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1. 发明申请

WO2011153186A1 TRANSGENIC BRASSICA EVENT MON 88302 AND METHODS OF USE THEREOF 审中-公开
标题翻译：转基因事件MON 88302及其使用方法
公开(公告)号：WO2011153186A1
公开(公告)日：2011-12-08
申请号：PCT/US2011/038684
申请日：2011-06-01
申请人： MONSANTO TECHNOLOGY LLC , BROWN, Andrew, J. , BYRNE, James, F. , COLE, Robert, H. , CROWLEY, James, H. , MIKLOS, John, A. , RIPLEY, Robert, C. , SEIFERT-HIGGINS, Simone , XIE, Jiali
发明人： BROWN, Andrew, J. , BYRNE, James, F. , COLE, Robert, H. , CROWLEY, James, H. , MIKLOS, John, A. , RIPLEY, Robert, C. , SEIFERT-HIGGINS, Simone , XIE, Jiali
IPC分类号： A01H5/00 , C12N15/82
CPC分类号： C12N15/8275 , A01N57/20
摘要： The invention provides plants comprising transgenic event MON 88302 that exhibit tolerance to glyphosate herbicide. The invention also provides seeds, plant parts, cells, commodity products, and methods related to the event. The invention also provides DNA molecules that are unique to the event and were created by the insertion of transgenic DNA into the genome of a Brassica napus plant.
摘要翻译：本发明提供了包含对草甘膦除草剂具有耐受性的转基因事件MON 88302的植物。本发明还提供与事件有关的种子，植物部分，细胞，商品和方法。本发明还提供了事件独有的DNA分子，并通过将转基因DNA插入到欧洲油菜植物的基因组中产生。

2. 发明申请

WO2007027866A8 TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS 审中-公开
标题翻译：具有增强农业条件的转基因植物
公开(公告)号：WO2007027866A8
公开(公告)日：2011-09-15
申请号：PCT/US2006033989
申请日：2006-08-30
申请人： MONSANTO TECHNOLOGY LLC , ABAD MARK , BELL ERIN , BRADSHAW TERRY , BRUNICK KIMBERLY , CASTIGLIONI PAOLO , CHAR SHOBHA , CHITRA RAJAM , CROWLEY JAMES , DEEBA FARAH , DEIKMAN JILL , DUFF STEPHEN , EDGERTON MICHAEL , FABBRI BRADON , FERNANDES MARY , GABBERT KAREN , GOLDMAN BARRY , H VEENA , HOUMARD NANCY , KARUNANANDAA BALASULOJINI , KJEMTRUP SUSANNE , LEE GARRETT , LELAND TIMOTHY , LI PENG , LUND ADRIAN , MCNABNAY MARCUS , PENG MING , QUI BO-XING , RAMANATH BHAT VIDYA , RAVANELLO MONICA , RUFF THOMAS , SAVAGE THOMAS , SAVIDGE BETH , SHARMA YOGESH , SHI LIFANG , SUDARSHANA PADMINI , THOMPSON REBECCA , URWIN CARL , VAL DALE , VOSS STEVE , ANURADHA MEANDER , BASRA AMARJIT , BENNETT KRISTEN , BENSEN ROBERT
发明人： ABAD MARK , BELL ERIN , BRADSHAW TERRY , BRUNICK KIMBERLY , CASTIGLIONI PAOLO , CHAR SHOBHA , CHITRA RAJAM , CROWLEY JAMES , DEEBA FARAH , DEIKMAN JILL , DUFF STEPHEN , EDGERTON MICHAEL , FABBRI BRADON , FERNANDES MARY , GABBERT KAREN , GOLDMAN BARRY , H VEENA , HOUMARD NANCY , KARUNANANDAA BALASULOJINI , KJEMTRUP SUSANNE , LEE GARRETT , LELAND TIMOTHY , LI PENG , LUND ADRIAN , MCNABNAY MARCUS , PENG MING , QUI BO-XING , RAMANATH BHAT VIDYA , RAVANELLO MONICA , RUFF THOMAS , SAVAGE THOMAS , SAVIDGE BETH , SHARMA YOGESH , SHI LIFANG , SUDARSHANA PADMINI , THOMPSON REBECCA , URWIN CARL , VAL DALE , VOSS STEVE , ANURADHA MEANDER , BASRA AMARJIT , BENNETT KRISTEN , BENSEN ROBERT
IPC分类号： A01H5/00
CPC分类号： C12N15/8261 , C07K14/415 , C12N15/8273 , Y02A40/146
摘要： This invention provides recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. Also provided by this invention is transgenic seed for growing a transgenic plant having recombinant DNA in its genome and exhibiting an enhance agronomic trait, i.e. enhanced nitrogen use efficiency, increased yield, enhanced water use efficiency, enhanced tolerance to cold stress and/or improved seed compositions. Also disclosed are methods for identifying such transgenic plants by screening for nitrogen use efficiency, yield, water use efficiency, growth under cold stress, and seed composition changes. This invention also discloses a method of identifying the target genes of a transcription factor.
摘要翻译：本发明提供用于表达可用于赋予转基因作物植物增强的农学性状的蛋白质的重组DNA。本发明还提供了用于在其基因组中生长具有重组DNA的转基因植物的转基因种子，其表现出增强的农艺性状，即增强的氮利用效率，增加的产量，增强的水分利用效率，增强的耐寒性和/或改良的种子成分。还公开了通过筛选氮利用效率，产量，水利用效率，冷应激下的生长和种子组成变化来鉴定这些转基因植物的方法。本发明还公开了鉴定转录因子的靶基因的方法。

3. 发明申请

WO2010002876A3 COMPOSITIONS AND METHODS FOR ENHANCED AMINO ACID LEVELS IN PLANTS 审中-公开
标题翻译：增强植物氨基酸水平的组合物和方法
公开(公告)号：WO2010002876A3
公开(公告)日：2010-03-11
申请号：PCT/US2009049233
申请日：2009-06-30
申请人： MONSANTO TECHNOLOGY LLC , CROWLEY JAMES H , GOLDMAN BARRY S , HUANG JINTAI , QI QUNGANG , RAPP WILLIAM D
发明人： CROWLEY JAMES H , GOLDMAN BARRY S , HUANG JINTAI , QI QUNGANG , RAPP WILLIAM D
IPC分类号： C12N15/54 , C12N15/82
CPC分类号： C12N9/1217 , C12N15/8251 , C12N15/8254
摘要： Threonine is an essential amino acid for humans and in the animal feed industry where its levels in feed rations can significantly impact the cost of production of important meat sources, such as swine and poultry. Threonine as well as essential amino acids lysine and methionine are all synthesized via the aspartate family pathway. Aspartate kinase (AK) is the first enzyme in the pathway, and catalyzes the ATP-dependent phosphorylation of aspartate to form ß-aspartyl phosphate. AK constitutes the main regulatory step controlling the metabolic flux through the pathway, and is subject to end product inhibition by Lys and/or Thr. The current invention provides a method to produce a transgenic high free threonine soybean via the overexpression of feedback-resistant AK enzymes in developing soybean plants and seeds. These modifications provide a method to enhance both plant nitrogen metabolism and crop growth performance.
摘要翻译：苏氨酸是人体必需的氨基酸，在动物饲料行业中，它的饲料日粮水平可以显着影响猪和家禽等重要肉类的生产成本。苏氨酸以及必需氨基酸赖氨酸和甲硫氨酸都是通过天冬氨酸家族途径合成的。天冬氨酸激酶（AK）是该途径中的第一种酶，并且催化天冬氨酸的ATP依赖性磷酸化以形成β-天冬氨酰磷酸。 AK构成控制通过途径的代谢通量的主要调节步骤，并且受到Lys和/或Thr的最终产物抑制。本发明提供了一种通过在发育中的大豆植物和种子中过量表达反馈抗性AK酶来生产转基因高游离苏氨酸大豆的方法。这些修改提供了一种提高植物氮代谢和作物生长性能的方法。

4. 发明申请

WO2010002876A2 COMPOSITIONS AND METHODS FOR ENHANCED AMINO ACID LEVELS IN PLANTS 审中-公开
标题翻译：植物中增强氨基酸水平的组成和方法
公开(公告)号：WO2010002876A2
公开(公告)日：2010-01-07
申请号：PCT/US2009/049233
申请日：2009-06-30
申请人： MONSANTO TECHNOLOGY LLC , CROWLEY, James, H. , GOLDMAN, Barry, S. , HUANG, Jintai , QI, Qungang , RAPP, William, D.
发明人： CROWLEY, James, H. , GOLDMAN, Barry, S. , HUANG, Jintai , QI, Qungang , RAPP, William, D.
IPC分类号： C12N15/54 , C12N15/82
CPC分类号： C12N9/1217 , C12N15/8251 , C12N15/8254
摘要： Threonine is an essential amino acid for humans and in the animal feed industry where its levels in feed rations can significantly impact the cost of production of important meat sources, such as swine and poultry. Threonine as well as essential amino acids lysine and methionine are all synthesized via the aspartate family pathway. Aspartate kinase (AK) is the first enzyme in the pathway, and catalyzes the ATP-dependent phosphorylation of aspartate to form β-aspartyl phosphate. AK constitutes the main regulatory step controlling the metabolic flux through the pathway, and is subject to end product inhibition by Lys and/or Thr. The current invention provides a method to produce a transgenic high free threonine soybean via the overexpression of feedback-resistant AK enzymes in developing soybean plants and seeds. These modifications provide a method to enhance both plant nitrogen metabolism and crop growth performance.
摘要翻译：苏氨酸是人类和动物饲料工业中必不可少的氨基酸，其饲料配给水平可以显着影响重要肉源的生产成本，如猪和家禽。苏氨酸以及必需氨基酸赖氨酸和甲硫氨酸均通过天冬氨酸家族途径合成。天冬氨酸激酶（AK）是途径中的第一个酶，并催化天冬氨酸的ATP依赖性磷酸化形成β-天冬氨酰磷酸酯。 AK构成控制通过该途径的代谢通量的主要调控步骤，并且受到Lys和/或Thr的最终产物抑制。本发明提供了一种通过在开发大豆植物和种子中反馈抗性AK酶的过表达产生转基因高游离苏氨酸大豆的方法。这些修饰提供了增强植物氮代谢和作物生长性能的方法。

5. 发明申请

WO2007027866A3 TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS 审中-公开
标题翻译：具有增强的农艺性状的转基因植物
公开(公告)号：WO2007027866A3
公开(公告)日：2007-11-29
申请号：PCT/US2006033989
申请日：2006-08-30
申请人： MONSANTO TECHNOLOGY LLC , ABAD MARK , BELL ERIN , BRADSHAW TERRY , BRUNICK KIMBERLY , CASTIGLIONI PAOLO , CHAR SHOBHA , CHITRA RAJAM , CROWLEY JAMES , DEEBA FARAH , DEIKMAN JILL , DUFF STEPHEN , EDGERTON MICHAEL , FABBRI BRADON , FERNANDES MARY , GABBERT KAREN , GOLDMAN BARRY , H VEENA , HOUMARD NANCY , KARUNANANDAA BALASULOJINI , KJEMTRUP SUSANNE , LEE GARRETT , LELAND TIMOTHY , LI PENG , LUND ADRIAN , MCNABNAY MARCUS , PENG MING , QUI BO-XING , RAMANATH BHAT VIDYA , RAVANELLO MONICA , RUFF THOMAS , SAVAGE THOMAS , SAVIDGE BETH , SHARMA YOGESH , SHI LIFANG , SUDARSHANA PADMINI , THOMPSON REBECCA , URWIN CARL , VAL DALE , VOSS STEVE , ANURADHA MEANDER , BASRA AMARJIT , BENNETT KRISTEN , BENSEN ROBERT
发明人： ABAD MARK , BELL ERIN , BRADSHAW TERRY , BRUNICK KIMBERLY , CASTIGLIONI PAOLO , CHAR SHOBHA , CHITRA RAJAM , CROWLEY JAMES , DEEBA FARAH , DEIKMAN JILL , DUFF STEPHEN , EDGERTON MICHAEL , FABBRI BRADON , FERNANDES MARY , GABBERT KAREN , GOLDMAN BARRY , H VEENA , HOUMARD NANCY , KARUNANANDAA BALASULOJINI , KJEMTRUP SUSANNE , LEE GARRETT , LELAND TIMOTHY , LI PENG , LUND ADRIAN , MCNABNAY MARCUS , PENG MING , QUI BO-XING , RAMANATH BHAT VIDYA , RAVANELLO MONICA , RUFF THOMAS , SAVAGE THOMAS , SAVIDGE BETH , SHARMA YOGESH , SHI LIFANG , SUDARSHANA PADMINI , THOMPSON REBECCA , URWIN CARL , VAL DALE , VOSS STEVE , ANURADHA MEANDER , BASRA AMARJIT , BENNETT KRISTEN , BENSEN ROBERT
IPC分类号： A01H5/00
CPC分类号： C12N15/8261 , C07K14/415 , C12N15/8273 , Y02A40/146
摘要： This invention provides recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. Also provided by this invention is transgenic seed for growing a transgenic plant having recombinant DNA in its genome and exhibiting an enhance agronomic trait, i.e. enhanced nitrogen use efficiency, increased yield, enhanced water use efficiency, enhanced tolerance to cold stress and/or improved seed compositions. Also disclosed are methods for identifying such transgenic plants by screening for nitrogen use efficiency, yield, water use efficiency, growth under cold stress, and seed composition changes. This invention also discloses a method of identifying the target genes of a transcription factor.
摘要翻译：本发明提供了用于表达可用于赋予转基因作物植物增强农学性状的蛋白质的重组DNA。本发明还提供了用于生长转基因植物的转基因种子，所述转基因植物在其基因组中具有重组DNA并且表现出增强的农学性状，即增强的氮利用效率，增加的产量，增强的水利用效率，增强的对冷胁迫的耐受性和/ 成分。还公开了通过筛选氮利用效率，产量，水分利用效率，冷胁迫下的生长和种子组成变化来鉴定此类转基因植物的方法。本发明还公开了鉴定转录因子的靶基因的方法。

6. 发明申请

WO2008131155A3 CORN PLANTS AND SEED ENHANCED FOR ASPARAGINE AND PROTEIN 审中-公开
标题翻译：增加了天冬酰胺和蛋白质的玉米植物和种子
公开(公告)号：WO2008131155A3
公开(公告)日：2009-01-29
申请号：PCT/US2008060721
申请日：2008-04-18
申请人： MONSANTO TECHNOLOGY LLC , ANDERSEN SCOTT , CROWLEY JAMES , DUFF STEPHEN M , FABRI BRADON J , QI QUNGANG , QIU BO-XING , SCREEN STEVEN
发明人： ANDERSEN SCOTT , CROWLEY JAMES , DUFF STEPHEN M , FABRI BRADON J , QI QUNGANG , QIU BO-XING , SCREEN STEVEN
IPC分类号： C12N9/00 , A01H5/00 , C07K14/415 , C12N15/82
CPC分类号： C12N15/8251 , C12N9/93
摘要： The present invention relates to a corn plant and seed with enhanced levels of protein and amino acids. The invention also relates to DNA constructs that provide expression in transgenic corn cells of an asparagine synthetase enzyme. The DNA constructs are used in a method to produce transgenic corn plants and seeds and to select for plants and seeds with enhanced levels of protein and amino acids.
摘要翻译：本发明涉及具有增强水平的蛋白质和氨基酸的玉米植物和种子。本发明还涉及在转基因玉米细胞中提供天冬酰胺合成酶的表达的DNA构建体。 DNA构建体用于产生转基因玉米植物和种子的方法中，并选择具有增强的蛋白质和氨基酸水平的植物和种子。

7. 发明申请

WO2008131155A2 CORN PLANTS AND SEED ENHANCED FOR ASPARAGINE AND PROTEIN 审中-公开
标题翻译：玉米植物和种子增强了阿糖胞苷和蛋白质
公开(公告)号：WO2008131155A2
公开(公告)日：2008-10-30
申请号：PCT/US2008/060721
申请日：2008-04-18
申请人： MONSANTO TECHNOLOGY LLC , ANDERSEN, Scott , CROWLEY, James , DUFF, Stephen, M. , FABRI, Bradon, J. , QI, Qungang , QIU, Bo-Xing , SCREEN, Steven
发明人： ANDERSEN, Scott , CROWLEY, James , DUFF, Stephen, M. , FABRI, Bradon, J. , QI, Qungang , QIU, Bo-Xing , SCREEN, Steven
IPC分类号： C12N15/82
CPC分类号： C12N15/8251 , C12N9/93
摘要： The present invention relates to a corn plant and seed with enhanced levels of protein and amino acids. The invention also relates to DNA constructs that provide expression in transgenic corn cells of an asparagine synthetase enzyme. The DNA constructs are used in a method to produce transgenic corn plants and seeds and to select for plants and seeds with enhanced levels of protein and amino acids.
摘要翻译：本发明涉及具有增强蛋白质和氨基酸水平的玉米植物和种子。本发明还涉及在天冬酰胺合成酶的转基因玉米细胞中提供表达的DNA构建体。 DNA构建体用于生产转基因玉米植物和种子的方法，并选择具有增强蛋白质和氨基酸水平的植物和种子。

8. 发明申请

WO2012101190A1 IMPLANT DEVICE 审中-公开
标题翻译：植入装置
公开(公告)号：WO2012101190A1
公开(公告)日：2012-08-02
申请号：PCT/EP2012/051173
申请日：2012-01-25
申请人： THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN , NATIONAL UNIVERSITY OF IRELAND, GALWAY , MURPHY, Bruce , CROWLEY, James , BREEN, Liam , EARLY, Michael
发明人： MURPHY, Bruce , CROWLEY, James , BREEN, Liam , EARLY, Michael
IPC分类号： A61F2/24
CPC分类号： A61F2/2463 , A61B17/0057 , A61B17/12036 , A61B17/12122 , A61B17/12168 , A61B2017/00632 , A61F2/2418 , A61F2/2457 , A61F2/246 , A61F2220/0008 , A61F2220/0016 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0071
摘要： An implant device for a heart having a first chamber and a second chamber and a native valve between the chambers, the device having an elongate body having opposing ends, the body being configured to be implanted within the heart and extend through the native valve with a first end in the first chamber and a second end in the second chamber; a first resiliently compressible part of the body being adapted to be compressively engaged by the heart within the first chamber; and a second resiliently compressible part of the body being adapted to be compressively engaged by the heart within the second chamber; so that the first and second parts hold the elongate body in a desired position within the heart by said compressive engagement. The device can be employed as a prosthetic device replace or supplement a native valve such as the mitral valve.
摘要翻译：一种用于心脏的植入装置，具有第一腔室和第二腔室以及腔室之间的自然瓣膜，所述装置具有细长体，其具有相对的端部，所述主体构造成植入心脏内并且延伸穿过天然瓣膜，在第一室中的第一端和第二室中的第二端; 身体的第一弹性可压缩部分适于被第一腔内心脏压缩地接合; 并且所述主体的第二弹性可压缩部分适于被所述第二腔内的心脏压缩地接合; 使得第一和第二部分通过所述压缩接合将细长体保持在心脏内的期望位置。该装置可以用作假体装置来代替或补充诸如二尖瓣的天然瓣膜。

9. 发明申请

WO2008131155A8 CORN PLANTS AND SEED ENHANCED FOR ASPARAGINE AND PROTEIN 审中-公开
标题翻译：玉米植物和种子增强了阿糖胞苷和蛋白质
公开(公告)号：WO2008131155A8
公开(公告)日：2009-11-19
申请号：PCT/US2008060721
申请日：2008-04-18
申请人： MONSANTO TECHNOLOGY LLC , ANDERSEN SCOTT , CROWLEY JAMES , DUFF STEPHEN M , FABBRI BRADON J , QI QUNGANG , QIU BO-XING , SCREEN STEVEN
发明人： ANDERSEN SCOTT , CROWLEY JAMES , DUFF STEPHEN M , FABBRI BRADON J , QI QUNGANG , QIU BO-XING , SCREEN STEVEN
IPC分类号： C12N9/00 , A01H5/00 , C07K14/415 , C12N15/82
CPC分类号： C12N15/8251 , C12N9/93
摘要： The present invention relates to a corn plant and seed with enhanced levels of protein and amino acids. The invention also relates to DNA constructs that provide expression in transgenic corn cells of an asparagine synthetase enzyme. The DNA constructs are used in a method to produce transgenic corn plants and seeds and to select for plants and seeds with enhanced levels of protein and amino acids.
摘要翻译：本发明涉及具有增强蛋白质和氨基酸水平的玉米植物和种子。本发明还涉及在天冬酰胺合成酶的转基因玉米细胞中提供表达的DNA构建体。 DNA构建体用于生产转基因玉米植物和种子的方法，并选择具有增强蛋白质和氨基酸水平的植物和种子。

10. 发明申请

WO2006124678A3 CORN PLANTS AND SEED ENHANCED FOR ASPARAGINE AND PROTEIN 审中-公开
标题翻译：玉米植物和种子增强了阿糖胞苷和蛋白质
公开(公告)号：WO2006124678A3
公开(公告)日：2007-02-15
申请号：PCT/US2006018560
申请日：2006-05-15
申请人： MONSANTO TECHNOLOGY LLC , FABBRI BRADON , ANDERSEN SCOTT , SCREEN STEVEN , CROWLEY JAMES , QIU BO-XING
发明人： FABBRI BRADON , ANDERSEN SCOTT , SCREEN STEVEN , CROWLEY JAMES , QIU BO-XING
IPC分类号： C12N15/82 , C07K14/415 , C12N9/00
CPC分类号： C12N15/8251 , C12N9/93
摘要： The present invention relates to a corn plant and seed with enhanced levels of protein and amino acids. The invention also relates to DNA constructs that provide expression in transgenic corn cells of an asparagine synthetase enzyme. The DNA constructs are used in a method to produce transgenic corn plants and seeds and to select for plants and seeds with enhanced levels of protein and amino acids.
摘要翻译：本发明涉及具有增强蛋白质和氨基酸水平的玉米植物和种子。本发明还涉及在天冬酰胺合成酶的转基因玉米细胞中提供表达的DNA构建体。 DNA构建体用于生产转基因玉米植物和种子的方法，并选择具有增强蛋白质和氨基酸水平的植物和种子。

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