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1. 发明申请

WO2008067362A3 MULTIPLE LUMEN DIFFUSION CATHETER 审中-公开
标题翻译：多功能扩散吸管
公开(公告)号：WO2008067362A3
公开(公告)日：2008-10-16
申请号：PCT/US2007085736
申请日：2007-11-28
申请人： MEDRAD INC , SCHWARTZ ROBERT S , VAN TASSEL ROBERT A , GELBLUM EUGENE A , HIRSCHMAN ALAN D , KALAFUT JOHN F , REILLY DAVID M , RHINEHART EDWARD J , TROMBLEY FREDERICK W , UBER ARTHUR E
发明人： SCHWARTZ ROBERT S , VAN TASSEL ROBERT A , GELBLUM EUGENE A , HIRSCHMAN ALAN D , KALAFUT JOHN F , REILLY DAVID M , RHINEHART EDWARD J , TROMBLEY FREDERICK W , UBER ARTHUR E
IPC分类号： A61M25/14
CPC分类号： A61M25/007 , A61M25/003
摘要： A method and device for the simultaneous or sequential introduction of multiple fluids into the bloodstream including a multiple lumen catheter with corresponding multiple hole sets. By introducing a second fluid such as saline, the concentration and bolus of a first fluid, such as a contrast agent, can be controlled and optimized.
摘要翻译：一种用于同时或顺序地将多种流体引入血流中的方法和装置，包括具有相应多孔组的多腔导管。通过引入诸如盐水的第二流体，可以控制和优化第一流体如造影剂的浓度和推注。

2. 发明申请

WO2007053779A3 DELIVERY OF AGENTS TO TISSUE 审中-公开
标题翻译：药剂运送到组织
公开(公告)号：WO2007053779A3
公开(公告)日：2007-11-08
申请号：PCT/US2006043134
申请日：2006-11-06
申请人： MEDRAD INC , UBER ARTHUR E III , TROMBLEY FREDERICK W III , GELBLUM EUGENE A , RHINEHART EDWARD J , REILLY DAVID M , CEDARHOLM PAGE , COWAN KEVIN P , TROCKI MARK , HIRSCHMAN ALAN D
发明人： UBER ARTHUR E III , TROMBLEY FREDERICK W III , GELBLUM EUGENE A , RHINEHART EDWARD J , REILLY DAVID M , CEDARHOLM PAGE , COWAN KEVIN P , TROCKI MARK , HIRSCHMAN ALAN D
IPC分类号： A61M5/30 , A61M31/00
CPC分类号： A61J1/1443 , A61J1/1456 , A61J1/1475 , A61M5/142 , A61M5/1723 , A61M5/3145 , A61M31/005 , B01L3/502 , B01L2300/044 , B01L2300/0681 , G06F19/3468
摘要： A system for injecting an injectate into patient includes a first pressurizable container for holding the injectate; a patient interface in fluid connection with the first pressurizable container, the patient interface being adapted to pass the injectate into tissue of the patient; a powered injector in operative connection with the first pressurizable container to pressurize the injectate; a controller system in operative connection with powered injector; and a stereotactic localization frame adapted to be placed in operative connection with the patient interface to assist in controlling localization of the patient interface. A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.
摘要翻译：一种用于将注射剂注入患者体内的系统包括用于保持注射剂的第一可加压容器; 与第一可加压容器流体连接的患者接口，患者接口适于将注射液传递到患者的组织; 动力注射器，其与第一可加压容器可操作地连接以对注射物加压; 与动力注射器可操作连接的控制器系统; 以及立体定位框架，适于与患者接口操作连接，以帮助控制患者接口的定位。用于处理细胞（和/或其他注射组分）的系统包括容器和适于可滑动地定位在容器内的柱塞。该系统包括流体可以通过其进入系统的至少一个入口和至少一个流出物可以通过其流出系统的流出口。柱塞部分与容器的内壁形成密封接合，使得柱塞的向后运动适于经由入口将流体吸入系统中，并且柱塞的向前运动适于通过流出物将流出物排出系统港口。

3. 发明申请

WO2008083313A3 METHODS AND SYSTEMS FOR INTEGRATED RADIOPHARMACEUTICAL GENERATION, PREPARATION, TRANSPORTATION, AND ADMINISTRATION 审中-公开
标题翻译：综合放射免疫法生成，制备，运输和管理的方法与系统
公开(公告)号：WO2008083313A3
公开(公告)日：2009-07-23
申请号：PCT/US2007089101
申请日：2007-12-28
申请人： MEDRAD INC , HIRSCHMAN ALAN D , UBER ARTHUR E III , COWAN KEVIN P , REILLY DAVID M , RHINEHART EDWARD J , KALAFUT JOHN F , UBER BRONWYN , TROMBLEY FREDERICK W III , REMIS STEVEN J , LEVIN PAUL , GRIFFITH SCOTT , DESCALZI DOUGLAS , DEWIT RICHARD
发明人： HIRSCHMAN ALAN D , UBER ARTHUR E III , COWAN KEVIN P , REILLY DAVID M , RHINEHART EDWARD J , KALAFUT JOHN F , UBER BRONWYN , TROMBLEY FREDERICK W III , REMIS STEVEN J , LEVIN PAUL , GRIFFITH SCOTT , DESCALZI DOUGLAS , DEWIT RICHARD
IPC分类号： A61M5/172 , A61B6/00 , G21G4/08
CPC分类号： A61N5/1001 , A61B5/0205 , A61B5/055 , A61B5/7289 , A61B6/032 , A61B6/037 , A61B6/0478 , A61B6/107 , A61B6/4057 , A61B6/4258 , A61B6/4423 , A61B6/507 , A61B6/508 , A61B6/5288 , A61B6/548 , A61M5/007 , A61M5/14546 , A61M5/1456 , A61M5/16827 , A61M5/16881 , A61M5/1723 , A61M5/1785 , A61M2205/3576 , A61N5/1071 , A61N2005/1021 , A61N2005/1094 , G06F19/3468 , G21F5/015 , G21G4/08
摘要： An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.
摘要翻译：公开了一种集成的放射性药物患者治疗系统，其包括具有相关联的患者刺激装置的患者支撑平台，靠近患者支撑平台的成像器，用于将放射性药物流体输入患者的放射性药物流体输送系统，与患者以及与患者刺激装置，成像器，放射性药物流体输送系统和患者监护器可操作地相关联以控制和协调其操作的集成系统控制器。在患者治疗系统内，可以包括放射性药物流体递送系统，包括放射性核素供应模块，放射性药物处理模块，质量控制模块，患者注射模块和控制器。进一步公开了一种危险的流体处理系统，其包括对接站和适于与对接站可拆卸地对接的危险流体输送装置。

4. 发明申请

WO2007056247A3 DELIVERY OF AGENTS SUCH AS CELLS TO TISSUE 审中-公开
标题翻译：递送代理作为细胞组织
公开(公告)号：WO2007056247A3
公开(公告)日：2009-05-07
申请号：PCT/US2006043133
申请日：2006-11-06
申请人： MEDRAD INC , UBER ARTHUR E III , HIRSCHMAN ALAN D , FACHER EVAN , GELBLUM EUGENE A , GRIFFITHS DAVID M , RHINEHART EDWARD J , REILLY DAVID M , COWAN KEVIN P , CEDARHOLM PAGE , TUCKER BARRY L , TROCKI MARK , MISHLER DAVID , BARTONY HENRY E JR , PARKS ROBERT
发明人： UBER ARTHUR E III , HIRSCHMAN ALAN D , FACHER EVAN , GELBLUM EUGENE A , GRIFFITHS DAVID M , RHINEHART EDWARD J , REILLY DAVID M , COWAN KEVIN P , CEDARHOLM PAGE , TUCKER BARRY L , TROCKI MARK , MISHLER DAVID , BARTONY HENRY E JR , PARKS ROBERT
IPC分类号： A61M31/00 , B65D25/04
CPC分类号： A61J1/1443 , A61J1/1456 , A61J1/1475 , A61M5/142 , A61M5/1723 , A61M5/3145 , A61M31/005 , B01L3/502 , B01L2300/044 , B01L2300/0681 , G06F19/3468
摘要： A system for delivering a fluid comprising cells to tissue of a patient, includes: a least a first container for holding an injection fluid in which the agent is carried; a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container; a control system in operative connection with the first powered drive and operative to control the first powered drive; a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient; a sensor system; and a communication system in connection with at least the control system and the sensor system. The communication system is adapted to provide information to the control system. The control system in adapted to transmit a control signal to at least the first powered drive based at least in part on information provided to the control system. The cells can for example be progenitor cells or stem cells.
摘要翻译：一种用于将包含细胞的流体输送到患者的组织的系统，包括：用于保持其中携带有药剂的注射液体的至少第一容器; 与容器操作性连接的第一动力驱动器，第一动力驱动器可操作以对容器的内容物进行加压; 控制系统，其与第一动力驱动器操作连接并且可操作以控制第一动力驱动; 与容器流体连接的流体路径，流体路径包括适于将细胞沉积在患者组织内的患者界面; 传感器系统; 以及至少与控制系统和传感器系统相关的通信系统。通信系统适于向控制系统提供信息。控制系统适于至少部分地基于提供给控制系统的信息将控制信号发送到至少第一动力驱动器。细胞可以例如是祖细胞或干细胞。

5. 发明申请

WO2007002154A3 MEDICAL FLUID INJECTION AND INFLATION SYSTEM 审中-公开
标题翻译：医用流体注射和灌注系统
公开(公告)号：WO2007002154A3
公开(公告)日：2007-04-05
申请号：PCT/US2006024081
申请日：2006-06-21
申请人： MEDRAD INC , GRIFFITHS DAVID M , ALMON-MARTIN ROSEMARY , HIRSCHMAN ALAN D , REILLY DAVID M , TROCKI MARK , TROMBLEY FREDERICK W , WEICH THOMAS R , JAECKLEIN WILLIAM J , SPOHN MICHAEL A , JOYCE THOMAS P
发明人： GRIFFITHS DAVID M , ALMON-MARTIN ROSEMARY , HIRSCHMAN ALAN D , REILLY DAVID M , TROCKI MARK , TROMBLEY FREDERICK W , WEICH THOMAS R , JAECKLEIN WILLIAM J , SPOHN MICHAEL A , JOYCE THOMAS P
IPC分类号： A61M31/00
CPC分类号： A61M25/10184 , A61M5/007 , A61M5/14566 , A61M5/16827 , A61M5/16854 , A61M25/007 , A61M25/104 , A61M2025/102 , A61M2025/1022
摘要： A combined fluid injection and inflation system is disclosed and includes a fluid delivery system including at least one pressurizing device, a fluid path, and a control unit. The fluid path is adapted to connect the pressurizing device to a patient via a catheter including a balloon and inserted in the patient. The control unit is operable to control the fluid delivery system. In operation, the control unit selectively actuates the fluid delivery system to operate in a fluid injection mode or in a balloon inflation mode. In the fluid injection mode the pressurizing device delivers fluid to the fluid path for a fluid injection procedure. In the balloon inflation mode, the pressurizing device delivers fluid to the fluid path for inflating the balloon associated with the catheter. An operator control may be connected to the control unit for controlling the fluid delivery system and may be a handheld device.
摘要翻译：公开了组合的流体注入和充气系统，并且包括包括至少一个加压装置，流体路径和控制单元的流体递送系统。流体路径适于经由包括球囊并且插入患者体内的导管将加压装置连接到患者。控制单元可操作以控制流体输送系统。在操作中，控制单元选择性地致动流体输送系统以流体注射模式或气球充气模式操作。在流体注射模式中，加压装置将流体输送到流体路径用于流体注射程序。在球囊膨胀模式中，加压装置将流体输送到流体路径，用于使与导管相关联的球囊膨胀。操作员控制可以连接到控制单元以控制流体输送系统，并且可以是手持装置。

6. 发明申请

WO2007124340A2 IMPROVEMENTS IN CENTRAL VENOUS CATHETERS AND RELATED EQUIPMENT 审中-公开
标题翻译：中央通风管和相关设备的改进
公开(公告)号：WO2007124340A2
公开(公告)日：2007-11-01
申请号：PCT/US2007066930
申请日：2007-04-19
申请人： MEDRAD INC , COWAN KEVIN P , HIRSCHMAN ALAN D , REILLY DAVID M , GELBLUM EUGENE A , RHINEHRT EDWARD J , TROMBLEY III FREDERICK W
发明人： COWAN KEVIN P , HIRSCHMAN ALAN D , REILLY DAVID M , GELBLUM EUGENE A , RHINEHRT EDWARD J , TROMBLEY III FREDERICK W
IPC分类号： A61M25/06 , A61F2/958
CPC分类号： A61M25/0125 , A61M25/0053 , A61M25/007 , A61M25/0082 , A61M25/0113 , A61M25/0116 , A61M25/0119 , A61M25/0122 , A61M2025/0058
摘要： Systems, devices, and methods towards improved diagnosis and therapy in connection with central venous catheters (including PICC lines). Included among the many improvements broadly contemplated herein are: arrangements via which a venous catheter can move passively into position in central venous circulation; arrangements via which a catheter can be actively guided without the use of a needle or guide wire; arrangements via which a catheter can be packaged to facilitate easy, rapid, and positionally accurate deployment by medical personnel while maintaining device sterility; and arrangements via which a catheter tip can be imaged during and after insertion.
摘要翻译：与中心静脉导管（包括PICC系）相关的改进诊断和治疗的系统，装置和方法。包括在这里广泛考虑的许多改进之中：静脉导管可以被动地移动到中心静脉循环中的位置的布置; 可以不使用针或引导线而可以主动地引导导管的布置; 导管可以被包装的布置，以便医疗人员容易，快速和定位准确的部署，同时保持装置不育; 以及在插入期间和之后可以使导管尖端成像的布置。

7. 发明申请

WO2005086874A2 ENERGY ASSISTED MEDICAL DEVICES, SYSTEMS AND METHODS 审中-公开
标题翻译：能量辅助医疗设备，系统和方法
公开(公告)号：WO2005086874A2
公开(公告)日：2005-09-22
申请号：PCT/US2005007829
申请日：2005-03-11
申请人： MEDRAD INC , UBER ARTHUR E III , GRIFFITHS DAVID M , HIRSCHMAN ALAN D
发明人： UBER ARTHUR E III , GRIFFITHS DAVID M , HIRSCHMAN ALAN D
IPC分类号： A61B10/02
CPC分类号： A61B10/0233 , A61B2010/0208
摘要： A device for penetrating tissue and removing a biological sample includes a biological sampling element to remove a biological sample. The biological sampling element includes a passage therethrough. The device further includes a penetrator positioned within the passage. The penetrator is energized in a repetitive manner to assist in penetrating tissue. The biological sample element can be adapted to remove a tissue sample or a biological fluid sample (for example, blood). A device for penetrating tissue and positioning a tissue resident conduit (for example, a catheter), includes a tissue resident conduit (for example, a catheter) including a passage therethrough; and a penetrator in operative connection with the catheter. A device for inserting a tissue resident conduit includes at least one component that is energized during penetration to assist in penetrating tissue. In one embodiment, the tissue resident conduit is flexible and the energized component is positioned or a forward end of the tissue resident conduit. The device can further include a mechanism for directing the penetration of the tissue resident conduit. A needle for penetrating tissue includes a first effector including a surface and at least one actuator in operative connection with the first effector. The actuator is adapted to cause motion of the first effector such that tearing of tissue takes place in regions where there is close proximity of tissue to the surface of the first effector.
摘要翻译：用于穿透组织并去除生物样品的装置包括用于去除生物样品的生物取样元件。生物采样元件包括通过其中的通道。该装置还包括定位在通道内的穿透器。穿透器以重复的方式通电以辅助穿透组织。生物样品元件可以适于去除组织样品或生物流体样品（例如血液）。用于穿透组织并定位组织驻留导管（例如导管）的装置包括组织驻留导管（例如导管），其包括穿过其中的通道; 以及与导管可操作地连接的穿透器。用于插入组织固定导管的装置包括至少一个在穿透期间被激发以帮助穿透组织的部件。在一个实施例中，组织驻留导管是柔性的，并且通电部件被定位或组织固定导管的前端。该装置还可以包括用于引导组织驻留导管穿透的机构。用于穿透组织的针包括包括表面的第一执行器和与第一执行器可操作地连接的至少一个致动器。致动器适于引起第一效应器的运动，使得组织的撕裂发生在组织靠近第一效应器的表面的区域中。

8. 发明申请

WO02056934A3 ENCODING AND SENSING OF SYRINGE INFORMATION 审中-公开
标题翻译：编码和感染注射信息
公开(公告)号：WO02056934A3
公开(公告)日：2003-10-30
申请号：PCT/US0201052
申请日：2002-01-16
申请人： MEDRAD INC , COWAN KEVIN P , IDDON BARRY , YANNIELLO MICHAEL J , BROSOVICH JOHN A , HIRSCHMAN ALAN D
发明人： COWAN KEVIN P , IDDON BARRY , YANNIELLO MICHAEL J , BROSOVICH JOHN A , HIRSCHMAN ALAN D
IPC分类号： G01R33/28 , A61B5/055 , A61M5/145
CPC分类号： G01D5/12 , A61M5/1452 , A61M5/3129 , A61M2005/3125 , A61M2205/6036 , A61M2205/6063
摘要： A syringe (1200) for use with a powered injector to inject a fluid into a patient inclides an encoder. The encoder includes at least a first indicator (1210A-1210E) positioned on the encoder. The first indicator is adapted to interact with at least a portion of energy being propagated through or adjacent the encoder in a manner that is detectable. The presence (or absence) of the first indicator provides or corresponds to information about the syringe configuration. The indicator(s) of the present invention can, for example, provide information about syringe configuration by the number and/or position thereof. A plurality or set of such syringes can be provided, with the configuration of each such syringe being represented by the presence or absence of indicator(s) of that syringe.
摘要翻译：一种与动力注射器一起使用以将流体注射到患者中的注射器（1200）倾斜编码器。编码器至少包括位于编码器上的第一指示器（1210A-1210E）。第一指示符适于与以可检测的方式与正在传播或邻近编码器的能量的至少一部分相互作用。第一个指示器的存在（或不存在）提供或对应于关于注射器配置的信息。例如，本发明的指示器可以通过其数量和/或位置提供关于注射器构造的信息。可以提供多个或一组这样的注射器，每个这样的注射器的构造由该注射器的指示器的存在或不存在表示。

9. 发明申请

WO2004091688A2 FLUID DELIVERY SYSTEMS, DEVICES AND METHODS FOR DELIVERY OF HAZARDOUS FLUIDS 审中-公开
标题翻译：流体输送系统，用于输送危险液体的装置和方法
公开(公告)号：WO2004091688A2
公开(公告)日：2004-10-28
申请号：PCT/US2004010824
申请日：2004-04-08
申请人： MEDRAD INC
发明人： UBER III ARTHUR E , HIRSCHMAN ALAN D , GRIFFITHS DAVID M , TROMBLEY III FREDERICK W , REILLY DAVID M
IPC分类号： A61M20060101 , A61M5/00 , A61M5/14 , A61M31/00 , A61M
CPC分类号： A61M25/0045 , A61J1/2096 , A61M5/007 , A61M5/1408 , A61M5/142 , A61M5/1452 , A61M5/44 , A61M2202/049 , A61N5/1001
摘要： A system for injecting a patient includes a container enclosing a hazardous pharmaceutical; a first pump to deliver a hazardous pharmaceutical to a patient and a fluid path operably connected to the first pump, the container, and the patient. The system further includes a hazardous material containment suitable to confine the hazardous pharmaceutical during connection of the hazardous pharmaceutical container to the fluid path.
摘要翻译：用于注射患者的系统包括封闭危险药物的容器; 向患者输送危险药物的第一泵和可操作地连接到第一泵，容器和患者的流体路径。该系统还包括适合于在将危险药物容器连接到流体路径期间限制危险药物的危险材料容纳物。

10. 发明申请

WO0192907A3 COMMUNICATION SYSTEMS FOR USE WITH MAGNETIC RESONANCE IMAGING SYSTEMS 审中-公开
标题翻译：用于磁共振成像系统的通信系统
公开(公告)号：WO0192907A3
公开(公告)日：2002-06-20
申请号：PCT/US0140826
申请日：2001-06-01
申请人： MEDRAD INC
发明人： FRAZIER MICHAEL G , REYNOLDS PAUL , HIRSCHMAN ALAN D , GARDNER JOHN R , ZATEZALO DOUGLAS M , FAZI BRUNO , HAVRILLA JOSEPH B
IPC分类号： A61B5/00 , A61B5/055 , G01R33/28
CPC分类号： G01R33/283 , A61B5/0017 , A61B5/002 , A61B5/055
摘要： A communication system for use in an MRI procedure includes a first communication unit positioned within a shielded housing on an interior side of the isolation barrier. The first communication unit includes a first receiver and a first transmitter. The communication system also includes a second communication unit positioned on an exterior side of the isolation barrier. The second communication unit includes a second receiver and a second transmitter. The first communication unit is in connection via optical cabling with a first light transmitting device positioned on an interior side of the isolation barrier adjacent a viewing window in the isolation barrier. The second communication unit is in connection via optical cabling with a second light transmitting device positioned on the exterior side of the isolation barrier adjacent a viewing window in the isolation barrier. The first communication unit and the second communication unit communicate via transmission of optical energy between the first light transmitting device and the second light-transmitting device.
摘要翻译：用于MRI程序的通信系统包括位于隔离屏障的内侧上的屏蔽外壳内的第一通信单元。第一通信单元包括第一接收机和第一发射机。通信系统还包括位于隔离屏障的外侧上的第二通信单元。第二通信单元包括第二接收机和第二发射机。第一通信单元通过光缆连接，第一光传输装置位于与隔离屏障中的观察窗相邻的隔离屏障的内侧。第二通信单元通过光缆连接，第二光发射装置位于隔离屏障的外侧，邻近隔离屏障中的观察窗。第一通信单元和第二通信单元通过第一光发送设备和第二光发送设备之间的光能的传输进行通信。

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