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1. 发明申请

WO2008006119A2 SYSTEM AND METHOD FOR PROMOTING INSTRINSIC CONDUCTION THROUGH ATRIAL MODIFICATION AND CALCULATION OF TIMING PARAMETERS 审中-公开
标题翻译：通过心房改变促进心脏传导并计算时序参数的系统和方法
公开(公告)号：WO2008006119A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/074306
申请日：2007-07-25
申请人： MEDTRONIC, INC. , SHELDON, Todd, J. , BELK, Paul, A. , SWEENEY, Michael, D.
发明人： SHELDON, Todd, J. , BELK, Paul, A. , SWEENEY, Michael, D.
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/3682
摘要： An atrial based pacing protocol promotes intrinsic conduction. An entire cardiac cycle is monitored for ventricular activity and permitted to lapse with ventricular activity. Ventricular pacing is available in a cardiac cycle immediately subsequent to such a skipped beat. When monitoring for intrinsic ventricular events, an event is expected within a given window. If no such event is detected, the cardiac cycle in truncated, leading to a shorter cycle that is devoid of ventricular activity. The subsequent cycle has a high likelihood of a ventricular sensed event and a greater than normal AV interval is provided prior to pacing.
摘要翻译：
基于心房的起搏协议促进内在传导。监测整个心动周期的心室活动，并允许心室活动失效。在这种跳动节拍之后立即可以在心动周期中进行心室起搏。当监测心室内事件时，预期在给定窗口内发生事件。如果未检测到此类事件，则心脏周期截断，导致周期缩短，缺乏心室活动。随后的周期很可能发生心室感知事件，并且在起搏之前提供大于正常的AV间隔。

2. 发明申请

WO2005113065A2 VENTRICULAR DEVICE EVENT FILTERING FOR AN IMPLANTABLE MEDICAL 审中-公开
标题翻译：室间隔装置事件过滤器实现可植入医疗
公开(公告)号：WO2005113065A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/019125
申请日：2005-05-21
申请人： MEDTRONIC, INC. , BETZHOLD, Robert, A. , CASAVANT, David, A. , BELK, Paul, A. , MULLEN, Thomas, J. , STROEBEL, John, C. , HORNBERGER, Steven, R. , SHELDON, Todd, J. , PETERSON, Douglas, A.
发明人： BETZHOLD, Robert, A. , CASAVANT, David, A. , BELK, Paul, A. , MULLEN, Thomas, J. , STROEBEL, John, C. , HORNBERGER, Steven, R. , SHELDON, Todd, J. , PETERSON, Douglas, A.
IPC分类号： A61N1/36
CPC分类号： A61N1/368 , A61N1/3688 , A61N1/3702
摘要： Pacing parameters are provided to address cross talk and intrinsic ventricular events occurring within a predefined blanking period following an atrial event. The parameters are used in conjunction with protocol for minimizing or reducing ventricular pacing, wherein ignoring intrinsic ventricular events during the blanking period might otherwise affect the performance of the protocol.
摘要翻译：提供起搏参数以解决在心房事件之后的预定消隐期内发生的串扰和固有心室事件。这些参数与最小化或减少心室起搏的方案一起使用，其中在消隐期忽略内在心室事件可能会影响方案的性能。

3. 发明申请

WO2007147172A2 SYSTEM AND METHOD FOR DETERMINING INTRINSIC AV INTERVAL TIMING 审中-公开
标题翻译：用于确定内部AV间隔时序的系统和方法
公开(公告)号：WO2007147172A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/074458
申请日：2007-07-26
申请人： MEDTRONIC, INC. , SHELDON, Todd, J. , BELK, Paul, A. , SWEENEY, Michael, O.
发明人： SHELDON, Todd, J. , BELK, Paul, A. , SWEENEY, Michael, O.
CPC分类号： A61N1/368 , A61N1/3682
摘要： An atrial based pacing protocol promotes intrinsic conduction. An entire cardiac cycle is monitored for ventricular activity and permitted to lapse with ventricular activity. Ventricular pacing is available in a cardiac cycle immediately subsequent to such a skipped beat. When monitoring for intrinsic ventricular events, an event is expected within a given window. If no such event is detected, the cardiac cycle in truncated, leading to a shorter cycle that is devoid of ventricular activity. The subsequent cycle has a high likelihood of a ventricular sensed event and a greater than normal AV interval is provided prior to pacing.
摘要翻译：基于心房的起搏方案促进内在传导。监测整个心动周期的心室活动，并允许心室活动失效。在这种跳过的搏动之后，心室起搏可以在心脏周期中使用。在监测内部心室事件时，预期在给定的窗口内会发生事件。如果没有检测到这样的事件，心脏周期被截断，导致没有心室活动的更短的周期。随后的周期具有心室感测事件的高可能性，并且在起搏之前提供大于正常的AV间隔。

4. 发明申请

WO2006057754A3 SELF LIMITED RATE RESPONSE 审中-公开
公开(公告)号：WO2006057754A3
公开(公告)日：2006-06-01
申请号：PCT/US2005/038419
申请日：2005-10-25
申请人： MEDTRONIC, INC. , BELK, Paul, A. , CASAVANT, David, A , BELK, Paul, A.
发明人： BELK, Paul, A. , CASAVANT, David, A , BELK, Paul, A.
IPC分类号： A61N1/37
摘要： Rate responsive pacing is limited in an atrial based pacing mode by the AV interval in order to avoid or minimize ventricular encroachment of atrial pacing. The AV or VA interval is used to permit rate responsiveness; modulate rate responsiveness or to determine a dynamic upper sensor rate.

5. 发明申请

WO2004098706A3 HISTORY-DEPENDENT PACING INTERVAL DETERMINATION FOR ANTITACHYCARDIA PACING 审中-公开
公开(公告)号：WO2004098706A3
公开(公告)日：2004-11-18
申请号：PCT/US2004/013817
申请日：2004-04-28
申请人： MEDTRONIC, INC. , BELK, Paul, A.
发明人： BELK, Paul, A.
IPC分类号： A61N1/362
摘要： A method and device (10) for delivering anti-tachycardia pacing pulses that may be used to treat episodes of atrial or ventricular tachycardia. Episodes of atrial or ventricular tachycardia can occur while the heart is at a normal rhythm or an accelerated rhythm. The method and device (10) is directed to determining an estimate of action potential duration of a heart (12) that experiences episodes of atrial or ventricular tachycardia for use in determining a pacing interval (112) for anti-tachycardia pacing pulses (114) that may more effectively terminate the tachycardia.

6. 发明申请

WO2005110533A1 METHOD AND APPARATUS TO CONTROL DELIVERY OF HIGH-VOLTAGE AND ANTI-TACHY PACING THERAPY IN AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于控制在可植入医疗装置中提供高电压和抗紫外线治疗的方法和装置
公开(公告)号：WO2005110533A1
公开(公告)日：2005-11-24
申请号：PCT/US2005/011934
申请日：2005-04-08
申请人： MEDTRONIC, INC. , BELK, Paul, A.
发明人： BELK, Paul, A.
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61N1/3962 , A61N1/3987
摘要： A method and device for delivering a therapy in response to detection of abnormal cardiac rhythms that includes delivering a first therapy during a first delivery period, substantially simultaneous with coupling of a charging circuit and an energy storage device to generate stored energy on the energy storage device. A determination is made as to whether to deliver the first therapy during a second delivery period subsequent to the first delivery period in response to the predetermined level of stored energy not being generated on the energy storage device. The device then delivers the first therapy during a third delivery period subsequent to the second delivery period in response to the first therapy not being delivered during the second delivery period and the predeternined level of stored energy not being generated on the energy storage device.
摘要翻译：一种用于响应于异常心律的检测而递送治疗的方法和装置，其包括在第一递送期间递送第一疗法，基本上与充电电路和能量存储装置的耦合同时在能量存储装置上产生储存的能量。确定在第一递送期间之后的第二递送期间是否响应于在能量存储装置上未生成的预定的存储能量水平来递送第一疗法。然后，装置在第二递送期间的第三递送期间响应于在第二递送期间不被递送的第一疗法以及在能量存储装置上未生成的预先存储的能量水平，递送第一疗法。

7. 发明申请

WO2010011730A1 METHODS FOR THE DETERMINATION OF T-SHOCK VULNERABLE WINDOW FROM FAR-FIELD ELECTROGRAMS IN IMPLANTABLE CARDIOVERTER DEFIBRILLATORS 审中-公开
标题翻译：用于确定可触发的减震器中的电场电场的T型可触发窗口的方法
公开(公告)号：WO2010011730A1
公开(公告)日：2010-01-28
申请号：PCT/US2009/051376
申请日：2009-07-22
申请人： MEDTRONIC, INC. , IMPERCEPTION , INC. , CAO, Jian , BELK, Paul, A. , GILLBERG, Jeffrey, M. , SWERDLOW, Charles, D.
发明人： CAO, Jian , BELK, Paul, A. , GILLBERG, Jeffrey, M. , SWERDLOW, Charles, D.
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3987 , A61B5/0452 , A61N1/3962
摘要： Implantable medical device for determination of timing for electrical shocks to the heart to determine shock strength necessary to defibrillate a fibrillating heart. The timing corresponds the window of most vulnerability in the heart, which occurs during the T-wave of a heartbeat. Using a derivatized T-wave representation, the timing of most vulnerability is determined by a center of the area method, peak amplitude method, width method, or other similar methods.
摘要翻译：用于确定心脏电击的时机的植入式医疗装置，以确定去纤维化原纤维心脏所需的冲击强度。时间对应于在心脏的T波期间发生的心脏中最脆弱的窗口。使用衍生的T波表示，大多数漏洞的时间由区域方法的中心，峰值振幅法，宽度法或其他类似方法确定。

8. 发明申请

WO2005056107A1 METHOD AND APPARATUS FOR PREDICTING ARRHYTHMIAS USING DIURNAL HEART RATE 审中-公开
标题翻译：方法和装置预测使用心脏心率的ARRHYTHMIAS
公开(公告)号：WO2005056107A1
公开(公告)日：2005-06-23
申请号：PCT/US2004/040522
申请日：2004-12-03
申请人： MEDTRONIC, INC. , BELK, Paul, A. , JACKSON, Troy, E.
发明人： BELK, Paul, A. , JACKSON, Troy, E.
IPC分类号： A61N1/365
CPC分类号： A61B5/7275 , A61B5/0031 , A61B5/0215 , A61B5/02405 , A61B5/02438 , A61B5/02455 , A61B5/0464 , A61N1/3622 , A61N1/365 , G06F19/00
摘要： A method of predicting an arrhythmia, such as ventricular tachycardia, for example, in a medical device using a quantitative measure in order to allow assessment of patient risk and to enable preventative interventions by the device and clinicians. The trending of day and night average heart rates, along with patient physical activity can be analyzed to provide prediction of impending arrhythmia within weeks. By examining day and night average heart rate for crossover points, where the night heart rate equals or exceeds the day rate, and monitoring for a concomitant elevation in the night heart rate from a reference value, specific days heralding an increased risk of arrhythmia can be determined and therapy can be updated accordingly.
摘要翻译：一种预测心律失常（例如室性心动过速）的方法，例如在使用定量测量的医疗装置中，以便允许评估患者风险并使得设备和临床医师能够进行预防性干预。可以分析昼夜平均心率的趋势以及患者的身体活动，以便在几周内提供即将发生的心律失常的预测。通过检查夜间心率等于或超过日间率的交叉点的日夜平均心率，并从参考值监测夜间心率的伴随升高，预测心律失常风险增加的特定天数可以是确定和治疗可以相应更新。

9. 发明申请

WO2007095612A2 METHOD AND DEVICE FOR DELIVERING ANTI-TACHYCARDIA PACING THERAPY 审中-公开
标题翻译：用于递送抗惊厥药治疗的方法和装置
公开(公告)号：WO2007095612A2
公开(公告)日：2007-08-23
申请号：PCT/US2007/062215
申请日：2007-02-15
申请人： MEDTRONIC, INC. , BELK, Paul, A. , JACKSON, Troy, E.
发明人： BELK, Paul, A. , JACKSON, Troy, E.
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/3621 , A61N1/3962
摘要： A method and device for delivering anti-tachycardia pacing (ATP) therapy that includes an electrode to sense cardiac signals and to deliver the therapy, sensing circuitry, electrically coupled to the electrode, to detect the tachycardia event in response to the sensed cardiac signals, and a processor to control delivery of the therapy. The processor determines whether a return cycle length generated subsequent to the delivery of a first plurality of pacing pulses is less than or equal to a cycle length associated with the tachycardia event, and adjusts delivery of a second plurality of pacing pulses in response to the return cycle length being less than or equal to the cycle length associated with the tachycardia event.
摘要翻译：一种用于递送抗心动过速起搏（ATP）治疗的方法和装置，其包括用于感测心脏信号的电极和递送电耦合到所述电极的所述治疗，感测电路，以响应于所感测到的心脏信号来检测心动过速事件，以及用于控制治疗递送的处理器。处理器确定在第一组多个起搏脉冲的递送之后产生的返回周期长度是否小于或等于与心动过速事件相关联的周期长度，并且响应于返回来调整第二组起搏脉冲的递送循环长度小于或等于与心动过速事件相关联的周期长度。

10. 发明申请

WO2005110541A1 METHOD AND APPARATUS TO CONTROL DELIVERY OF HIGH-VOLTAGE AND ANTI-TACHY PACING THERAPY IN AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于控制在可植入医疗装置中提供高电压和抗紫外线治疗的方法和装置
公开(公告)号：WO2005110541A1
公开(公告)日：2005-11-24
申请号：PCT/US2005/011935
申请日：2005-04-08
申请人： MEDTRONIC, INC. , BELK, Paul, A.
发明人： BELK, Paul, A.
IPC分类号： A61N1/39
CPC分类号： A61N1/3962 , A61N1/3622
摘要： A method and device for delivering a therapy in response to detection of abnormal cardiac rhythms that includes a first circuit delivering a first therapy and a second circuit delivering a second therapy, the second circuit including an energy storage device for storing energy associated with the second therapy and a charging circuit selectively coupled to the storage device to generate the stored energy. A control circuit controls the first circuit and the second circuit to deliver the first therapy substantially simultaneous with the charging of the energy storage device in response to the predetermined event being detected, and decouples the energy storage device from the charging circuit during a redetect period subsequent to delivery of the first therapy. The control circuit recouples the energy storage device and the charging circuit in response to the microprocessor detecting the predetermined event during the redetect period.
摘要翻译：一种用于响应于异常心律的检测而递送治疗的方法和装置，其包括递送第一疗法的第一电路和递送第二疗法的第二电路，所述第二电路包括用于存储与第二疗法相关联的能量的能量存储装置以及选择性地耦合到存储装置以产生所存储的能量的充电电路。控制电路控制第一电路和第二电路，以响应于检测到的预定事件，基本上与能量存储装置的充电同时传送第一次治疗，并且在重新检测时段期间将能量存储装置与充电电路解耦交付第一疗法。响应于微处理器在重新检测期间检测到预定事件，控制电路对储能装置和充电电路进行补偿。

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