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1. 发明申请

WO2011014311A1 ALGORITHM TO MODULATE ATRIAL-VENTRICULAR DELAY AND RATE RESPONSE BASED ON AUTONOMIC FUNCTION 审中-公开
标题翻译：基于自动功能调节心律延迟和速率响应的算法
公开(公告)号：WO2011014311A1
公开(公告)日：2011-02-03
申请号：PCT/US2010/039202
申请日：2010-06-18
申请人： MEDTRONIC, INC. , FISCHER, Trent, M. , HETTRICK, Douglas, A. , SHELDON, Todd, J. , BELK, Paul, A. , MULLEN, Thomas, J. , RUETER, John, C. , KAISER, Daniel, R.
发明人： FISCHER, Trent, M. , HETTRICK, Douglas, A. , SHELDON, Todd, J. , MULLEN, Thomas, J. , RUETER, John, C. , KAISER, Daniel, R.
IPC分类号： A61N1/362 , A61N1/368 , A61N1/365 , A61B5/0205
CPC分类号： A61N1/3627 , A61B5/0456 , A61N1/36514 , A61N1/36542 , A61N1/36557 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3688
摘要： An implantable medical device and associated method provide atrial pacing and measure an atrial ventricular (AV) delay. An autonomic function index is computed using the AV delay. The autonomic function index may be compiled in a medical report. In some embodiments, the autonomic function index is used to adjust atrial pacing control parameters.
摘要翻译：可植入医疗器械和相关方法提供心房起搏并测量心房（AV）延迟。使用AV延迟计算自主功能指数。自主功能指数可以在医疗报告中编制。在一些实施例中，自主功能指数用于调节心房起搏控制参数。

2. 发明申请

WO2006116550A1 ATRIAL CAPTURE MANAGEMENT IN MINIMAL VENTRICULAR PACING SYSTEM AND METHOD 审中-公开
标题翻译：最小静态PAC系统和方法的ATRIAL捕获管理
公开(公告)号：WO2006116550A1
公开(公告)日：2006-11-02
申请号：PCT/US2006/015927
申请日：2006-04-27
申请人： MEDTRONIC, INC. , RUETER, John, C. , SHELDON, Todd, J.
发明人： RUETER, John, C. , SHELDON, Todd, J.
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3714
摘要： Embodiments of the invention provide systems and methods for an implantable medical device comprising means for selecting between an atrial chamber reset (ACR) test and an atrioventricular conduction (AVC) test to provide atrial capture management and means for switching between an atrial-based pacing mode and a dual chamber pacing mode based on detecting relatively reliable atrioventricular conduction.
摘要翻译：本发明的实施例提供了一种用于可植入医疗装置的系统和方法，包括用于在房室复位（ACR）测试和房室传导（AVC）测试之间进行选择以提供心房捕获管理的装置和用于在基于心房的起搏模式之间切换的装置以及基于检测相对可靠的房室传导的双室起搏模式。

3. 发明申请

WO2005009529A2 ATRIAL CAPTURE MANAGEMENT DURING ATRIAL AND VENTRICULAR PACING 审中-公开
标题翻译： ATRIAL和VENTRICULAR PACING期间的ATRIAL捕获管理
公开(公告)号：WO2005009529A2
公开(公告)日：2005-02-03
申请号：PCT/US2004/023556
申请日：2004-07-22
申请人： MEDTRONIC, INC. , SHELDON, Todd, J. , RUETER, John, C.
发明人： SHELDON, Todd, J. , RUETER, John, C.
IPC分类号： A61N1/00
CPC分类号： A61N1/3712 , A61N1/362 , A61N1/3714
摘要： In an atrial pacing system, the A-PACE pulse energy, defined by the pulse width and pulse amplitude, sufficient to reliably capture the atrium without being wasteful of battery energy is periodically determined in accordance with atrial capture management (ACM) algorithms. The ACM algorithms allow a slow intrinsic atrial heart rate that is suppressed by delivered A-PACE pulses resulting in A-CAPTURE and that occurs when delivered test A-PACE pulses result in ALOC to be detected. ALOC is declared if an A-EVENT of the slow intrinsic atrial heart rate is detected either during an ACM test window timed from the last delivered test A-PACE pulse or during delivery of a sequence of test A-PACE pulses delivered within or defining the ACM test window correlated to the slow intrinsic atrial heart rate.
摘要翻译：在心房起搏系统中，根据心房捕获管理（ACM）算法周期性地确定由脉冲宽度和脉冲幅度定义的足够可靠地捕获心房而不浪费电池能量的A-PACE脉冲能量。 ACM算法允许由传递的A-PACE脉冲抑制的内在心房心率慢，导致A-CAPTURE，并且当递送的测试A-PACE脉冲导致检测到ALOC时发生。如果在从最后传送的测试A-PACE脉冲定时的ACM测试窗口期间或在递送在其中传送或定义的测试A-PACE脉冲序列期间检测到慢内在心房心率的A-EVENT，则ALOC被声明 ACM测试窗口与内在心房心率缓慢相关。

4. 发明申请

WO2004101067A2 CAPTURE MANAGEMENT IMPROVEMENTS 审中-公开
标题翻译：捕获管理改进
公开(公告)号：WO2004101067A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/014481
申请日：2004-05-07
申请人： MEDTRONIC, INC. , RUETER, John, C. , MANRODT, Christopher, M. , BUSACKER, James, W. , SHELDON, Todd, J.
发明人： RUETER, John, C. , MANRODT, Christopher, M. , BUSACKER, James, W. , SHELDON, Todd, J.
IPC分类号： A61N1/37
CPC分类号： A61N1/368 , A61N1/371 , A61N1/3712 , A61N1/3714 , A61N2001/083
摘要： A capture detection algorithm detects and distinguishes atrial capture . Atrial chamber reset (ACR) and AV conduction (AVC) algorithms are implemented to measure an atrial pacing threshold The data that is used to choose between ACR and AVC methods is used to determine the progression of the patient's disease state. Some of the significant aspects of the invention include enablement of accurate threshold measurements, including calculation of stability criteria, precise interval measurements and the use of reference interval to determine capture and loss of capture.
摘要翻译：捕获检测算法检测并区分心房捕获。实施房室复位（ACR）和AV传导（AVC）算法来测量心房起搏阈值用于在ACR和AVC方法之间选择的数据用于确定患者疾病状态的进展。本发明的一些重要方面包括启用准确的阈值测量，包括稳定性标准的计算，精确的间隔测量以及参考间隔的使用以确定捕获和捕获的丢失。

5. 发明申请

WO2005070496A1 DYNAMIC ADJUSTMENT OF CAPTURE MANAGEMENT "SAFETY MARGIN" 审中-公开
标题翻译：捕捞管理的动态调整“安全守则”
公开(公告)号：WO2005070496A1
公开(公告)日：2005-08-04
申请号：PCT/US2005/001745
申请日：2005-01-20
申请人： MEDTRONIC, INC. , RUETER, John, C.
发明人： RUETER, John, C.
IPC分类号： A61N1/37
CPC分类号： A61N1/3712
摘要： A cardiac stimulation system and associated capture management method are provided in which a safety factor, used in setting pacing pulse output energy, is automatically adjusted in response to the detection of indicators of a likely increase in pacing threshold. The method includes monitoring for increased pacing threshold indicators, which may also be associated with a compromised ability to perform a pacing threshold search. Such indicators may include, but are not limited to, the presence of arrhythmias, arrhythmia episode duration, pacing mode switches, refractory sensed events, and/or lead impedance changes. In response to the detection of a selected indicator of increased pacing threshold, the safety factor is automatically increased. After an increased pacing threshold indicator has not be detected for an interval of time, or if a pacing threshold search yields a result, the safety factor may be restored to a programmed value.
摘要翻译：提供了一种心脏刺激系统和相关联的捕获管理方法，其中响应于检测到起搏阈值可能增加的指标，自动调整用于设置起搏脉冲输出能量的安全系数。该方法包括监视增加的起搏阈值指示器，其也可能与执行起搏阈值搜索的受损能力相关联。这些指标可以包括但不限于心律失常，心律不齐发作持续时间，起搏模式切换，难以感测的事件和/或引线阻抗变化的存在。响应于选定的起搏阈值指示器的检测，安全系数自动增加。在一段时间内没有检测到增加的起搏阈值指示符后，或者如果起搏阈值搜索产生结果，安全系数可以恢复到编程值。

6. 发明申请

WO2006115867A1 SYSTEM AND METHOD FOR CAPTURE MANAGEMENT 审中-公开
标题翻译：用于捕获管理的系统和方法
公开(公告)号：WO2006115867A1
公开(公告)日：2006-11-02
申请号：PCT/US2006/014332
申请日：2006-04-17
申请人： MEDTRONIC, INC. , RUETER, John, C.
发明人： RUETER, John, C.
IPC分类号： A61N1/37
CPC分类号： A61N1/3712 , A61N1/3716
摘要： An implantable medical device (IMD) includes both evoked response and algorithmic based threshold testing methodologies. The leads used with the IMD are evaluated to determine whether they are high or low polarization. The evoked response methodology is only utilized if the leads are low polarization.
摘要翻译：可植入医疗器械（IMD）包括诱发反应和基于算法的阈值测试方法。评估与IMD一起使用的引线，以确定它们是高极化还是低极化。诱发反应方法仅在引线为低极化时才被使用。

7. 发明申请

WO2006060806A3 PATIENT MANAGEMENT NETWORK 审中-公开
公开(公告)号：WO2006060806A3
公开(公告)日：2006-06-08
申请号：PCT/US2005/044034
申请日：2005-12-02
申请人： MEDTRONIC, INC. , GOTTESMAN, Janell, M. , MARKOWITZ, H. Toby , WILLENBRING, James, E. , MANRODT, Christopher, M. , VANDANACKER, John, P. , BURNES, John, E. , RUETER, John, C. , DVORAK, David, P. , AUDET, Sarah, A. , CARNEY, James, K. , HILL, Gerald, J.
发明人： GOTTESMAN, Janell, M. , MARKOWITZ, H. Toby , WILLENBRING, James, E. , MANRODT, Christopher, M. , VANDANACKER, John, P. , BURNES, John, E. , RUETER, John, C. , DVORAK, David, P. , AUDET, Sarah, A. , CARNEY, James, K. , HILL, Gerald, J.
IPC分类号： G06F19/00
摘要： An intelligent patient management system collects data from a variety of sources, processes that information, and provides relevant information to an appropriate caregiver in context at the proper time. The system has multiple information sources available from which to gather additional information based upon conclusions drawn or issues identified from the patient data.

8. 发明申请

WO2006069033A1 AUTOMATIC LV / RV CAPTURE VERIFICATION AND DIAGNOSTICS 审中-公开
标题翻译：自动LV / RV捕获验证和诊断
公开(公告)号：WO2006069033A1
公开(公告)日：2006-06-29
申请号：PCT/US2005/046055
申请日：2005-12-20
申请人： MEDTRONIC, INC. , SHETH, Nirav, Vijay , RUETER, John, C. , BURNES, John, E. , MONGEON, Luc, R. , KLECKNER, Karen, J. , YERICH, Charles, G.
发明人： SHETH, Nirav, Vijay , RUETER, John, C. , BURNES, John, E. , MONGEON, Luc, R. , KLECKNER, Karen, J. , YERICH, Charles, G.
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3712
摘要： The present invention provides a technique for verifying pacing capture of a ventricular chamber, particularly to ensure desired delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or "CRT"). The invention also provides for ventricular capture management by delivering a single ventricular pacing stimulus and checking inter-ventricular conduction during a temporal window to determine if the ventricular pacing stimulus captured the chamber. If a loss-of-capture (LOC) signal results from the capture management testing, then the characteristics of the applied pacing pulses are modified and the conduction test repeated. In the event that the LOC signal persists, a pacing mode-switch to an atrial-based pacing therapy and/or non-bi-ventricular pacing regimen can be implemented.
摘要翻译：本发明提供了用于验证心室腔室的起搏捕获，特别是确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的期望输送的技术。本发明还提供了通过递送单个心室起搏刺激和检查时间窗期间的心室间传导来确定心室起搏刺激是否捕获室的心室俘获管理。如果捕获管理测试产生捕获丢失（LOC）信号，则修改所施加的起搏脉冲的特性并重复传导测试。如果LOC信号持续存在，则可以实施起搏模式 - 切换至基于心房的起搏治疗和/或非双心室起搏治疗。

9. 发明申请

WO2005123178A3 ALGORITHM FOR THE AUTOMATIC DETERMINATION OF OPTIMAL PACING INTERVALS 审中-公开
公开(公告)号：WO2005123178A3
公开(公告)日：2005-12-29
申请号：PCT/US2005/018920
申请日：2005-05-26
申请人： MEDTRONIC, INC. , BRUNES, John, E. , IGEL, David, E. , RUETER, John, C. , ZLINSKI, Jody , CHO, Yong, Kyun , MONGEON, Luc, R. , STONE, Harold, E.
发明人： BRUNES, John, E. , IGEL, David, E. , RUETER, John, C. , ZLINSKI, Jody , CHO, Yong, Kyun , MONGEON, Luc, R. , STONE, Harold, E.
IPC分类号： A61N1/362 , A61N1/365
摘要： Impedance, e.g. sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change. Other methods vary the AA interval to maximize impedance change over the entire cardiac cycle or during the atrial cycle.

10. 发明申请

WO2004112898A3 CARDIAC PACING APPARATUS AND METHOD FOR CONTINUOUS CAPTURE MANAGEMENT 审中-公开
公开(公告)号：WO2004112898A3
公开(公告)日：2004-12-29
申请号：PCT/US2004/019362
申请日：2004-06-16
申请人： MEDTRONIC, INC. , RUETER, John, C. , COMBS, William, J.
发明人： RUETER, John, C. , COMBS, William, J.
IPC分类号： A61N1/37
摘要： An implantable cardiac stimulation system (20) and method having continuous capture management capabilities are provided. Continuous capture management is realized by continuously monitoring for secondary effects of loss of capture, thereby effectively providing continuous capture management in any heart chamber without encountering the limitations normally associated with evoked response sensing. A pacing threshold search (425) is triggered upon detecting a secondary indicator of loss of capture. Secondary indicators of loss of capture may be lead-related changes, changes related to the occurrence of atrial sensed events, changes related to the occurrence of ventricular sensed or paced events, and/or changes related to a monitored physiological condition.

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