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1. 发明申请

WO2013021056A1 METHOD FOR THE CONTROLLED INTRACELLULAR DELIVERY OF NUCLEIC ACIDS 审中-公开
标题翻译：用于控制细胞内输送核酸的方法
公开(公告)号：WO2013021056A1
公开(公告)日：2013-02-14
申请号：PCT/EP2012/065735
申请日：2012-08-10
申请人： LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN , BESHEER, Ahmed , NOGA, Matthäus , WINTER, Gerhard , WAGNER, Ernst , EDINGER, Daniel
发明人： BESHEER, Ahmed , NOGA, Matthäus , WINTER, Gerhard , WAGNER, Ernst , EDINGER, Daniel
IPC分类号： A61K47/48
CPC分类号： A61K47/36 , A61K31/713 , A61K47/59 , A61K47/61
摘要： The present invention relates to a method for the controlled intracellular delivery of nucleic acid molecules into one or more target cells, in particular tumor cells, the method comprising: providing a polymeric complex formed between one or more nucleic acid molecules to be delivered and one or more cationic carrier molecules, wherein at least a part of the one or more carrier molecules in the polymeric complex are covalently attached to hydroxyalkyl starch, and wherein the hydroxyalkyl starch is shielding the polymeric complex; allowing the shielded polymeric complex to get into contact with the one or more target cells; deshielding the polymeric complex by removing the hydroxyalkyl starch; and allowing the deshielded polymeric complex to internalize into the one or more target cells. Removal of the hydroxyalkyl starch can be accomplished enzymatically by exposing the polymeric complex to amylase. The invention also concerns the use of such method for the prevention and/or treatment of a condition selected from the group consisting of cancer, immune diseases, cardiovascular diseases, neuronal diseases, infections, and inflammatory diseases.
摘要翻译：本发明涉及将核酸分子受控的细胞内递送到一个或多个靶细胞，特别是肿瘤细胞中的方法，所述方法包括：提供在待递送的一个或多个核酸分子之间形成的聚合物复合体，更多的阳离子载体分子，其中聚合物络合物中的一个或多个载体分子的至少一部分共价连接到羟烷基淀粉上，并且其中羟烷基淀粉屏蔽聚合复合物; 允许屏蔽聚合物复合物与一个或多个靶细胞接触; 通过除去羟烷基淀粉去除聚合物复合物; 并且允许未屏蔽的聚合物络合物内化到一个或多个靶细胞中。可以通过将聚合物复合物暴露于淀粉酶来酶促去除羟烷基淀粉。本发明还涉及使用这种方法来预防和/或治疗选自癌症，免疫疾病，心血管疾病，神经元疾病，感染和炎性疾病的病症。

2. 发明申请

WO2007084797A1 CHEMICALLY MODIFIED POLYCATION POLYMER FOR SIRNA DELIVERY 审中-公开
标题翻译：用于SIRNA交付的化学改性聚合物
公开(公告)号：WO2007084797A1
公开(公告)日：2007-07-26
申请号：PCT/US2007/002024
申请日：2007-01-23
申请人： ABBOTT LABORATORIES , TARCHA, Peter , MERDAN, Thomas , WAGNER, Ernst , KLÖCKNER, Julia
发明人： TARCHA, Peter , MERDAN, Thomas , WAGNER, Ernst , KLÖCKNER, Julia
IPC分类号： A61K47/00 , A61K47/48 , C08G73/00 , C08G73/02 , C12N15/00 , C12N15/11
CPC分类号： C08G73/0226 , A61K47/59 , A61K47/60 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2320/32
摘要： The present invention provides a unique non-viral carrier for nucleic acid delivery in vitro and in vivo , and methods of using thereof.
摘要翻译：本发明提供用于体外和体内核酸递送的独特的非病毒载体及其使用方法。

3. 发明申请

WO2011154331A1 POLYMERS FOR DELIVERY OF NUCLEIC ACIDS 审中-公开
标题翻译：用于交付核酸的聚合物
公开(公告)号：WO2011154331A1
公开(公告)日：2011-12-15
申请号：PCT/EP2011/059239
申请日：2011-06-06
申请人： F. HOFFMANN-LA ROCHE AG , LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN , DOHMEN, Christian , GUENTHER, Michael , LAECHELT, Ulrich , SCHAFFERT, David , TROIBER, Christina , WAGNER, Ernst
发明人： DOHMEN, Christian , GUENTHER, Michael , LAECHELT, Ulrich , SCHAFFERT, David , TROIBER, Christina , WAGNER, Ernst
IPC分类号： C08G73/02 , C08G69/26 , C08G69/08 , A61K47/34 , C12N15/113 , A61K48/00
CPC分类号： C08G73/028 , A61K9/0019 , A61K48/0041 , C08G69/08 , C08G69/26 , C12N15/111 , C12N2310/14 , C12N2310/351 , C12N2320/32
摘要： Polyamide polymers containing defined oligo (alkylene amino) acids, methods for their production, their use as a delivery reagent for nucleic acids, pharmaceutical compositions containing said polyamide polymers, and uses thereof are provided.
摘要翻译：提供含有限定的寡（亚烷基氨基）酸的聚酰胺聚合物，其制备方法，它们作为核酸的递送试剂的用途，含有所述聚酰胺聚合物的药物组合物及其用途。

4. 发明申请

WO2003040240A1 METHOD OF REDUCING THE ORGANIC CARBON CONTENT OF PRODUCTION WASTE WATER IN THE COURSE OF THE PREPARATION OF CONCENTRATED SOLUTIONS OF ANIONIC ORGANIC COMPOUNDS 审中-公开
标题翻译：减少生产废水的有机碳含量的方法在制备有机化合物浓缩溶液的过程中
公开(公告)号：WO2003040240A1
公开(公告)日：2003-05-15
申请号：PCT/EP2002/012161
申请日：2002-10-31
申请人： CIBA SPECIALTY CHEMICALS HOLDING INC. , HUBER, Kurt , LUCAS, Rolf , MALISZ, Jacek , WAGNER, Ernst
发明人： HUBER, Kurt , LUCAS, Rolf , MALISZ, Jacek , WAGNER, Ernst
IPC分类号： C09B67/54
CPC分类号： C09B67/0096 , C02F1/442 , C02F1/444 , C02F2101/30 , C02F2101/308 , C02F2103/28 , C09B67/0073
摘要： The present invention relates to a method of reducing the total organic carbon (TOC) content of waste water in the course of the preparation of concentrated solutions or suspensions of anionic organic compounds, which method comprises increasing the concentration of an aqueous solution or suspension of an anionic organic compound in the form of its free acid or its alkali metal salt, having a salt content of less than 5% of extraneous salt by weight based on the total solution or suspension, by microfiltration, ultrafiltration and/or nanofiltration, a) the membrane pore size being so selected that compounds having molecular weights in the range from 300 to 1000 Daltons or higher are retained, and b) the content of anionic compound in the concentrate being so adjusted to from 10 to 50% by weight that the total organic carbon (TOC) content of the permeate is less than 0.5% by weight, based on the total permeate, and c) optionally, after increasing the concentration of a suspension, dissolving the anionic organic compound by adding a suitable base. The invention relates also to the solutions and suspensions prepared by that means and to the use of such solutions or suspensions in dyeing or optically whitening paper or textile materials.
摘要翻译：本发明涉及一种在制备阴离子有机化合物的浓缩溶液或悬浮液的过程中降低废水总有机碳（TOC）含量的方法，该方法包括增加阴离子有机化合物的水溶液或悬浮液的浓度其游离酸或其碱金属盐形式的阴离子有机化合物，其盐含量基于总溶液或悬浮液，通过微量过滤，超滤和/或纳滤，重量小于外来盐的5％，a）膜孔径选择为保留分子量在300至1000道尔顿或更高范围内的化合物，和b）将浓缩物中阴离子化合物的含量调节至10至50重量％，使总有机物基于总渗透物，渗透物的碳（TOC）含量小于0.5重量％，c）任选地，在增加悬浮液的浓度后，通过加入合适的碱来洗涤阴离子有机化合物。本发明还涉及通过这种方法制备的溶液和悬浮液以及这种溶液或悬浮液在染色或光学增白纸或纺织材料中的用途。

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