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1. 发明申请

WO2008106659A2 METHODS OF TREATING BIPOLAR DISORDER AND MEMORY AND/OR COGNITIVE IMPAIRMENT ASSOCIATED THEREWITH 审中-公开
标题翻译：治疗双极性疾病的方法和与之相关的记忆和/或认知障碍
公开(公告)号：WO2008106659A2
公开(公告)日：2008-09-04
申请号：PCT/US2008055562
申请日：2008-02-29
申请人： MEMORY PHARM CORP , LOWE DAVID , LEONARD CHRISTOPHER J , DE VIVO MICHAEL , TOMBAUGH GEOFFREY
发明人： LOWE DAVID , LEONARD CHRISTOPHER J , DE VIVO MICHAEL , TOMBAUGH GEOFFREY
IPC分类号： A61K31/44 , A61K31/435
CPC分类号： A61K31/435 , A61K31/44 , A61K45/06 , A61K2300/00
摘要： The present invention is a method of treating or preventing mixed and/or manic episodes associated with bipolar I disorder or memory and/or cognitive impairment associated therewith in a patient in need thereof by administering an effective amount of at least one calcium channel modulator selected from (1 ) amlodipine, bepridil, clevidipine, felodipine, isradipine, lacidipine, lercanidipine, manidipine, niguldipine, nilvadipine, nisoldipine, or nitrendipine, or (2) the R-enantiomer of a 1,4-dihydropyridine compound, other than (+)-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)- l,4- dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylate.
摘要翻译：本发明是通过施用有效量的至少一种选自以下的钙通道调节剂的治疗或预防与有此需要的患者相关的双相I障碍或记忆和/或与之相关的认知障碍的混合和/或躁狂发作的方法：（1）氨氯地平，替泊霉素，氯维地平，非洛地平，伊拉地平，拉西地平，替卡西平，马尼地平，尼古地平，尼伐地平，尼索地平或尼群地平，或（2） 4-（2-氯-3-氰基 - 苯基）-1,4-二氢-2,6-二甲基 - 吡啶-3,5-二羧酸2-异丙基-2-甲氧基乙酯。

2. 发明申请

WO2008115246A3 APPARATUS AND METHODS FOR INTERLOCKING STENT SEGMENTS 审中-公开
标题翻译：装置和方法互锁支架部分
公开(公告)号：WO2008115246A3
公开(公告)日：2008-12-04
申请号：PCT/US2007070764
申请日：2007-06-08
申请人： XTENT INC , KAO STEPHEN , DITTMER JEREMY , LOWE DAVID
发明人： KAO STEPHEN , DITTMER JEREMY , LOWE DAVID
IPC分类号： A61B17/08 , A61B17/12 , A61F20060101 , A61F2/82
CPC分类号： A61B17/12022 , A61B17/12118 , A61B17/12163 , A61B2017/1205 , A61F2/852 , A61F2/91 , A61F2/915 , A61F2/95 , A61F2/958 , A61F2002/30329 , A61F2002/30545 , A61F2002/30599 , A61F2002/826 , A61F2002/828 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91541 , A61F2002/9155 , A61F2002/91591 , A61F2002/9665 , A61F2220/0025 , A61F2250/001 , A61F2250/0063 , A61F2250/0071
摘要： Apparatus and methods for interlocking stent segments which provide for a secure engagement between the expanded stent segments are described herein. Stent segments which are able to slide freely relative to one another along the deployment catheter prior to expansion may be secured to one another when expanded and/or deployed into the vessel. Securement upon expansion of the stent segments may be accomplished, in part, by utilizing one or more coupling mechanisms between adjacent stent segments which securely interlock the segments to one another by taking advantage of the changing geometry of the stents during expansion.
摘要翻译：本文描述了用于互锁支架节段的装置和方法，所述支架节段在扩张的支架节段之间提供安全接合。在膨胀之前能够沿着展开导管相对于彼此自由地滑动的支架节段可以在膨胀和/或展开到血管中时彼此固定。部分地通过利用相邻支架节段之间的一个或多个耦合机构来实现扩张支架节段时的支架，所述相邻支架节段之间的一个或多个耦合机构通过在扩张期间利用支架的变化几何形状而将节段彼此安全地互锁。

3. 发明申请

WO2005116659A3 COMPOSITIONS AND METHODS RELATING TO ALZHEIMER'S DISEASE 审中-公开
标题翻译：关于阿尔茨海默病的组合物和方法
公开(公告)号：WO2005116659A3
公开(公告)日：2006-09-08
申请号：PCT/US2005017263
申请日：2005-05-18
申请人： NEURODX LLC , LOWE DAVID , SCHULMAN HOWARD
发明人： LOWE DAVID , SCHULMAN HOWARD
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： Compositions, kits, and methods for diagnosing, characterizing, and treating Alzheimer's Disease (AD) are disclosed. Polypeptides and non-peptide small molecules, which were identified as differentially expressed in samples obtained from AD subjects as compared to samples obtained from non-AD subjects can be used as polypeptide markers and metabolite markers, respectively. The markers can be used alone or in combination.
摘要翻译：公开了用于诊断，表征和治疗阿尔茨海默病（AD）的组合物，试剂盒和方法。与从AD患者获得的样品相比，从AD受试者获得的样品中鉴定出差异表达的多肽和非肽小分子可分别用作多肽标记和代谢标记。标记可以单独使用或组合使用。

4. 发明申请

WO2006108051A3 COMPOSITIONS AND METHODS RELATING TO ALZHEIMER'S DISEASE 审中-公开
标题翻译：关于阿尔茨海默病的组合物和方法
公开(公告)号：WO2006108051A3
公开(公告)日：2008-10-09
申请号：PCT/US2006012681
申请日：2006-04-05
申请人： NEURODX LLC , SCHULMAN HOWARD , LOWE DAVID , BECKER CHRISTOPHER H , ZHOU HAIHONG , ROY SUSHMITA MIMI
发明人： SCHULMAN HOWARD , LOWE DAVID , BECKER CHRISTOPHER H , ZHOU HAIHONG , ROY SUSHMITA MIMI
IPC分类号： C12Q1/00 , A01N61/00 , A61K38/00 , A61K38/03 , C07K16/00 , G01N33/53
CPC分类号： C12Q1/6883
摘要： The present invention provides compositions, methods and kits useful for the diagnosis and treatment of Alzheimer's disease (AD). In particular, the invention provides polypeptides and metabolites that are markers of AD, polynucleotides that encode the polypeptides and antibodies that specifically bind to the polypeptides. The invention also provides fragments, precursors, successors and modified versions of the foregoing polypeptides, metabolites, polynucleotides and antibodies. The invention also provides compositions comprising the foregoing polypeptides, metabolites, polynucleotides and antibodies. The invention also provides methods for using the polypeptides, metabolites, polynucleotides and antibodies in the diagnosis and treatment of AD, monitoring progression of the disease and screening of candidate therapeutic compounds.
摘要翻译：本发明提供了可用于诊断和治疗阿尔茨海默病（AD）的组合物，方法和试剂盒。特别地，本发明提供作为AD标记的多肽和代谢物，编码多肽的多核苷酸和与多肽特异性结合的抗体。本发明还提供前述多肽，代谢物，多核苷酸和抗体的片段，前体，后继和修饰形式。本发明还提供包含前述多肽，代谢物，多核苷酸和抗体的组合物。本发明还提供了在AD的诊断和治疗中使用多肽，代谢物，多核苷酸和抗体的方法，监测疾病进展和候选治疗化合物的筛选。

5. 发明申请

WO2008034018A3 FILLING, IDENTIFYING, VALIDATING, AND SERVICING TIP FOR FLUID-EJECTION DEVICE 审中-公开
标题翻译：流体输送装置的填充，识别，检验和维护提示
公开(公告)号：WO2008034018A3
公开(公告)日：2008-07-10
申请号：PCT/US2007078425
申请日：2007-09-13
申请人： HEWLETT PACKARD DEVELOPMENT CO , KENT BLAIR M , AXTELL JAMES P , BENJAMIN TRUDY , LOWE DAVID , SEU PRESTON
发明人： KENT BLAIR M , AXTELL JAMES P , BENJAMIN TRUDY , LOWE DAVID , SEU PRESTON
IPC分类号： B41J2/17 , B41J2/175 , B41J3/36
CPC分类号： B41J2/17506 , B41J3/36 , B41J3/407
摘要： A tip to be placed on a fluid-ejection device is filled with fluid (1000). The fluid may be introduced into a substantially hollow body of the tip at a first end of the body (1002). The body of the tip has a second end at which a fluid-ejection mechanism is disposed to eject the fluid as controlled by the fluid-ejection device. The fluid may be introduced into the substantially hollow body of the tip through of the fluid-ejection mechanism disposed at the second end of the body of the tip (1004). The tip may further be identified and/or serviced, and the tip and/or the fluid-ejection device may further be validated.
摘要翻译：放置在流体喷射装置上的尖端填充有流体（1000）。流体可以在主体（1002）的第一端处被引入尖端的基本上中空的主体中。尖端的主体具有第二端，在该第二端处设置有流体喷射机构，以便由流体喷射装置控制地喷射流体。流体可以通过设置在尖端（1004）的主体的第二端处的流体排出机构引入尖端的基本上中空的主体中。尖端还可以被识别和/或维修，并且可以进一步验证尖端和/或流体喷射装置。

6. 发明申请

WO2012134938A3 APPARATUS FOR CONTROLLING A LOAD ON A HIP JOINT 审中-公开
标题翻译：用于控制HIP接头上的负载的装置
公开(公告)号：WO2012134938A3
公开(公告)日：2013-01-10
申请号：PCT/US2012030071
申请日：2012-03-22
申请人： MOXIMED INC , GABRIEL STEFAN , O'CONNELL MARY , CLIFFORD ANTON G , LOWE DAVID , LANDRY MICHAEL E
发明人： GABRIEL STEFAN , O'CONNELL MARY , CLIFFORD ANTON G , LOWE DAVID , LANDRY MICHAEL E
IPC分类号： A61B17/56 , A61F2/32
CPC分类号： A61B17/562 , A61B2017/567 , A61F2/32
摘要： An apparatus and related method for controlling a load on a human hip joint during normal gait while preserving motion. The approach is intended to treat osteoarthritis of the hip without substantially resisting an angular displacement associated with full mobility of the pelvis and femur bones.
摘要翻译：一种用于在正常步态期间控制人髋关节上的负荷同时保持运动的装置和相关方法。该方法旨在治疗髋关节骨性关节炎，而不会基本上抵抗与骨盆和股骨骨骼的完全移动相关的角位移。

7. 发明申请

WO2008034015A3 HANDHELD AND/OR MOUNTABLE FLUID-EJECTION DEVICE RECEPTIVE TO TIP CONTAINING FLUID AND FLUID-EJECTION MECHANISM 审中-公开
标题翻译：含有流体和流体喷射机构的手持式和/或安装的流体输送装置
公开(公告)号：WO2008034015A3
公开(公告)日：2008-05-08
申请号：PCT/US2007078422
申请日：2007-09-13
申请人： HEWLETT PACKARD DEVELOPMENT CO , AXTELL JAMES P , KENT BLAIR M , NIELSEN JEFFREY A , GIRI MANISH , BENJAMIN TRUDY , LOWE DAVID , ANDERSON RONALD R , SEU PRESTON
发明人： AXTELL JAMES P , KENT BLAIR M , NIELSEN JEFFREY A , GIRI MANISH , BENJAMIN TRUDY , LOWE DAVID , ANDERSON RONALD R , SEU PRESTON
IPC分类号： B41J3/36 , B41J2/175 , B41J3/407
CPC分类号： B41J2/17546 , B41J2/16535 , B41J2/175 , B41J3/36
摘要： A fluid-ejection device (100) includes a handheld and/or mountable enclosure (104), a pneumatic fitting (220), an electrical connector (209), and a controller (208). The pneumatic fitting extends from and/or through the enclosure and is receptive to placement of a tip (102) thereon. The tip contains a supply of fluid, a fluid-ejection mechanism (510), and an electrical connector (512) for the fluid-ejection mechanism. The electrical connector (209) extends from and/or through the enclosure and is receptive to electrical coupling of the electrical connector (512) of the tip. The controller is situated within the enclosure to cause the tip to eject the fluid via the electrical coupling of the electrical connectors and the fluid-ejection device.
摘要翻译：流体喷射装置（100）包括手持和/或可安装的外壳（104），气动接头（220），电连接器（209）和控制器（208）。气动配件从外壳延伸和/或穿过外壳，并且可接受在其上放置尖端（102）。尖端包含流体供应源，流体排出机构（510）和用于流体排出机构的电连接器（512）。电连接器（209）从壳体延伸和/或穿过外壳并且接受尖端的电连接器（512）的电耦合。控制器位于外壳内，以使顶端通过电连接器和流体喷射装置的电耦合来喷射流体。

8. 发明申请

WO2013006290A2 METHODS AND DEVICES FOR JOINT LOAD CONTROL DURING HEALING OF JOINT TISSUE 审中-公开
标题翻译：联合组织治疗期间联合负荷控制的方法和装置
公开(公告)号：WO2013006290A2
公开(公告)日：2013-01-10
申请号：PCT/US2012043963
申请日：2012-06-25
申请人： MOXIMED INC , LANDRY MICHAEL E , CLIFFORD ANTON G , ROBINS ANTHONY J , LOWE DAVID , GABRIEL STEFAN
发明人： LANDRY MICHAEL E , CLIFFORD ANTON G , ROBINS ANTHONY J , LOWE DAVID , GABRIEL STEFAN
CPC分类号： A61F2/3836 , A61B17/56 , A61B17/6425 , A61B2017/567 , A61F2/30756 , A61L27/3817 , A61L27/3852 , A61L2430/24
摘要： Various methods for treating a joint are disclosed herein. According to one method, a joint is surgically treated by performing a surgical repair treatment on tissue within the joint capsule; implanting a load reducing device at the joint and entirely outside of the joint capsule to reduce load transmitted by the treated tissue to allow for the tissue within the joint capsule to heal; and partially unloading the joint during healing of the surgical repair site.
摘要翻译：本文公开了用于治疗关节的各种方法。根据一种方法，通过对关节囊内的组织进行手术修复治疗来对关节进行手术治疗; 在关节处并且完全在关节囊外部植入负荷减轻装置以减少被处理组织传递的负担，以使关节囊内的组织愈合; 并在外科修复部位的愈合期间部分地卸下关节。

9. 发明申请

WO2011056756A3 POSITIONING SYSTEMS AND METHODS FOR IMPLANTING AN ENERGY ABSORBING SYSTEM 审中-公开
标题翻译：用于植入能量吸收系统的定位系统和方法
公开(公告)号：WO2011056756A3
公开(公告)日：2011-09-01
申请号：PCT/US2010054999
申请日：2010-11-01
申请人： MOXIMED INC , REGALA ALAN C , O'CONNELL MARY , LANDRY MICHAEL , CLIFFORD ANTON G , RODE MICHAEL , SCHIFF EZRA T , LOWE DAVID , SLONE CLINTON N
发明人： REGALA ALAN C , O'CONNELL MARY , LANDRY MICHAEL , CLIFFORD ANTON G , RODE MICHAEL , SCHIFF EZRA T , LOWE DAVID , SLONE CLINTON N
IPC分类号： A61B17/88 , A61B17/56 , A61F2/38 , A61F2/46
CPC分类号： A61B17/8872 , A61B17/1764 , A61B17/56 , A61B17/8061 , A61B17/808 , A61B17/8897 , A61B2017/567 , A61B2090/061 , A61F2/0811 , A61F2/3836 , A61F2/4657 , A61F2002/0823 , A61F2002/0864 , A61F2002/0888 , A61F2002/30563
摘要： Positioning instruments and related methods are described for implanting an energy absorbing system for treating joints. The positioning instruments and methods allow the energy absorbing system to be positioned at a joint such that the desired motion will occur for the particular design of a particular energy absorbing system which is to be implanted. The positioning instruments include a locating instrument for locating an anatomical feature and a target location for implantation of the energy absorbing system, a verification instrument for verification of the target location, a placement guide for guiding placement of a part of the energy absorbing system, and positioning device for aligning portions of the energy absorbing system.
摘要翻译：描述了用于植入用于治疗关节的能量吸收系统的定位仪器和相关方法。定位仪器和方法允许能量吸收系统定位在关节处，使得对于待植入的特定能量吸收系统的特定设计将发生期望的运动。定位仪器包括用于定位解剖特征的定位仪器和用于植入能量吸收系统的目标位置，用于验证目标位置的验证仪器，用于引导能量吸收系统的一部分的放置的放置引导件，以及定位装置用于对准能量吸收系统的部分。

10. 发明申请

WO2010100398A8 WATERMARK ENCODING AND DECODING 审中-公开
标题翻译： WATERMARK编码和解码
公开(公告)号：WO2010100398A8
公开(公告)日：2011-02-03
申请号：PCT/GB2010000308
申请日：2010-02-22
申请人： UNIV ASTON , LOWE DAVID , MATAM RAJESWARI BASAVA
发明人： LOWE DAVID , MATAM RAJESWARI BASAVA
IPC分类号： G06T1/00
CPC分类号： G06T1/0071 , H04N1/32187 , H04N1/3232
摘要： A method of watermark encoding for embedding payload data within carrier data, the method comprising: transforming the carrier data into a plurality of corresponding source vectors using a separating matrix for an independent component analysis for the carrier data; selecting one of the source vectors based, at least in part, on a robustness criterion for the sources; modifying one or more elements of the selected source vector so that the modified one or more elements represent the payload data; and transforming the modified source vector and the plurality of source vectors other than the selected source vector using a mixing matrix for the independent component analysis for the carrier data to generate an output watermarked version of the carrier data.
摘要翻译：一种用于在载波数据内嵌入有效负载数据的水印编码方法，所述方法包括：使用分离矩阵将所述载波数据变换为多个对应的源向量，用于载波数据的独立分量分析; 至少部分地基于源的鲁棒性标准来选择一个源向量; 修改所选择的源向量的一个或多个元素，使得经修改的一个或多个元素表示有效载荷数据; 以及使用用于载波数据的独立分量分析的混合矩阵来变换所选择的源向量以外的修改源向量和多个源向量，以生成载波数据的输出水印版本。

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