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1. 发明申请

WO2005046755A2 ADJUSTABLE NEEDLE FILLING AND LASER SEALING APPARATUS AND METHOD 审中-公开
标题翻译：可调节针头填充和激光密封装置和方法
公开(公告)号：WO2005046755A2
公开(公告)日：2005-05-26
申请号：PCT/US2004/037341
申请日：2004-11-08
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , ADAMO, Benoit , GUTHY, John
发明人： PY, Daniel , ADAMO, Benoit , GUTHY, John
IPC分类号： A61M
CPC分类号： B65B3/006 , A61L2/10 , A61M5/1782 , B29C66/80 , B65B3/003 , B65B43/00 , B65B51/00 , Y10T29/49716
摘要： An assembly includes a support and drive assembly, a first structure and a second structure. The first structure is in operable communication with and supported by the support and drive assembly. The first structure includes at least one needle assembly and is adjustable to receive a plurality of needle assemblies. The second structure is supported by the support and drive assembly. The second structure includes at least one seal assembly and is adjustable to receive a plurality of seal assemblies. A method includes determining a number of vials that are to be filled concurrently and adjusting an assembly to include at least one needle assembly and at least one seal assembly. A number of the needle assemblies and the seal assemblies equals the number of vials.
摘要翻译：组件包括支撑和驱动组件，第一结构和第二结构。第一结构与支撑和驱动组件可操作地连通并由其支撑。第一结构包括至少一个针组件，并且可调节以接收多个针组件。第二个结构由支撑和驱动组件支撑。第二结构包括至少一个密封组件，并且可调节以接收多个密封组件。一种方法包括确定要同时填充的小瓶的数量并且调整组件以包括至少一个针组件和至少一个密封组件。许多针组件和密封组件等于小瓶的数量。

2. 发明申请

WO2006063000A2 ONE-WAY VALVE, APPARATUS AND METHOD OF USING THE VALVE 审中-公开
标题翻译：单向阀，使用该阀的装置和方法
公开(公告)号：WO2006063000A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/044167
申请日：2005-12-05
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , CHAN, Julian, V. , ADAMO, Benoit
发明人： PY, Daniel , CHAN, Julian, V. , ADAMO, Benoit
IPC分类号： G06Q10/00
CPC分类号： B67D1/0004 , B65B39/004 , B67D1/0007 , B67D1/0009 , B67D1/0082 , B67D1/10 , B67D1/108 , B67D1/1279 , B67D3/04 , B67D2001/0827 , F04B43/1238 , F04B53/1037 , Y10T137/7761
摘要： An apparatus has a valve body defining a first passageway, a valve seat, and a flow aperture extending through the valve body and coupled in fluid communication with the first passageway. A valve cover of the apparatus is formed of an elastic material and includes a cover base mounted on the valve body and fixedly secured against movement relative thereto, and a valve portion overlying the valve seat. The valve portion defines a predetermined radial thickness and forms an interference fit with the valve seat. The valve portion and the valve seat define a normally closed, axially-extending valve opening therebetween. The valve portion is movable between a normally closed position with the valve portion engaging the valve seat, and an open position with at least a segment of the valve portion spaced away from the valve seat to connect the valve opening in fluid communication with the flow aperture to thereby allow the passage of fluid from the flow aperture through the valve opening. A hermetically sealed variable-volume storage chamber stores therein multiple portions of the fluid and is connectible in fluid communication with the one-way valve assembly. A pump is coupled between the variable-volume storage chamber and the one-way valve assembly, and is configured to pump discrete portions of fluid from the variablevolume storage chamber, through the flow aperture, and through the valve opening to dispense the portions of fluid through the valve assembly.
摘要翻译：装置具有限定第一通道，阀座和延伸穿过阀体并与第一通道流体连通地联接的流动孔的阀体。该设备的阀盖由弹性材料形成，并且包括安装在阀体上并且固定地防止相对于其移动的盖基座以及覆盖阀座的阀门部分。阀部分限定预定的径向厚度并与阀座形成过盈配合。阀部分和阀座在它们之间限定了常闭的轴向延伸的阀开口。阀部分可在阀部分与阀座接合的常闭位置和打开位置之间移动，其中阀部分的至少一段与阀座隔开以将阀开口与流动孔口流体连通地连接从而允许流体从流动孔通过阀开口。密封的可变容积存储腔室在其中存储流体的多个部分并且可与单向阀组件流体连通地连接。泵联接在可变容积存储腔室和单向阀组件之间，并且被配置为从可变容积存储腔室抽出离散的部分流体，穿过流动孔并且通过阀门开口以分配部分流体通过阀门组件。

3. 发明申请

WO2007133297A2 ONE-WAY VALVE AND APPARATUS AND METHOD OF USING THE VALVE 审中-公开
标题翻译：单向阀和装置以及使用阀的方法
公开(公告)号：WO2007133297A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/000419
申请日：2007-01-05
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , CHAN, Julian, V. , ADAMO, Benoit , HOULE, Nathaniel
发明人： PY, Daniel , CHAN, Julian, V. , ADAMO, Benoit , HOULE, Nathaniel
IPC分类号： H01L21/44
CPC分类号： B67D1/0004 , B67D1/0082 , B67D1/10 , B67D1/108 , B67D2001/0827 , F16K15/145
摘要： A flexible pouch and valve assembly is provided for aseptically storing a substance, dispensing multiple portions of the stored substance therefrom, and maintaining substance remaining in the pouch in an aseptic condition sealed with respect to ambient atmosphere. The flexible pouch and valve assembly are receivable within a relatively rigid housing, and are adapted to cooperate with a pump for pumping discrete portions of substance from the pouch and through the one-way valve to dispense the substance therefrom. The assembly comprises a Flexible pouch defining therein a variable-volume storage chamber sealed with respect to the ambient atmosphere for aseptically storing therein multiple portions of the substance. A one way valve of the assembly includes a valve body defining an axially-extending valve seat and at least one flow aperture extending through the valve body and/or the valve seat. A valve cover is mounted on the valve body, and includes an axially-extending portion formed of an elastic material overlying the valve seat and covering a substantial axially-extending portion thereof. The valve portion defines a predetermined radial thickness and forms an interference fit with the valve seat. The valve portion and the valve seat define an axially-extending seam therebetween forming a normally closed, axially-extending valve opening, and the valve portion is movable radially between (i) a normally closed position with the valve portion engaging the valve seat, and (ii) an open position with at least a segment of the valve portion spaced radially away from the valve seat to connect the valve opening in fluid communication with the at least one flow aperture and thereby allow the passage of substance from the variable-volume storage chamber through the valve opening. In the normally closed and open positions, the one-way valve maintains substance remaining in the variable- volume storage chamber in an aseptic condition and sealed with respect to the ambient atmosphere.
摘要翻译：提供了一种柔性袋和阀组件，用于无菌存储物质，从其中分配多部分储存物质，并将残留在袋中的物质保持在相对于环境大气密封的无菌状态。柔性袋和阀组件可接收在相对刚性的壳体内，并且适于与泵协作，用于泵送物质的离散部分并且通过单向阀从其分配物质。组件包括柔性袋，其中限定有相对于环境大气密封的可变容积存储室，用于将物质的多个部分无菌存储。组件的单向阀包括限定轴向延伸的阀座的阀体和延伸穿过阀体和/或阀座的至少一个流动孔。阀盖安装在阀体上，并且包括由弹性材料形成的轴向延伸部分，该弹性材料覆盖在阀座上并覆盖其基本上轴向延伸的部分。阀部分限定预定的径向厚度并与阀座形成过盈配合。阀部分和阀座在其间限定了一个轴向延伸的接缝，形成一个常闭的，轴向延伸的阀门开口，阀部分在（i）与阀座接合的阀部分的常闭位置和（ii）打开位置，其中所述阀部分的至少一个段与所述阀座径向间隔开，以将所述阀开口与所述至少一个流动孔流体连通，从而允许所述物质从所述可变容积存储器室通过阀门开口。在常开和常开位置，单向阀将物质保持在可变容积的储存室中，处于无菌状态，并相对于环境大气密封。

4. 发明申请

WO2007117228A3 CONTAINER AND CLOSURE ASSEMBLY FOR A FAT CONTAINING LIQUID PRODUCT 审中-公开
公开(公告)号：WO2007117228A3
公开(公告)日：2007-10-18
申请号：PCT/US2006/002766
申请日：2006-01-25
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , ASSION, Norbert , HOULE, Nathaniel , SAHOO, Debashis , WILLEY, M., Jeffrey , HARTMAN, Eric, E. , GUTHY, John
发明人： PY, Daniel , ASSION, Norbert , HOULE, Nathaniel , SAHOO, Debashis , WILLEY, M., Jeffrey , HARTMAN, Eric, E. , GUTHY, John
IPC分类号： B65D47/36 , B65D51/20 , B65D41/20
摘要： The present invention consists of a container and closure assembly for a fat containing liquid product. The closure assembly further comprises a stopper, sealing member, and securing member. The container and closure assembly are made of materials which do not leach a significant amount of a leachable substance into the liquid product. Also disclosed is a method for filling the containers, comprising the steps of advancing a needle filling assembly through the closure assembly, filling the container, removing the needle assembly, and thermally sealing the needle aperture. These steps may also be preceded by the step of sterilizing the outside of the container with a liquid, then blowing away the liquid with a sterile gas before the container reaches the filling assembly.

5. 发明申请

WO2009055833A1 DISPENSER WITH PLURAL PRODUCT CHAMBERS FOR SEPARATE STORAGE AND INTERMIXING OF PRODUCTS PRIOR TO USE, AND RELATED METHOD 审中-公开
标题翻译：具有广泛产品的分配器，用于单独存储和使用前的产品的介绍以及相关方法
公开(公告)号：WO2009055833A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/081396
申请日：2008-10-27
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel
发明人： PY, Daniel
IPC分类号： B67D5/60
CPC分类号： B65D47/36 , A61J1/202 , A61J9/00 , A61J9/008 , A61J11/04 , B65B3/04 , B65D47/063 , B65D47/265 , B65D47/32 , B65D51/002
摘要： A container including a body defining an outflow opening and at least one chamber adapted for storing a product, such as a fat containing liquid product, and a container closure including a primary seal for hermetically sealing the product within the chamber during storage. The container closure includes a sealing member forming a substantially fluid-tight seal between the container closure and the body, and a dispensing member in fluid communication with the chamber. The container closure and body move relative to each other between a first position where the primary seal is seated about the outflow port to hermetically seal the product in the chamber during storage, and a second position where the primary seal is displaced from the outflow port to allow product to pass from the chamber through the outflow port and into dispensing member to dispense the product.
摘要翻译：一种容器，其包括限定流出开口的主体和适于储存产品（例如含脂肪的液体产品）的至少一个室，以及容器盖，该容器封闭件包括用于在储存期间气密地密封室内的产品的主密封件。容器封闭件包括在容器封闭件和主体之间形成基本上流体密封的密封件和与腔室流体连通的分配构件的密封构件。容器封闭件和主体在第一位置和第二位置之间移动，第一位置和第二位置之间，第一位置处主要密封件围绕流出端口安置，以便在存储期间将产品气密地密封在腔室中;以及第二位置，其中主密封件从流出端口移位到允许产品从腔室通过流出口并进入分配构件以分配产品。

6. 发明申请

WO2009055832A1 LIQUID NUTRITION PRODUCT DISPENSER WITH PLURAL PRODUCT CHAMBERS FOR SEPARATE STORAGE AND INTERMIXING PRIOR TO USE, AND RELATED METHOD 审中-公开
标题翻译：液体营养产品分配器，具有单独存储和使用前的独立存储和相关方法的相关方法
公开(公告)号：WO2009055832A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/081395
申请日：2008-10-27
申请人： MEDICAL INSTILL TECHNOLOGIES INC. , NESTEC LTD. , PY, Daniel
发明人： PY, Daniel
IPC分类号： B67D5/56
CPC分类号： B65D47/36 , A61J1/202 , A61J9/00 , A61J9/008 , A61J11/04 , B65B3/04 , B65D47/063 , B65D47/265 , B65D47/32 , B65D51/002
摘要： A container including a body defining an outflow opening and at least one chamber adapted for storing a product, such as a fat containing liquid product, and a container closure including a primary seal for hermetically sealing the product within the chamber during storage. The container closure includes a sealing member forming a substantially fluid-tight seal between the container closure and the body, and a dispensing member in fluid communication with the chamber. The container closure and body move relative to each other between a first position where the primary seal is seated about the outflow port to hermetically seal the product in the chamber during storage, and a second position where the primary seal is displaced from the outflow port to allow product to pass from the chamber through the outflow port and into dispensing member to dispense the product.
摘要翻译：一种容器，其包括限定流出开口的主体和适于储存产品（例如含脂肪的液体产品）的至少一个室，以及容器盖，该容器封闭件包括用于在储存期间气密地密封室内的产品的主密封件。容器封闭件包括在容器封闭件和主体之间形成基本上流体密封的密封件和与腔室流体连通的分配构件的密封构件。容器封闭件和主体在第一位置和第二位置之间移动，第一位置和第二位置之间，第一位置处主要密封件围绕流出端口安置，以便在存储期间将产品气密地密封在腔室中;以及第二位置，其中主密封件从流出端口移位到允许产品从腔室通过流出口并进入分配构件以分配产品。

7. 发明申请

WO2007127286A3 NEEDLE PENETRABLE AND LASER RESEALABLE LYOPHILIZATION DEVICE AND RELATED METHOD 审中-公开
公开(公告)号：WO2007127286A3
公开(公告)日：2007-11-08
申请号：PCT/US2007/010100
申请日：2007-04-24
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel
发明人： PY, Daniel
IPC分类号： B65D83/06
摘要： A device and related method are provided for lyophiliziπg a substance within the device and storing the lyophilized substance. The device is penetrable by a needle for filling the device with the substance to be lyophilized, and a resulting needle hole in the device is laser resealable by transmitting thereon laser radiation from a laser source. The device defines a chamber for receiving therein the substance to be lyophilized. A needle penetrable and laser resealable portion of the device is pierceable with a needle to form a needle aperture therethrough to fill the chamber with the substance to be lyophilized through the needle, and is laser resealable to hermetically seal the needle aperture by applying laser radiation thereto.

8. 发明申请

WO2007120719A3 READY TO DRINK CONTAINER WITH NIPPLE AND NEEDLE PENETRABLE AND LASER RESEALABLE PORTION, AND RELATED METHOD 审中-公开
公开(公告)号：WO2007120719A3
公开(公告)日：2007-10-25
申请号：PCT/US2007/008961
申请日：2007-04-10
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel
发明人： PY, Daniel
IPC分类号： B65B1/04
摘要： A container is provided for storing a product, such as a fat containing liquid product, and includes a body defining a chamber for receiving the product; and a container closure including a sealing portion for sealing the product within the chamber. The container closure includes a member forming a substantially fluid-tight seal between the container closure and the body; a nipple in fluid communication with the chamber that seals the chamber with respect to the ambient atmosphere during storage of the product in the chamber and that can be opened to dispense product from the chamber therethrough; and a needle penetrable and laser resealable portion that is penetrable by the needle for aseptically filling the chamber with the product, and that is thermally resealable by the application of laser radiation thereto to seal the product within the chamber.

9. 发明申请

WO2005072427A3 DISPENSER HAVING VARIABLE-VOLUME STORAGE CHAMBER AND DEPRESSIBLE ONE-WAY VALVE ASSEMBLY FOR DISPENSING CREAMS AND OTHER SUBSTANCES 审中-公开
公开(公告)号：WO2005072427A3
公开(公告)日：2005-08-11
申请号：PCT/US2005/003035
申请日：2005-01-27
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel
发明人： PY, Daniel
IPC分类号： B67D5/40
摘要： A dispenser has a housing, and a variable-volume storage chamber formed within the housing and defining a substantially fluid-tight seal between the chamber and exterior of the housing for storing a substance to be dispensed. A piston is mounted within the housing, and a one-way valve is mounted within the housing and coupled in fluid communication with the variable-volume storage chamber. A compression chamber is coupled in fluid communication between the piston and one-way valve, and at least one of the piston and valve is manually depressible relative to the other between (i) a first position in which the piston is located at least partially outside of the compression chamber for permitting substance to flow from the variable-volume storage chamber into the compression chamber, and (ii) a second position in which the piston is located at least partially within the compression chamber for pressurizing substance within the compression chamber aboye a valve opening pressuring and, in turn, dispensing substance through the one-way valve and out of the dispenser.

10. 发明申请

WO2004096113A2 CONTAINER WITH VALVE ASSEMBLY FOR FILLING AND DISPENSING SUBSTANCES, AND APPARATUS AND METHOD FOR FILLING 审中-公开
标题翻译：具有用于填充和分配物质的阀组件的容器，以及用于填充的装置和方法
公开(公告)号：WO2004096113A2
公开(公告)日：2004-11-11
申请号：PCT/US2004/012985
申请日：2004-04-28
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel
发明人： PY, Daniel
IPC分类号： A61J
CPC分类号： B65B55/08 , A61J1/1425 , A61J1/1431 , A61J1/1468 , A61J1/1481 , A61J1/1487 , A61J1/18 , A61J1/2037 , A61J1/2041 , A61J1/2055 , A61J1/2096 , A61M2207/00 , B65B3/003 , B65D47/248
摘要： A vial has a body defining a chamber for receiving a substance therein; and a valve assembly coupled in fluid communication with the chamber and defining (i) an open position permitting at least one of (a) passage of the substance through the valve assembly and into the chamber for storing the substance in the chamber, and (b) passage of the substance out of the chamber for dispensing the substance therefrom; and (ii) a closed position forming a fluid-tight seal between the chamber and exterior of the container. A filling member engages a flexible valve member of the valve assembly to move the valve member between the closed and open positions to fill and seal the vial, respectively. A syringe is connectable to the vial. The valve assembly opens upon connecting the syringe to the vial to allow the substance within the vial to be withdrawn from the vial and into the syringe by actuating a plunger of the syringe, and the valve assembly closes upon disconnecting the vial and syringe to hermetically seal and store the substance remaining in the syringe for later use.
摘要翻译：小瓶具有限定用于在其中接收物质的室的主体; 以及阀组件，其与所述腔室流体连通地联接并且限定（i）允许所述物质通过所述阀组件并进入所述腔室中的至少一个的打开位置，以将所述物质存储在所述腔室中，并且（b ）物质从室中通过以从其中分配物质; 和（ii）在容器和容器的外部之间形成流体密封的封闭位置。填充构件接合阀组件的柔性阀构件以在闭合位置和打开位置之间移动阀构件以分别填充和密封小瓶。注射器可连接到小瓶。在将注射器连接到小瓶上时，阀组件打开，以通过致动注射器的柱塞来使小瓶内的物质从小瓶中取出并进入注射器，并且在断开小瓶和注射器之后阀组件关闭以气密密封并将剩余的物质储存在注射器中以备后用。

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