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1. 发明申请

WO0012832A3 RADIALLY EXPANDABLE DEVICE 审中-公开
标题翻译：可扩展的装置
公开(公告)号：WO0012832A3
公开(公告)日：2000-06-15
申请号：PCT/US9919457
申请日：1999-08-26
申请人： MOLECULAR GEODESICS INC , CLIFFORD DALE TIMOTHY , INGBER DONALD E
发明人： CLIFFORD DALE TIMOTHY , INGBER DONALD E
IPC分类号： A61B17/00 , A61B17/02 , A61B17/11 , A61B17/16 , A61F2/00 , A61F2/04 , A61F2/30 , A61F2/82 , A61F2/90 , A61F2/95 , A61F13/15 , A61F13/20 , E04B1/344 , E04H5/12 , E04H12/18 , A61F2/06
CPC分类号： A61F2/90 , A61B17/02 , A61B17/11 , A61B17/1615 , A61B17/164 , A61B2017/00539 , A61B2017/00867 , A61F2/04 , A61F2/30723 , A61F2/82 , A61F2/95 , A61F13/2051 , A61F13/36 , A61F13/4702 , A61F2002/30092 , A61F2013/00097 , A61F2013/00119 , A61F2210/0014 , A61F2230/005 , A61F2230/0054 , A61F2230/0078 , A61F2310/00017 , A61F2310/00023 , E04B1/3441 , E04H5/12 , E04H12/18
摘要： An expandable device is provided that includes a plurality of elongated members that are positioned and arranged to define a lattice structure having crossing points (or nodes) along interior positions of the elongated members. Preferably, the lattice structure is a hyperboloid of revolution. The device includes a plurality of flexible interconnectors located at the crossing points for securing one elongated member to another. The device is radially compressible and expandable. The device may include flexible joiner elements at that join at least two elongated members together at their ends to form an apex. The device may be used in a variety of applications including medical applications such as surgical retractors, space creators, endoluminal prosthesis, such as catheters, dilators or stents, mechanisms for expanding stents, controllably catheters, drains or valves and connectors for hollow organs. The device may also be used in building and construction applications such as emergency shelters, housing structural supports, receptacles, masts and cooling tower support structures.
摘要翻译：提供了一种可扩张装置，其包括多个细长构件，这些细长构件被定位和布置成限定具有沿着细长构件的内部位置的交叉点（或节点）的网格结构。优选地，晶格结构是旋转双曲面。该装置包括位于交叉点处的多个柔性互连器，用于将一个细长构件固定到另一个细长构件。该装置是径向可压缩和可扩展的。该装置可以包括柔性接合器元件，在该接合器元件处将至少两个细长构件在其端部连接在一起以形成顶点。该装置可以用于各种应用，包括医疗应用，例如手术牵开器，空间创造器，腔内假体，诸如导管，扩张器或支架，用于扩张支架的机构，可控导管，排水管或用于中空器官的阀和连接器。该设备还可用于建筑和施工应用，如应急避难所，房屋结构支撑，容器，桅杆和冷却塔支撑结构。

2. 发明申请

WO9933641A9 FOAM SCAFFOLD MATERIALS 审中-公开
标题翻译：泡沫材料
公开(公告)号：WO9933641A9
公开(公告)日：1999-09-30
申请号：PCT/US9827397
申请日：1998-12-23
申请人： MOLECULAR GEODESICS INC , INGBER DONALD E , MEUSE ARTHUR J , ROBERTS ERIC R
发明人： INGBER DONALD E , MEUSE ARTHUR J , ROBERTS ERIC R
IPC分类号： A61L27/56 , B29C67/00 , A61L27/00 , B29C33/38 , C08J9/00
CPC分类号： A61L27/56
摘要： A foam structure comprising a scaffold material including a predetermined repeating arrangement of polyhedral modules may have shapes of truncated octahedra, Kelvin minimal surface tetrakaidecahedra, or other polyhedral shapes. The foam may be open-cell, in which the polyhedral modules are formed of elongated members defining their edges, or closed-cell, in which the polyhedral modules are formed of substantially planar members defining their faces. The foam can be formed by computer-aided manufacturing techniques, self-assembly techniques, or lost core molding techniques. With this arrangement, a variety of idealized foam material shapes and sizes can be provided, for use in a variety of applications. In addition, the foam material can be designed to be multi-functional and to provide mechanical load-bearing along with other desired properties as required.
摘要翻译：包括支架材料的泡沫结构体包括多面体模块的预定重复排列可以具有截断的八面体，开尔文最小表面四面体开口或其它多面体形状的形状。泡沫可以是开孔的，其中多面体模块由限定其边缘的细长构件或闭孔形成，其中多面体模块由限定其面的基本平坦的构件形成。泡沫可以通过计算机辅助制造技术，自组装技术或失去的芯成型技术形成。通过这种布置，可以提供各种理想化的泡沫材料形状和尺寸，用于各种应用中。此外，泡沫材料可以被设计为多功能的，并且根据需要提供机械承载以及其它所需的性能。

3. 发明申请

WO0009307A9 A MOLD FOR MAKING A THREE-DIMENSIONAL COMPLEX STRUCTURE, SAID MOLD COMPRISING AT LEAST THREE MOLD PORTIONS, METHOD OF MAKING SAID MOLD, AND USE OF SAID MOLD FOR MAKING THREE-DIMENSIONAL COMPLEX STRUCTURES 审中-公开
公开(公告)号：WO0009307A9
公开(公告)日：2000-08-03
申请号：PCT/US9918209
申请日：1999-08-11
申请人： MOLECULAR GEODESICS INC , INGBER DONALD E , BUTZ DAVID E , ROBERTS ERIC R , CLIFFORD DALE , KUMMAILIL JOHN J
发明人： INGBER DONALD E , BUTZ DAVID E , ROBERTS ERIC R , CLIFFORD DALE , KUMMAILIL JOHN J
IPC分类号： B29C33/00 , B29C33/30 , B29C33/38 , B29C33/42 , B29C33/44 , B29C33/52 , A61L27/00
CPC分类号： B29C33/301 , B29C33/0033 , B29C33/3857 , B29C33/42 , B29C33/448 , B29C33/52
摘要： Molds, methods of forming the molds, and methods of using the molds to form complex unitary three-dimensional structures are provided. The complex unitary three-dimensional structures and its complement have a high degree of interlocking. The molds include at least three mold portions constructed and arranged to include a complement of complex three-dimensional unitary structure when in an assembled configuration, and a portion of the complement when in an unassembled configuration. The structure is not removable from the mold portions without destroying at least a portion of the mold. The method involves providing a mold that includes a complement of the complex unitary three-dimensional structure, introducing a fluid material into the mold, and removing the complex unitary three-dimensional structure from the mold.

4. 发明申请

WO0009307A3 A MOLD FOR MAKING A THREE-DIMENSIONAL COMPLEX STRUCTURE, SAID MOLD COMPRISING AT LEAST THREE MOLD PORTIONS, METHOD OF MAKING SAID MOLD, AND USE OF SAID MOLD FOR MAKING THREE-DIMENSIONAL COMPLEX STRUCTURES 审中-公开
标题翻译：用于制造三维复杂结构的模具，包含至少三个模具部分的模具，制造所述模具的方法以及使用所述模具制造三维复杂结构
公开(公告)号：WO0009307A3
公开(公告)日：2000-06-08
申请号：PCT/US9918209
申请日：1999-08-11
申请人： MOLECULAR GEODESICS INC , INGBER DONALD E , BUTZ DAVID E , ROBERTS ERIC R , CLIFFORD DALE , KUMMAILIL JOHN J
发明人： INGBER DONALD E , BUTZ DAVID E , ROBERTS ERIC R , CLIFFORD DALE , KUMMAILIL JOHN J
IPC分类号： B29C33/00 , B29C33/30 , B29C33/38 , B29C33/42 , B29C33/44 , B29C33/52 , A61L27/00
CPC分类号： B29C33/301 , B29C33/0033 , B29C33/3857 , B29C33/42 , B29C33/448 , B29C33/52
摘要： Molds, methods of forming the molds, and methods of using the molds to form complex unitary three-dimensional structures are provided. The complex unitary three-dimensional structures and its complement have a high degree of interlocking. The molds include at least three mold portions constructed and arranged to include a complement of complex three-dimensional unitary structure when in an assembled configuration, and a portion of the complement when in an unassembled configuration. The structure is not removable from the mold portions without destroying at least a portion of the mold. The method involves providing a mold that includes a complement of the complex unitary three-dimensional structure, introducing a fluid material into the mold, and removing the complex unitary three-dimensional structure from the mold.
摘要翻译：提供了模具，形成模具的方法以及使用模具形成复杂的单一三维结构的方法。复杂的酉三维结构及其互补具有高度的互锁性。模具包括至少三个模具部分，所述模具部分被构造和布置成当处于组装构造时包括复杂的三维一体结构的补充以及处于未组装构造时的补充物的一部分。在不破坏模具的至少一部分的情况下，结构不能从模具部分移除。该方法包括提供包括复杂的单一三维结构的补充的模具，将流体材料引入模具中，并且从模具中移除复杂的单一三维结构。

5. 发明申请

WO9922861B1 BIOMIMETIC MATERIALS FOR FILTRATION, CHEMICAL PROCESSING AND DETOXIFICATION 审中-公开
标题翻译：用于过滤，化学处理和脱氧的生物材料
公开(公告)号：WO9922861B1
公开(公告)日：1999-07-22
申请号：PCT/US9823589
申请日：1998-11-05
申请人： MOLECULAR GEODESICS INC , RICE UNIVERSITY
发明人： INGBER DONALD E , LIU QUING , LIU ZEWEN , MIKOS ANTONIOS G , BAHULEKAR RAMAN V
IPC分类号： B01D53/02 , B01J20/26 , B01J20/32 , B01D15/08 , B01J32/00
CPC分类号： B01D53/02 , B01J20/26 , B01J20/3204 , B01J20/3212 , B01J20/3274 , B01J20/3287 , B01J20/3291
摘要： Materials that utilize porous skeleton materials coated with hydrogels to provide an improved, low resistance filtration capability for removal of pathogens, toxins, or other contaminants from a contaminated gas or liquid and an enhanced capacity for binding, sequestering, or catalytic processing of chemical, biological, or molecular substrates.
摘要翻译：使用涂覆有水凝胶的多孔骨架材料的材料提供改进的低电阻过滤能力，用于从污染的气体或液体中除去病原体，毒素或其他污染物，以及增强化学，生物学的结合，隔离或催化加工的能力，或分子底物。

6. 发明申请

WO2012118956A3 THERMAL MANAGEMENT OF TRANSPARENT MEDIA 审中-公开
标题翻译：透明媒体的热管理
公开(公告)号：WO2012118956A3
公开(公告)日：2012-11-08
申请号：PCT/US2012027253
申请日：2012-03-01
申请人： HARVARD COLLEGE , INGBER DONALD E , HATTON BENJAMIN D , WHEELDON IAN R
发明人： INGBER DONALD E , HATTON BENJAMIN D , WHEELDON IAN R
IPC分类号： H05B3/84
CPC分类号： E06B3/6715 , E06B3/66323 , E06B3/66333 , E06B3/6722 , F24D17/0015 , F24J2/0433 , F24J2/20 , Y02B10/20 , Y02E10/44
摘要： A bio-inspired window can be created by applying one or more heat exchange layers to one or more surfaces of a window of a building, boat, vehicle or any other structure. The heat exchange layer can include an interconnected network or array of channels or microchannels that can be used to flow a fluid over the surface of the window. The fluid can be used to heat or cool the surface of the window panel to control the flow of heat across the window and reduce the heating or cooling energy load of building. The fluid can be heated or cooled using the ambient air in the building. The refractive index of the fluid can be adjusted to change of optical transparency properties of the window. In some embodiments, the window can appear nearly as clear as an ordinary panel of glass. In other embodiments, the window can color, block or scatter the incoming light.
摘要翻译：可以通过将一个或多个热交换层施加到建筑物，船，车辆或任何其他结构的窗户的一个或多个表面来创建生物启发的窗户。热交换层可以包括可用于使流体在窗口表面上流动的通道或微通道的互连网络或阵列。流体可用于加热或冷却窗户面板的表面，以控制跨过窗户的热量流动，并减少建筑物的加热或冷却能量负荷。流体可以使用建筑物中的环境空气进行加热或冷却。可以调节流体的折射率以改变窗口的光学透明性。在一些实施例中，窗口可以看起来像普通的玻璃板几乎一样清楚。在其他实施例中，窗口可以着色，阻挡或散射入射光。

7. 发明申请

WO0189788A2 PATTERNING OF SURFACES UTILIZING MICROFLUIDIC STAMPS INCLUDING THREE-DIMENSIONALLY ARRAYED CHANNEL NETWORKS 审中-公开
标题翻译：使用包括三维阵列通道网络在内的微流感标记的表面图案
公开(公告)号：WO0189788A2
公开(公告)日：2001-11-29
申请号：PCT/US0117246
申请日：2001-05-25
申请人： HARVARD COLLEGE , CHILDRENS MEDICAL CENTER , CHIU DANIEL T , JEON NOO LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
发明人： CHIU DANIEL T , JEON NOO-LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
IPC分类号： B01F13/00 , B01L3/00 , B01L3/02 , B29C31/04 , B29C33/42 , B29C39/10 , B81B1/00 , B81C1/00 , C40B40/10 , C40B60/14 , G01N33/50 , B29C
CPC分类号： C12N11/00 , B01F13/0059 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00725 , B01J2219/00743 , B01L3/0258 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/424 , B29C39/10 , B33Y80/00 , B81B1/00 , B81C99/009 , B82Y5/00 , B82Y30/00 , C40B40/10 , C40B60/14 , G01N33/5005 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks can be fabricated via replica molding processes utilizing mold masters including surfaces having topological features formed by photolithography. The present invention also involves microfluidic systems and methods for fabricating complex patterns of materials, such as biological materials and cells, on surfaces utilizing the microfluidic systems. Specifically, the invention provides microfluidic surface patterning systems and methods for fabricating complex, discontinuous patterns on surfaces that can incorporate or deposit multiple materials onto the surfaces. The present invention also provides improved microfluidic stamps or applicators for microcontact surface patterning, which are able to pattern onto a surface arbitrary two-dimensional patterns, and which are able to pattern multiple substances onto a surface without the need for multiple steps of registration or stamping during patterning and without the need to selectively "ink" different regions of the stamp with different materials.
摘要翻译：本发明描述了改进的微流体系统和用于制造改进的微流体系统的程序，其包含一个或多个水平的微流体通道。用于制造所公开的系统的方法可以为拓扑复杂和改进的微流体系统提供方便的途径。微流体系统可以包括其中的流体流动路径的三维排列的网络，其中包括在交叉点处交叉的网络上或下方的通道，而没有物理交叉点。微流体网络可以通过使用模具主体的复制模制工艺制造，其中包括具有通过光刻形成的拓扑特征的表面。本发明还涉及在利用微流体系统的表面上制造诸如生物材料和细胞的复杂图案的微流体系统和方法。具体地，本发明提供了微流体表面图案化系统和用于在表面上制造复杂的不连续图案的方法，所述图案可以将多种材料结合或沉积到表面上。本发明还提供了用于微接触表面图案化的改进的微流体标记或涂布器，其能够将图案图案化成任意的二维图案，并且能够将多种物质图案化到表面上，而不需要多个对准或冲压的步骤在图案化期间，并且不需要使用不同材料选择性地“印刷”印模的不同区域。

8. 发明申请

WO2008156904A3 SYSTEMS AND METHODS FOR NANOMAGNETIC ACTUATION OF MOLECULAR CELL SIGNALING 审中-公开
标题翻译：用于分子细胞信号的纳米分解的系统和方法
公开(公告)号：WO2008156904A3
公开(公告)日：2009-03-19
申请号：PCT/US2008059738
申请日：2008-04-09
申请人： CHILDRENS MEDICAL CENTER , INGBER DONALD E , MANNIX ROBERT J , KUMAR SANJAY
发明人： INGBER DONALD E , MANNIX ROBERT J , KUMAR SANJAY
IPC分类号： A61K47/48 , A61N2/02
CPC分类号： A61K41/0052 , A61K47/48507 , A61K47/6835 , A61N2/00 , Y10S977/904
摘要： The present invention relates to signaling mechanisms that transduce magnetic inputs into physiological cellular outputs. More particularly, the present invention relates to systems and methods for non-invasively controlling cellular signaling functions and behaviors by harnessing receptor-mediated and intracellular molecular-mediated signal transduction using nanomagnetic cellular switches.
摘要翻译：本发明涉及将磁输入转换成生理细胞输出的信号传导机制。更具体地，本发明涉及通过利用纳米磁性细胞开关利用受体介导的和细胞内分子介导的信号转导来非侵入性地控制细胞信号传导功能和行为的系统和方法。

9. 发明申请

WO2008127295A2 GUIDED SELF-ASSEMBLY OF MATRICES WITH ORDERD NANO-SCALE STRUCTURE FOR TISSUE ENGINEERING 审中-公开
标题翻译：指导用于组织工程的订单纳米尺度结构的矩阵自组装
公开(公告)号：WO2008127295A2
公开(公告)日：2008-10-23
申请号：PCT/US2007022397
申请日：2007-10-22
申请人： CHILDRENS MEDICAL CENTER , INGBER DONALD E
发明人： INGBER DONALD E
IPC分类号： H04Q7/22
CPC分类号： C12N5/0075 , C12N2533/56 , C12N2535/10
摘要： Described herein are methods for producing structures useful, for example, for tissue engineering. In their most general form, the methods described herein involve an enzyme activity immobilized on a surface, which is placed in contact with a solution comprising polypeptide monomers. The activity of the enzyme modifies the polypeptide monomers to promote polymerization of the monomers to form polymer structures associated with the surface. Thus, the methods described herein provide a guided self-assembly of polypeptide structures. In preferred embodiments, the self assembly is guided to form regular lattices or other specific structures by specifying the arrangement of the surfaces to which the enzyme, optionally with one or more co-factors, is attached.
摘要翻译：这里描述的是用于产生可用于例如组织工程的结构的方法。在其最一般的形式中，本文描述的方法涉及固定在表面上的酶活性，其被置于与包含多肽单体的溶液接触。酶的活性改变多肽单体以促进单体的聚合以形成与表面相关的聚合物结构。因此，本文所述的方法提供多肽结构的引导自组装。在优选的实施方案中，通过指定酶，任选地与一个或多个辅因子连接的表面的布置，引导自组装形成规则晶格或其它特定结构。

10. 发明申请

WO2007044642A3 DEVICE AND METHOD FOR COMBINED MICROFLUIDIC-MICROMAGNETIC SEPARATION OF MATERIAL IN CONTINUOUS FLOW 审中-公开
标题翻译：用于连续流动的材料组合微流化 - 微磁性分离的装置和方法
公开(公告)号：WO2007044642A3
公开(公告)日：2007-11-15
申请号：PCT/US2006039344
申请日：2006-10-06
申请人： HARVARD COLLEGE , INGBER DONALD E , XIA SHANNON , HUNT TOM P , WESTERVELT ROBERT M
发明人： INGBER DONALD E , XIA SHANNON , HUNT TOM P , WESTERVELT ROBERT M
IPC分类号： B01D35/06
CPC分类号： A61M1/3618 , A61M1/36 , A61M2205/0244 , A61M2206/11 , B01L3/502761 , B01L2200/0636 , B01L2200/0668 , B01L2300/06 , B01L2300/0864 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N2015/149 , Y10T436/25375
摘要： A miniaturized, integrated, microfluidic device pulls materials bound to magnetic particles from one laminar flow path to another by applying a local magnetic field gradient. The device removes microbial and mammalian cells from flowing biological fluids without any wash steps. A microfabricated high-gradient magnetic field concentrator (HGMC) is integrated at one side of a microfluidic channel. When magnetic particles are introduced into one flow path, they remain limited to that flow path. When the HGMC is magnetized, the magnetic beads are pulled from the initial flow path into the collection stream, thereby cleansing the fluid. The microdevice allows large numbers of beads and materials to be sorted simultaneously, has no capacity limit, does not lose separation efficiency as particles are removed, and is useful for cell separations from blood and other biological fluids. This on-chip separator allows cell separations to be performed in the field outside of hospitals and laboratories.
摘要翻译：小型化，集成化的微流体装置通过施加局部磁场梯度将结合到磁性粒子的材料从一个层流路径拉到另一层流路径。该装置不需要任何清洗步骤即可从流动的生物流体中去除微生物和哺乳动物细胞微制造的高梯度磁场集中器（HGMC）集成在微流体通道的一侧。当磁性颗粒被引入到一个流动路径中时，它们仍然限于该流动路径。当HGMC被磁化时，磁珠从初始流动路径被拉入收集流中，从而清洁流体。微装置允许大量的珠子和材料同时分选，没有容量限制，不会因为颗粒被去除而失去分离效率，并且可用于从血液和其他生物流体中分离细胞。这种片上分离器可以在医院和实验室以外的地方进行细胞分离。

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