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1. 发明申请

WO2012057860A1 HEART FAILURE MONITORING AND NOTIFICATION 审中-公开
标题翻译：心脏失效监测和通报
公开(公告)号：WO2012057860A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/033991
申请日：2011-04-26
申请人： MEDTRONIC, INC. , HETTRICK, Douglas, A. , SARKAR, Shantanu , OUSDIGIAN, Kevin, T.
发明人： HETTRICK, Douglas, A. , SARKAR, Shantanu , OUSDIGIAN, Kevin, T.
IPC分类号： G06F19/00
CPC分类号： A61B5/7275 , A61B5/0022 , A61B5/0031 , A61B5/0205 , A61B5/02405 , A61B5/046 , A61B5/0464 , A61B5/0538 , A61B5/1118 , A61B5/4875 , A61B5/686 , G06F19/00 , G06F19/3418 , G16H50/30
摘要： Techniques for generating a heart failure risk score with detected patient metrics are described. An implantable medical device (IMD) may collect and store patient data regarding therapy use statistics, thoracic impedance, heart rate, patient activity, and other patient metrics. Based on the number of patient metrics exceeding their respective metric thresholds, the IMD may automatically generate a risk score that indicates the likelihood that the patient will suffer from heart failure. The risk score may identify a patient as requiring immediate medical attention to reduce the risk of heart failure. The IMD may push an alert of the heart failure risk score to a clinician, and the clinician may review the patient metric data on an external device. In some examples, a clinician may prioritize patient treatment with a presented list ranking patients with the most severe heart failure risk scores.
摘要翻译：描述用于产生具有检测到的患者度量的心力衰竭风险评分的技术。可植入医疗设备（IMD）可以收集和存储关于治疗使用统计，胸部阻抗，心率，患者活动和其他患者度量的患者数据。基于超过其各自度量阈值的患者指标的数量，IMD可以自动产生指示患者将患有心力衰竭的可能性的风险评分。风险评分可能会确定患者需要立即就医以减少心力衰竭的风险。 IMD可以向临床医生推荐心力衰竭风险评分的警报，并且临床医生可以在外部设备上检查患者度量数据。在一些例子中，临床医生可以用列出的列表对患者治疗进行优先级排序，排除具有最严重心力衰竭风险评分的患者。

2. 发明申请

WO2010014931A1 ESTIMATING CARDIOVASCULAR PRESSURE AND VOLUME USING IMPEDANCE MEASUREMENTS 审中-公开
标题翻译：使用阻力测量估算心血管压力和体积
公开(公告)号：WO2010014931A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/052450
申请日：2009-07-31
申请人： MEDTRONIC, INC. , HETTRICK, Douglas, A. , CHO, Yong, K. , ROUW, Mattias , SARKAR, Shantanu , ZIELINSKI, Todd, M.
发明人： HETTRICK, Douglas, A. , CHO, Yong, K. , ROUW, Mattias , SARKAR, Shantanu , ZIELINSKI, Todd, M.
IPC分类号： A61B5/0215 , A61B5/053 , A61N1/365
CPC分类号： A61N1/36521 , A61B5/021 , A61B5/0215 , A61B5/02158 , A61B5/053 , A61B5/0535 , A61B5/0538 , A61B5/7239 , A61N1/36564
摘要： Techniques for estimating a cardiac chamber or vascular pressure based upon impedance are described. A device or system may measure an impedance between at least two electrodes implanted within or proximate to a cardiovascular system. The device or system may estimate a pressure of an element of the cardiovascular system based on a relationship between impedance and volume of the element, and based on a empirical relationship between the volume and the pressure. The device or system may also estimate the dimension of the element based on the impedance-volume relationship, or other characteristics based on the impedance. Because the impedance measurements may be obtained, in some examples, by using electrodes and leads implanted within the cardiovascular system and coupled to an implantable medical device, a practical estimation of a cardiovascular pressure can be obtained on a chronic basis without requiring the use other invasive sensors, such as micronanometer transducers.
摘要翻译：描述了基于阻抗估计心室或血管压力的技术。装置或系统可以测量植入在心血管系统内或其附近的至少两个电极之间的阻抗。装置或系统可以基于元件的阻抗和体积之间的关系，并且基于体积和压力之间的经验关系来估计心血管系统的元件的压力。装置或系统还可以基于阻抗 - 体积关系或基于阻抗的其它特性来估计元件的尺寸。由于可以获得阻抗测量值，在一些示例中，通过使用植入心血管系统内并连接到可植入医疗装置的电极和引线，可以长期获得心血管压力的实际估计，而不需要使用其它侵入性传感器，如微量计传感器。

3. 发明申请

WO2007059383A2 PACING DEVICE FOR MINIMIZING VENTRICULAR PAUSES AFTER DELIVERY OF ATRIAL ANTI-TACHYCARDIA PACING THERAPY 审中-公开
标题翻译：输送ATRA抗感染药物治疗后最小化静脉血栓的装置
公开(公告)号：WO2007059383A2
公开(公告)日：2007-05-24
申请号：PCT/US2006/060513
申请日：2006-11-03
申请人： MEDTRONIC, INC. , ZIEGLER, Paul, D. , HETTRICK, Douglas, A. , KRAUSE, Paul, G. , ANDERSON, Katherine, H.
发明人： ZIEGLER, Paul, D. , HETTRICK, Douglas, A. , KRAUSE, Paul, G. , ANDERSON, Katherine, H.
CPC分类号： A61N1/3622 , A61N1/3624
摘要： A pacing control is used in a multiple-chamber cardiac pacing system, which, upon detecting an atrial arrhythmia, automatically switches to a special therapy mode and administers a selected anti-tachycardia pacing (ATP) therapy in the atrium, and which switches to a standard pacing mode following delivery of the ATP therapy. The pacing control adjusts the timing of pacing pulses to be delivered to the atrium and/or the ventricle to minimize any potential ventricular pauses that may result from the switch from the therapy mode to the standard pacing mode.
摘要翻译：起搏控制用于多室心脏起搏系统，其在检测到心房心律失常时自动切换到特殊治疗模式，并在心房中进行选择的抗心动过速起搏（ATP）治疗，并且切换到 ATP疗法运送后的标准起搏模式。起搏控制调节将被输送到心房和/或心室的起搏脉冲的定时，以最小化从治疗模式切换到标准起搏模式可能导致的任何潜在心室停搏。

4. 发明申请

WO2006104869A9 METHOD AND APPARATUS FOR EVALUATING VENTRICULAR PERFORMANCE DURING ISOVOLUMIC CONTRACTION 审中-公开
标题翻译：在ISOVOLUMIC CONTRACTION中评估井眼性能的方法和装置
公开(公告)号：WO2006104869A9
公开(公告)日：2006-11-16
申请号：PCT/US2006010713
申请日：2006-03-23
申请人： MEDTRONIC INC , HETTRICK DOUGLAS A , EULER DAVID E
发明人： HETTRICK DOUGLAS A , EULER DAVID E
IPC分类号： A61N1/362 , A61B8/00 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61B8/0858 , A61N1/36528 , A61N1/3684
摘要： A method of evaluating ventricular performance of a heart employing sensors to measure a ventricular dimension signal and deriving indices of ventricular performance therefrom. Premature Shortening (PS) and Isovolumic Lengthening (IL) comprise two indices of ventricular performance determined from analysis of the left ventricular dimension signal during the transition from ventricular filling to ventricular ejection. Measured values of PS and IL are compared to other measured values or reference values to determine if ventricular performance has improved (or worsened). In some embodiments, the dimension sensors may comprise piezoelectric sonomicrometer crystals that operate as ultrasound transmitters and receivers. The sensors may be mounted in relation to a ventricle of the heart either temporarily or permanently, and may be configured either separately from or integrally with cardiac pacing leads.
摘要翻译：评估使用传感器测量心室尺寸信号并从其导出心室性能指数的心脏心室性能的方法。过早缩短（PS）和等压延长（IL）包括从心室充填到心室射血的过渡期间从左心室尺寸信号的分析确定的两个心室指数指数。将PS和IL的测量值与其他测量值或参考值进行比较，以确定心室性能是否改善（或恶化）。在一些实施例中，尺寸传感器可以包括作为超声波发射器和接收器操作的压电经济测量晶体。传感器可以相对于心脏的心室临时或永久地安装，并且可以与心脏起搏引线分开地或与心脏起搏引线一体地配置。

5. 发明申请

WO2006115815A2 REMOTELY ENABLED PACEMAKER AND IMPLANTABLE SUBCUTANEOUS CARDIOVERTER/DEFIBRILLATOR SYSTEM 审中-公开
标题翻译：远程启动的遥控器和可植入的辅助放大器/除颤器系统
公开(公告)号：WO2006115815A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/013956
申请日：2006-04-12
申请人： MEDTRONIC. INC. , MARKOWITZ, H., Toby , HETTRICK, Douglas, A. , COMBS, William, J. , SHELDON, Todd, J. , THOMPSON, David, L. , GHANEM, Raja, N. , WANASEK, Kevin, A.
发明人： MARKOWITZ, H., Toby , HETTRICK, Douglas, A. , COMBS, William, J. , SHELDON, Todd, J. , THOMPSON, David, L. , GHANEM, Raja, N. , WANASEK, Kevin, A.
IPC分类号： A61N1/372
CPC分类号： A61N1/3962 , A61N1/025 , A61N1/37211 , A61N1/37229 , A61N1/37288
摘要： Subcutaneous Implantable cardioverter-defibrillators (SubQ ICDs) are disclosed that are entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and provide distributed cardioversion-defibrillation sense and stimulation electrodes for delivery of cardioversion-defibrillation shock and pacing therapies across the heart when necessary. The SubQ ICD is implemented with other implantable and external medical devices and communicates to provide drugs and therapy in a coordinated and synergistic manner.
摘要翻译：皮下植入式心律转复除颤器（SubQ ICD）被公开，其完全可植入皮下，以最小的手术入侵患者体内，并提供分布式心脏复律除颤感和刺激电极，用于在整个心脏中递送心脏复律除颤休克和起搏疗法必要。 SubQ ICD与其他植入式和外部医疗设备一起实施，并以协调和协同的方式进行通信以提供药物和治疗。

6. 发明申请

WO2006105394A1 SYSTEM AND METHODS FOR IMPROVING PACING PARAMETERS USING ACUTE HEMODYNAMIC FEEDBACK DURING DEVICE IMPLANT 审中-公开
标题翻译：用于在设备植入期间使用急性HEMODYMM反馈改善PAC参数的系统和方法
公开(公告)号：WO2006105394A1
公开(公告)日：2006-10-05
申请号：PCT/US2006/011897
申请日：2006-03-30
申请人： MEDTRONIC, INC. , HETTRICK, Douglas, A. , ZIEGLER, Paul, D.
发明人： HETTRICK, Douglas, A. , ZIEGLER, Paul, D.
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/36528
摘要： The efficacy of cardiac resynchronization therapy applied to a patient's heart by an implantable device are improved by obtaining acute hemodynamic feedback during implantation of a pacing device. A first and a second ultrasound transducer are temporarily placed proximate to a portion of the patient's heart during device implant, and a distance between the ultrasound transducers is monitored as the therapy is applied. A parameter (e.g. lead location, biventricular pacing, pacing rate, or the like) of the cardiac therapy is adjusted in response to the distance between the ultrasound transducers until a desired result is obtained, after which the first and second ultrasound transducers can be removed from the patient.
摘要翻译：通过在植入装置期间获得急性血流动力学反馈来改善通过可植入装置应用于患者心脏的心脏再同步治疗的功效。在装置植入期间，第一和第二超声换能器临时放置在患者心脏的一部分附近，并且当应用治疗时，监测超声换能器之间的距离。响应于超声换能器之间的距离来调整心脏疗法的参数（例如引导位置，双心室起搏，起搏速率等），直到获得期望的结果，然后可以去除第一和第二超声换能器来自病人。

7. 发明申请

WO2006104844A2 SYSTEM FOR CHARACTERIZING CHRONIC PHYSIOLOGICAL DATA 审中-公开
标题翻译：系统表征慢性生理数据
公开(公告)号：WO2006104844A2
公开(公告)日：2006-10-05
申请号：PCT/US2006010589
申请日：2006-03-23
申请人： MEDTRONIC INC , ZIEGLER PAUL D , HETTRICK DOUGLAS A , SARKAR SHANTANU
发明人： ZIEGLER PAUL D , HETTRICK DOUGLAS A , SARKAR SHANTANU
IPC分类号： A61B5/0464
CPC分类号： A61B5/0031 , A61B5/7257
摘要： An implantable medical device (IMD) senses physiological episodes and stores data associated with the physiological episodes in the IMD. The data is then processed based on a pattern of recurrence of the physiological episodes.
摘要翻译：可植入医疗设备（IMD）感测生理事件并在IMD中存储与生理事件相关的数据。然后基于生理事件的复发模式处理数据。

8. 发明申请

WO2012078957A1 IMPEDANCE MEASUREMENT TO MONITOR ORGAN PERFUSION OR HEMODYNAMIC STATUS 审中-公开
标题翻译：对监测器的灌注或血液动力学状态的阻抗测量
公开(公告)号：WO2012078957A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/064104
申请日：2011-12-09
申请人： MEDTRONIC, INC. , ZIELINSKI, Todd M. , HETTRICK, Douglas A. , SCHEINER, Avram , CHO, Yong K. , KARAMANOGLU, Mustafa
发明人： ZIELINSKI, Todd M. , HETTRICK, Douglas A. , SCHEINER, Avram , CHO, Yong K. , KARAMANOGLU, Mustafa
IPC分类号： A61B5/053 , A61B18/12 , A61B17/00
CPC分类号： A61B5/027 , A61B5/0002 , A61B5/0295 , A61B5/0538 , A61B18/1492 , A61B2017/00026 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00875
摘要： A system and method for deliverying an ablation therapy that includes delivering the ablation therapy, delivering drive signals to establish a drive signal vector fields, determining impedance signals in response to the drive signals, determining a first impedance parameter in response to the first impedance signal and a second impedance parameter in response to the second impedance signal, determining whether there is a change in a hemodynamic status of the tissue subsequent to delivery of the ablation therapy in response to the first impedance parameter and the second impedance parameter, and adjusting delivery of the ablation therapy in response to determining whether there is a change in a hemodynamic status of the tissue.
摘要翻译：一种用于递送消融治疗的系统和方法，包括递送消融治疗，递送驱动信号以建立驱动信号矢量场，响应于驱动信号确定阻抗信号，响应于第一阻抗信号确定第一阻抗参数，以及响应于所述第二阻抗信号的第二阻抗参数，确定响应于所述第一阻抗参数和所述第二阻抗参数在所述消融治疗的递送之后所述组织的血液动力学状态是否存在变化，以及调整所述第二阻抗参数响应于确定组织的血液动力学状态是否存在变化而进行的消融治疗。

9. 发明申请

WO2012078954A1 IMPEDANCE MEASUREMENT TO MONITOR ORGAN PERFUSION OR HEMODYNAMIC STATUS 审中-公开
标题翻译：对监测器的灌注或血液动力学状态的阻抗测量
公开(公告)号：WO2012078954A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/064095
申请日：2011-12-09
申请人： MEDTRONIC, INC. , ZIELINSKI, Todd M. , HETTRICK, Douglas A. , SCHEINER, Avram , CHO, Yong K. , KARAMANOGLU, Mustafa
发明人： ZIELINSKI, Todd M. , HETTRICK, Douglas A. , SCHEINER, Avram , CHO, Yong K. , KARAMANOGLU, Mustafa
IPC分类号： A61B5/027 , A61B5/053
CPC分类号： A61B5/027 , A61B5/0002 , A61B5/0295 , A61B5/0538 , A61B18/1492 , A61B2017/00026 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00875
摘要： An implantable medical device system and associated method deliver drive signals having different frequencies to establish vector fields comprising an arterial volume and a venous volume corresponding to targeted portion of a patient's body. Impedance signals are determined in response to drive signals having different frequencies. Impedance parameter values are determined over time. A change in the hemodynamic status of a targeted portion of the patient's body is identified in response to the impedance parameter values.
摘要翻译：可植入医疗装置系统和相关方法提供具有不同频率的驱动信号以建立包括对应于患者身体的目标部分的动脉体积和静脉体积的矢量场。响应于具有不同频率的驱动信号来确定阻抗信号。阻抗参数值随时间确定。响应于阻抗参数值来识别患者身体的目标部分的血液动力学状态的变化。

10. 发明申请

WO2010056426A1 HEART FAILURE DECOMPENSATION DETERMINATION 审中-公开
标题翻译：心脏衰竭解决决定
公开(公告)号：WO2010056426A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/059151
申请日：2009-10-01
申请人： MEDTRONIC, INC. , CHO, Yong, K. , SARKAR, Shantanu , HETTRICK, Douglas, A. , TAEPKE, Robert, T., II
发明人： CHO, Yong, K. , SARKAR, Shantanu , HETTRICK, Douglas, A. , TAEPKE, Robert, T., II , BENNETT, Thomas, D.
IPC分类号： A61B5/021 , A61B5/053
CPC分类号： A61B5/0452 , A61B5/0215 , A61B5/053 , A61B5/0538 , A61N1/3627 , A61N1/36521 , A61N1/36564
摘要： Heart failure decompensation is detected by sensing at least one physiological signal. Values of at least two different heart failure variables are derived using one or more physiological signals and a threshold for the first heart failure variable is adjusted in response to the value of the second heart failure variable. The value of the first heart failure variable is compared to first threshold for detecting a heart failure condition.
摘要翻译：通过感测至少一个生理信号来检测心力衰竭失代偿。使用一个或多个生理信号导出至少两个不同的心力衰竭变量的值，并且响应于第二心力衰竭变量的值调整第一心力衰竭变量的阈值。将第一心力衰竭变量的值与用于检测心力衰竭状况的第一阈值进行比较。

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