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1. 发明申请

WO2017150536A1 ペプチド审中-公开
标题翻译：肽
公开(公告)号：WO2017150536A1
公开(公告)日：2017-09-08
申请号：PCT/JP2017/007812
申请日：2017-02-28
申请人：国立大学法人京都大学 , 公益財団法人かずさDNA研究所
发明人：大日向　耕作 , 中戸　絢也 , 青木　隼人 , 岩倉　浩 , 鈴木　秀幸
IPC分类号： C07K14/47 , A23J3/08 , A23L33/18 , A61K38/08 , A61K38/17 , A61P3/04 , C07K1/12 , C07K16/04
摘要：Ｎ末端にアミノ酸配列LIVTQTMKG（配列番号１）を有するペプチド。
摘要翻译：在N末端具有氨基酸序列LIVTQTMKG（SEQ ID NO：1）的肽。

2. 发明申请

WO2011087364A1 MILK DERIVED ANTIGEN SPECIFIC ANTIBODIES FOR INDUCING AN ADAPTIVE IMMUNE RESPONSE, METHODS OF PREPARATION AND USES THEREOF 审中-公开
标题翻译：用于诱导自适应免疫应答的抗体抗原特异性抗体，其制备方法及其用途
公开(公告)号：WO2011087364A1
公开(公告)日：2011-07-21
申请号：PCT/NL2011/050025
申请日：2011-01-14
申请人： FRIESLAND BRANDS B.V. , VAN NEERVEN, Ruprecht Jules Joost
发明人： VAN NEERVEN, Ruprecht Jules Joost
IPC分类号： C07K16/04 , A61K39/395
CPC分类号： C07K16/04 , A61K2039/505 , C07K2317/12 , C07K2317/20
摘要： The invention relates to the field of antibodies. In particular the invention relates to milk-derived antigen specific antibodies for generating an adaptive immune response, methods of preparation, and uses thereof.
摘要翻译：本发明涉及抗体领域。特别地，本发明涉及用于产生适应性免疫应答的乳衍生抗原特异性抗体，其制备方法及其应用。

3. 发明申请

WO2010125565A2 ANTI-LPS ENRICHED IMMUNOGLOBULIN PREPARATION FOR USE IN TREATMENT AND/OR PROPHYLAXIS OF A PATHOLOGIC DISORDER 审中-公开
标题翻译：抗LPS增强的免疫球蛋白制剂用于治疗和/或预防病理学疾病的预防
公开(公告)号：WO2010125565A2
公开(公告)日：2010-11-04
申请号：PCT/IL2010/000339
申请日：2010-04-27
申请人： HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , ILAN, Yaron , LALAZAR, Gadi , ADAR, Tomer , MIZRAHI, Meir , BEN-YA'ACOV, Ami
发明人： ILAN, Yaron , LALAZAR, Gadi , ADAR, Tomer , MIZRAHI, Meir , BEN-YA'ACOV, Ami
IPC分类号： C07K16/04 , C07K16/12 , A61K39/395 , A61K35/20 , G01N33/68 , C07K16/26
CPC分类号： A61K39/39508 , A61K2039/505 , A61K2039/507 , C07K16/04 , C07K16/1232 , C07K16/26 , C07K2317/12
摘要： The invention relates to the use of preparations enriched with anti LPS antibodies, such as those derived from mammalian colostrum or avian eggs, and optionally further antibodies against disease-associated antigens, colostrums, milk or milk product component/s and any adjuvants for treating, delaying or preventing the progression of a pathologic disorder such as chronic liver disease, cirrhosis and any complication or disorder associated therewith. The invention further relates to combined compositions comprising a combination of anti-LPS enriched antibody preparations and antibodies recognizing at least one antigen specific for a pathologic disorder and uses thereof in the treatment of immune-related disorders.
摘要翻译：本发明涉及富含抗LPS抗体的制剂的使用，例如衍生自哺乳动物初乳或禽卵的那些制剂，以及任选的抗疾病相关抗原，初乳，乳或乳制品组分的任何其它抗体以及任何用于治疗，延缓或预防慢性肝病，肝硬化以及与之相关的任何并发症或紊乱等病理疾病的进展。本发明还涉及组合的组合物，其包含抗LPS富集的抗体制剂和识别至少一种对病理学病症特异性的抗原的抗体的组合及其在治疗免疫相关疾病中的用途。

4. 发明申请

WO2010080062A1 SEPARATION METHOD USING SINGLE POLYMER PHASE SYSTEMS 审中-公开
标题翻译：使用单个聚合物相系统的分离方法
公开(公告)号：WO2010080062A1
公开(公告)日：2010-07-15
申请号：PCT/SE2010/050008
申请日：2010-01-07
申请人： GE HEALTHCARE BIO-SCIENCES AB , VAN ALSTINE, James , SHANAGAR, Jamil , HJORTH, Rolf , HALL, Martin , ESTMER NILSSON, Camilla
发明人： VAN ALSTINE, James , SHANAGAR, Jamil , HJORTH, Rolf , HALL, Martin , ESTMER NILSSON, Camilla
IPC分类号： C07K1/14 , C07K1/36 , C07K16/00 , C07K16/04 , C07K16/06
CPC分类号： C07K16/00 , C07K1/14 , C07K1/36 , C07K16/04 , C07K16/065 , C07K2317/10
摘要： The present invention relates to a process of enriching one target compound from a liquid, which process comprises at least one step of isolation performed by differentially partitioning between two aqueous phases. In the present invention the phases are formed by adding a thermally responsive, self-associating (i.e. clouding) hydrophilic polymer, and if needed some additional salts, to an aqueous biotechnical solution (such as a fermentation sample or bioseparation process stream) under thermal and other conditions where the solution separates into a one polymer, two-phase system with one phase enriched in the polymer. The target compound is to be found in the phase not enriched in the polymer, while a significant though varying percentage of contaminants may differentially partition to the phase interface or the polymer enriched phase. With minor or no modification the target containing phase solution can be further processed via standard unit operations such as precipitation, chromatography, and filtration to further purify target and remove any residual polymer.
摘要翻译：本发明涉及从液体中富集一种目标化合物的方法，该方法包括通过在两个水相之间进行差异分配而进行的至少一个分离步骤。在本发明中，通过将热响应，自缔合（即，混浊）的亲水聚合物和如果需要的话添加一些额外的盐，在热和/或热处理下，向水生物技术溶液（例如发酵样品或生物分离工艺流）溶液分离成一种聚合物的其它条件，两相体系中一相富集聚合物。目标化合物可以在不富集聚合物的相中找到，而显着的不同百分比的污染物可以差异地分配到相界面或聚合物富集相。通过微量或不改变，可以通过标准单元操作（如沉淀，色谱和过滤）进一步处理含有相溶液的溶液，以进一步纯化目标物并除去任何残留的聚合物。

5. 发明申请

WO2009092383A3 PRODUCTS AND METHODS TO PREVENT INFECTION 审中-公开
标题翻译：防止感染的产品和方法
公开(公告)号：WO2009092383A3
公开(公告)日：2009-10-01
申请号：PCT/DK2009050016
申请日：2009-01-22
申请人： BISGAARD-FRANTZEN KIRSTEN , MULTIMERICS APS
发明人： BISGAARD-FRANTZEN KIRSTEN
IPC分类号： A23K1/16 , A23C3/00 , A23C3/08 , A23C9/20 , A23K1/18 , A23L1/30 , A61K35/20 , A61K39/395 , A61L2/00 , C07K16/04 , C07K16/06
CPC分类号： A61K35/20 , A23C3/08 , A23C9/206 , A23K20/10 , A23K20/147 , A23K50/60 , A23L3/3472 , A23L33/19 , A23L33/40 , A61L2/0082 , C07K16/04
摘要： The present invention relates to products and methods for preventing, ameliorating and/or treating infections and other diseases. In one aspect, the products of the present invention relates to compositions comprising germ free colostrum. In another aspect, the products of the present invention relates to compositions comprising synthetically multimerised immunoglobulins. In a third aspect, the products of the present invention relates to compositions comprising germ free colostrum enriched with synthetically multimerised immunoglobulins. The invention also relates to use of said compositions as a pharmaceutical e.g. for prophylactic or ameliorating treatment of infections and other diseases. In addition the invention comprises methods for production of said compositions.
摘要翻译：本发明涉及用于预防，改善和/或治疗感染和其它疾病的产品和方法。一方面，本发明的产品涉及包含无菌初乳的组合物。另一方面，本发明的产品涉及包含合成多聚化免疫球蛋白的组合物。在第三方面，本发明的产品涉及含有富含合成多聚化免疫球蛋白的无菌初乳的组合物。本发明还涉及所述组合物作为药物的用途。用于预防或改善感染和其他疾病的治疗。此外，本发明包括生产所述组合物的方法。

6. 发明申请

WO2008148149A1 METHOD OF TREATMENT OR INHIBITION OF ENTEROVIRUS 71 INFECTION 审中-公开
标题翻译：治疗或抑制肠毒素71感染的方法
公开(公告)号：WO2008148149A1
公开(公告)日：2008-12-11
申请号：PCT/AU2008/000786
申请日：2008-06-03
申请人： ANADIS LTD , RAWLIN, Grant, Thomas , ROBINS-BROWNE, Roy, Michael , ROSENBERG, Zeil
发明人： RAWLIN, Grant, Thomas , ROBINS-BROWNE, Roy, Michael , ROSENBERG, Zeil
IPC分类号： A61K39/42 , A61K39/125 , C07K16/02 , C07K16/04 , C07K16/08
CPC分类号： C07K16/1009 , A61K2039/505 , A61K2039/507 , C07K2317/12 , C07K2317/23 , C12N2770/32311
摘要： A composition for oral dosage for passive immunization of a subject against EV71 comprising polyclonal antibodies and a method for raising polyclonal antibodies against EV71 antigen in hyperimmune ungulate colostrum or hyperimmune avian eggs.
摘要翻译：用于针对EV71的受试者针对EV71的被动免疫的组合物，包括多克隆抗体和在超免疫有限免蹄初乳或超免疫禽卵中提高针对EV71抗原的多克隆抗体的方法。

7. 发明申请

WO2005003173A1 PROCESS OF OBTAINING A FREEZE-DRIED COMPLEX FROM MAMMAL GLAND SECRETION 审中-公开
标题翻译：从乳腺分泌物中获得冷冻干燥复合物的方法
公开(公告)号：WO2005003173A1
公开(公告)日：2005-01-13
申请号：PCT/BR2003/000088
申请日：2003-07-07
申请人： MESQUITA, Luiz, Fernando
发明人： MESQUITA, Luiz, Fernando
IPC分类号： C07K16/04
CPC分类号： C07K16/065 , A61K2039/505 , A61K2039/54 , C07K16/04
摘要： Patent invention for "Process of Obtaining a Freeze-Dried Complex from Secretion Extracted from mammal Gland, Use thereof in the treatment of Immunodeficiencies, and Method of Treatment Thereof". The innovation proposed herein refers to a process of obtaining a freeze-dried complex of purified immunoglobulins from lacteal secretions of mammals, preferably from a family of bovines, caprines,equines, and ovines among others, which either mixed or unmixed and subjected to depuration, separation, purification, and heating steps, among others, the use thereof as an aid in treating immunodeficiencies, and method of treatment thereof.
摘要翻译： “从哺乳动物腺体提取的分泌物中获得冷冻干燥复合物的方法”，“用于治疗免疫缺陷的用途及其治疗方法”的专利发明。本文提出的创新是指从哺乳动物的哺乳动物分泌物获得纯化的免疫球蛋白的冷冻干燥复合物的方法，优选来自牛，家族，马和羊等家族，其混合或未混合并经历净化，分离，纯化和加热步骤等，其作为辅助治疗免疫缺陷的用途及其治疗方法。

8. 发明申请

WO01030168A1 METHOD OF OBTAINING IMMUNOGLOBULINS FROM COLOSTRUM AND DAIRY SOURCES 审中-公开
标题翻译：从乳杆菌和乳源获得免疫球蛋白的方法
公开(公告)号：WO01030168A1
公开(公告)日：2001-05-03
申请号：PCT/NZ2000/000211
申请日：2000-10-26
IPC分类号： A23C9/146 , A23J1/20 , C07K16/04 , A23J3/08 , A61K39/395
CPC分类号： C07K16/04 , A23C9/1465 , A23J1/20 , A23V2002/00 , A23V2250/5434 , A23V2300/30
摘要： The present invention relates to a method of obtaining products containing immunoglobulin(s) from a dairy and/or colostrum source by ion-exchange. The method has particular application for the preparation of products containing IgG. The method involves taking a feedstock from a dairy source and/or colostrum, adjusting the pH of the feedstock to a pH in the range 4.5 to 6.5, and subjecting the feedstock to ion-exchange to produce a high purity immunoglobulin fraction and non-bound fraction containing commercially useful amounts of immunoglobulin(s). The high purity fraction and/or the non-bound fraction may be employed in the manufacture of dietary or nutritional supplements.
摘要翻译：本发明涉及通过离子交换从奶制品和/或初乳来源获得含有免疫球蛋白的产品的方法。该方法具有用于制备含有IgG的产品的特殊应用。该方法包括从乳源和/或初乳获取原料，将原料的pH调节至4.5至6.5范围内的pH，并使原料进行离子交换以产生高纯度的免疫球蛋白级分和未结合的含有商业上有用量的免疫球蛋白的级分。高纯度级分和/或非结合级分可用于制备膳食或营养补品。

9. 发明申请

WO01003515A1 METHOD OF OBTAINING PROTEIN ISOLATES AND CONCENTRATES FROM COLOSTRUM 审中-公开
标题翻译：获取蛋白质分离物和浓缩物的方法
公开(公告)号：WO01003515A1
公开(公告)日：2001-01-18
申请号：PCT/NZ2000/000120
申请日：2000-07-07
IPC分类号： A23C9/142 , A23C9/20 , A23J1/20 , A61K35/20 , C07K16/04 , A23C9/14 , A23C23/00 , A61K39/395
CPC分类号： A23J1/20 , A23C9/1422 , A23C9/206 , A23C2210/206 , A23V2002/00 , A61K35/20 , C07K16/04 , C07K2317/12 , A23V2250/5434 , A23V2300/34
摘要： This invention relates to a method of producing protein isolates and concentrates by microfiltration of colostrum, and the production of products fortified with immunoglobulins. The method involves taking a skim colostrum stream, derived from colostrum by the separation of fat and other particulate and cellular material, or by reconstituting skim colostrum powder and water, and microfiltration of that skim colostrum stream to produce a permeate rich in colostral serum proteins and a serum deplete retentate including an enhanced ratio of casein:whey protein. The invention also relates to a method of producing a colostrum powder deplete in whey proteins from colostrum in which an intermediate permeate from the microfiltration, rich in colostral serum proteins, is concentrated and then mixed back with the serum deplete retentate, the mixture optionally being concentrated before drying to produce a colostrum powder deplete in whey proteins. The invention also includes a colostral serum isolate including a protein content of at least 70 %, a colostrum protein concentrate which is serum deplete and includes an enhanced ratio of casein:whey protein and a colostrum powder deplete in whey proteins.
摘要翻译：本发明涉及通过初乳微滤制备蛋白质分离物和浓缩物的方法，以及用免疫球蛋白强化的产物的生产。该方法包括通过分离脂肪和其它颗粒和细胞材料，或通过重构脱脂初乳粉末和水以及该脱脂初乳流的微量过滤来获得源自初乳的脱脂初乳流，以产生富含初级血清蛋白的渗透物，以及含有酪蛋白：乳清蛋白比例增加的血清消耗滞留物。本发明还涉及一种从初乳的乳清蛋白中产生初乳粉末的方法，其中来自富含初步血清蛋白的微量过滤的富含初级血清蛋白的中间渗透物被浓缩，然后与血清消耗的滞留物混合，所述混合物任选地被浓缩在干燥之前产生乳清粉末中的初乳粉末。本发明还包括初乳血清分离物，其包含至少70％的蛋白质含量，初乳蛋白浓缩物，其是血清消耗的，并且包括酪蛋白：乳清蛋白和在乳清蛋白中消耗的初乳粉末的比例增加。

10. 发明申请

WO99008708A3 METHOD AND FOOD PRODUCT FOR INCREASING MUSCLE PROTEIN AND REDUCING FAT IN ANIMALS 审中-公开
标题翻译：用于增强动物增加肌肉蛋白质和减少脂肪的方法和食品
公开(公告)号：WO99008708A3
公开(公告)日：1999-04-15
申请号：PCT/US1998/017052
申请日：1998-08-18
IPC分类号： A23K1/16 , A61K35/20 , A61K35/54 , A61K39/395 , A61P3/06 , A61P21/00 , A61P21/06 , A61P43/00 , C07K16/02 , C07K16/04 , C07K16/26 , C12P21/08
CPC分类号： C07K16/26 , A23K20/00 , C07K16/02 , C07K16/04 , Y10S424/809
摘要： The invention is directed to a method and food product for achieving at least one of the following: increasing muscle protein or reducing fat in an animal. The method comprises administering to the animal an effective amount of a composition comprising a gastrointestinal neuro-modulator antibody in order to neutralize the gatrointestinal neuro-modulator.
摘要翻译：本发明涉及用于在动物中获得肌肉蛋白质增加和/或脂肪减少的方法和食品。该方法包括向受试动物施用足够量的包含胃肠神经调节剂抗体的组合物，该抗体中和胃肠神经调节剂。

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