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1. 发明申请

WO2011152932A1 IMPLANTABLE MEDICAL PUMP WITH PRESSURE SENSOR 审中-公开
标题翻译：带压力传感器的可植入医用泵
公开(公告)号：WO2011152932A1
公开(公告)日：2011-12-08
申请号：PCT/US2011/034068
申请日：2011-04-27
申请人： MEDTRONIC, INC. , MIESEL, Keith A. , HAASE, James M. , PAIDOSH, Chris J. , JANZIG, Darren A. , DENISON, Timothy J.
发明人： MIESEL, Keith A. , HAASE, James M. , PAIDOSH, Chris J. , JANZIG, Darren A. , DENISON, Timothy J.
IPC分类号： A61M5/142 , A61M39/02
CPC分类号： A61M5/14276 , A61M39/0208 , A61M2205/3317 , A61M2205/3331 , G01L9/0072 , G01L15/00 , G01L19/0023 , G01L19/0069 , G01L19/086 , G01L19/143 , G01L19/148 , G01L19/149
摘要： The disclosure is directed to a pressure sensor (26) of an implantable medical device (16). The pressure sensor may utilize detect fluid pressure based on a changing capacitance between two capacitive elements. The pressure sensor may define at least a portion of a fluid enclosure of the IMD. In one example, the pressure sensor has a self - aligning housing shape that occludes an opening in the pump bulkhead (14) of the IMD. An operative surface of the pressure and the portion of the fluid enclosure may be formed of a corrosion resistant and/or biocompatible material. A first capacitive element of the pressure sensor may be a metal alloy diaphragm that deflects in response to external fluid pressure. A second capacitive element of the pressure sensor may be a metal coating on a rigid insulator sealed from the fluid by the diaphragm and a housing of the sensor.
摘要翻译：本公开涉及可植入医疗装置（16）的压力传感器（26）。压力传感器可以利用基于两个电容元件之间的变化的电容的检测流体压力。压力传感器可以限定IMD的流体外壳的至少一部分。在一个示例中，压力传感器具有封闭IMD的泵隔板（14）中的开口的自对准壳体形状。压力的操作表面和流体外壳的一部分可以由耐腐蚀和/或生物相容的材料形成。压力传感器的第一电容元件可以是响应于外部流体压力而偏转的金属合金膜片。压力传感器的第二电容元件可以是通过隔膜和传感器的壳体与流体密封的刚性绝缘体上的金属涂层。

2. 发明申请

WO2011152933A1 CAPACITIVE PRESSURE SENSOR ASSEMBLY 审中-公开
标题翻译：电容式压力传感器总成
公开(公告)号：WO2011152933A1
公开(公告)日：2011-12-08
申请号：PCT/US2011/034071
申请日：2011-04-27
申请人： MEDTRONIC, INC. , MIESEL, Keith A. , HAASE, James M. , PAIDOSH, Chris J. , JANZIG, Darren A. , DENISON, Timothy J.
发明人： MIESEL, Keith A. , HAASE, James M. , PAIDOSH, Chris J. , JANZIG, Darren A. , DENISON, Timothy J.
IPC分类号： G01L9/00
CPC分类号： G01L9/0072 , G01L19/142 , G01L19/143 , G01L19/147 , H01L2224/48472 , Y10T29/49002 , Y10T29/53265
摘要： The disclosure is directed to a capacitive pressure sensor, and the assembly of a capacitive pressure sensor, that may be used within an implantable medical pump. In one example, a housing ferrule that encloses one capacitive plate and includes at least one protrusion for attaching a support structure of the capacitive plate. The at least one protrusion defines a smaller inner diameter as a reference point for securing the support structure while the ferrule provides a larger inner diameter to allow the support structure to tilt inside the ferrule to orient the capacitive plate into a desired plane. Despite manufacturing irregularities, the capacitive plate can be mounted in the desired plane parallel to another capacitive plate, a diaphragm, mounted to an edge of the ferrule. In another example, an assembly tool provides a stage to orient the capacitive plate and support structure within the ferrule at a desired depth.
摘要翻译：本公开涉及电容式压力传感器以及可在可植入医疗泵内使用的电容式压力传感器的组件。在一个示例中，壳体套圈包围一个电容板并且包括用于附接电容板的支撑结构的至少一个突起。所述至少一个突出部限定较小的内径作为用于固定支撑结构的参考点，同时套圈提供更大的内径以允许支撑结构在套圈内部倾斜以将电容板定向到期望的平面。尽管制造不规则，但是电容板可以安装在平行于另一个电容板的所需平面中，该电容板安装在套圈的边缘上。在另一示例中，组装工具提供了将电容板和支撑结构定位在套圈内的所需深度的阶段。

3. 发明申请

WO2010123907A1 BLADDER SENSING USING IMPEDANCE AND POSTURE 审中-公开
标题翻译：使用阻力和姿态进行刮板感应
公开(公告)号：WO2010123907A1
公开(公告)日：2010-10-28
申请号：PCT/US2010/031760
申请日：2010-04-20
申请人： MEDTRONIC, INC. , MIESEL, Keith A. , DENISON, Timothy J.
发明人： MIESEL, Keith A. , DENISON, Timothy J.
IPC分类号： A61N1/36 , A61B5/03
CPC分类号： A61N1/36007 , A61B5/053 , A61B5/1116 , A61B5/204 , A61B5/686 , A61B5/6883 , A61B5/7203 , A61B2560/0462 , A61B2562/0219
摘要： This disclosure provides techniques for bladder sensing. In accordance with the techniques described in this disclosure, a device may measure the impedance of a bladder, determine the posture of a patient, and determine a status of the bladder based on the impedance and posture.
摘要翻译：本公开提供了用于膀胱感测的技术。根据本公开中描述的技术，装置可以测量膀胱的阻抗，确定患者的姿势，并且基于阻抗和姿势来确定膀胱的状态。

4. 发明申请

WO2013002846A1 DEVICES AND METHODS FOR DETECTING CATHETER COMPLICATIONS 审中-公开
标题翻译：用于检测导管连接的装置和方法
公开(公告)号：WO2013002846A1
公开(公告)日：2013-01-03
申请号：PCT/US2012/023277
申请日：2012-01-31
申请人： MEDTRONIC, INC. , KALPIN, Scott L. , MIESEL, Keith A. , SOLEFACK, Lucien Bell
发明人： KALPIN, Scott L. , MIESEL, Keith A. , SOLEFACK, Lucien Bell
IPC分类号： A61M5/168 , A61M5/172 , A61M5/142 , A61M27/00
CPC分类号： A61M5/14276 , A61M5/16854 , A61M5/16859 , A61M5/1723 , A61M27/006 , A61M2005/1726 , A61M2025/0003 , A61M2202/0464 , A61M2205/3331 , A61M2205/3344 , A61M2205/3355 , A61M2210/0693 , A61M2230/005 , A61M2230/04 , A61M2230/06 , A61M2230/40 , A61M2230/42 , A61M2230/63
摘要： A method for determining status of an implanted catheter includes acquiring raw pressure data ( 20 ) from a pressure sensor of in an implantable infusion device. The pressure sensor is in communication with a lumen of the catheter operably coupled to the infusion device. The catheter has a delivery region, in communication with the lumen, intended to be positioned in a fluid- filled target location of a patient. The method further includes filtering the raw pressure data to remove the DC component, leaving the AC component within a relevant physiological frequency range; rectifying the AC component to produce a rectified pressure signal; calculating a mean magnitude of the rectified signal; and determining whether the mean magnitude is below a predetermined threshold. If the mean magnitude is below the threshold, the catheter is determined to be in a state other than a normal state.
摘要翻译：用于确定植入导管的状态的方法包括从可植入输注装置中的压力传感器获取原始压力数据（20）。压力传感器与可操作地连接到输注装置的导管的内腔连通。导管具有与内腔连通的输送区域，旨在定位在患者的流体填充的目标位置。该方法还包括过滤原始压力数据以去除DC分量，将AC分量留在相关的生理频率范围内; 整流交流分量以产生整流压力信号; 计算整流信号的平均幅度; 以及确定平均幅度是否低于预定阈值。如果平均值低于阈值，则确定导管处于正常状态以外的状态。

5. 发明申请

WO2011136862A1 DETECTING EMPTY MEDICAL PUMP RESERVOIR 审中-公开
标题翻译：检测清洁液体储存罐
公开(公告)号：WO2011136862A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/023115
申请日：2011-01-31
申请人： MEDTRONIC, INC. , ALI, Irfan Z. , MIESEL, Keith A. , KALPIN, Scott L. , SARKINEN, Scott A.
发明人： ALI, Irfan Z. , MIESEL, Keith A. , KALPIN, Scott L. , SARKINEN, Scott A.
IPC分类号： A61M5/142
CPC分类号： A61M5/14276 , A61B5/1116 , A61M5/14212 , A61M5/172 , A61M2205/18 , A61M2205/3317 , A61M2205/50
摘要： A medical device system (10) comprises a reservoir (30) configured to store a therapeutic fluid and a medical pump (40) configured to deliver the therapeutic fluid from the reservoir to a patient. The system also comprises a sensor (100) that can detect a characteristic associated with the pump and a processor to determine if the characteristic detected indicates the reservoir is empty or near empty. The characteristic may comprise a property associated with the energization of an actuation mechanism configured to be energized to provide a pump stroke. The characteristic may also comprise a characteristic of a noise made by an actuator within the pump at the end of a pump stroke.
摘要翻译：医疗设备系统（10）包括被配置为存储治疗流体的储存器（30）和构造成将治疗流体从储存器输送到患者的医疗泵（40）。该系统还包括可以检测与泵相关联的特征的传感器（100）和处理器，以确定检测到的特征是否指示储存器是空的还是近空的。特征可以包括与致动机构的通电相关联的特性，该致动机构配置成被激励以提供泵冲程。特征还可以包括在泵冲程结束时由泵内的致动器产生的噪声的特性。

6. 发明申请

WO2013052579A1 RATIOMETRIC PLUNGER ASSEMBLY FOR VOLUME SENSING APPLICATIONS 审中-公开
标题翻译：用于体积传感应用的比例计算器组件
公开(公告)号：WO2013052579A1
公开(公告)日：2013-04-11
申请号：PCT/US2012/058614
申请日：2012-10-04
申请人： MEDTRONIC, INC. , MIESEL, Keith A.
发明人： MIESEL, Keith A.
IPC分类号： A61M5/168 , G01F23/16 , G01F23/54
CPC分类号： A61M5/1684 , A61M5/14 , A61M5/14276 , A61M2205/3317 , G01F17/00 , G01F23/14
摘要： A volume sensing system for use in determining a volume of a variable volume reservoir can include a lower plunger (126) that can have a first end (190) adapted to move with a bottom (68) of the reservoir (34). An upper plunger (122) can be slidable relative to the lower plunger (126). A lower biasing member (134, 230) can be positioned substantially between a base (68) of the reservoir (34) and the upper plunger (122), and the upper biasing member (130, 226) can be positioned between the upper plunger (122) and an interference member (118). The upper biasing member (130, 226) can have a predetermined stiffness relative to the lower biasing member (134, 230) such that upon movement of the lower plunger (126), the upper plunger (122) can move at a predetermined fraction of the amount of movement of the lower plunger (126), where the predetermined fraction can be determined at least in part by the predetermined stiffness of the upper biasing member (130, 226) relative to the lower biasing member (134, 230).
摘要翻译：用于确定可变体积储存器的体积的体积感测系统可以包括下柱塞（126），其可以具有适于与储存器（34）的底部（68）一起移动的第一端（190）。上柱塞（122）可以相对于下柱塞（126）滑动。下偏压构件（134,230）可以基本上位于储存器（34）的基部（68）和上柱塞（122）之间，并且上偏压构件（130,226）可以定位在上柱塞（122）和干涉构件（118）。上偏置构件（130,226）可以具有相对于下偏置构件（134,230）的预定刚度，使得在下活塞（126）移动时，上活塞（122）可以以预定的一部分下部柱塞（126）的移动量，其中预定分数可以至少部分地由上偏压构件（130,226）相对于下偏压构件（134,230）的预定刚度确定。

7. 发明申请

WO2008121581A1 CATHETER MALFUNCTION DETERMINATIONS USING PHYSIOLOGIC PRESSURE 审中-公开
标题翻译：使用生理压力进行导管畸变测定
公开(公告)号：WO2008121581A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/057792
申请日：2008-03-21
申请人： MEDTRONIC, INC. , MIESEL, Keith A. , COFFEY, Robert J.
发明人： MIESEL, Keith A. , COFFEY, Robert J.
IPC分类号： A61M5/142
CPC分类号： A61M5/14276 , A61M5/16859 , A61M2005/1726 , A61M2202/0464
摘要： System for determining whether an implanted catheter used to deliver fluids to a selected internal delivery site is malfunctioning. The malfunctions may include that the infusion section of the catheter is not located at or has migrated away from the selected internal delivery site, is leaking, is blocked, etc. The determination is made by analyzing the pressure modulation of fluid within the catheter and determining whether the pressure of the fluid in the catheter is modulated by physiologic pressure changes experienced at the selected internal delivery site. The physiologic pressure modulations at the selected internal delivery site may be caused by, e.g., cardiac activity, respiration, changes in patient's posture, etc.
摘要翻译：用于确定用于将流体输送到选定的内部递送部位的植入导管是否发生故障的系统。故障可能包括导管的输液部分不位于或已经偏离所选择的内部输送部位，正在泄漏，被阻塞等。通过分析导管内的流体的压力调节并确定导管中液体的压力是否受选择的内部递送部位所经历的生理压力变化的调节。选择的内部递送部位的生理压力调节可以由例如心脏活动，呼吸，患者姿势变化等引起。

8. 发明申请

WO2007130132A1 IMPLANTABLE THERAPEUTIC SUBSTANCE DELIVERY DEVICE WITH RESERVOIR VOLUME SENSOR 审中-公开
标题翻译：具有储存体积传感器的可植入的治疗物质输送装置
公开(公告)号：WO2007130132A1
公开(公告)日：2007-11-15
申请号：PCT/US2006/044994
申请日：2006-11-21
申请人： MEDTRONIC, INC. , MIESEL, Keith A.
发明人： MIESEL, Keith A.
IPC分类号： A61M5/142
CPC分类号： A61M5/14276 , A61F2/022 , A61M2205/3317 , A61M2205/3379 , A61M2205/3389 , A61M2209/045
摘要： An implantable medical device for delivering therapeutic substance including a housing and a volume sensor assembly. The housing includes a stationary wall and maintains a reservoir containing the therapeutic substance and including a base wall movable relative to the stationary wall such that reservoir volume is a function of base wall/stationary wall spacing. The volume sensor assembly includes a cap, a shaft, a target, and circuitry. The cap defines a passage extending from an open end, and is mounted to the stationary wall such that the open end is open relative to a stationary wall inner face. The shaft has a first end attached to the base wall and a second end maintaining the target otherwise movably arranged within the passage. The circuitry generates information indicative of a longitudinal position of the target relative to the cap, and thus of the reservoir volume.
摘要翻译：一种用于输送治疗物质的可植入医疗装置，包括壳体和体积传感器组件。壳体包括固定壁并且保持容纳治疗物质的储存器并且包括相对于静止壁可移动的底壁，使得储存器容积是底壁/静止壁间隔的函数。体积传感器组件包括盖，轴，靶和电路。盖限定了从开口端延伸的通道，并且安装到固定壁，使得开口端相对于固定壁内表面敞开。轴具有附接到基壁的第一端和保持目标的第二端，否则可移动地布置在通道内。电路产生指示靶相对于盖的纵向位置的信息，因此产生储存器容积的信息。

9. 发明申请

WO2013142551A1 Filling Methods and Apparatus for Implanted Medical Therapy Delivery Devices 审中-公开
标题翻译：植入式医疗输送装置的灌装方法与装置
公开(公告)号：WO2013142551A1
公开(公告)日：2013-09-26
申请号：PCT/US2013/033060
申请日：2013-03-20
申请人： MEDTRONIC, INC.
发明人： MIESEL, Keith A. , SARKINEN, Scott A. , AKPAN, Emem , HENTGES, Douglas E. , DUNLAP, Mark E. , SCHAUBLE, Darrin , KONEN, Cindy R. , BILITZ, Mark R.
IPC分类号： A61M5/32 , A61M5/46
CPC分类号： A61B17/3417 , A61M5/329 , A61M5/46 , A61M39/0208 , A61M2039/0226 , A61M2039/0244
摘要： Transdermal insertion of a transcutaneous filling apparatus, for the purpose of filling a fill chamber of an implanted therapy delivery device, is monitored by measuring each impedance between pairs of electrodes of a needle of the apparatus, and comparing each to a threshold impedance; the electrodes, preferably at least three in number, are isolated and spaced apart from one another along a length of the needle. A confirmation signal is generated when at least one of the measured impedances is greater than the threshold impedance, and another is less than the threshold, the condition indicating that one of the electrodes is located within a nonconductive septum, through which the apparatus must pass to access the fill chamber. A detection circuit, which may be located in a housing of the apparatus that is attached to a proximal end of the needle, measures and compares the impedances.
摘要翻译：通过测量装置针的电极对之间的每个阻抗，并将每个阻抗与阈值阻抗进行比较来监测用于填充植入的治疗输送装置的填充室的经皮填充装置的透皮插入; 优选地，至少三个数量的电极被隔离并沿着针的长度彼此间隔开。当所测量的阻抗中的至少一个大于阈值阻抗并且另一个小于阈值时，产生确认信号，表示电极中的一个位于非导电隔膜内的状态，设备必须通过该阻挡通过进入填充室。可以位于装置的外壳中的检测电路，其连接到针的近端，测量并比较阻抗。

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