会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 2. 发明申请
    • METHOD AND APPARATUS FOR IFDMA/DFT-S-OFDM TRANSMISSION
    • 用于IFDMA / DFT-S-OFDM传输的方法和设备
    • WO2007040985A2
    • 2007-04-12
    • PCT/US2006/036477
    • 2006-09-19
    • MOTOROLA, INC.TAN, JunGHOSH, AmitavaWANG, Fan
    • TAN, JunGHOSH, AmitavaWANG, Fan
    • H04K1/10
    • H04L5/0048H04L5/0016H04L25/0226H04L25/03159H04L27/2613H04L2025/03414
    • Various embodiments are described to provide for the transmission of data in an improved manner. Data transmission is improved by including in a transmitter a null generator (310) to embed frequency domain nulls into a data symbol sequence to produce a null-embedded data symbol sequence. A symbol inserter (320) inserts a control symbol sequence into the frequency domain nulls of the null-embedded data symbol sequence to produce a combined symbol sequence. A modulator (330) then encodes the combined symbol sequence using IFDMA / DFT-S-OFDM. This approach allows the assignment of a single IFDMA / DFT-S-OFDM code to each user for data and control (pilot, e.g.) signaling, simplifying code management. Frequency hopping techniques may also be employed to lower the pilot overhead.
    • 描述了各种实施例以提供以改进的方式传输数据。 通过在发射机中包括空发生器(310)以将频域空值嵌入到数据符号序列中以产生空嵌入数据符号序列来改进数据传输。 符号插入器(320)将控制符号序列插入到空嵌入数据符号序列的频域中以产生组合符号序列。 调制器(330)然后使用IFDMA / DFT-S-OFDM对组合的符号序列进行编码。 这种方法允许为每个用户分配单个IFDMA / DFT-S-OFDM码,用于数据和控制(导频,例如)信令,简化了代码管理。 跳频技术也可以用来降低导频开销。
    • 6. 发明申请
    • HUCBC TREATMENT OF AMYLOID ASSOCIATED DISEASE
    • 乳腺癌相关疾病的治疗
    • WO2009023814A2
    • 2009-02-19
    • PCT/US2008/073265
    • 2008-08-15
    • UNIVERSITY OF SOUTH FLORIDATAN, JunSANBERG, Paul, R.
    • TAN, JunSANBERG, Paul, R.
    • A61K48/00C12N5/08
    • A61K35/16A61K35/44A61K2035/122
    • Administration of human umbilical cord blood cells (HUCBC) or HUCBC-derived plasma is used to treat amyloid-based diseases, such as Alzheimer's disease, Huntington's disease, cerebral amyloid antigopathy, and type-II diabetes. Modulating inflammatory reactions by infusing HUCBC resulted in a marked reduction of amyloid plaques and immune-associated cellular damage. HUCBC infusion also significantly reduced cerebral amyloid angiopathy in mice models. These effects were associated with suppression of the CD40-CD40L interaction and a reduction in surface expressed CD-40 was observed on immune cells. Further, A? phagocytic activity was increased and soluble and insoluble AB protein levels were modulated by treatment. HUCBC-infused sera also significantly increased phagocytosis of AB 1-42 peptide and inhibited immune cell CD40 expression and reduced cerebral amyloid angiopathy.
    • 使用人脐带血细胞(HUCBC)或HUCBC衍生血浆来治疗淀粉样蛋白病,如阿尔茨海默氏病,亨廷顿舞蹈病,脑淀粉样蛋白病和II型糖尿病。 通过输注HUCBC调节炎症反应导致淀粉样蛋白斑块和免疫相关细胞损伤的显着减少。 HUCBC输注也显着降低了小鼠模型中的脑淀粉样血管病变。 这些作用与CD40-CD40L相互作用的抑制有关,并且在免疫细胞上观察到表达CD-40的表达减少。 此外,A? 吞噬活性增加,可溶性和不溶性AB蛋白水平通过处理调节。 HUCBC输注的血清也显着增加了AB 1-42肽的吞噬作用,抑制了免疫细胞CD40的表达,降低了脑淀粉样血管病变。
    • 8. 发明申请
    • A TRANSGENIC MODEL OF ALZHEIMER'S DISEASE
    • 阿尔茨海默病的转移模型
    • WO2012103218A1
    • 2012-08-02
    • PCT/US2012/022549
    • 2012-01-25
    • UNIVERSITY OF SOUTH FLORIDATAN, JunOBREGON, Demian ForestHOU, Huayan
    • TAN, JunOBREGON, Demian ForestHOU, Huayan
    • A01K67/027G01N33/15G01N33/68
    • A01K67/0275A01K2217/05A01K2227/105A01K2267/0312C12N15/8509
    • Evidence indicates dysregulation of the immunoregulatory molecule CD45 occurs in Alzheimer's disease (AD). Transgenic mice overproducing amyloid-β peptide (Αβ) and deficient in CD45 (PSAPP/CD45 T) recapitulate AD neuropathology. Increased cerebral intracellular and extracellular soluble oligomeric and insoluble Αβ, decreased plasma soluble Αβ, increased microglial neurotoxic cytokines TNF-a and I L-1 β, and neuronal loss were found in PSAPP/CD45T mice compared with CD45-sufficient PSAPP littermates. After CD45 ablation, in vitro and in vivo studies demonstrate a microglial phenotype whereby microglia phagocytose less Αβ but display proinflammatory properties. This microglial activation occurs with elevated Αβ oligomers and neural injury and loss as determined by decreased ratio of anti-apoptotic Bcl-xL to proapoptotic Bax, increased activated caspase-3, mitochondrial dysfunction, and loss of cortical neurons in PSAPP/CD45 T mice. These data show that deficiency in CD45 activity leads to brain accumulation of neurotoxic Αβ oligomers and validate CD45-mediated microglial clearance of oligomeric Αβ as a novel AD therapeutic target.
    • 证据表明免疫调节分子CD45的异常调节发生在阿尔茨海默病(AD)中。 过量产生淀粉样蛋白β肽(ββ)和缺陷CD45(PSAPP / CD45T)的转基因小鼠重现AD神经病理学。 与CD45-足够的PSAPP同窝出生相比,在PSAPP / CD45T小鼠中发现脑细胞内和细胞外可溶性寡聚和不溶性ββ降低,小胶质细胞神经毒性细胞因子TNF-α和I L-1β增加,神经元损失增加。 在CD45消融后,体外和体内研究证明小胶质细胞表型,其中小胶质细胞吞噬作用较少β但显示促炎特性。 通过降低PSAPP / CD45 T小鼠抗细胞凋亡Bcl-xL与促细胞凋亡Bax,增加的活化半胱天冬酶-3,线粒体功能障碍和皮层神经元的损失比例确定,这种小胶质细胞活化发生在升高的β低聚物和神经损伤和损失 。 这些数据表明,CD45活性缺乏导致神经毒性βß寡聚体的脑积聚,并验证寡聚ß的CD45介导的小胶质细胞清除作为新型AD治疗靶点。
    • 10. 发明申请
    • METHOD OF TREATMENT USING ATRANORIN
    • 使用ATRANORIN治疗的方法
    • WO2008109521A2
    • 2008-09-12
    • PCT/US2008/055655
    • 2008-03-03
    • UNIVERSITY OF SOUTH FLORIDATAN, JunSHYTLE, Roland DouglasOBREGON, Demian
    • TAN, JunSHYTLE, Roland DouglasOBREGON, Demian
    • A61K31/7048A61K31/353
    • A61K31/353A61K31/7048A61K36/09A61K2300/00
    • Disclosed herein is a method of treating a neurodegenerative disease, comprising the step of administering a therapeutically effective amount of Atranorin, or a closely related compound thereof. The neurodegenerative disease is Alzheimer's disease in one embodiment. The closely related compound is selected from the group consisting of chloroatranorin, evernic acid, barbatic acid, 4-O-demethyl-barbatic acid, lecanoric acid, diffratic acid and gyrophoric acid. Also disclosed is a method of treating a cellular proliferative disease, comprising the step of administering a therapeutically effective amount of Atranorin, or a closely related compound thereof. The cellular proliferative disease is cancer in one embodiment. The method of claim 1 wherein the closely related compound is selected from the group consisting of chloroatranorin, evernic acid, barbatic acid, 4-O-demethyl-barbatic acid, lecanoric acid, diffratic acid and gyrophoric acid
    • 本文公开了治疗神经退行性疾病的方法,其包括施用治疗有效量的Atranorin或其紧密相关化合物的步骤。 在一个实施方案中,神经退行性疾病是阿尔茨海默氏病。 紧密相关的化合物选自氯代亚麻酸,vernic acid,巴比妥酸,4-O-去甲基 - 巴比妥酸,偏苯三酸,偏乙酸和回acid酸。 还公开了治疗细胞增殖性疾病的方法,其包括施用治疗有效量的Atranorin或其紧密相关化合物的步骤。 在一个实施例中,细胞增殖性疾病是癌症。 2.根据权利要求1所述的方法,其中所述密切相关的化合物选自氯代阿拉
      诺林,鞣酸,巴比妥酸,4-O-去甲基 - 巴比妥酸,偏苯三酸,难辨酸和回
      火酸,