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1. 发明申请

WO2014123795A3 TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HEPATITIS C 审中-公开
标题翻译：四环杂环化合物及其用于治疗丙型肝炎的方法
公开(公告)号：WO2014123795A3
公开(公告)日：2014-10-30
申请号：PCT/US2014014365
申请日：2014-02-03
申请人： MERCK SHARP & DOHME , HE SHUWEN , DAI XING , PALANI ANANDAN , NARGUND RAVI , LAI ZHONG , ZORN NICOLAS , XIAO DONG , DANG QUN , LI PENG , PENG XUANJIA , SOLL RICHARD
发明人： HE SHUWEN , DAI XING , PALANI ANANDAN , NARGUND RAVI , LAI ZHONG , ZORN NICOLAS , XIAO DONG , DANG QUN , LI PENG , PENG XUANJIA , SOLL RICHARD
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： C07D498/14 , A61K31/5365 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system. I
摘要翻译：本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，此类化合物的合成，以及此类化合物用于抑制HCV NS5B聚合酶活性的用途的式（I）化合物，用于治疗或预防HCV感染并用于在基于细胞的系统中抑制HCV病毒复制和/或病毒产生。一世

2. 发明申请

WO2011106992A8 INHIBITORS OF HEPATITIS C VIRUS NS5B POLYMERASE 审中-公开
标题翻译： HEPATITIS C VIRUS NS5B聚合酶抑制剂
公开(公告)号：WO2011106992A8
公开(公告)日：2012-02-09
申请号：PCT/CN2011000332
申请日：2011-03-02
申请人： MERCK SHARP & DOHME , MCCOMAS CASEY CAMERON , LIVERTON NIGEL J , SOLL RICHARD , LI PENG , PENG XUANJIA , WU HAO , NARJES FRANK , HABERMANN JOERG , KOCH UWE , LIU SHILAN , ANGELETTI P IST RICHERCHE BIO
发明人： MCCOMAS CASEY CAMERON , LIVERTON NIGEL J , SOLL RICHARD , LI PENG , PENG XUANJIA , WU HAO , NARJES FRANK , HABERMANN JOERG , KOCH UWE , LIU SHILAN
IPC分类号： C07D307/84 , A61K31/343 , A61P31/14 , C07D405/04 , C07D405/10
CPC分类号： C07D307/84 , A61K31/343 , A61K45/06 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/10 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D473/00 , C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04 , A61K2300/00
摘要： Disclosed are compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and /or viral production in a cell-based system.
摘要翻译：公开了用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的式（I）化合物，这些化合物的合成，以及这些化合物用于抑制HCV NS5B聚合酶活性的用途，用于治疗或预防HCV感染和抑制在基于细胞的系统中HCV病毒复制和/或病毒生产。

3. 发明申请

WO2012037517A2 BIT ERROR RATE CHECKER RECEIVING SERIAL DATA SIGNAL FROM AN EYE VIEWER 审中-公开
标题翻译：从眼睛观察器接收串行数据信号的位错误率检查器
公开(公告)号：WO2012037517A2
公开(公告)日：2012-03-22
申请号：PCT/US2011052028
申请日：2011-09-16
申请人： ALTERA CORP , DING WEIQI , PAN MINGDE , LI PENG , SHUMARAYEV SERGEY , SHIMANOUCHI MASASHI
发明人： DING WEIQI , PAN MINGDE , LI PENG , SHUMARAYEV SERGEY , SHIMANOUCHI MASASHI
IPC分类号： H04L1/00 , G01R29/02
CPC分类号： H04L1/203 , G01R31/3171
摘要： An IC that includes an eye viewer and a BER checker coupled to the eye viewer, where the BER checker receives a serial data signal from the eye viewer, is provided. In one implementation, the BER checker receives the serial data signal from the eye viewer without the serial data signal passing through a deserializer. In one implementation, the BER checker compares the serial data signal against a reference data signal to determine the BER for the serial data signal. In one implementation, the IC includes an IC core coupled to the eye viewer and the BER checker, where the BER checker is outside the IC core. In one implementation, the BER checker is a dedicated BER checker. In one implementation, the BER checker includes an exclusive OR gate, a programmable delay circuit coupled to the exclusive OR gate, and an error counter coupled to the exclusive OR gate.
摘要翻译：提供了一种IC，其包括耦合到眼睛观察者的眼睛观察器和BER检查器，其中BER检查器从眼睛观察器接收串行数据信号。在一个实现中，BER检查器从眼睛观察器接收串行数据信号，而不经过串行数据信号通过解串器。在一个实现中，BER检验器将串行数据信号与参考数据信号进行比较，以确定串行数据信号的BER。在一个实现中，IC包括耦合到眼睛观察器和BER检查器的IC核心，其中BER检验器在IC核心之外。在一个实现中，BER检查器是专用的BER检查器。在一个实现中，BER检查器包括异或门，耦合到异或门的可编程延迟电路和耦合到异或门的错误计数器。

4. 发明申请

WO2006020759A2 IMPROVED WAVEFORMS ANALYZER 审中-公开
标题翻译：改进的波形分析仪
公开(公告)号：WO2006020759A2
公开(公告)日：2006-02-23
申请号：PCT/US2005028534
申请日：2005-08-09
申请人： WAVECREST CORP , HAMRE JOHN DAVID , LI PENG , WILSTRUP JAN BRIAN , MCCOY STEVEN JOHN
发明人： HAMRE JOHN DAVID , LI PENG , WILSTRUP JAN BRIAN , MCCOY STEVEN JOHN
IPC分类号： H04L1/20 , G01R29/26 , G11B20/10
CPC分类号： G11B20/24 , G01R13/32 , G01R31/31709 , G01R31/3171 , G01R31/31711 , G11B20/10009 , G11B20/10046 , G11B20/10212 , H04L1/205 , H04L1/24
摘要： A method and system for removing the effect of intersymbol interference (ISI) from a data record indicating times of logic level transitions exhibited by a data signal that has been distorted by ISI exhibited by a system having a particular step response may perform the following acts. The data record may be received, and a transition from within the data may be selected record for removal of ISI. Preceding transitions within the data record are then inspected. A time defect is obtained, based at least in part upon the inspected preceding transitions. Finally, the data record is adjusted, based upon the time defect, to indicate a new time of transition for the selected transition, thereby removing the effect of ISI for the selected transition.
摘要翻译：从具有由具有特定阶跃响应的系统所展示的由ISI失真的数据信号所展示的逻辑电平转换的数据记录的数据记录中消除符号间干扰（ISI）的影响的方法和系统可以执行以下动作。可以接收数据记录，并且可以选择从数据内进行的转换以便删除ISI。然后检查数据记录中的先前转换。至少部分地基于所检查的先前转换获得时间缺陷。最后，基于时间缺陷来调整数据记录，以指示所选择的转换的新的转换时间，从而消除所选转换的ISI的影响。

5. 发明申请

WO2007027866A8 TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS 审中-公开
标题翻译：具有增强农业条件的转基因植物
公开(公告)号：WO2007027866A8
公开(公告)日：2011-09-15
申请号：PCT/US2006033989
申请日：2006-08-30
申请人： MONSANTO TECHNOLOGY LLC , ABAD MARK , BELL ERIN , BRADSHAW TERRY , BRUNICK KIMBERLY , CASTIGLIONI PAOLO , CHAR SHOBHA , CHITRA RAJAM , CROWLEY JAMES , DEEBA FARAH , DEIKMAN JILL , DUFF STEPHEN , EDGERTON MICHAEL , FABBRI BRADON , FERNANDES MARY , GABBERT KAREN , GOLDMAN BARRY , H VEENA , HOUMARD NANCY , KARUNANANDAA BALASULOJINI , KJEMTRUP SUSANNE , LEE GARRETT , LELAND TIMOTHY , LI PENG , LUND ADRIAN , MCNABNAY MARCUS , PENG MING , QUI BO-XING , RAMANATH BHAT VIDYA , RAVANELLO MONICA , RUFF THOMAS , SAVAGE THOMAS , SAVIDGE BETH , SHARMA YOGESH , SHI LIFANG , SUDARSHANA PADMINI , THOMPSON REBECCA , URWIN CARL , VAL DALE , VOSS STEVE , ANURADHA MEANDER , BASRA AMARJIT , BENNETT KRISTEN , BENSEN ROBERT
发明人： ABAD MARK , BELL ERIN , BRADSHAW TERRY , BRUNICK KIMBERLY , CASTIGLIONI PAOLO , CHAR SHOBHA , CHITRA RAJAM , CROWLEY JAMES , DEEBA FARAH , DEIKMAN JILL , DUFF STEPHEN , EDGERTON MICHAEL , FABBRI BRADON , FERNANDES MARY , GABBERT KAREN , GOLDMAN BARRY , H VEENA , HOUMARD NANCY , KARUNANANDAA BALASULOJINI , KJEMTRUP SUSANNE , LEE GARRETT , LELAND TIMOTHY , LI PENG , LUND ADRIAN , MCNABNAY MARCUS , PENG MING , QUI BO-XING , RAMANATH BHAT VIDYA , RAVANELLO MONICA , RUFF THOMAS , SAVAGE THOMAS , SAVIDGE BETH , SHARMA YOGESH , SHI LIFANG , SUDARSHANA PADMINI , THOMPSON REBECCA , URWIN CARL , VAL DALE , VOSS STEVE , ANURADHA MEANDER , BASRA AMARJIT , BENNETT KRISTEN , BENSEN ROBERT
IPC分类号： A01H5/00
CPC分类号： C12N15/8261 , C07K14/415 , C12N15/8273 , Y02A40/146
摘要： This invention provides recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. Also provided by this invention is transgenic seed for growing a transgenic plant having recombinant DNA in its genome and exhibiting an enhance agronomic trait, i.e. enhanced nitrogen use efficiency, increased yield, enhanced water use efficiency, enhanced tolerance to cold stress and/or improved seed compositions. Also disclosed are methods for identifying such transgenic plants by screening for nitrogen use efficiency, yield, water use efficiency, growth under cold stress, and seed composition changes. This invention also discloses a method of identifying the target genes of a transcription factor.
摘要翻译：本发明提供用于表达可用于赋予转基因作物植物增强的农学性状的蛋白质的重组DNA。本发明还提供了用于在其基因组中生长具有重组DNA的转基因植物的转基因种子，其表现出增强的农艺性状，即增强的氮利用效率，增加的产量，增强的水分利用效率，增强的耐寒性和/或改良的种子成分。还公开了通过筛选氮利用效率，产量，水利用效率，冷应激下的生长和种子组成变化来鉴定这些转基因植物的方法。本发明还公开了鉴定转录因子的靶基因的方法。

6. 发明申请

WO2007027866A3 TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS 审中-公开
标题翻译：具有增强的农艺性状的转基因植物
公开(公告)号：WO2007027866A3
公开(公告)日：2007-11-29
申请号：PCT/US2006033989
申请日：2006-08-30
申请人： MONSANTO TECHNOLOGY LLC , ABAD MARK , BELL ERIN , BRADSHAW TERRY , BRUNICK KIMBERLY , CASTIGLIONI PAOLO , CHAR SHOBHA , CHITRA RAJAM , CROWLEY JAMES , DEEBA FARAH , DEIKMAN JILL , DUFF STEPHEN , EDGERTON MICHAEL , FABBRI BRADON , FERNANDES MARY , GABBERT KAREN , GOLDMAN BARRY , H VEENA , HOUMARD NANCY , KARUNANANDAA BALASULOJINI , KJEMTRUP SUSANNE , LEE GARRETT , LELAND TIMOTHY , LI PENG , LUND ADRIAN , MCNABNAY MARCUS , PENG MING , QUI BO-XING , RAMANATH BHAT VIDYA , RAVANELLO MONICA , RUFF THOMAS , SAVAGE THOMAS , SAVIDGE BETH , SHARMA YOGESH , SHI LIFANG , SUDARSHANA PADMINI , THOMPSON REBECCA , URWIN CARL , VAL DALE , VOSS STEVE , ANURADHA MEANDER , BASRA AMARJIT , BENNETT KRISTEN , BENSEN ROBERT
发明人： ABAD MARK , BELL ERIN , BRADSHAW TERRY , BRUNICK KIMBERLY , CASTIGLIONI PAOLO , CHAR SHOBHA , CHITRA RAJAM , CROWLEY JAMES , DEEBA FARAH , DEIKMAN JILL , DUFF STEPHEN , EDGERTON MICHAEL , FABBRI BRADON , FERNANDES MARY , GABBERT KAREN , GOLDMAN BARRY , H VEENA , HOUMARD NANCY , KARUNANANDAA BALASULOJINI , KJEMTRUP SUSANNE , LEE GARRETT , LELAND TIMOTHY , LI PENG , LUND ADRIAN , MCNABNAY MARCUS , PENG MING , QUI BO-XING , RAMANATH BHAT VIDYA , RAVANELLO MONICA , RUFF THOMAS , SAVAGE THOMAS , SAVIDGE BETH , SHARMA YOGESH , SHI LIFANG , SUDARSHANA PADMINI , THOMPSON REBECCA , URWIN CARL , VAL DALE , VOSS STEVE , ANURADHA MEANDER , BASRA AMARJIT , BENNETT KRISTEN , BENSEN ROBERT
IPC分类号： A01H5/00
CPC分类号： C12N15/8261 , C07K14/415 , C12N15/8273 , Y02A40/146
摘要： This invention provides recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. Also provided by this invention is transgenic seed for growing a transgenic plant having recombinant DNA in its genome and exhibiting an enhance agronomic trait, i.e. enhanced nitrogen use efficiency, increased yield, enhanced water use efficiency, enhanced tolerance to cold stress and/or improved seed compositions. Also disclosed are methods for identifying such transgenic plants by screening for nitrogen use efficiency, yield, water use efficiency, growth under cold stress, and seed composition changes. This invention also discloses a method of identifying the target genes of a transcription factor.
摘要翻译：本发明提供了用于表达可用于赋予转基因作物植物增强农学性状的蛋白质的重组DNA。本发明还提供了用于生长转基因植物的转基因种子，所述转基因植物在其基因组中具有重组DNA并且表现出增强的农学性状，即增强的氮利用效率，增加的产量，增强的水利用效率，增强的对冷胁迫的耐受性和/ 成分。还公开了通过筛选氮利用效率，产量，水分利用效率，冷胁迫下的生长和种子组成变化来鉴定此类转基因植物的方法。本发明还公开了鉴定转录因子的靶基因的方法。

7. 发明申请

WO2004071003A8 N-DIMENSIONAL DETERMINATION OF BIT-ERROR RATES 审中-公开
标题翻译：位错误差的N维测定
公开(公告)号：WO2004071003A8
公开(公告)日：2006-04-20
申请号：PCT/US2004002078
申请日：2004-01-27
申请人： WAVECREST CORP , LI PENG , WILSTRUP JAN BRIAN , HAMRE JOHN DAVID
发明人： LI PENG , WILSTRUP JAN BRIAN , HAMRE JOHN DAVID
IPC分类号： G06F11/00 , H04L1/20 , H04L1/24
CPC分类号： H04L1/24 , H04L1/205
摘要： A method for measuring a bit error rate in a communication system that includes a transmitter, a medium, and a receiver. The method may include identifying a plurality of causes of bit errors. For each cause, the communication system is measured to determine a corresponding probability density function. Each of the corresponding probability density functions is integrated over an interval representing a range in which the corresponding cause creates a bit error, thereby generating a plurality of integrated quantities. The integrated quantities are summed to arrive at a bit error rate for the communication system. An apparatus may be programmed to execute the foregoing method.
摘要翻译：一种用于测量包括发射器，介质和接收器的通信系统中的误码率的方法。该方法可以包括识别位错误的多个原因。对于每个原因，测量通信系统以确定相应的概率密度函数。每个相应的概率密度函数在表示相应原因产生比特误差的范围的区间内积分，由此产生多个积分量。将积分量相加以得到通信系统的误码率。可以对装置进行编程以执行前述方法。

8. 发明申请

WO2013004852A3 MAGNETIC BEAD AGGREGATION ASSAY SYSTEM AND METHOD FOR ANALYSING AND CHARACTERISING MAGNETIC BEAD AGGREGATION AND DETECTION OF TARGET ANALYTES 审中-公开
标题翻译：用于分析和表征磁珠聚集的磁珠分离测定系统和方法和目标分析仪的检测
公开(公告)号：WO2013004852A3
公开(公告)日：2014-11-06
申请号：PCT/EP2012063440
申请日：2012-07-09
申请人： UNIV DUBLIN , LEE GIL , LI PENG , PLATT MARK , CANNON GEMMA
发明人： LEE GIL , LI PENG , PLATT MARK , CANNON GEMMA
IPC分类号： B03C1/032 , B03C1/24 , B03C1/28 , G01N27/74 , G01N33/543
CPC分类号： G01N33/54306 , B03C1/032 , B03C1/24 , B03C1/288 , B03C2201/18 , B03C2201/24 , B03C2201/26 , G01N27/745 , G01N33/54326 , G01N33/54346
摘要： There is provided a method of aggregating a plurality of beads in a magnetic bead aggregation assay for subsequent analysis comprising: - providing magnetic beads comprising a capture probe for binding with said target analyte; - reacting the magnetic beads with the sample including a target analyte in a reaction chamber aggregating the magnetic beads in the presence of a magnetic field with the target analyte to allow formation of magnetic bead aggregates having physical properties detectable to enable characterisation of the aggregates on an aggregate by aggregate basis using a detector to measure the physical properties of the aggregates. Further provided are a method and system for detecting analytes in a sample by characterising the magnetic bead aggregates on an aggregate by aggregate basis by measuring physical properties of the aggregates.
摘要翻译：提供了一种在磁珠聚集测定中聚集多个珠子以进行后续分析的方法，包括：提供包含用于与所述目标分析物结合的捕获探针的磁珠; - 使磁珠与包含靶分析物的样品在反应室中反应，所述反应室在磁场存在下与目标分析物聚集磁珠，以允许形成具有可检测的物理性质的磁珠聚集体，以使得能够在使用检测器以聚集为基础的聚集体来测量聚集体的物理性质。进一步提供了一种通过测量聚集体的物理性质通过聚集体来表征聚集体上的磁珠聚集体来检测样品中的分析物的方法和系统。

9. 发明申请

WO2012021332A3 CIRCUITRY ON AN INTEGRATED CIRCUIT FOR PERFORMING OR FACILITATING OSCILLOSCOPE, JITTER, AND/OR BIT-ERROR-RATE TESTER OPERATIONS 审中-公开
标题翻译：用于执行或促进OSCILLOSCOPE，JITTER和/或BIT错误率测试仪操作的集成电路的电路
公开(公告)号：WO2012021332A3
公开(公告)日：2012-04-12
申请号：PCT/US2011046239
申请日：2011-08-02
申请人： ALTERA CORP , LI PENG , SHIMANOUCHI MASASHI , SHUMARAYEV SERGEY , DING WEIQI , NARAYAN SRIRAM , CHOW DANIEL TUN LAI , PAN MINGDE
发明人： LI PENG , SHIMANOUCHI MASASHI , SHUMARAYEV SERGEY , DING WEIQI , NARAYAN SRIRAM , CHOW DANIEL TUN LAI , PAN MINGDE
IPC分类号： G01R31/303
CPC分类号： G01R31/31709 , G01R31/3171 , G01R31/31716 , H04L7/0337
摘要： An integrated circuit ("IC") may include circuitry for use in testing a serial data signal. The IC may include circuitry for transmitting the serial data signal with optional jitter, optional noise, and/or controllably variable drive strength. The IC may also include circuitry for receiving the serial data signal and performing a bit error rate ("BER") analysis in such a signal. The IC may provide output signals indicative of results of its operations. The IC can operate in various modes to perform or at least emulate functions of an oscilloscope, a bit error rate tester, etc., for testing signals and circuitry with respect to jitter-tolerance, noise-tolerance, etc.
摘要翻译：集成电路（“IC”）可以包括用于测试串行数据信号的电路。 IC可以包括用于以可选的抖动，可选的噪声和/或可控地变化的驱动强度来发送串行数据信号的电路。 IC还可以包括用于接收串行数据信号并且在这种信号中执行误码率（“BER”）分析的电路。 IC可以提供指示其操作结果的输出信号。 IC可以以各种模式运行，以执行或至少模拟示波器，误码率测试仪等的功能，用于测试关于抖动容差，噪声容限等的信号和电路。

10. 发明申请

WO2011110119A3 APPLICATION PRICING METHOD AND APPARATUS 审中-公开
标题翻译：应用定价方法和设备
公开(公告)号：WO2011110119A3
公开(公告)日：2012-03-22
申请号：PCT/CN2011073158
申请日：2011-04-22
申请人： HUAWEI TECH CO LTD , ZHANG JIE , LIU FENG , LI PENG
发明人： ZHANG JIE , LIU FENG , LI PENG
IPC分类号： G06Q40/00 , G06Q30/02
CPC分类号： G06Q30/0605 , G06Q30/02
摘要： An application pricing method and apparatus of the wireless broadband field are provided. The method comprises: packaging multiple applications and getting an application package; obtaining the price of each application in the application package in a predetermined charging mode; computing and getting the price of the application package in the predetermined charging mode according to the price of each application. The scheme can determine the price of the application package conveniently and quickly, and brings the flexible and diversified charging mode of the application package.
摘要翻译：提供了无线宽带领域的应用定价方法和装置。该方法包括：打包多个应用程序并获取应用程序包; 以预定的充电模式获得应用包中的每个应用的价格; 根据每个应用的价格计算并获得预定充电模式中的应用包的价格。该方案可以方便快捷地确定应用程序包的价格，并为应用程序包带来灵活多样的收费模式。

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