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1. 发明申请

WO2011014311A1 ALGORITHM TO MODULATE ATRIAL-VENTRICULAR DELAY AND RATE RESPONSE BASED ON AUTONOMIC FUNCTION 审中-公开
标题翻译：基于自动功能调节心律延迟和速率响应的算法
公开(公告)号：WO2011014311A1
公开(公告)日：2011-02-03
申请号：PCT/US2010/039202
申请日：2010-06-18
申请人： MEDTRONIC, INC. , FISCHER, Trent, M. , HETTRICK, Douglas, A. , SHELDON, Todd, J. , BELK, Paul, A. , MULLEN, Thomas, J. , RUETER, John, C. , KAISER, Daniel, R.
发明人： FISCHER, Trent, M. , HETTRICK, Douglas, A. , SHELDON, Todd, J. , MULLEN, Thomas, J. , RUETER, John, C. , KAISER, Daniel, R.
IPC分类号： A61N1/362 , A61N1/368 , A61N1/365 , A61B5/0205
CPC分类号： A61N1/3627 , A61B5/0456 , A61N1/36514 , A61N1/36542 , A61N1/36557 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3688
摘要： An implantable medical device and associated method provide atrial pacing and measure an atrial ventricular (AV) delay. An autonomic function index is computed using the AV delay. The autonomic function index may be compiled in a medical report. In some embodiments, the autonomic function index is used to adjust atrial pacing control parameters.
摘要翻译：可植入医疗器械和相关方法提供心房起搏并测量心房（AV）延迟。使用AV延迟计算自主功能指数。自主功能指数可以在医疗报告中编制。在一些实施例中，自主功能指数用于调节心房起搏控制参数。

2. 发明申请

WO2005113065A2 VENTRICULAR DEVICE EVENT FILTERING FOR AN IMPLANTABLE MEDICAL 审中-公开
标题翻译：室间隔装置事件过滤器实现可植入医疗
公开(公告)号：WO2005113065A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/019125
申请日：2005-05-21
申请人： MEDTRONIC, INC. , BETZHOLD, Robert, A. , CASAVANT, David, A. , BELK, Paul, A. , MULLEN, Thomas, J. , STROEBEL, John, C. , HORNBERGER, Steven, R. , SHELDON, Todd, J. , PETERSON, Douglas, A.
发明人： BETZHOLD, Robert, A. , CASAVANT, David, A. , BELK, Paul, A. , MULLEN, Thomas, J. , STROEBEL, John, C. , HORNBERGER, Steven, R. , SHELDON, Todd, J. , PETERSON, Douglas, A.
IPC分类号： A61N1/36
CPC分类号： A61N1/368 , A61N1/3688 , A61N1/3702
摘要： Pacing parameters are provided to address cross talk and intrinsic ventricular events occurring within a predefined blanking period following an atrial event. The parameters are used in conjunction with protocol for minimizing or reducing ventricular pacing, wherein ignoring intrinsic ventricular events during the blanking period might otherwise affect the performance of the protocol.
摘要翻译：提供起搏参数以解决在心房事件之后的预定消隐期内发生的串扰和固有心室事件。这些参数与最小化或减少心室起搏的方案一起使用，其中在消隐期忽略内在心室事件可能会影响方案的性能。

3. 发明申请

WO2010011553A1 IMPROVEMENTS TO CARDIAC PACING METHODS AND APPARATUS 审中-公开
标题翻译： CARDIAC PACING方法和设备的改进
公开(公告)号：WO2010011553A1
公开(公告)日：2010-01-28
申请号：PCT/US2009/050798
申请日：2009-07-16
申请人： MEDTRONIC, INC. , HETTRICK, Douglas, A. , ZIEGLER, Paul, D. , SHELDON, Todd, J. , EULER, David, E.
发明人： HETTRICK, Douglas, A. , ZIEGLER, Paul, D. , SHELDON, Todd, J. , EULER, David, E.
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3682
摘要： A method and apparatus is provided for determining whether a current atrial-ventricular (AV) delay during cardiac pacing is appropriate for proper mechanical coupling of the atrium and ventricle. If proper mechanical coupling is determined to not exist, an additional atrial contraction is induced within the same ventricular cycle to maintain atrial-ventricular mechanical coupling.
摘要翻译：提供了一种用于确定心脏起搏期间当前心房（AV）延迟是否适合于心房和心室的适当机械耦合的方法和装置。如果确定不存在适当的机械耦合，则在相同心室周期内诱发另外的心房收缩以维持心房 - 心室机械耦合。

4. 发明申请

WO2006116550A1 ATRIAL CAPTURE MANAGEMENT IN MINIMAL VENTRICULAR PACING SYSTEM AND METHOD 审中-公开
标题翻译：最小静态PAC系统和方法的ATRIAL捕获管理
公开(公告)号：WO2006116550A1
公开(公告)日：2006-11-02
申请号：PCT/US2006/015927
申请日：2006-04-27
申请人： MEDTRONIC, INC. , RUETER, John, C. , SHELDON, Todd, J.
发明人： RUETER, John, C. , SHELDON, Todd, J.
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3714
摘要： Embodiments of the invention provide systems and methods for an implantable medical device comprising means for selecting between an atrial chamber reset (ACR) test and an atrioventricular conduction (AVC) test to provide atrial capture management and means for switching between an atrial-based pacing mode and a dual chamber pacing mode based on detecting relatively reliable atrioventricular conduction.
摘要翻译：本发明的实施例提供了一种用于可植入医疗装置的系统和方法，包括用于在房室复位（ACR）测试和房室传导（AVC）测试之间进行选择以提供心房捕获管理的装置和用于在基于心房的起搏模式之间切换的装置以及基于检测相对可靠的房室传导的双室起搏模式。

5. 发明申请

WO2005009529A2 ATRIAL CAPTURE MANAGEMENT DURING ATRIAL AND VENTRICULAR PACING 审中-公开
标题翻译： ATRIAL和VENTRICULAR PACING期间的ATRIAL捕获管理
公开(公告)号：WO2005009529A2
公开(公告)日：2005-02-03
申请号：PCT/US2004/023556
申请日：2004-07-22
申请人： MEDTRONIC, INC. , SHELDON, Todd, J. , RUETER, John, C.
发明人： SHELDON, Todd, J. , RUETER, John, C.
IPC分类号： A61N1/00
CPC分类号： A61N1/3712 , A61N1/362 , A61N1/3714
摘要： In an atrial pacing system, the A-PACE pulse energy, defined by the pulse width and pulse amplitude, sufficient to reliably capture the atrium without being wasteful of battery energy is periodically determined in accordance with atrial capture management (ACM) algorithms. The ACM algorithms allow a slow intrinsic atrial heart rate that is suppressed by delivered A-PACE pulses resulting in A-CAPTURE and that occurs when delivered test A-PACE pulses result in ALOC to be detected. ALOC is declared if an A-EVENT of the slow intrinsic atrial heart rate is detected either during an ACM test window timed from the last delivered test A-PACE pulse or during delivery of a sequence of test A-PACE pulses delivered within or defining the ACM test window correlated to the slow intrinsic atrial heart rate.
摘要翻译：在心房起搏系统中，根据心房捕获管理（ACM）算法周期性地确定由脉冲宽度和脉冲幅度定义的足够可靠地捕获心房而不浪费电池能量的A-PACE脉冲能量。 ACM算法允许由传递的A-PACE脉冲抑制的内在心房心率慢，导致A-CAPTURE，并且当递送的测试A-PACE脉冲导致检测到ALOC时发生。如果在从最后传送的测试A-PACE脉冲定时的ACM测试窗口期间或在递送在其中传送或定义的测试A-PACE脉冲序列期间检测到慢内在心房心率的A-EVENT，则ALOC被声明 ACM测试窗口与内在心房心率缓慢相关。

6. 发明申请

WO2004101067A2 CAPTURE MANAGEMENT IMPROVEMENTS 审中-公开
标题翻译：捕获管理改进
公开(公告)号：WO2004101067A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/014481
申请日：2004-05-07
申请人： MEDTRONIC, INC. , RUETER, John, C. , MANRODT, Christopher, M. , BUSACKER, James, W. , SHELDON, Todd, J.
发明人： RUETER, John, C. , MANRODT, Christopher, M. , BUSACKER, James, W. , SHELDON, Todd, J.
IPC分类号： A61N1/37
CPC分类号： A61N1/368 , A61N1/371 , A61N1/3712 , A61N1/3714 , A61N2001/083
摘要： A capture detection algorithm detects and distinguishes atrial capture . Atrial chamber reset (ACR) and AV conduction (AVC) algorithms are implemented to measure an atrial pacing threshold The data that is used to choose between ACR and AVC methods is used to determine the progression of the patient's disease state. Some of the significant aspects of the invention include enablement of accurate threshold measurements, including calculation of stability criteria, precise interval measurements and the use of reference interval to determine capture and loss of capture.
摘要翻译：捕获检测算法检测并区分心房捕获。实施房室复位（ACR）和AV传导（AVC）算法来测量心房起搏阈值用于在ACR和AVC方法之间选择的数据用于确定患者疾病状态的进展。本发明的一些重要方面包括启用准确的阈值测量，包括稳定性标准的计算，精确的间隔测量以及参考间隔的使用以确定捕获和捕获的丢失。

7. 发明申请

WO2008006119A2 SYSTEM AND METHOD FOR PROMOTING INSTRINSIC CONDUCTION THROUGH ATRIAL MODIFICATION AND CALCULATION OF TIMING PARAMETERS 审中-公开
标题翻译：通过心房改变促进心脏传导并计算时序参数的系统和方法
公开(公告)号：WO2008006119A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/074306
申请日：2007-07-25
申请人： MEDTRONIC, INC. , SHELDON, Todd, J. , BELK, Paul, A. , SWEENEY, Michael, D.
发明人： SHELDON, Todd, J. , BELK, Paul, A. , SWEENEY, Michael, D.
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/3682
摘要： An atrial based pacing protocol promotes intrinsic conduction. An entire cardiac cycle is monitored for ventricular activity and permitted to lapse with ventricular activity. Ventricular pacing is available in a cardiac cycle immediately subsequent to such a skipped beat. When monitoring for intrinsic ventricular events, an event is expected within a given window. If no such event is detected, the cardiac cycle in truncated, leading to a shorter cycle that is devoid of ventricular activity. The subsequent cycle has a high likelihood of a ventricular sensed event and a greater than normal AV interval is provided prior to pacing.
摘要翻译：
基于心房的起搏协议促进内在传导。监测整个心动周期的心室活动，并允许心室活动失效。在这种跳动节拍之后立即可以在心动周期中进行心室起搏。当监测心室内事件时，预期在给定窗口内发生事件。如果未检测到此类事件，则心脏周期截断，导致周期缩短，缺乏心室活动。随后的周期很可能发生心室感知事件，并且在起搏之前提供大于正常的AV间隔。

8. 发明申请

WO2007147172A2 SYSTEM AND METHOD FOR DETERMINING INTRINSIC AV INTERVAL TIMING 审中-公开
标题翻译：用于确定内部AV间隔时序的系统和方法
公开(公告)号：WO2007147172A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/074458
申请日：2007-07-26
申请人： MEDTRONIC, INC. , SHELDON, Todd, J. , BELK, Paul, A. , SWEENEY, Michael, O.
发明人： SHELDON, Todd, J. , BELK, Paul, A. , SWEENEY, Michael, O.
CPC分类号： A61N1/368 , A61N1/3682
摘要： An atrial based pacing protocol promotes intrinsic conduction. An entire cardiac cycle is monitored for ventricular activity and permitted to lapse with ventricular activity. Ventricular pacing is available in a cardiac cycle immediately subsequent to such a skipped beat. When monitoring for intrinsic ventricular events, an event is expected within a given window. If no such event is detected, the cardiac cycle in truncated, leading to a shorter cycle that is devoid of ventricular activity. The subsequent cycle has a high likelihood of a ventricular sensed event and a greater than normal AV interval is provided prior to pacing.
摘要翻译：基于心房的起搏方案促进内在传导。监测整个心动周期的心室活动，并允许心室活动失效。在这种跳过的搏动之后，心室起搏可以在心脏周期中使用。在监测内部心室事件时，预期在给定的窗口内会发生事件。如果没有检测到这样的事件，心脏周期被截断，导致没有心室活动的更短的周期。随后的周期具有心室感测事件的高可能性，并且在起搏之前提供大于正常的AV间隔。

9. 发明申请

WO2006115815A2 REMOTELY ENABLED PACEMAKER AND IMPLANTABLE SUBCUTANEOUS CARDIOVERTER/DEFIBRILLATOR SYSTEM 审中-公开
标题翻译：远程启动的遥控器和可植入的辅助放大器/除颤器系统
公开(公告)号：WO2006115815A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/013956
申请日：2006-04-12
申请人： MEDTRONIC. INC. , MARKOWITZ, H., Toby , HETTRICK, Douglas, A. , COMBS, William, J. , SHELDON, Todd, J. , THOMPSON, David, L. , GHANEM, Raja, N. , WANASEK, Kevin, A.
发明人： MARKOWITZ, H., Toby , HETTRICK, Douglas, A. , COMBS, William, J. , SHELDON, Todd, J. , THOMPSON, David, L. , GHANEM, Raja, N. , WANASEK, Kevin, A.
IPC分类号： A61N1/372
CPC分类号： A61N1/3962 , A61N1/025 , A61N1/37211 , A61N1/37229 , A61N1/37288
摘要： Subcutaneous Implantable cardioverter-defibrillators (SubQ ICDs) are disclosed that are entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and provide distributed cardioversion-defibrillation sense and stimulation electrodes for delivery of cardioversion-defibrillation shock and pacing therapies across the heart when necessary. The SubQ ICD is implemented with other implantable and external medical devices and communicates to provide drugs and therapy in a coordinated and synergistic manner.
摘要翻译：皮下植入式心律转复除颤器（SubQ ICD）被公开，其完全可植入皮下，以最小的手术入侵患者体内，并提供分布式心脏复律除颤感和刺激电极，用于在整个心脏中递送心脏复律除颤休克和起搏疗法必要。 SubQ ICD与其他植入式和外部医疗设备一起实施，并以协调和协同的方式进行通信以提供药物和治疗。

10. 发明申请

WO2007073514A1 LV THRESHOLD MEASUREMENT AND CAPTURE MANAGEMENT 审中-公开
标题翻译： LV阈值测量和捕获管理
公开(公告)号：WO2007073514A1
公开(公告)日：2007-06-28
申请号：PCT/US2006/060813
申请日：2006-11-13
申请人： MEDTRONIC, INC. , PAIRKH, Purvee, P. , STROEBEL, John, C. , SHELDON, Todd, J. , KLECKNER, Karen, J.
发明人： PAIRKH, Purvee, P. , STROEBEL, John, C. , SHELDON, Todd, J. , KLECKNER, Karen, J.
IPC分类号： A61N1/362 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： The invention provides methods and apparatus for determining in a non-tracking pacing mode (e.g., DDI/R, VVI/R) whether a ventricular pacing stimulus is capturing a paced ventricle, including some or all of the following aspects. For example, increasing a ventricular pacing rate a nominal amount to an overdrive pacing rate higher than a most recent heart rate and evaluating a conduction interval from a first pacing ventricle to a second sensing ventricle and then continuing to monitor the underlying rate to ensure that a threshold testing pacing rate will not exceed a predetermined minimum interval and providing pacing stimulation to the first ventricle and sensing the second ventricle to determine whether the pacing stimulation to the first ventricle was one of sub-threshold and supra-threshold. The methods and apparatus are especially useful in conjunction with ensuring actual delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or "CRT").
摘要翻译：本发明提供了用于在非跟踪起搏模式（例如，DDI / R，VVI / R）中确定心室起搏刺激是否捕获节奏心室的方法和装置，包括以下方面的一些或全部。例如，将心室起搏速率增加到高于最近心率的超速起搏速率的标称值，并评估从第一起搏心室到第二感测心室的传导间隔，然后继续监测潜在速率，以确保阈值测试起搏速率不会超过预定的最小间隔，并且向第一脑室提供起搏刺激并且感测第二脑室以确定对第一脑室的起搏刺激是否是亚阈值和超阈值之一。所述方法和装置与确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的实际递送相结合特别有用。

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