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1. 发明申请

WO2005063377A1 METHOD FOR PRODUCING COLLOIDAL NANOPARTICLES WITH A COMPOUNDER 审中-公开
标题翻译：用化合物生产胶体纳米颗粒的方法
公开(公告)号：WO2005063377A1
公开(公告)日：2005-07-14
申请号：PCT/EP2004/014684
申请日：2004-12-23
申请人： MEDIGENE ONCOLOGY GMBH , HAAS, Heinrich , WAIBLER, Saskia , WINTER, Gerhard
发明人： HAAS, Heinrich , WAIBLER, Saskia , WINTER, Gerhard
IPC分类号： B01J13/00
CPC分类号： A61K9/1277 , B01J13/0086
摘要： The invention relates to an improved method for producing homogenous colloidal nanoparticles, preferably liposomes, using a compounder.
摘要翻译：本发明涉及使用混合器制备均质胶体纳米粒子，优选脂质体的改进方法。

2. 发明申请

WO2008055628A1 LIPOSOME PREPARATION BY SINGLE-PASS PROCESS 审中-公开
标题翻译：通过单程过程制备脂质体
公开(公告)号：WO2008055628A1
公开(公告)日：2008-05-15
申请号：PCT/EP2007/009531
申请日：2007-11-02
申请人： MEDIGENE AG , LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN , WIGGENHORN, Michael , WINTER, Gerhard , HAAS, Heinrich , DREXLER, Klaus
发明人： WIGGENHORN, Michael , WINTER, Gerhard , HAAS, Heinrich , DREXLER, Klaus
IPC分类号： A61K9/127 , B01D1/18
CPC分类号： A61K9/1277 , A61K9/1272 , A61K9/1617 , B01D1/18 , B01J2/06 , B01J13/04
摘要： The present invention relates to a method of preparing liposomes in a singlepass mode. The method comprises the extusion of a solution or suspension through a porous device and subsequently passing said suspension or solution through a nozzle. Passing the suspension through said nozzle may result in an atomisation of the suspension or solution into droplets which might be employed in a subsequent spray-drying or spray-freezing process.
摘要翻译：本发明涉及以单通模式制备脂质体的方法。该方法包括通过多孔装置引出溶液或悬浮液，随后使所述悬浮液或溶液通过喷嘴。将悬浮液通过所述喷嘴可能导致悬浮液或溶液雾化成液滴，这可能用于随后的喷雾干燥或喷雾冷冻过程。

3. 发明申请

WO2008049633A3 SPRAY-FREEZE-DRYING PROCESS FOR THE PREPARATION OF PELLETS COMPRISING PERCOLATION DRYING 审中-公开
公开(公告)号：WO2008049633A3
公开(公告)日：2008-05-02
申请号：PCT/EP2007/009325
申请日：2007-10-26
申请人： MEDIGENE AG , LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN KÖRPERSCHAFT DES ÖFFENTLICHEN RECHTS , HAAS, Heinrich , DREXLER, Klaus , WIGENHORN, Michael , WINTER, Gerhard
发明人： HAAS, Heinrich , DREXLER, Klaus , WIGENHORN, Michael , WINTER, Gerhard
IPC分类号： A61K9/16 , A61K9/19 , A61K9/127
摘要： The present invention relates to dry particles and methods of preparing the same, in particular to methods of producing dry particles comprising a thermally labile component such as a colloidal system or a thermally labile biopharmaceutical compound, to the use of such dry particles, and to pharmaceutical compositions comprising the same.

4. 发明申请

WO2019180080A1 TREATMENT OF STAPHYLOCOCCUS RELATED DISEASES 审中-公开
公开(公告)号：WO2019180080A1
公开(公告)日：2019-09-26
申请号：PCT/EP2019/056958
申请日：2019-03-20
申请人： FÖRSTER, Beatrix , WINTER, Gerhard , GEH, Katharina
发明人： FÖRSTER, Beatrix , WINTER, Gerhard , GEH, Katharina
IPC分类号： C07K16/04 , A61P31/04 , C07K16/12 , A61K39/00 , A61L27/52
摘要： The present invention relates to antibodies for treating or preventing infections of Staphylococcus genus bacteria and/or Staphylococcus genus bacteria-related diseases. Especially, the invention relates to S. intermedius group bacteria infections and diseases. Furthermore, the invention relates to respective pharmaceutical compositions and methods of manufacturing a medicament comprising anti- S. aureus alpha-hemolysin protein antibodies.

5. 发明申请

WO2011039012A1 PRE-FILTRATION ADJUSTMENT OF BUFFER SOLUTES 审中-公开
标题翻译：缓冲解决方案的预滤波调整
公开(公告)号：WO2011039012A1
公开(公告)日：2011-04-07
申请号：PCT/EP2010/062554
申请日：2010-08-27
申请人： F. HOFFMANN-LA ROCHE AG , LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN , HEPBILDIKLER, Stefan , KUHNE, Wolfgang , ROSENBERG, Eva , WINTER, Gerhard
发明人： HEPBILDIKLER, Stefan , KUHNE, Wolfgang , ROSENBERG, Eva , WINTER, Gerhard
IPC分类号： C07K16/06 , C07K1/34
CPC分类号： C07K1/14 , B01D61/00 , B01D61/14 , C07K1/34 , C07K16/065 , C07K16/18
摘要： Herein is reported a tangential flow filtration method with a pre-filtration solute concentration adjustment in order to ensure a defined concentration of the components of the solution after tangential flow filtration.
摘要翻译：本文报道了具有预过滤溶质浓度调节的切向流过滤方法，以便在切向流过滤之后确保溶液的组分的确定浓度。

6. 发明申请

WO2006037606A2 WOUND DRESSING COMPOSITIONS, ESPECIALLY FOR DELIVERY OF PROTEASE INHIBITORS 审中-公开
标题翻译：创新的洗涤组合物，特别是递送蛋白酶抑制剂
公开(公告)号：WO2006037606A2
公开(公告)日：2006-04-13
申请号：PCT/EP2005/010674
申请日：2005-10-04
申请人： SWITCH BIOTECH AKTIENGESELLSCHAFT , LUDWIG-MAXIMILIANS- UNIVERSITÄT MÜNCHEN , SCHMIDT, Roland , WINTER, Gerhard
发明人： SCHMIDT, Roland , WINTER, Gerhard
CPC分类号： A61L26/0023 , A61L15/28 , C08L5/00 , C08L1/26
摘要： The present invention relates to a wound dressing composition comprising a cellulose ether, preferably a hydroxyethyl cellulose and a gellan gum.
摘要翻译：本发明涉及包含纤维素醚，优选羟乙基纤维素和结冷兰胶的伤口敷料组合物。

7. 发明申请

WO2005084650A1 PHARMACEUTICAL COMPOSITION FOR TOPICAL USE IN FORM OF XEROGELS OR FILMS AND METHODS FOR PRODUCTION 审中-公开
标题翻译：用于XERGELS或膜形式的局部使用的药物组合物和生产方法
公开(公告)号：WO2005084650A1
公开(公告)日：2005-09-15
申请号：PCT/EP2005/002261
申请日：2005-03-03
申请人： SWITCH BIOTECH AG , LUDWIG-MAXIMILIAN- UNIVERSITÄT , STABENAU, Anke , WINTER, Gerhard , SCHMIDT, Roland
发明人： STABENAU, Anke , WINTER, Gerhard , SCHMIDT, Roland
IPC分类号： A61K9/70
CPC分类号： A61K9/06 , A61K8/042 , A61K9/7007 , A61L15/44 , A61L2300/252 , A61L2300/258 , A61L2300/412 , A61L2300/602 , A61L2300/622 , A61Q19/00 , B01J13/0091
摘要： The present invention relates to dry delivery system comprising a xerogel or film with applied active ingredients for topical active ingredient delivery or other purposes. Said delivery system are obtainable by a method according to the invention. The present invention also provides for methods for achieving defined localization of stable or unstable active substances on dry xerogels or films, which can be reconstituted into hydrogels. From the obtained delivery systems, the active substances are released with advantageous release kinetics.
摘要翻译：本发明涉及包含具有用于局部活性成分递送或其它目的的施加的活性成分的干凝胶或薄膜的干燥递送系统。所述递送系统可通过根据本发明的方法获得。本发明还提供了用于在干燥干凝胶或膜上实现稳定或不稳定的活性物质的定义的方法，其可以重构成水凝胶。从获得的递送系统中，活性物质被释放并具有有利的释放动力学。

8. 发明申请

WO2013021056A1 METHOD FOR THE CONTROLLED INTRACELLULAR DELIVERY OF NUCLEIC ACIDS 审中-公开
标题翻译：用于控制细胞内输送核酸的方法
公开(公告)号：WO2013021056A1
公开(公告)日：2013-02-14
申请号：PCT/EP2012/065735
申请日：2012-08-10
申请人： LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN , BESHEER, Ahmed , NOGA, Matthäus , WINTER, Gerhard , WAGNER, Ernst , EDINGER, Daniel
发明人： BESHEER, Ahmed , NOGA, Matthäus , WINTER, Gerhard , WAGNER, Ernst , EDINGER, Daniel
IPC分类号： A61K47/48
CPC分类号： A61K47/36 , A61K31/713 , A61K47/59 , A61K47/61
摘要： The present invention relates to a method for the controlled intracellular delivery of nucleic acid molecules into one or more target cells, in particular tumor cells, the method comprising: providing a polymeric complex formed between one or more nucleic acid molecules to be delivered and one or more cationic carrier molecules, wherein at least a part of the one or more carrier molecules in the polymeric complex are covalently attached to hydroxyalkyl starch, and wherein the hydroxyalkyl starch is shielding the polymeric complex; allowing the shielded polymeric complex to get into contact with the one or more target cells; deshielding the polymeric complex by removing the hydroxyalkyl starch; and allowing the deshielded polymeric complex to internalize into the one or more target cells. Removal of the hydroxyalkyl starch can be accomplished enzymatically by exposing the polymeric complex to amylase. The invention also concerns the use of such method for the prevention and/or treatment of a condition selected from the group consisting of cancer, immune diseases, cardiovascular diseases, neuronal diseases, infections, and inflammatory diseases.
摘要翻译：本发明涉及将核酸分子受控的细胞内递送到一个或多个靶细胞，特别是肿瘤细胞中的方法，所述方法包括：提供在待递送的一个或多个核酸分子之间形成的聚合物复合体，更多的阳离子载体分子，其中聚合物络合物中的一个或多个载体分子的至少一部分共价连接到羟烷基淀粉上，并且其中羟烷基淀粉屏蔽聚合复合物; 允许屏蔽聚合物复合物与一个或多个靶细胞接触; 通过除去羟烷基淀粉去除聚合物复合物; 并且允许未屏蔽的聚合物络合物内化到一个或多个靶细胞中。可以通过将聚合物复合物暴露于淀粉酶来酶促去除羟烷基淀粉。本发明还涉及使用这种方法来预防和/或治疗选自癌症，免疫疾病，心血管疾病，神经元疾病，感染和炎性疾病的病症。

9. 发明申请

WO2010133700A1 PHARMACEUTICAL COMPOSITION COMPRISING MICROBUBBLES FOR TARGETED TUMOR THERAPY 审中-公开
标题翻译：包含针对肿瘤治疗的微生物的药物组合物
公开(公告)号：WO2010133700A1
公开(公告)日：2010-11-25
申请号：PCT/EP2010/057164
申请日：2010-05-25
申请人： LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN , RUPPRECHT-KARLS-UNIVERSITÄT HEIDELBERG , WINTER, Gerhard , TINKOV, Steliyan , BEKEREDJIAN, Raffi , COESTER, Conrad
发明人： WINTER, Gerhard , TINKOV, Steliyan , BEKEREDJIAN, Raffi , COESTER, Conrad
IPC分类号： A61K9/127 , A61K49/22 , A61K31/704 , A61K9/133
CPC分类号： A61K41/0028 , A61K9/0009 , A61K9/1271 , A61K49/223
摘要： The present invention relates to a pharmaceutical composition for the targeted delivery of a pharmaceutically active compound, the composition comprising soft, gas-filled particles having an envelope monolayer comprising one or more surfactants and a pharmaceutically active compound. More particularly, the invention relates to a pharmaceutical composition, wherein the envelope monolayer of the gas-filled particles have a negative overall net charge, and wherein the pharmaceutically active compound has a positive overall net charge and is directly bound to one or more surfactants by both electrostatic and hydrophobic interactions. The present invention also relates to a method of producing said pharmaceutical composition comprising the steps of providing a pharmaceutical active compound- loaded liposomal preparation and the subsequent formation of gas-filled particles by adding a pharmaceutically acceptable gas to the liposomal preparation. Furthermore, the invention relates to the use of said pharmaceutical composition in the treatment of tumors.
摘要翻译：本发明涉及用于靶向递送药物活性化合物的药物组合物，该组合物包含软的充气颗粒，其具有包含一种或多种表面活性剂的包膜单层和药物活性化合物。更具体地说，本发明涉及一种药物组合物，其中充气颗粒的包膜单层具有负整体净电荷，并且其中药物活性化合物具有正的总净电荷并且通过以下方式直接与一种或多种表面活性剂结合：静电和疏水相互作用。本发明还涉及制备所述药物组合物的方法，其包括以下步骤：提供载有药物活性化合物的脂质体制剂，随后通过向脂质体制剂中加入药学上可接受的气体形成气体填充的颗粒。此外，本发明涉及所述药物组合物在治疗肿瘤中的用途。

10. 发明申请

WO2008121301A1 CRYSTALLINE ANTI-HUMAN IL-12 ANTIBODIES 审中-公开
标题翻译：结晶抗人IL-12抗体
公开(公告)号：WO2008121301A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/004006
申请日：2008-03-27
申请人： ABBOTT LABORATORIES , BORHANI, David W. , FRAUNHOFER, Wolfgang , KRAUSE, Hans-Juergen , KOENIGSDORFER, Anette , WINTER, Gerhard , GOTTSCHALK, Stefan
发明人： BORHANI, David W. , FRAUNHOFER, Wolfgang , KRAUSE, Hans-Juergen , KOENIGSDORFER, Anette , WINTER, Gerhard , GOTTSCHALK, Stefan
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： C07K16/244 , A61K39/39591 , C07K2299/00 , C30B7/00 , Y02A50/401
摘要： The invention relates to batch crystallization methods for crystallizing an anti-hIL-12 antibody that allows the production of the antibody on an industrial scale, antibody crystals obtained according to the methods, compositions containing the crystals, and methods of using the crystals and the compositions.
摘要翻译：本发明涉及用于结晶能够以工业规模生产抗体的抗-hIL-12抗体的分批结晶方法，根据该方法获得的抗体晶体，含有晶体的组合物，以及使用晶体和组合物的方法。

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