROBERT , TAM SHUI-PANG , ANCSIN JOHN B , JIA ZONGCHAO
发明人： KISILEVSKY ROBERT , TAM SHUI-PANG , ANCSIN JOHN B , JIA ZONGCHAO
IPC分类号： A61K38/00 , C07K7/08 , C07K14/775 , C07K14/47 , A61K38/10 , A61K38/17 , A61K47/48
CPC分类号： C07K7/08 , A61K38/00 , C07K14/775
摘要： Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
摘要翻译：提供哺乳动物血清淀粉样蛋白A同种型2.1（SAA2.1）的选定结构域的肽和模拟物及其化合物及其组合物，其增强对巨噬细胞胆固醇酯水解酶活性的影响和/或抑制酰基CoA：胆固醇酰基转移酶活性。还提供了使用这些组合物治疗和/或预防动脉粥样硬化以及冠心病和心血管疾病的方法。

4. 发明申请

WO2004080543A2 METHOD OF DECOMPOSING ORGANOPHOSPHORUS COMPOUNDS 审中-公开
标题翻译：分解有机磷化合物的方法
公开(公告)号：WO2004080543A2
公开(公告)日：2004-09-23
申请号：PCT/CA2004000379
申请日：2004-03-12
申请人： UNIV KINGSTON , BROWN R STANLEY , NEVEROV ALEXEI A , TSANG JOSEPHINE S W
发明人： BROWN R STANLEY , NEVEROV ALEXEI A , TSANG JOSEPHINE S W
IPC分类号： A62D3/30 , A62D3/36 , A62D101/02 , A62D101/04 , A62D101/26 , C07C29/12 , A62D3/00
CPC分类号： A62D3/30 , A62D3/36 , A62D2101/02 , A62D2101/04 , A62D2101/26
摘要： Methods and kits for decomposing organophosphorus compounds in non-aqueous media at ambient conditions are described. Insecticides, pesticides, and chemical warfare agents can be quickly decomposed to non-toxic products. The method comprises combining the organophosphorus compound with a non-aqueous solution, preferably an alcohol, comprising metal ions and at least a trace amount of alkoxide ions. In a first preferred embodiment, the metal ion is a lanthanum ion. In a second preferred embodiment, the metal ion is a transition metal.
摘要翻译：描述了在环境条件下在非水介质中分解有机磷化合物的方法和试剂盒。杀虫剂，杀虫剂和化学战剂可以迅速分解为无毒产品。该方法包括将有机磷化合物与包含金属离子和至少痕量醇盐离子的非水溶液，优选醇混合。在第一优选实施方案中，金属离子是镧离子。在第二优选实施方案中，金属离子是过渡金属。

5. 发明申请

WO2004009559A3 DIHYDROURACIL COMPOUNDS AS ANTI-ICTOGENIC OR ANTI-EPILEPTOGENIC AGENTS 审中-公开
标题翻译：作为抗致敏剂或抗癫痫剂的二氢嘧啶化合物
公开(公告)号：WO2004009559A3
公开(公告)日：2004-04-01
申请号：PCT/CA0301082
申请日：2003-07-18
申请人： UNIV KINGSTON , JONES KATHRYN A , WEAVER DONALD F , TIEDJE KATHRYN E
发明人： JONES KATHRYN A , WEAVER DONALD F , TIEDJE KATHRYN E
IPC分类号： A61P25/08 , C07D239/22 , A61K31/513
CPC分类号： C07D239/22
摘要： Methods and compounds useful for the inhibition of convulsive disorders, including epilepsy, are disclosed. The methods and compounds of the invention inhibit or prevent or treat ictogenesis, epileptogenesis, or epileptogenesis-associated conditions. Methods for preparing the compounds of the invention are also described. Particularly preferred compounds of the invention include Formula 1 as described herein.
摘要翻译：公开了用于抑制惊厥性障碍（包括癫痫症）的方法和化合物。本发明的方法和化合物抑制或预防或治疗发作，癫痫发生或癫痫发生相关病症。还描述了制备本发明化合物的方法。本发明特别优选的化合物包括如本文所述的式1。

6. 发明申请

WO03004693A3 METHODS AND COMPOSITIONS FOR MODULATING ADENOSINE TRIPHOSPHATE (ATP) IN CELLS AND PREVENTING CELL INJURY OR DEATH VIA POST-TRANSLATIONAL MODIFICATIONS TO ATP SYNTHASE 审中-公开
标题翻译：调节细胞内腺苷三磷酸（ATP）的方法和组合物以及通过对ATP合成酶的翻译后修饰预防细胞损伤或死亡
公开(公告)号：WO03004693A3
公开(公告)日：2003-04-10
申请号：PCT/CA0201014
申请日：2002-07-04
申请人： UNIV KINGSTON , VAN EYK JENNIFER E , ARRELL DAVID KENT
发明人： VAN EYK JENNIFER E , ARRELL DAVID KENT
IPC分类号： C12Q1/34 , G01N33/68 , C12Q1/42
CPC分类号： G01N33/6893 , C12Q1/34 , G01N2500/00
摘要： Compositions and methods for modulating adenosine triphosphate (ATP) in cells via altering post-translational modifications of ATP synthase subunits or precursors thereof such as the ATP synthase beta chain and its precursor are provided. These compositions and methods are useful in preconditioning organs and preventing cell injury or cell death via regulating ATP synthesis or hydrolysis in cells of the organs.
摘要翻译：提供了通过改变ATP合酶亚基或其前体如ATP合酶β链及其前体的翻译后修饰来调节细胞中三磷酸腺苷（ATP）的组合物和方法。这些组合物和方法可用于预调节器官，并通过调节器官细胞中的ATP合成或水解来防止细胞损伤或细胞死亡。

7. 发明申请

WO0103680A3 COMPOUNDS FOR INHIBITING DISEASES AND PREPARING CELLS FOR TRANSPLANTATION 审中-公开
标题翻译：用于抑制疾病和制备细胞进行移植的化合物
公开(公告)号：WO0103680A3
公开(公告)日：2002-07-11
申请号：PCT/GB0002623
申请日：2000-07-07
申请人： ISIS INNOVATION , NEUROCHEM INC , UNIV KINGSTON , CLARK ANNE , FRASER PAUL , VERCHERE BRUCE , GUPTA AJAY , MIGNEAULT DAVID , SZAREK WALTER , WEAVER DONALD
发明人： CLARK ANNE , FRASER PAUL , VERCHERE BRUCE , GUPTA AJAY , MIGNEAULT DAVID , SZAREK WALTER , WEAVER DONALD
IPC分类号： A61K31/00 , A61K31/185 , A61K31/194 , A61K31/44 , A61K31/47 , A61K31/472 , A61P3/00 , A61P25/00 , C07K14/47 , A61K31/145 , A61K31/445 , A61K31/451 , A61K31/662
CPC分类号： A61K31/662 , A61K31/00 , A61K31/185 , A61K31/194 , A61K31/44 , A61K31/47 , A61K31/472 , C07K14/4711
摘要： Methods and compositions are provided for inhibiting, preventing and treating amyloid depositions, e.g. in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. Accordingly, the compositions and method of the invention are useful for inhibiting diabetes. The invention also provides a process for the preparation of cells suitable for transplantation into a mammal, which cells are capable of forming fibrils, said process comprising contacting the cells with an inhibitor of fibril formation. In particular the process prepares cells for use in a method of treating diabetes. Also provided are a culture medium comprising the inhibitor more particularly selected from the group consisting of 3-(3-hydroxy-1-propy)amino-1-propanesulfonic acid; DL-2-amino-5-phosphovaleric acid; 4-Phenyl-1-(3'-sulfopropyl)-1,2,3,6-tetrahydropyridine, cyclohexylsulfamic acid, O-phospho-L-serine, hexafluoroglutaric acid, 8-methoxyquinoline-5-sulfonic acid, 3-amino-2hydroxy-1-propanesulfonic acid, and 3-dimethylamino-1-propanesulfonic acid and 1,2,3,4-tetrahydroisoquinoleine.
摘要翻译：提供了用于抑制，预防和治疗淀粉样蛋白沉积的方法和组合物，例如。在胰岛中，淀粉样蛋白沉积物是胰岛淀粉样蛋白多肽（IAPP）相关的淀粉样蛋白沉积或沉积物。因此，本发明的组合物和方法可用于抑制糖尿病。本发明还提供了一种制备适于移植到哺乳动物中的细胞的方法，所述细胞能够形成原纤维，所述方法包括使细胞与原纤维形成抑制剂接触。特别地，该方法准备细胞用于治疗糖尿病的方法。还提供了包含更特别选自3-（3-羟基-1-丙基）氨基-1-丙磺酸的抑制剂的培养基; DL-2-氨基-5-磷酸戊酸; 4-苯基-1-（3'-磺基丙基）-1,2,3,6-四氢吡啶，环己基氨基磺酸，O-磷酸-L-丝氨酸，六氟戊二酸，8-甲氧基喹啉-5-磺酸，3-氨基 - 2-羟基-1-丙磺酸和3-二甲基氨基-1-丙磺酸和1,2,3,4-四氢异喹啉。

8. 发明申请

WO9805760A3 PHOSPHATE STARVATION-INDUCIBLE PROTEINS 审中-公开
标题翻译：磷酸盐诱导诱导蛋白
公开(公告)号：WO9805760A3
公开(公告)日：1998-10-08
申请号：PCT/CA9700532
申请日：1997-07-30
申请人： UNIV KINGSTON , LEFEBVRE DANIEL D , MALBOOBI MOHAMMAD A
发明人： LEFEBVRE DANIEL D , MALBOOBI MOHAMMAD A
IPC分类号： C07K14/415 , C12N9/12 , C12N9/24 , C12N15/29 , C12N15/82 , A01H5/00 , C12N5/10 , C12N9/42 , C12N15/54 , C12N15/56
CPC分类号： C12N9/1205 , C07K14/415 , C12N9/2445 , C12N15/8261 , C12N15/827 , C12N15/8271 , C12N15/8273 , C12Y302/01021 , Y02A40/146
摘要： This invention provides proteins, especially protein kinases, glucosidases, and phosphate transporters which are expressed under conditions of phosphate deprivation. Further provided are nucleic acids and nucleic acid constructs encoding these proteins, cells containing the nucleic acids described and transgenic photosynthetic organisms with altered phosphate-inducible enzyme activity.

9. 发明申请

WO9740809A3 METHOD OF ENHANCING EFFECT OF NEUROTROPHIN WITH ANALOGUES OF P75367-379 审中-公开
标题翻译：增强神经营养因子与P75 367-379类似物的作用的方法
公开(公告)号：WO9740809A3
公开(公告)日：1998-03-26
申请号：PCT/CA9700271
申请日：1997-04-23
申请人： UNIV KINGSTON , RIOPELLE RICHARD J , WEAVER DONALD F , ROSS GREGORY M , SHAMOVSKY IGOR L
发明人： RIOPELLE RICHARD J , WEAVER DONALD F , ROSS GREGORY M , SHAMOVSKY IGOR L
IPC分类号： A61K38/00 , C07K14/705 , A61K
CPC分类号： C07K14/70578 , A61K38/00
摘要： The present invention provides methods and compositions for enhancing an effect or effects of a neurotrophin, preferably, but not limited to, enhancing the growth and survival promoting properties of neurotrophins. The cytoplasmic region of the common neurotrophin receptor (p75NTR) (rat, human, chick) contains a putative membrane-associating domain implicated in intracellular signalling. A peptide (R3) identical to this domain (p75NTR367-379) and various analogues of this peptide displayed circular dichroism spectra in aqueous and non-polar environments identical to the amphiphilic tetradecapeptide mastoparan (MP), and were internalized by PC12 rat pheochromocytoma cells. The R3 peptide enhanced neurite growth in PC12 cells, chick embryo primary sensory neurons, and fetal rat primary sensory neurons in vitro in the presence of sub-saturating concentrations of NGF. Peptide analogues of R3 not faithful to the distance and angular relationships of ionic groups, and the putative amphiphilic structure of p75NTR367-379, while still providing some enhancement, nevertheless displayed reduced potency to enhance NGF-mediated neurite growth. The common neurotrophin receptor p75NTR activates and translocates the nuclear transcription factor NFkB and displays pro-apoptotic effects similar to other members of the TNF receptor superfamily. A peptide mimic of the amphiphilic domain 367-379 of p75NTR that enhances TrkA mediated neurite growth by NGF, was used to affinity purify cytoplasmic proteins from PC12 cells. Isolated proteins contained a predominant species with an apparent molecular weight of 65 kDa. The affinity purified 65 kDa protein, as well as a protein of similar molecular mass from crude cell extracts, were identified by immunoblotting with antibody to NFkB. The 65 kDa species was chemically cross-linked to the radiolabeled analogue of the peptide mimic of p75NTR and immunoprecipitated by antibody to NFkB. These observations, taken together with the finding that a p75NTR-selective NGF antagonist blocked mediated neurite growth in limiting NGF conditions, support the view that p75NTR participates in neurite growth via a signaling pathway involving the translocation of NFkB.

10. 发明申请

WO2013033830A1 METHOD FOR THE DETECTION OF CHEMICAL WARFARE AGENTS 审中-公开
标题翻译：检测化学战剂的方法
公开(公告)号：WO2013033830A1
公开(公告)日：2013-03-14
申请号：PCT/CA2012000837
申请日：2012-09-10
申请人： UNIV KINGSTON , NEVEROV ALEXEI A
发明人： NEVEROV ALEXEI A
IPC分类号： G01N31/22 , G01N21/64 , G01N21/77 , G01N21/78
CPC分类号： G01N21/643 , G01N21/78 , G01N31/22 , G01N2021/7786
摘要： Methods and kits for detecting, decomposing and monitoring decomposition of organophosphorus compounds or toxic industrial chemicals in non-aqueous media at ambient conditions are described. Insecticides, pesticides, and chemical warfare agents can be quickly detected and decomposed to non-toxic products and decomposition can be monitored. The method comprises combining the organophosphorus compound or toxic industrial chemical with a non-aqueous solution, preferably an alcohol, comprising metal ions and at least a trace amount of alkoxide ions, in the presence of an indicator compound.
摘要翻译：描述了在环境条件下检测，分解和监测非水介质中有机磷化合物或有毒工业化学品的分解的方法和试剂盒。杀虫剂，杀虫剂和化学战剂可迅速检测并分解成无毒产品，并可对其进行分解监测。该方法包括在指示剂化合物存在下，将有机磷化合物或有毒工业化学品与包含金属离子和至少痕量醇盐离子的非水溶液，优选醇混合。

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