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1. 发明申请

WO2005117906A1 COMBINATION FOR INHIBITING BONE RESORPTION COMPRISING A BISPHOSPONATE (ALENDRONA) AND A VITAMIN D (CHOLECALCIFEROL) 审中-公开
标题翻译：用于抑制包含二磷酸（ALENDRONA）和维生素D（CHOLECALCIFEROL）的骨骼再吸收的组合
公开(公告)号：WO2005117906A1
公开(公告)日：2005-12-15
申请号：PCT/US2004/015743
申请日：2004-05-19
申请人： MERCK & CO., INC. , DAIFOTIS, Anastasia, G. , DENKER, Andrew , IKEDA, Craig , MATUSZEWSKI, Bogdan, K. , MAZEL, Sid , PORRAS, Arturo, G. , SANTORA, Art , SEBURG, Randal, Alan , ZHU, Limin , YATES, John , KIRSCH, John, D.
发明人： DAIFOTIS, Anastasia, G. , DENKER, Andrew , IKEDA, Craig , MATUSZEWSKI, Bogdan, K. , MAZEL, Sid , PORRAS, Arturo, G. , SANTORA, Art , SEBURG, Randal, Alan , ZHU, Limin , YATES, John , KIRSCH, John, D.
IPC分类号： A61K31/663
CPC分类号： A61K31/59 , A61K31/593 , A61K31/663 , A61K31/69 , Y02A50/401 , A61K2300/00
摘要： Disclosed are compositions and methods for preventing, inhibiting, reducing and treating conditions and diseases associated with abnormal bone resorption in mammals, including for example osteoporosis. Embodiments of compositions of the invention comprise a pharmaceutically effective amount of alendronate and vitamin D 3 suitable for once-weekly dosing. Compositions and methods of the invention provide vitamin D nutrition during bisphosphonate treatment to facilitate normal bone formation and mineralization while minimizing the occurrence of or potential for the complications associated with vitamin D insufficiency, such as hypocalcaemia and osteomalacia. Also disclosed are methods for manufacturing compositions of the present invention, for measuring stability and degradation of those compositions, and for measuring blood plasma levels of vitamin D.
摘要翻译：公开了用于预防，抑制，减少和治疗与哺乳动物异常骨吸收相关的病症和疾病的组合物和方法，包括例如骨质疏松症。本发明组合物的实施方案包含适合于每周一次给药的药学有效量的阿仑膦酸盐和维生素D3。本发明的组合物和方法在双膦酸盐治疗期间提供维生素D营养以促进正常的骨形成和矿化，同时最小化与维生素D不足相关的并发症的发生或潜在发生，例如低钙血症和骨软化。还公开了用于制备本发明的组合物的方法，用于测量那些组合物的稳定性和降解，以及用于测量维生素D的血浆水平。

2. 发明申请

WO2003086415A1 METHOD FOR INHIBITING BONE RESORPTION WITH AN ALENDRONATE AND VITAMIN D FORMULATION 审中-公开
标题翻译：用阿芬酸和维生素D配方抑制骨骼吸收的方法
公开(公告)号：WO2003086415A1
公开(公告)日：2003-10-23
申请号：PCT/US2003/009799
申请日：2003-04-01
申请人： MERCK & CO., INC. , DAIFOTIS, Anastasia, G. , MAZEL, Sidney , YATES, John
发明人： DAIFOTIS, Anastasia, G. , MAZEL, Sidney , YATES, John
IPC分类号： A61K31/66
CPC分类号： A61K31/59 , A61K31/675 , A61K45/06 , A61K2300/00
摘要： Composition and method for preventing or treating abnormal bone resorption in mammals, the composition characterized as containing, a supplementary effective amount of a non-activated metabolite of vitamin D 2 and/or D 3 and a pharmaceutically effective amount of bisphosphonate to provide vitamin D nutrition during treatment to facilitate normal bone formation and mineralization, while minimizing the occurrence of or potential for the complications associated with vitamin D insufficiency, such as hypocalcemia and osteomalacia. The method of preventing or treating may be further characterized by concomitantly administering the components simultaneously or alternately at dosing intervals selected from once-weekly, twice-weekly, bi-weekly, monthly, and bi-monthly.
摘要翻译：用于预防或治疗哺乳动物异常骨吸收的组合物和方法，该组合物特征在于含有补充有效量的维生素D2和/或D3的非活化代谢物和药学有效量的二膦酸盐以在治疗期间提供维生素D营养以促进正常的骨形成和矿化，同时最小化与维生素D不足相关的并发症的发生或潜在性，例如低钙血症和骨软化。预防或治疗的方法的进一步特征在于同时或交替地以每周一次，每周两次，每两周一次，每月一次和每两个月一次的给药间隔同时施用组分。

3. 发明申请

WO2003049720A1 COMBINATION THERAPY COMPRISING A CYCLOOYGENASE-2 INHIBITOR 审中-公开
标题翻译：包含CYCLOOYGENASE-2抑制剂的组合治疗
公开(公告)号：WO2003049720A1
公开(公告)日：2003-06-19
申请号：PCT/US2002/038376
申请日：2002-12-03
申请人： MERCK & CO., INC. , MURRAY, Richard, K. , YATES, John
发明人： MURRAY, Richard, K. , YATES, John
IPC分类号： A61K9/20
CPC分类号： A61K31/415 , A61K31/135 , A61K31/44 , A61K31/60 , A61K2300/00
摘要： The present invention encompasses a method and kit for treating a chronic cyclooxygenase-2 mediated disease or condition and reducing the risk of a thrombotic cardiovascular event in a human patient in need of such treatment and at risk of a thrombotic cardiovascular event comprising orally administering to said patient a cyclooxygenase-2 selective inhibitor on a once or twice daily basis in an amount effective to treat the cyclooxygenase-2 mediated disease or condition and orally administering to said patient aspirin once every two to seven days in an amount effective to reduce the risk of the thrombotic cardiovascular event while maintaining a high level of upper gastrointestinal safety and tolerability.
摘要翻译：本发明包括用于治疗慢性环氧合酶-2介导的疾病或病症并降低需要这种治疗的患者的血栓性心血管事件的风险的方法和试剂盒，并且具有血栓性心血管事件的风险，包括口服给予所述患者环氧合酶-2选择性抑制剂，每天一次或两次，其用量有效地治疗环氧合酶-2介导的疾病或病症，并且口服给予所述患者阿司匹林，每二至七天一次，其量有效降低血栓性心血管事件同时保持高水平的上消化道安全性和耐受性。

4. 发明申请

WO2010039470A3 POLY(ARYLENE ETHER) COMPOSITION WITH IMPROVED MELT FLOW AND METHOD FOR THE PREPARATION THEREOF 审中-公开
公开(公告)号：WO2010039470A3
公开(公告)日：2010-04-08
申请号：PCT/US2009/057612
申请日：2009-09-21
申请人： SABIC INNOVATIVE PLASTICS IP B.V. , GUO, Hua , YATES, John , TODT, Michael
发明人： GUO, Hua , YATES, John , TODT, Michael
IPC分类号： C08L71/12 , C08L25/04 , C08L77/00 , C08L67/00 , C08L23/00 , C08L81/04
摘要： A thermoplastic composition is prepared by melt blending a poly(arylene ether) and an other resin, where the poly(arylene ether) has a particular molecular weight distribution. The thermoplastic composition exhibits significantly increased melt flow compared to compositions containing poly(arylene ether)s with similar intrinsic viscosities but different molecular weight distributions. The increased melt flow facilitates preparation of the thermoplastic composition and subsequent article fabrication procedures.

5. 发明申请

WO2011064554A1 ANTI-MICROBIAL WIPES 审中-公开
标题翻译：抗微生物制品
公开(公告)号：WO2011064554A1
公开(公告)日：2011-06-03
申请号：PCT/GB2010/002191
申请日：2010-11-26
申请人： BYOTROL PLC , FALDER, Stephen, Brian , FRANCIS, Thomas, Trevor , YATES, John
发明人： FALDER, Stephen, Brian , FRANCIS, Thomas, Trevor , YATES, John
IPC分类号： A01N33/12 , C11D1/62 , C11D1/835 , C11D3/00 , C11D17/04
CPC分类号： C11D3/48 , A01N33/12 , C11D17/049 , A01N25/34 , A01N2300/00
摘要： The present invention provides an anti-microbial wipe comprising a substrate comprising from 1 to 100% by weight of a cellulosic material and incorporating a composition comprising (i) an anti-microbial component; (ii) a non-ionic surfactant; (iii) a polar solvent; and optionally (iv) a hydrophobic material; wherein the anti-microbial component (i) comprises (a) at least one quaternary ammonium compound of formula (A) R 1 R 2 R 3 R 4 N + X - , wherein R 1 , R 2 , R 3 and R 4 represent, independently a substituted or unsubstituted and/or straight chain or branched and/or interrupted or uninterrupted alkyl, aryl, alkylaryl, arylalkyl, cycloalkyl, heterocyclyl or alkenyl group, and wherein the total number of carbon atoms in the groups R 1 , R 2 , R 3 and R 4 is at least 4; wherein the substituents for the groups R 1 , R 2 , R 3 and R 4 are selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, heterocyclyl, substituted heterocyclyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, F, Cl, Br, I, -OR', -NR'R", -CF 3 , -CN, -NO 2 , -C 2 R', - SR', -N 3 , -C(=O)NR'R", -NR'C(=O) R", -C(=O)R', -C(=O)OR', -OC(=O)R', -O(CR'R") r C(=O)R' -O(CR'R") r NR"C(=O)R', -O(CR'R") r NR"SO2R', -OC(=O)NR'R", -NR'C(=O)OR", -SO 2 R', - SO 2 NR'R", and -NR'SO 2 R"; wherein R' and R" are individually hydrogen, C 1 -C 8 alkyl, cycloalkyl, heterocyclyl, aryl, or arylalkyl, and r is an integer from 1 to 6, or R' and R" together form a cyclic functionality; wherein the term "substituted" as applied to alkyl, alkenyl, heterocyclyl, cycloalkyl, aryl, alkylaryl and arylalkyl refers to the substituents described above, starting with F and ending with -NR'SO 2 R"; and wherein X - is halide or sulphonate; and optionally (b) one or more additional anti-microbial agents, and wherein the composition is substantially free of anionic surfactant.
摘要翻译：本发明提供了一种抗微生物擦拭物，其包含基材，其包含1至100重量％的纤维素材料并掺入包含（i）抗微生物成分的组合物; （ii）非离子表面活性剂; （iii）极性溶剂; 和（iv）疏水性材料; 其中所述抗微生物组分（i）包含（a）至少一种式（A）的季铵化合物，R1R2R3R4N + X-，其中R1，R2，R3和R4独立地表示取代或未取代的和/或直链或支链和/或中断或不间断的烷基，芳基，烷基芳基，芳基烷基，环烷基，杂环基或烯基，并且其中基团R1，R2，R3和R4中的总碳原子数至少为4; 基团R1，R2，R3和R4的取代基选自烷基，取代的烷基，烯基，取代的烯基，杂环基，取代的杂环基，环烷基，取代的环烷基，芳基，取代的芳基，烷基芳基，取代的烷基芳基，芳基烷基，取代芳基烷基，F，Cl，Br，I，-OR'， - NR'R“，-CF 3，-CN，-NO 2，-C 2 R'， - SR'，-N 3，-C（= O）NR 'R“，-NR'C（= O）R”，-C（= O）R'， - C（= O）OR'，-OC（= O）R'， - O（CR'R“ rC（= O）R'-O（CR'R“）rNR”C（= O）R'，-O（CR'R“）rNR”SO2R'，-OC（= O）NR'R“ NR'C（= O）OR“，-SO 2 R'， - SO 2 NR'R”和-NR'SO 2 R“; 其中R'和R“分别为氢，C 1 -C 8烷基，环烷基，杂环基，芳基或芳烷基，r为1至6的整数，或R'和R”一起形成环状官能团; 其中应用于烷基，烯基，杂环基，环烷基，芳基，烷基芳基和芳烷基的术语“取代的”是指以F开始并以-NR'SO 2 R“结束的上述取代基;其中X是卤化物或磺酸盐; 和任选地（b）一种或多种另外的抗微生物剂，并且其中所述组合物基本上不含阴离子表面活性剂。

6. 发明申请

WO2009037445A1 FORMULATIONS COMPRISING AN ANTL-MICROBIAL COMPOSITION 审中-公开
标题翻译：包含ANTL-微生物组合物的制剂
公开(公告)号：WO2009037445A1
公开(公告)日：2009-03-26
申请号：PCT/GB2008/003149
申请日：2008-09-17
申请人： BYOTROL PLC , SCHWARZ, Ulrich , FALDER, Stephen, Brian , YATES, John
发明人： SCHWARZ, Ulrich , FALDER, Stephen, Brian , YATES, John
IPC分类号： C11D3/00 , C11D1/62 , C11D1/835 , C11D1/94 , C11D3/16 , C11D3/18 , C11D3/37 , A61K8/31 , A61K8/41 , A61Q19/00 , A23L3/00
CPC分类号： C11D3/48 , A23L3/3463 , A23L3/3526 , A61K8/416 , A61K8/442 , A61K8/585 , A61Q17/005 , C11D1/62 , C11D1/835 , C11D1/94 , C11D3/162 , C11D3/18 , C11D3/373
摘要： The present invention describes a formulation comprising: (A) at least one surfactant; and (B) an anti-microbial composition that comprises (i) an anti-microbial agent with surfactant properties; (ii) a hydrophobic material and (iii) a polar solvent.
摘要翻译：本发明描述了一种制剂，其包含：（A）至少一种表面活性剂; 和（B）抗微生物组合物，其包含（i）具有表面活性剂性质的抗微生物剂; （ii）疏水性材料和（iii）极性溶剂。

7. 发明申请

WO2003076570A3 ANTIGENS AND THEIR USE AS DIAGNOSTICS AND VACCINES AGAINST SPECIES OF PLASMODIUM 审中-公开
公开(公告)号：WO2003076570A3
公开(公告)日：2003-09-18
申请号：PCT/US2003/006324
申请日：2003-03-04
申请人： THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY , CARUCI, Daniel , YATES, John , FLORENS, Laurence , WU, Yimin
发明人： CARUCI, Daniel , YATES, John , FLORENS, Laurence , WU, Yimin
IPC分类号： C07H21/04
摘要： Two proteins and their use as substrates for vaccines intended to initiate an immune response in a mammalian subject against infection with species of Plasmodium for use in the diagnosis of Plasmodium infection and for their use in the development of antimalarial drugs. This invention also relates to the diagnostic, isolation and purification assays based on these Plasmodium proteins. This invention further relates to immunological reagents, specifically antibodies directed against these Plasmodium proteins.

8. 发明申请

WO2009099631A1 NOVEL PLASMINOGEN RECEPTOR, POLYPEPTIDES & ANTIBODIES THEREOF 审中-公开
标题翻译：新型PLASMINOGEN受体，其多肽和抗体
公开(公告)号：WO2009099631A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/000744
申请日：2009-02-06
申请人： MILES, Lindsey A. , YATES, John , CHEN, Emily I. , BAIK, Nagyung , PARMER, Robert J.
发明人： MILES, Lindsey A. , YATES, John , CHEN, Emily I. , BAIK, Nagyung , PARMER, Robert J.
IPC分类号： C07K14/435
CPC分类号： C07K14/745
摘要： The invention relates to C9orf46 homolog, a novel murine membrane protein, and its orthologs in human, mouse and all other species, termed Plg-R KT , or analogs, thereof and the isolation method. The function of this molecule is to bind to plasminogen, plasminogen fragments such as angiostatin 1 and other plasminongen fragments having angiostatic activity, tissue plasminogen activator and Lipoprotein(a). Plasminogen receptors function to modulate cell surface proteolysis and physiological and pathophysiological processes requiring cell migration, including, but not limited to, cell migration during inflammation, tissue remodeling, wound healing, tumor cell invasion and metastasis, skeletal myogenesis, neurite outgrowth. Plasminogen receptors also modulate apoptosis and cell death. The invention also relates to antibodies that inhibit plasminogen, plasminogen fragments such as angiostatin 1 and other plasminongen fragments having angiostatic activity, tissue plasminogen activator or Lipoprotein(a) binding to Plg-R KT and/or immunoreact with Plg-R KT .
摘要翻译：本发明涉及C9orf46同源物，一种新型鼠膜蛋白及其在人，小鼠和所有其他物种中的直向同源物，称为Plg-RKT或其类似物，以及分离方法。该分子的功能是结合纤溶酶原，纤溶酶原片段如血管抑素1和具有血管抑制活性的其它纤溶酶原片段，组织纤溶酶原激活物和脂蛋白（a）。纤溶酶原受体起调节细胞表面蛋白水解和需要细胞迁移的生理和病理生理过程，包括但不限于炎症，组织重塑，伤口愈合，肿瘤细胞侵袭和转移中的细胞迁移，骨骼肌发生，神经突生长。纤溶酶原受体也调节凋亡和细胞死亡。本发明还涉及抑制纤溶酶原，纤溶酶原片段如血管抑素1和具有血管抑制活性的其它纤溶酶原片段，组织纤溶酶原激活物或脂蛋白（a）结合Plg-RKT和/或与Plg-RKT的免疫反应的抗体。

9. 发明申请

WO2008009988A2 COMPOSITE STRUCTURE AND METHOD OF MANUFACTURE 审中-公开
标题翻译：复合结构及其制造方法
公开(公告)号：WO2008009988A2
公开(公告)日：2008-01-24
申请号：PCT/GB2007/050401
申请日：2007-07-13
申请人： AIRBUS UK LIMITED , YATES, John , INSTON, David, Graham
发明人： YATES, John , INSTON, David, Graham
CPC分类号： B64C3/187 , B29C53/822 , B29C70/32 , B29C70/845 , B29D22/00 , B29L2031/748 , B64C9/16 , B64C9/22 , Y02T50/43
摘要： A method of manufacture of a structural member comprising, providing a number of intern al elements, each having an aperture formed therein, sequentially assembling the internal elements onto a longitudinal element such that the longitudinal element passes through the aperture of each internal element, and wrapping an outer skin around the assembled internal elements and longitudinal element. A structural member is thus produced having a number of internal elements, each internal element having a longitudinal axis aligned with the longitudinal axis of the remaining internal elements, and having a continuous outer skin formed over the internal elements.
摘要翻译：一种制造结构构件的方法，包括：提供多个内部元件，每个元件具有形成在其中的孔，将内部元件顺序地组装到纵向元件上，使得纵向元件穿过每个内部元件的孔，并且包裹围绕组装的内部元件和纵向元件的外部皮肤。因此，制造具有多个内部元件的结构构件，每个内部元件具有与其余内部元件的纵向轴线对准的纵向轴线，并且在内部元件上形成有连续的外部皮肤。

10. 发明申请

WO2003076570A2 ANTIGENS AND THEIR USE AS DIAGNOSTICS AND VACCINES AGAINST SPECIES OF PLASMODIUM 审中-公开
标题翻译：抗生素及其作为抗菌物质的诊断和疫苗使用
公开(公告)号：WO2003076570A2
公开(公告)日：2003-09-18
申请号：PCT/US2003/006324
申请日：2003-03-04
申请人： THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY , CARUCI, Daniel , YATES, John , FLORENS, Laurence , WU, Yimin
发明人： CARUCI, Daniel , YATES, John , FLORENS, Laurence , WU, Yimin
IPC分类号： C12N
CPC分类号： C07K14/445 , A61K39/00 , Y02A50/412
摘要： Two proteins and their use as substrates for vaccines intended to initiate an immune response in a mammalian subject against infection with species of Plasmodium for use in the diagnosis of Plasmodium infection and for their use in the development of antimalarial drugs. This invention also relates to the diagnostic, isolation and purification assays based on these Plasmodium proteins. This invention further relates to immunological reagents, specifically antibodies directed against these Plasmodium proteins.
摘要翻译：两种蛋白质及其用作疫苗的底物，旨在启动哺乳动物受试者免受疟原虫感染的免疫应答，用于诊断疟原虫感染并用于开发抗疟疾药物。本发明还涉及基于这些疟原虫蛋白质的诊断，分离和纯化测定。本发明还涉及免疫试剂，特别是针对这些疟原虫蛋白质的抗体。

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