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1. 发明申请

WO2011152932A1 IMPLANTABLE MEDICAL PUMP WITH PRESSURE SENSOR 审中-公开
标题翻译：带压力传感器的可植入医用泵
公开(公告)号：WO2011152932A1
公开(公告)日：2011-12-08
申请号：PCT/US2011/034068
申请日：2011-04-27
申请人： MEDTRONIC, INC. , MIESEL, Keith A. , HAASE, James M. , PAIDOSH, Chris J. , JANZIG, Darren A. , DENISON, Timothy J.
发明人： MIESEL, Keith A. , HAASE, James M. , PAIDOSH, Chris J. , JANZIG, Darren A. , DENISON, Timothy J.
IPC分类号： A61M5/142 , A61M39/02
CPC分类号： A61M5/14276 , A61M39/0208 , A61M2205/3317 , A61M2205/3331 , G01L9/0072 , G01L15/00 , G01L19/0023 , G01L19/0069 , G01L19/086 , G01L19/143 , G01L19/148 , G01L19/149
摘要： The disclosure is directed to a pressure sensor (26) of an implantable medical device (16). The pressure sensor may utilize detect fluid pressure based on a changing capacitance between two capacitive elements. The pressure sensor may define at least a portion of a fluid enclosure of the IMD. In one example, the pressure sensor has a self - aligning housing shape that occludes an opening in the pump bulkhead (14) of the IMD. An operative surface of the pressure and the portion of the fluid enclosure may be formed of a corrosion resistant and/or biocompatible material. A first capacitive element of the pressure sensor may be a metal alloy diaphragm that deflects in response to external fluid pressure. A second capacitive element of the pressure sensor may be a metal coating on a rigid insulator sealed from the fluid by the diaphragm and a housing of the sensor.
摘要翻译：本公开涉及可植入医疗装置（16）的压力传感器（26）。压力传感器可以利用基于两个电容元件之间的变化的电容的检测流体压力。压力传感器可以限定IMD的流体外壳的至少一部分。在一个示例中，压力传感器具有封闭IMD的泵隔板（14）中的开口的自对准壳体形状。压力的操作表面和流体外壳的一部分可以由耐腐蚀和/或生物相容的材料形成。压力传感器的第一电容元件可以是响应于外部流体压力而偏转的金属合金膜片。压力传感器的第二电容元件可以是通过隔膜和传感器的壳体与流体密封的刚性绝缘体上的金属涂层。

2. 发明申请

WO2011123208A1 PATIENT DATA DISPLAY 审中-公开
标题翻译：患者数据显示
公开(公告)号：WO2011123208A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/026654
申请日：2011-03-01
申请人： MEDTRONIC, INC. , GIFTAKIS, Jonathon, E. , DENISON, Timothy, J.
发明人： GIFTAKIS, Jonathon, E. , DENISON, Timothy, J.
IPC分类号： A61B5/0476
CPC分类号： A61B5/0476 , A61B5/1116 , A61B5/4094 , A61B5/6823 , A61B5/6828 , A61B5/686 , A61B5/6868 , A61B5/742 , A61B5/7435 , A61B5/744 , A61B2560/0219 , A61B2562/043 , G06F19/00
摘要： The temporal correlation between a bioelectrical brain signal (76) of a patient and patient motion data (78), such as a signal indicative of patient motion or a patient posture indicator, is displayed by a display device. In some examples, the patient posture indicator comprises a graphical representation (80) of at least a portion of a body of the patient. In some examples, the temporal correlation between a bioelectrical brain signal, a signal indicative of patient motion, and a signal indicative of cardiac activity of the patient is displayed by the display device.
摘要翻译：显示装置显示患者的生物电脑信号（76）与患者运动数据（78）之间的时间相关性，例如指示患者运动的信号或患者姿势指示器。在一些示例中，患者姿势指示器包括患者身体的至少一部分的图形表示（80）。在一些示例中，显示装置显示生物电脑信号，指示患者运动的信号与指示患者的心脏活动的信号之间的时间相关性。

3. 发明申请

WO2010126624A1 PATIENT STATE DETECTION BASED ON SUPPORT VECTOR MACHINE BASED ALGORITHM 审中-公开
标题翻译：基于支持向量机的患者状态检测算法
公开(公告)号：WO2010126624A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/022114
申请日：2010-01-26
申请人： MEDTRONIC, INC. , CARLSON, David, L. , DENISON, Timothy, J. , SHOEB, Ali, H.
发明人： CARLSON, David, L. , DENISON, Timothy, J. , SHOEB, Ali, H.
IPC分类号： A61N1/36 , G06F19/00 , A61B5/0476 , A61B5/11
CPC分类号： A61N1/36082 , G06F2221/2101 , G06F2221/2105 , G06K9/6268 , G06N99/005 , G16H50/50
摘要： A patient state is detected with at least one classification boundary generated by a supervised machine learning technique, such as a support vector machine. In some examples, the patient state detection is used to at least one of control the delivery of therapy to a patient, to generate a patient notification, to initiate data recording, or to evaluate a patient condition. In addition, an evaluation metric can be determined based on a feature vector, which is determined based on characteristics of a patient parameter signal, and the classification boundary. Example evaluation metrics can be based on a distance between at least one feature vector and the classification boundary and/or a trajectory of a plurality of feature vectors relative to the classification boundary over time.
摘要翻译：用监督机器学习技术（例如支持向量机）生成的至少一个分类边界来检测病人状态。在一些示例中，患者状态检测用于控制对患者的治疗递送，产生患者通知，开始数据记录或评估患者状况中的至少一个。此外，可以基于基于患者参数信号的特性确定的特征向量和分类边界来确定评估度量。示例评估度量可以基于至少一个特征向量与分类边界之间的距离和/或相对于分类边界随时间的多个特征向量的轨迹。

4. 发明申请

WO2010126540A1 THERAPY SYSTEM INCLUDING MULTIPLE POSTURE SENSORS 审中-公开
标题翻译：包括多个姿势传感器的治疗系统
公开(公告)号：WO2010126540A1
公开(公告)日：2010-11-04
申请号：PCT/US2009/049396
申请日：2009-07-01
申请人： MEDTRONIC, INC. , SKELTON, Dennis, M. , DAVIS, Jon, P. , MIESEL, Keith, A. , DENISON, Timothy, J.
发明人： SKELTON, Dennis, M. , DAVIS, Jon, P. , MIESEL, Keith, A. , DENISON, Timothy, J.
IPC分类号： A61N1/365
CPC分类号： A61M5/14276 , A61B5/11 , A61B5/1116 , A61B5/4836 , A61B2562/0219 , A61M2005/14208 , A61M2205/17 , A61M2210/0693 , A61M2210/1053 , A61M2210/1078 , A61M2210/1089 , A61M2230/62 , A61N1/3605 , A61N1/37247
摘要： Posture-responsive therapy is delivered by the medical system based on posture state input from only one of multiple posture sensors at any given time. An example implantable medical system includes a first posture sensor and a second sensor. A processor controls therapy delivery to the patient based on at least one of a patient posture state or a patient activity level determined based on input from only one of the first or second posture sensors. In some examples, one of multiple posture sensors of an implantable posture-responsive medical system is used to automatically reorient another posture sensor (of the system), which has become disoriented. The disoriented posture sensor may be automatically reoriented for one or more posture states at a time.
摘要翻译：姿态反应治疗由医疗系统基于在任何给定时间仅从多个姿势传感器中的一个输入的姿势状态来传送。示例性可植入医疗系统包括第一姿态传感器和第二传感器。处理器基于基于仅从第一或第二姿态传感器中的一个输入确定的患者姿势状态或患者活动水平中的至少一个来控制对患者的治疗递送。在一些示例中，使用植入式姿势响应医疗系统的多个姿势传感器中的一个来自动地重新定向已经变得迷失方向的另一姿态传感器（该系统）。错位姿态传感器可以一次自动地重新定向一个或多个姿势状态。

5. 发明申请

WO2010062451A1 DETERMINING INTERCARDIAC IMPEDANCE 审中-公开
标题翻译：确定心血管阻抗
公开(公告)号：WO2010062451A1
公开(公告)日：2010-06-03
申请号：PCT/US2009/058127
申请日：2009-09-24
申请人： MEDTRONIC, INC. , WHALSTRAND, John, D. , DENISON, Timothy, J. , SANTA, Wesley, A.
发明人： WHALSTRAND, John, D. , DENISON, Timothy, J. , SANTA, Wesley, A.
IPC分类号： A61B5/053 , G01R27/02 , H03F3/00 , A61B5/026 , A61N1/372 , A61N1/39 , A61N1/365
CPC分类号： A61B5/053 , A61B5/026 , A61B5/0538 , A61B5/6846 , A61B5/7217 , A61N1/36521
摘要： A system and method for determining complex intercardiac impedance to detect various cardiac functions are disclosed involving a signal generator means for providing an adjustable direct current signal, a modulator for modulating the adjustable direct current signal to produce a modulated signal, at least one electrode for propagating the modulated signal across a myocardium, at least one sensor for detecting an outputted modulated signal from the myocardium, and at least one circuit to reduce the influence of process noise (aggressors) in the outputted modulated signal. The at least one circuit comprises an amplifier, a demodulator, and an integrator. The amplitude and phase of the final outputted modulated signal indicate the complex impedance of the myocardium. Changes in the complex impedance patterns of the myocardium provide indication of reduced oxygen and blood flow to the myocardium. The apparatus can be employed in implantable devices, including cardiac pacemakers and implantable cardioverter defibrillators.
摘要翻译：公开了一种用于确定复杂心脏间阻抗以检测各种心脏功能的系统和方法，其涉及用于提供可调直流信号的信号发生器装置，用于调制可调直流信号以产生调制至少一个用于在心肌上传播调制信号的电极，至少一个用于检测来自心肌的输出调制信号的传感器，以及至少一个用于减少输出的调制信号中的过程噪声（攻击者）的影响的电路。该至少一个电路包括放大器，解调器和积分器。最终输出的调制信号的幅度和相位指示心肌的复阻抗。心肌复杂阻抗模式的变化提供了向心肌减少的氧气和血流量的指示。该装置可用于植入式装置，包括心脏起搏器和植入式心脏复律除颤器。

6. 发明申请

WO2009129478A3 TIMING THERAPY EVALUATION TRIALS 审中-公开
标题翻译：定时疗法评估试验
公开(公告)号：WO2009129478A3
公开(公告)日：2009-12-17
申请号：PCT/US2009040988
申请日：2009-04-17
申请人： MEDTRONIC INC , GIFTAKIS JONATHON E , RISE MARK T , STYPULKOWSKI PAUL H , DENISON TIMOTHY J
发明人： GIFTAKIS JONATHON E , RISE MARK T , STYPULKOWSKI PAUL H , DENISON TIMOTHY J
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3561 , A61M2205/3592 , A61M2210/0693 , A61N1/08 , A61N1/36025 , A61N1/36082 , A61N1/37211 , G06F19/3481 , G16H40/40 , G16H40/63
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy delivery dissipates. Monitoring a washout period may be useful for timing the delivery of therapy according to different therapy programs during a therapy evaluation period. For example, at least one physiological signal of the patient may be monitored to automatically determine when a washout period has ended, e.g., when stimulation and carryover effects of therapy delivery according to a first therapy program have substantially dissipated, in order to determine when therapy delivery according to a second therapy program can be initiated.
摘要翻译：可以基于患者的生理参数确定根据治疗程序向患者递送治疗之后的清除期的特征。清除期包括治疗输送带来的滞留效应消失的时间段。在治疗评估期间，根据不同的治疗计划，监测清除期可能对于定时递送治疗有用。例如，可以监测患者的至少一个生理信号以自动确定清洗期何时结束，例如，当根据第一治疗程序的治疗递送的刺激和遗留效应已基本消散时，以便确定何时治疗可以启动根据第二疗法程序的输送。

7. 发明申请

WO2009131719A1 FLOW SENSOR CONTROLLED INFUSION DEVICE 审中-公开
标题翻译：流量传感器控制输液装置
公开(公告)号：WO2009131719A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/030837
申请日：2009-01-13
申请人： MEDTRONIC, INC. , SEELEY, Dale F. , DENISON, Timothy J.
发明人： SEELEY, Dale F. , DENISON, Timothy J.
IPC分类号： A61M5/168
CPC分类号： A61M5/14276 , A61M5/16804
摘要： An implantable infusion device includes an outlet and a reservoir. A flow path in fluid communication with the reservoir and the outlet includes a pressure regulator and a flow restrictor. The pressure regulator includes a major chamber and a diaphragm that divides the major chamber into first and second minor chambers. The flow restrictor is in fluid communication with the first and second minor chambers of the pressure regulator and is disposed downstream of the first minor chamber and upstream of the second minor chamber. The device also includes a processor coupled to a flow sensor to detect information regarding flow rate of the fluid downstream of the flow restrictor and a pressure adjustment actuator assembly. The processor provides regulates the flow of the fluid by adjusting the pressure in the first minor chamber relative to pressure in the second minor chamber based on the information from the sensor.
摘要翻译：植入式输注装置包括出口和储存器。与储存器和出口流体连通的流路包括压力调节器和限流器。压力调节器包括主室和隔膜，其将主室分成第一和第二小室。限流器与压力调节器的第一和第二小室流体连通并且设置在第一小室的下游和第二小室的上游。该装置还包括耦合到流量传感器的处理器，以检测关于限流器下游的流体的流量的信息和压力调节致动器组件。处理器基于来自传感器的信息，通过相对于第二小室中的压力调节第一小室中的压力来调节流体的流动。

8. 发明申请

WO2009042313A1 CHOPPER-STABILIZED ANALOG-TO-DIGITAL CONVERTER 审中-公开
标题翻译： CHOPPER稳定的模拟数字转换器
公开(公告)号：WO2009042313A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/073458
申请日：2008-08-18
申请人： MEDTRONIC, INC. , DENISON, Timothy J. , HEINKS, Michael W. , ANDERSON, Joel A.
发明人： DENISON, Timothy J. , HEINKS, Michael W. , ANDERSON, Joel A.
IPC分类号： H03M3/02
CPC分类号： A61B5/7203 , A61B5/04012 , A61B5/7217 , A61B5/7228 , A61B5/7242 , H03M3/34 , H03M3/39
摘要： This disclosure describes a chopper-stabilized sigma-delta analog-to-digital converter (ADC). The ADC is configured to provide accurate output at low frequency with relatively low power. The chopper stabilized ADC substantially reduces or eliminates noise and offset from an output signal produced by the mixer amplifier. Dynamic limitations, i.e., glitching that result from chopper stabilization at low power are substantially eliminated or reduced through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the ADC operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. In this manner, the chopper-stabilized ADC can be used in a low power system, such as an implantable medical device (IMD), to provide a stable, low-noise output signal.
摘要翻译：本公开描述了斩波稳定的Σ-Δ模数转换器（ADC）。 ADC配置为以较低功率提供低频精确输出。斩波稳定ADC大大减少或消除了由混频放大器产生的输出信号的噪声和偏移。通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除或减少动态限制，即，在低功率下由斩波器稳定产生的啁啾。 ADC的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或进入信号通道的外部信号的最小混叠。以这种方式，斩波稳定的ADC可以用在诸如可植入医疗设备（IMD）的低功率系统中，以提供稳定的低噪声输出信号。

9. 发明申请

WO2008133624A1 CHOPPER MIXER TELEMETRY CIRCUIT 审中-公开
标题翻译： CHOPPER混频器电视电路
公开(公告)号：WO2008133624A1
公开(公告)日：2008-11-06
申请号：PCT/US2007/010383
申请日：2007-04-30
申请人： MEDTRONIC, INC. , GREVIOUS, John, J. , DENISON, Timothy, J.
发明人： GREVIOUS, John, J. , DENISON, Timothy, J.
IPC分类号： H03D3/00
CPC分类号： H03D3/007 , A61N1/3727 , H03F3/393
摘要： This disclosure describes a chopper mixer telemetry circuit for use in a wireless receiver. The receiver may be located in an implantable medical device (IMD) or external programmer. The chopper mixer telemetry circuit may include a mixer amplifier that operates as a synchronous demodulator to provide selective extraction of wireless signals received from a transmitter while suppressing out-of- band noise that can undermine the reliability of the telemetry link between an IMD or programmer and another device. The mixer amplifier may utilize parallel signal paths to convert the received telemetry signal into an in-phase (I) signal component and a quadrature (Q) signal component and recombine the I and Q signal components to reconstruct the total signal independently of the phase mismatch between the transmitter and receiver. Each signal path may include a chopper- stabilized mixer amplifier that amplifies telemetry signals within a desired band while suppressing out-of-band noise.
摘要翻译：本公开描述了一种用于无线接收机的斩波混频器遥测电路。接收器可以位于可植入医疗装置（IMD）或外部编程器中。斩波器混频器遥测电路可以包括混频器放大器，其作为同步解调器操作以提供从发射机接收的无线信号的选择性提取，同时抑制可能破坏IMD或编程器之间的遥测链路的可靠性的带外噪声，另一台设备。混频器放大器可以利用并行信号路径将接收到的遥测信号转换为同相（I）信号分量和正交（Q）信号分量，并重新组合I和Q信号分量，以独立于相位失配重构总信号在发射机和接收机之间。每个信号路径可以包括斩波稳定的混频放大器，其在抑制带外噪声的同时放大期望频带内的遥测信号。

10. 发明申请

WO2006105314A1 CAPACITIVE SENSOR WITH DAMPING 审中-公开
标题翻译：具有阻尼功能的电容式传感器
公开(公告)号：WO2006105314A1
公开(公告)日：2006-10-05
申请号：PCT/US2006/011679
申请日：2006-03-28
申请人： ANALOG DEVICES, INC. , DENISON, Timothy, J. , HOLLOCHER, David , GEEN, John, A.
发明人： DENISON, Timothy, J. , HOLLOCHER, David , GEEN, John, A.
IPC分类号： G01P15/125 , G01P1/00
CPC分类号： G01C19/5719 , G01P1/003 , G01P15/125 , G01P15/18 , G01P2015/082
摘要： A capacitive accelerometer. The capacitive accelerometer includes a first fixed electrode and second fixed electrode. The first fixed electrode is separated from the second fixed electrode by a gap. A movable electrode is positioned between the first and second fixed electrodes, the movable electrode being movable between the first and second fixed electrodes. The movable electrode is dimensioned to produce a squeeze damping effect between the movable and fixed electrodes to damp movement of the movable electrode. Circuitry determines the position of the movable electrode in any position across substantially the entire gap between the first and second fixed electrodes.
摘要翻译：电容式加速度计电容加速度计包括第一固定电极和第二固定电极。第一固定电极通过间隙与第二固定电极分离。可动电极位于第一和第二固定电极之间，可动电极可在第一和第二固定电极之间移动。可移动电极的尺寸被设计成在可移动电极和固定电极之间产生挤压阻尼效应，以阻止可动电极的运动。电路确定可移动电极在跨过第一和第二固定电极之间的整个间隙的任何位置的位置。

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