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1. 发明申请

WO2005056108A3 METHOD AND APPARATUS FOR DETERMINING AN EFFICACIOUS ATRIOVENTRICULAR DELAY INTERVAL 审中-公开
标题翻译：用于确定有效的心律失常延迟间隔的方法和装置
公开(公告)号：WO2005056108A3
公开(公告)日：2005-09-09
申请号：PCT/US2004040521
申请日：2004-12-03
申请人： MEDTRONIC INC , CHINCHOY EDWARD , SHETH NIRAV VIJAY , HILPISCH KATHRYN E , MULLEN THOMAS J , BURNES JOHN E
发明人： CHINCHOY EDWARD , SHETH NIRAV VIJAY , HILPISCH KATHRYN E , MULLEN THOMAS J , BURNES JOHN E
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Determining an optimal atrioventricular interval is of interest for proper delivery of cardiac resynchronization therapy. Although device optimization is gradually and more frequently being performed through a referral process with which the patient undergoes an echocardiographic optimization, the decision of whether to optimize or not is still generally reserved for the implanting physician. Recent abstracts have suggested a formulaic approach for setting A-V interval based on intrinsic electrical sensing, that may possess considerable appeal to clinicians versus a patient average nominal A-V setting of 100 ms. The present invention presents a methods of setting nominal device settings based on entering patient cardiac demographics to determine what A-V setting may be appropriate. The data is based on retrospective analysis of the MIRACLE trial to determine what major factors determined baseline A-V settings.
摘要翻译：确定最佳房室间隔对于正确递送心脏再同步治疗是有意义的。尽管通过与患者经历超声心动图优化的转诊过程逐渐且更频繁地进行装置优化，但仍然通常为植入医生保留是否优化的决定。最近的摘要提出了一种基于固有电学感测设置A-V间隔的公式化方法，这可能对临床医生具有相当大的吸引力，而患者平均标称A-V设置为100 ms。本发明提供了一种基于输入患者心脏人口统计学来设定标称装置设置以确定什么A-V设置可能适合的方法。数据基于MIRACLE试验的回顾性分析，以确定确定基线A-V设置的主要因素。

2. 发明申请

WO2006069033A9 AUTOMATIC LV / RV CAPTURE VERIFICATION AND DIAGNOSTICS 审中-公开
标题翻译：自动LV / RV捕获验证和诊断
公开(公告)号：WO2006069033A9
公开(公告)日：2006-10-12
申请号：PCT/US2005046055
申请日：2005-12-20
申请人： MEDTRONIC INC , SHETH NIRAV VIJAY , RUETER JOHN C , BURNES JOHN E , MONGEON LUC R , KLECKNER KAREN J , YERICH CHARLES G
发明人： SHETH NIRAV VIJAY , RUETER JOHN C , BURNES JOHN E , MONGEON LUC R , KLECKNER KAREN J , YERICH CHARLES G
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3712
摘要： The present invention provides a technique for verifying pacing capture of a ventricular chamber, particularly to ensure desired delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or "CRT"). The invention also provides for ventricular capture management by delivering a single ventricular pacing stimulus and checking inter-ventricular conduction during a temporal window to determine if the ventricular pacing stimulus captured the chamber. If a loss-of-capture (LOC) signal results from the capture management testing, then the characteristics of the applied pacing pulses are modified and the conduction test repeated. In the event that the LOC signal persists, a pacing mode-switch to an atrial-based pacing therapy and/or non-bi-ventricular pacing regimen can be implemented.
摘要翻译：本发明提供了一种用于验证心室的起搏捕获的技术，特别是确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的期望递送。本发明还通过递送单个心室起搏刺激和在时间窗口期间检查心室间传导来确定心室起搏刺激是否捕获腔室来提供心室捕获管理。如果捕获管理测试产生捕获损失（LOC）信号，则应用起搏脉冲的特性被修改，并重复传导测试。在LOC信号持续存在的情况下，可以实现起搏模式切换到基于心房的起搏治疗和/或非双心室起搏方案。

3. 发明申请

WO03063961A8 METHOD AND ARRANGEMENT FOR USING ATRIAL PACING TO PREVENT EARLY RECURRENCE OF ATRIAL FIBRILLATION 审中-公开
标题翻译：使用ATRIAL PACING预防ATRIAL FIBRILLATION早期复发的方法和布置
公开(公告)号：WO03063961A8
公开(公告)日：2004-02-19
申请号：PCT/US0302426
申请日：2003-01-27
申请人： MEDTRONIC INC
发明人： UJHELYI MICHAEL R , EULER DAVID R , CASAVANT DAVID A , SHETH NIRAV VIJAY
IPC分类号： A61B5/0402 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/395
摘要： A method for preventing early recurrence of atrial fibrillation by pacing a heart in AAI mode at a rate faster than the intrinsic rate for a selected period of time immediately after delivering therapy to terminate the fibrillation. Ventricular backup pacing in VVI mode may also be provided during the atrial pacing.
摘要翻译：一种通过在递送治疗之后立即在选择的时间段内的速率快于AAI模式的心脏起搏以预防心房颤动的早期复发的方法来终止原纤维颤动。在心房起搏期间也可以提供VVI模式的心室起搏。

4. 发明申请

WO03022355B1 ARRHYTHMIA NOTIFICATION 审中-公开
标题翻译： ARRHYTHMIA通知
公开(公告)号：WO03022355B1
公开(公告)日：2003-06-19
申请号：PCT/US0226466
申请日：2002-08-20
申请人： MEDTRONIC INC
发明人： UJHELYI MICHAEL R , MEHRA RAHUL , HESS MICHAEL F , SHETH NIRAV VIJAY
IPC分类号： A61B5/00 , A61B5/046 , A61B5/0464 , A61N1/372 , A61N1/362 , A61N1/37
CPC分类号： A61N1/37258 , A61B5/0031 , A61B5/046 , A61B5/0464 , A61N1/37282
摘要： Notifying a patient or another person of an arrhythmia episode facilitates management of atrial fibrillation (AF) and other arrhythmias, including atrial flutter, atrial tachycardia, and supra ventricular tachycardia, thus enabling the patient to take corrective action even in the absence of symptoms or latent cardiac problems. For example, the patient may be prompted to take a medication, to initiate electrical therapy in the form of pacing or defibrillation, or to seek medical attention. Notification may be issued either by an implantable medical device (12) or by an external device (58) in communication with the implantable medical device (12). Various types of notifications may be issued under a variety of conditions, some of which may be associated with the duration of an episode.
摘要翻译：通知患者或其他人心律失常事件有利于管理心房颤动（AF）和其他心律失常，包括心房扑动，房性心动过速和室上性心动过速，从而使患者即使在没有症状或潜伏期的情况下也能采取矫正措施心脏问题。例如，可以提示患者服用药物，以起搏或除颤的形式开始电疗法，或寻求医疗护理。可由可植入医疗装置（12）或与可植入医疗装置（12）通信的外部装置（58）发出通知。可以在各种条件下发布各种类型的通知，其中一些可能与情节的持续时间相关联。

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