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1. 发明申请

WO2012021308A2 METHOD FOR RETROVIRUS REMOVAL 审中-公开
标题翻译：去除逆转录病毒的方法
公开(公告)号：WO2012021308A2
公开(公告)日：2012-02-16
申请号：PCT/US2011/045905
申请日：2011-07-29
申请人： MILLIPORE CORPORATION , KAS, Onur, Y. , KOZLOV, Mikhail , TKACIK, Gabriel , MOYA, Wilson , GODDARD, Philip , LEON, Sherry , HAO, Jibin
发明人： KAS, Onur, Y. , KOZLOV, Mikhail , TKACIK, Gabriel , MOYA, Wilson , GODDARD, Philip , LEON, Sherry , HAO, Jibin
IPC分类号： C12Q1/70 , C12Q1/24 , C12M1/12 , C12R1/92
CPC分类号： B01D39/1623 , A61L2/022 , B01D39/00 , B01D39/04 , B01D39/14 , B01D39/16 , B01D39/1607 , B01D39/1615 , B01D39/18 , B01D61/14 , B01D67/0004 , B01D67/002 , B01D69/02 , B01D69/10 , B01D2239/0208 , B01D2239/0216 , B01D2239/025 , B01D2239/0442 , B01D2239/0631 , B01D2239/10 , B01D2239/1233 , B01D2323/39 , B01D2323/42 , B01D2325/20 , C12N7/00 , C12N2740/16051 , D01D1/02 , D01D5/0092 , D01F6/96 , D10B2505/04
摘要： A method for removing retroviruses from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism intention is disclosed. Retroviruses are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a retrovirus LRV greater than about 6, and the nanofiber(s) has a diameter from about 10 nm to about 100 nm. The filtration medium can be in the form of a fibrous electrospun polymeric nanofiber liquid filtration medium mat.
摘要翻译：公开了一种从液体样品中去除逆转录病毒的方法以及同时表现出高液体渗透性和高微生物意图的含纳米纤维的液体过滤介质。通过使液体通过具有大于约6的逆转录病毒LRV的含有多孔纳米纤维的过滤介质并且纳米纤维具有大约10nm至大约100nm的直径，从液体中除去逆转录病毒。过滤介质可以是纤维状电纺聚合物纳米纤维液体过滤介质垫的形式。

2. 发明申请

WO2010107503A1 REMOVAL OF MICROORGANISMS FROM FLUID SAMPLES USING NANOFIBER FILTRATION MEDIA 审中-公开
标题翻译：使用NANOFIBER过滤介质从流体样品中去除微生物
公开(公告)号：WO2010107503A1
公开(公告)日：2010-09-23
申请号：PCT/US2010/000826
申请日：2010-03-19
申请人： MILLIPORE CORPORATION , KOZLOV, Mikhail , MOYA, Wilson , TKACIK, Gabriel
发明人： KOZLOV, Mikhail , MOYA, Wilson , TKACIK, Gabriel
IPC分类号： A61L2/02 , A61L2/00 , B01D39/16
CPC分类号： A61L2/0017 , B01D39/1623 , B01D67/0004 , B01D67/002 , B01D69/00 , B01D2239/025 , B01D2323/39 , C02F1/444 , C02F2303/04
摘要： A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta , are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electrospun polymeric nanofiber liquid filtration medium mat.
摘要翻译：一种从液体样品中除去微生物的方法和含有液体过滤介质的纳米纤维，同时具有高液体渗透性和高微生物保留性。通过使液体通过含有大于约9的B.Diminuta LRV的过滤介质的多孔纳米纤维，从细菌，特别是B.Diminuta中除去微生物，并且纳米纤维具有约10nm的直径至约1000nm。用于除去微生物如细菌和Mycloplasma的另一种方法包括使液体通过含有微生物LRV大于约8的过滤介质的多孔纳米纤维，并且纳米纤维的直径为约10nm至约1,000nm。过滤介质可以是纤维电纺聚合物纳米纤维液体过滤介质垫的形式。

3. 发明申请

WO2013013241A3 NANOFIBER CONTAINING COMPOSITE STRUCTURES 审中-公开
公开(公告)号：WO2013013241A3
公开(公告)日：2013-01-24
申请号：PCT/US2012/047865
申请日：2012-07-23
申请人： EMD MILLIPORE CORPORATION , KAS, Onur, Y. , KOZLOV, Mikhail , TKACIK, Gabriel , NHIEM, David , GODDARD, Philip , LEON, Sherry, Ashby
发明人： KAS, Onur, Y. , KOZLOV, Mikhail , TKACIK, Gabriel , NHIEM, David , GODDARD, Philip , LEON, Sherry, Ashby
IPC分类号： B01D69/12 , B01D35/00 , B01D39/16 , B01D39/08 , B01D69/02
摘要： A nanofiber liquid filtration medium featuring an electrospun polymeric nanofiber layer produced on a smooth non-woven substrate.

4. 发明申请

WO2011140406A1 ENHANCED CLARIFICATION MEDIA 审中-公开
标题翻译：增强澄清媒体
公开(公告)号：WO2011140406A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/035444
申请日：2011-05-06
申请人： MILLIPORE CORPORATION , CHENG, Ks , RAMASWAMY, Senthil , GAGNON, Brian , WOO, Maybelle , KOZLOV, Mikhail
发明人： CHENG, Ks , RAMASWAMY, Senthil , GAGNON, Brian , WOO, Maybelle , KOZLOV, Mikhail
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： B01J20/3212 , B01J20/3274 , B01J20/3282
摘要： Media and devices, such as nitrocellulose-based filters, wherein the media is coated with a polymer such as a polyallylamine. The resulting device offers strong binding of protein impurities and superior removal of host cell proteins from biological samples.
摘要翻译：介质和装置，例如基于硝酸纤维素的过滤器，其中介质用聚合物如聚烯丙基胺涂覆。所产生的装置提供蛋白质杂质的强烈结合，并优异地从生物样品中除去宿主细胞蛋白质。

5. 发明申请

WO2012015908A3 CHROMATOGRAPHY MEDIA AND METHOD 审中-公开
公开(公告)号：WO2012015908A3
公开(公告)日：2012-02-02
申请号：PCT/US2011/045519
申请日：2011-07-27
申请人： EMD MILLIPORE CORPORATION , YAVORSKY, David , AMARA, John , UMANA, Joaquin , CATALDO, William , KOZLOV, Mikhail , STONE, Matthew
发明人： YAVORSKY, David , AMARA, John , UMANA, Joaquin , CATALDO, William , KOZLOV, Mikhail , STONE, Matthew
IPC分类号： B01D15/36 , B01J20/285 , C07K1/18 , B01J20/28
摘要： Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).

6. 发明申请

WO2010098867A1 MEMBRANE WITH SULFONIC GROUPS FOR REMOVING PROTEIN AGGREGATES 审中-公开
标题翻译：具有消除蛋白质聚集体的磺基组织的膜
公开(公告)号：WO2010098867A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/000578
申请日：2010-02-26
申请人： MILLIPORE CORPORATION , KOZLOV, Mikhail , RAUTIO, Kevin
发明人： KOZLOV, Mikhail , RAUTIO, Kevin
IPC分类号： B01D69/12 , B01D71/56 , B01D67/00 , C07K1/34 , C07K1/36
CPC分类号： B01D71/56 , B01D67/0006 , B01D67/009 , B01D69/125 , B01D2323/30 , B01D2323/34 , B01D2325/14 , B01D2325/30 , C07K1/24 , C07K1/34
摘要： A negatively charged microporous filtration medium having a high charge density comprising a porous substrate and a polymerized cross-linked polymeric coating located on the inner and outer surfaces of the substrate. The coating may be formed from a reactant solution comprising negatively charged cross-linkable polymerizeable acrylamidoalkyl monomers and acrylamido cross-linking agents which are polymerized in situ on the substrate. The negatively charged microporous filtration medium are suitable for use as prefiltration membranes for selectively removing protein aggregates from a protein solution.
摘要翻译：具有高电荷密度的带负电荷的微孔过滤介质，包括多孔基底和位于基底的内表面和外表面上的聚合的交联聚合物涂层。涂层可以由包含带负电荷的可交联聚合性丙烯酰氨基烷基单体和丙烯酰胺交联剂的反应物溶液形成，所述交联剂在基材上原位聚合。带负电荷的微孔过滤介质适用于从蛋白质溶液中选择性去除蛋白聚集体的预过滤膜。

7. 发明申请

WO2013028330A2 METHODS OF REDUCING LEVEL OF ONE OF MORE IMPURITIES IN A SAMPLE DURING PROTEIN PURIFICATION 审中-公开
标题翻译：在蛋白质纯化过程中降低样品中更多污染物水平的方法
公开(公告)号：WO2013028330A2
公开(公告)日：2013-02-28
申请号：PCT/US2012/049351
申请日：2012-08-02
申请人： EMD MILLIPORE CORPORATION , BIAN, Nanying , GILLESPIE, Christopher , STONE, Matthew , KOZLOV, Mikhail , CHEN, Jie , SIWAK, Martin
发明人： BIAN, Nanying , GILLESPIE, Christopher , STONE, Matthew , KOZLOV, Mikhail , CHEN, Jie , SIWAK, Martin
IPC分类号： C07K1/16 , C07K1/36 , C07K1/18 , C07K1/34 , C07K16/00 , B01D15/08
CPC分类号： C07K1/36 , B01D15/125 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3809 , B01J20/20 , B01J20/282 , B01J39/26 , B01J41/20 , B01J43/00 , B01J47/04 , C07K1/16 , C07K1/20 , C07K16/00 , C07K2317/10
摘要： The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.
摘要翻译：本发明提供新颖和改进的蛋白质纯化方法，其包含某些类型的碳质材料，并且导致有效和选择性地除去某些不需要的杂质，而不会不利地影响所需蛋白质产物的产率。

8. 发明申请

WO2011140405A1 ENHANCED CLARIFICATION MEDIA 审中-公开
标题翻译：增强澄清媒体
公开(公告)号：WO2011140405A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/035443
申请日：2011-05-06
申请人： MILLIPORE CORPORATION , RAMASWAMY, Senthil , GAGNON, Brian , WOO, Maybelle , CHENG, Ks , KOZLOV, Mikhail
发明人： RAMASWAMY, Senthil , GAGNON, Brian , WOO, Maybelle , CHENG, Ks , KOZLOV, Mikhail
IPC分类号： C12N5/00
CPC分类号： B01D39/18 , B01D15/00 , B01D2239/0407 , B01D2239/0464 , B01J20/14 , B01J20/28023 , B01J20/2803 , B01J20/3212 , B01J20/3282 , B01J2220/46
摘要： Media and devices, such as depth filters including such media, wherein the media is impregnated with a polymer such as a polyallylamine. The resulting device offers strong binding of protein impurities and superior removal of host cell proteins from biological samples.
摘要翻译：介质和装置，例如包括这种介质的深度过滤器，其中介质用诸如聚烯丙基胺的聚合物浸渍。所产生的装置提供蛋白质杂质的强烈结合，并优异地从生物样品中除去宿主细胞蛋白质。

9. 发明申请

WO2013135251A1 A METHOD FOR MULTI-MODE, MULTI-LOAD, AND MULTI-DOMAIN OPTIMIZATION OF A MULTI-CHANNEL NEAR-FIELD RF TRANSMITTER 审中-公开
标题翻译：一种用于多通道近场RF发射机的多模，多负载和多域优化的方法
公开(公告)号：WO2013135251A1
公开(公告)日：2013-09-19
申请号：PCT/EP2012/001144
申请日：2012-03-14
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V. , KOZLOV, Mikhail , TURNER, Robert
发明人： KOZLOV, Mikhail , TURNER, Robert
IPC分类号： G01R33/561
CPC分类号： G01R33/54 , G01R33/3607 , G01R33/5612
摘要： The invention relates to a method for optimization of a performance of a multi-channel transmitter comprising several transmit elements, particularly in a magnetic resonance imaging device, wherein the method comprises the following steps: (a) Exciting the transmit elements of the multi-channel transmitter by electric excitation signals comprising a specific power, wherein the power of the excitation signals is partially reflected by the transmit elements of the multichannel transmitter, (b) Determining a reflected power which is reflected by the multi-channel transmitter during excitation of the transmit elements, (c) Determining reflection coefficients S xx of the multi-channel transmitter, (d) Determining reflection coefficients S xy of the multi-channel transmitter, (e) Calculating a performance criterion representing the performance of the multi-channel transmitter, wherein the performance criterion is based on el) the reflected power and e2) the reflection coefficients S xx and e3) the reflection coefficients S xy , (f) Tuning the multi-channel transmitter so that the performance criterion is optimized.
摘要翻译：本发明涉及一种用于优化包括几个发射元件的多信道发射机的性能的方法，特别是在磁共振成像设备中，其中该方法包括以下步骤：（a）激发多信道的发射元件发射机通过包括特定功率的电激励信号，其中所述激励信号的功率被所述多信道发射机的发射元件部分地反射，（b）确定所述多信道发射机在所述发射激励期间反射的反射功率（c）确定多声道发射机的反射系数Sxx，（d）确定多声道发射机的反射系数Sxy，（e）计算表示多声道发射机性能的性能标准，其中性能标准基于el）反射功率和e2）反射系数Sxx和e3）反射系数Sxy，（f）调谐多通道发射机，使性能标准得到优化。

10. 发明申请

WO2011005375A2 FABRICATION OF BISCROLLED FIBER USING CARBON NANOTUBE SHEET 审中-公开
标题翻译：使用碳纳米管片的双晶硅纤维的制造
公开(公告)号：WO2011005375A2
公开(公告)日：2011-01-13
申请号：PCT/US2010/036378
申请日：2010-05-27
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , BAUGHMAN, Ray, H. , FANG, Shaoli , LIMA, Marcio, Dias , OVALLE-ROBLES, Raquel , LEPRO-CHAVEZ, Xavier, N. , HAQUE, Mohammad, H. , ZAKHIDOV, Anvar, A. , KOZLOV, Mikhail , LEWIS-AZAD, Chihye , NOVITSKI, David, Michael , CASTILLO-MARTINEZ, Elizabeth , CARRETERO-GONZALEZ, Javier , HAINES, Carter, Sebastian
发明人： BAUGHMAN, Ray, H. , FANG, Shaoli , LIMA, Marcio, Dias , OVALLE-ROBLES, Raquel , LEPRO-CHAVEZ, Xavier, N. , HAQUE, Mohammad, H. , ZAKHIDOV, Anvar, A. , KOZLOV, Mikhail , LEWIS-AZAD, Chihye , NOVITSKI, David, Michael , CASTILLO-MARTINEZ, Elizabeth , CARRETERO-GONZALEZ, Javier , HAINES, Carter, Sebastian
IPC分类号： H01L31/0264
CPC分类号： H01M4/04 , A61K9/7007 , A61L15/18 , A61L17/04 , A61L31/024 , A61L31/16 , A61L2300/108 , A61L2300/414 , A61L2300/418 , A61L2400/12 , B01J21/063 , B01J21/18 , B01J21/185 , B01J23/42 , B01J35/0006 , B01J35/004 , B01J35/06 , B01J37/0215 , B01J37/0238 , B05D3/12 , B05D5/00 , C23C14/04 , C23C14/58 , C23C16/04 , C23C16/56 , D01F9/12 , D02G3/16 , D10B2101/122 , H01B12/06 , H01G11/86 , H01M4/0402 , H01M4/131 , H01M4/133 , H01M4/1391 , H01M4/1393 , H01M4/5825 , H01M4/587 , H01M4/96 , H01M8/00 , H01M10/0525 , Y02E60/122 , Y02E60/50 , Y10T428/2918 , Y10T428/2929
摘要： Fabrication of yarns or other shaped articles from materials in powder form (or nanoparticles or nanofibers) using carbon nanotube/nanofiber sheet as a platform (template). This includes methods for fabricating biscrolled yarns using carbon nanotube/nanofiber sheets and biscrolled fibers fabricated thereby.
摘要翻译：使用碳纳米管/纳米纤维片作为平台（模板）从粉末形式的材料（或纳米颗粒或纳米纤维）制造纱线或其他成形制品。这包括使用碳纳米管/纳米纤维片材制造双向卷线纱的方法和由此制造的双曲线纤维。

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