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1. 发明申请

WO2006063000A2 ONE-WAY VALVE, APPARATUS AND METHOD OF USING THE VALVE 审中-公开
标题翻译：单向阀，使用该阀的装置和方法
公开(公告)号：WO2006063000A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/044167
申请日：2005-12-05
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , CHAN, Julian, V. , ADAMO, Benoit
发明人： PY, Daniel , CHAN, Julian, V. , ADAMO, Benoit
IPC分类号： G06Q10/00
CPC分类号： B67D1/0004 , B65B39/004 , B67D1/0007 , B67D1/0009 , B67D1/0082 , B67D1/10 , B67D1/108 , B67D1/1279 , B67D3/04 , B67D2001/0827 , F04B43/1238 , F04B53/1037 , Y10T137/7761
摘要： An apparatus has a valve body defining a first passageway, a valve seat, and a flow aperture extending through the valve body and coupled in fluid communication with the first passageway. A valve cover of the apparatus is formed of an elastic material and includes a cover base mounted on the valve body and fixedly secured against movement relative thereto, and a valve portion overlying the valve seat. The valve portion defines a predetermined radial thickness and forms an interference fit with the valve seat. The valve portion and the valve seat define a normally closed, axially-extending valve opening therebetween. The valve portion is movable between a normally closed position with the valve portion engaging the valve seat, and an open position with at least a segment of the valve portion spaced away from the valve seat to connect the valve opening in fluid communication with the flow aperture to thereby allow the passage of fluid from the flow aperture through the valve opening. A hermetically sealed variable-volume storage chamber stores therein multiple portions of the fluid and is connectible in fluid communication with the one-way valve assembly. A pump is coupled between the variable-volume storage chamber and the one-way valve assembly, and is configured to pump discrete portions of fluid from the variablevolume storage chamber, through the flow aperture, and through the valve opening to dispense the portions of fluid through the valve assembly.
摘要翻译：装置具有限定第一通道，阀座和延伸穿过阀体并与第一通道流体连通地联接的流动孔的阀体。该设备的阀盖由弹性材料形成，并且包括安装在阀体上并且固定地防止相对于其移动的盖基座以及覆盖阀座的阀门部分。阀部分限定预定的径向厚度并与阀座形成过盈配合。阀部分和阀座在它们之间限定了常闭的轴向延伸的阀开口。阀部分可在阀部分与阀座接合的常闭位置和打开位置之间移动，其中阀部分的至少一段与阀座隔开以将阀开口与流动孔口流体连通地连接从而允许流体从流动孔通过阀开口。密封的可变容积存储腔室在其中存储流体的多个部分并且可与单向阀组件流体连通地连接。泵联接在可变容积存储腔室和单向阀组件之间，并且被配置为从可变容积存储腔室抽出离散的部分流体，穿过流动孔并且通过阀门开口以分配部分流体通过阀门组件。

2. 发明申请

WO2007133297A2 ONE-WAY VALVE AND APPARATUS AND METHOD OF USING THE VALVE 审中-公开
标题翻译：单向阀和装置以及使用阀的方法
公开(公告)号：WO2007133297A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/000419
申请日：2007-01-05
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , CHAN, Julian, V. , ADAMO, Benoit , HOULE, Nathaniel
发明人： PY, Daniel , CHAN, Julian, V. , ADAMO, Benoit , HOULE, Nathaniel
IPC分类号： H01L21/44
CPC分类号： B67D1/0004 , B67D1/0082 , B67D1/10 , B67D1/108 , B67D2001/0827 , F16K15/145
摘要： A flexible pouch and valve assembly is provided for aseptically storing a substance, dispensing multiple portions of the stored substance therefrom, and maintaining substance remaining in the pouch in an aseptic condition sealed with respect to ambient atmosphere. The flexible pouch and valve assembly are receivable within a relatively rigid housing, and are adapted to cooperate with a pump for pumping discrete portions of substance from the pouch and through the one-way valve to dispense the substance therefrom. The assembly comprises a Flexible pouch defining therein a variable-volume storage chamber sealed with respect to the ambient atmosphere for aseptically storing therein multiple portions of the substance. A one way valve of the assembly includes a valve body defining an axially-extending valve seat and at least one flow aperture extending through the valve body and/or the valve seat. A valve cover is mounted on the valve body, and includes an axially-extending portion formed of an elastic material overlying the valve seat and covering a substantial axially-extending portion thereof. The valve portion defines a predetermined radial thickness and forms an interference fit with the valve seat. The valve portion and the valve seat define an axially-extending seam therebetween forming a normally closed, axially-extending valve opening, and the valve portion is movable radially between (i) a normally closed position with the valve portion engaging the valve seat, and (ii) an open position with at least a segment of the valve portion spaced radially away from the valve seat to connect the valve opening in fluid communication with the at least one flow aperture and thereby allow the passage of substance from the variable-volume storage chamber through the valve opening. In the normally closed and open positions, the one-way valve maintains substance remaining in the variable- volume storage chamber in an aseptic condition and sealed with respect to the ambient atmosphere.
摘要翻译：提供了一种柔性袋和阀组件，用于无菌存储物质，从其中分配多部分储存物质，并将残留在袋中的物质保持在相对于环境大气密封的无菌状态。柔性袋和阀组件可接收在相对刚性的壳体内，并且适于与泵协作，用于泵送物质的离散部分并且通过单向阀从其分配物质。组件包括柔性袋，其中限定有相对于环境大气密封的可变容积存储室，用于将物质的多个部分无菌存储。组件的单向阀包括限定轴向延伸的阀座的阀体和延伸穿过阀体和/或阀座的至少一个流动孔。阀盖安装在阀体上，并且包括由弹性材料形成的轴向延伸部分，该弹性材料覆盖在阀座上并覆盖其基本上轴向延伸的部分。阀部分限定预定的径向厚度并与阀座形成过盈配合。阀部分和阀座在其间限定了一个轴向延伸的接缝，形成一个常闭的，轴向延伸的阀门开口，阀部分在（i）与阀座接合的阀部分的常闭位置和（ii）打开位置，其中所述阀部分的至少一个段与所述阀座径向间隔开，以将所述阀开口与所述至少一个流动孔流体连通，从而允许所述物质从所述可变容积存储器室通过阀门开口。在常开和常开位置，单向阀将物质保持在可变容积的储存室中，处于无菌状态，并相对于环境大气密封。

3. 发明申请

WO2006063360A2 CONTAINER AND VALVE ASSEMBLY FOR STORING AND DISPENSING SUBSTANCES, AND RELATED METHOD 审中-公开
标题翻译：用于储存和分配物质的集装箱和阀组件及相关方法
公开(公告)号：WO2006063360A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/045110
申请日：2005-12-12
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , CHAN, Julian, V.
发明人： PY, Daniel , CHAN, Julian, V.
IPC分类号： B65D37/00
CPC分类号： B65D35/46 , B65D47/205 , B65D47/2056 , B65D47/2081
摘要： A container and valve assembly for storing and dispensing substances including edible substances. The container is a tubular body that defines a storage chamber for storing the substance and a head portion for supports the valve assembly. The valve assembly includes a valve body and a valve seat surrounded by a flexible outer cover that includes a valve portion. A seem between the valve portion and valve seat form a one-way release valve wherein a portion of the seam remains closed when the substance is dispensed. To dispense the substance, pressure is applied to the body forcing the substance into the valve assembly, which in turn, controls the flow and release of the substance without exposing the remaining substance to the external atmosphere; thus, the sterility of the storage chamber and remaining substance is maintained, and the shelf life of the substance is increased.
摘要翻译：用于储存和分配包括可食用物质的物质的容器和阀组件。容器是限定用于储存物质的储存室的管状体和用于支撑阀组件的头部。阀组件包括阀体和由包括阀部分的柔性外盖包围的阀座。在阀部分和阀座之间似乎形成单向释放阀，其中当物质被分配时，接缝的一部分保持关闭。为了分配物质，将压力施加到身体，迫使物质进入阀组件，这进而控制物质的流动和释放，而不将剩余物质暴露于外部大气; 因此，保持储存室和剩余物质的不育性，并且物质的保存期限增加。

4. 发明申请

WO2005058743A2 CONTAINER AND ONE-WAY VALVE ASSEMBLY FOR STORING AND DISPENSING SUBSTANCES, AND RELATED METHOD 审中-公开
标题翻译：用于储存和分配物质的集装箱和单向阀组件及相关方法
公开(公告)号：WO2005058743A2
公开(公告)日：2005-06-30
申请号：PCT/US2004/041369
申请日：2004-12-10
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , CHAN, Julian, V. , RODRIGUEZ, Giovanni
发明人： PY, Daniel , CHAN, Julian, V. , RODRIGUEZ, Giovanni
IPC分类号： B67D
CPC分类号： B65D51/226 , B65D47/2075
摘要： A device for storing and dispensing a substance includes a container having a body defining therein a storage chamber for receiving and storing the substance. The container includes a head located at one end of the body and a first passageway that is in fluid communication with the storage chamber of the body and defines a flow path therebetween. The container also includes a pierceable wall located on an opposite side of the passageway relative to the storage chamber, and a first connecting portion for connecting another component thereto. The device also includes a one-way valve assembly that includes a valve body including a body base defining a second passageway and at least one piercing portion engageable with the pierceable wall of the container. The valve assembly includes a second connecting portion that is connectable to the first connecting portion of the container for fixedly securing the valve assembly to the container when the valve assembly and container are located in the second position. The valve assembly includes a valve seat and at least one flow aperture extending through the valve body adjacent to the valve seat and in fluid communication with the second passageway for receiving the substance from the storage chamber therethrough.
摘要翻译：用于存储和分配物质的装置包括具有在其中限定有用于接收和存储物质的储存室的主体的容器。容器包括位于主体一端的头部和与主体的储存室流体连通并限定其间的流路的第一通道。容器还包括位于通道相对于储存室的相对侧上的可穿透壁，以及用于将另一部件连接到其上的第一连接部分。该装置还包括单向阀组件，该单向阀组件包括阀体，该阀体包括限定第二通道的主体基座和与容器的可刺穿壁可接合的至少一个穿孔部分。阀组件包括可连接到容器的第一连接部分的第二连接部分，用于当阀组件和容器位于第二位置时将阀组件固定地固定到容器。阀组件包括阀座和至少一个流动孔，其延伸穿过与阀座相邻的阀体，并与第二通道流体连通，用于通过其从储存室接收物质。

5. 发明申请

WO2004037708A3 FLUID DISPENSER HAVING A RIGID VIAL AND FLEXIBLE INNER BLADDER 审中-公开
公开(公告)号：WO2004037708A3
公开(公告)日：2004-05-06
申请号：PCT/US2003/033503
申请日：2003-10-21
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , ASSION, Norbert, M. , CHAN, Julian, V. , TING, Joseph, M.
发明人： PY, Daniel , ASSION, Norbert, M. , CHAN, Julian, V. , TING, Joseph, M.
IPC分类号： B65D35/56
摘要： An ophthalmic dispenser has a rigid housing defining a fluid-receiving chamber, a flexible bladder receivable within the fluid-receiving chamber, a pump coupled in fluid communication with the fluid-receiving chamber, and a nozzle having a valve defining an annular, axially extending valve seat, an outlet aperture coupled in fluid communication between the valve seat and the pump, and a flexible valve cover extending about the valve seat and forming an annular, axially-extending interface therebetween. The valve interface is connectable in fluid communication with the outlet aperture, and at least part of the valve cover is movable between (i) a normally closed position with the valve cover engaging the valve seat to close the interface and form a fluid-tight seal therebetween, and (ii) an open position with at least part of the valve cover spaced away from the valve seat in response to pumped fluid flowing through the outlet aperture at a pressure greater than a valve opening pressure to allow the passage of pressurized fluid therebetween. A spring is drivingly connected to the housing and moves at least one of the pump and housing relative to the other to actuate the pump. The rigid housing is mountable within a cartridge which, in turn, is mountable within a dispenser housing including an eyelid depressor and a trigger for simultaneously actuating the eyelid depressor and pump.

6. 发明申请

WO2003033363A1 DISPENSER WITH SEALED CHAMBER AND ONE-WAY VALVE FOR PROVIDING METERED AMOUNTS OF SUBSTANCES 审中-公开
标题翻译：具有密封室和单向阀的分配器，用于提供物质的计量金额
公开(公告)号：WO2003033363A1
公开(公告)日：2003-04-24
申请号：PCT/US2002/032935
申请日：2002-10-16
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , ASSION, Norbert , CHAN, Julian, V.
发明人： PY, Daniel , ASSION, Norbert , CHAN, Julian, V.
IPC分类号： B65D5/22
CPC分类号： B65D47/2031 , A45D40/26 , A61M5/31586 , A61M5/31595 , A61M5/50 , A61M5/502 , B65D35/06 , B65D35/08 , B65D35/38 , B65D35/44 , G01F11/027
摘要： A syringe (10) is provided for the delivery of controlled, metered amounts of any of numerous different substances to humans or animals, such as medicaments, pharmaceuticals, cosmetics, and food products, or to deliver materials which may react upon exposure to air, such as glue. The syringe (10) includes a body (12) and a plunger (14). Means (34, 48) are provided in the syringe body (12) and the plunger (14) to effect controlled movement of the plunger (14) into the syringe (10) to permit delivery of a pre-detemined amount of the substance contained in the syringe (10) . A one-way valve (54) is provided at the dispensing tip (16) of the syringe (10) to hermetically seal the portion of the syringe (10) containing the subtance to be dispensed.
摘要翻译：提供注射器（10），用于向人或动物（例如药物，药物，化妆品和食品）递送受控量的计量量的许多不同物质，或者输送在暴露于空气中可能反应的材料，如胶水。注射器（10）包括主体（12）和柱塞（14）。装置（34,48）设置在注射器主体（12）和柱塞（14）中以实现柱塞（14）进入注射器（10）的受控运动，以允许递送预定量的所含物质在注射器（10）中。单向阀（54）设置在注射器（10）的分配尖端（16）处，以密封包含要分配的突出物的注射器（10）的部分。

7. 发明申请

WO2004101027A2 DISPENSER AND APPARATUS AND METHOD FOR FILLING A DISPENSER 审中-公开
标题翻译：分配器和装置以及填充分配器的方法
公开(公告)号：WO2004101027A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/014823
申请日：2004-05-12
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , CHAN, Julian, V.
发明人： PY, Daniel , CHAN, Julian, V.
IPC分类号： A61M
CPC分类号： B65D83/62 , A61J1/00 , A61J1/1443 , B65B3/30 , B65B31/044 , B65D83/425
摘要： A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with an evacuating/dispensing member to evacuate the storage chamber, and by introducing fluid from the filling member through the open filling valve and into the storage chamber. The filling member is withdrawn from the valve, and a spring moves the valve to a closed position to hermetically seal the fluid within the dispenser.
摘要翻译：用于保持多个剂量的流体或其它物质并用于分配物质的分配器具有小瓶，容纳在小瓶内的柔性囊，以及形成在膀胱和小瓶之间的可变体积存储室。填充阀与储存室流体连通地联接并且限定（1）将储存室与环境大气密封的常闭密封的流体密封位置，和（2）允许流体通过阀门的打开位置两者都抽真空储存室并引入流体通过阀门填充储存室。泵与储存室流体连通地联接，用于将流体泵出储存室。分配阀与泵流体连通地联接并限定（1）常闭的，流体密封的位置，防止流体从分配器通过，以及（2）用于分配泵送的流体通过的打开位置。密封的空分配器被灭菌，例如通过对其施加γ射线。然后，通过使填充阀与排气/分配构件接合以消除储存室，并且通过将来自填充构件的流体通过打开的填充阀引入并进入储存室，灭菌的密封的空分配器充满流体。填充构件从阀中取出，并且弹簧将阀移动到关闭位置以将分配器内的流体气密地密封。

8. 发明申请

WO2003041763A2 INTRADERMAL DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：内部递送装置和方法
公开(公告)号：WO2003041763A2
公开(公告)日：2003-05-22
申请号：PCT/US2002/036617
申请日：2002-11-14
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , CHAN, Julian, V.
发明人： PY, Daniel , CHAN, Julian, V.
IPC分类号： A61M
CPC分类号： A61M5/425 , A61M5/24 , A61M5/3158 , A61M5/31591 , A61M5/3287 , A61M5/46
摘要： The subject intradermal delivery device provides for penetration to a fixed depth without requiring special expertise by the user. The device consists of a syringe nested inside an inner shell and an outer shell. An elongated annular channel is formed between the inner shell and the outer shell. A housing receives the syringe and concentric shells in a sliding engagement. A first seal on the distal end of the housing forms a variable length channel in communication with the elongated annular channel via a port formed in the outer shell. When the device is applied to the skin, the housing and syringe are slid towards the skin, and the variable length channel generates a vacuum which forces the skin to bulge into the elongated annular channel. As a result, the skin is tensioned across the inner shell to form a substantially planar, taut target area of skin. The taut target area of skin in combination with a stop on the housing determines the insertion depth of the syringe.
摘要翻译：受试者皮内递送装置提供穿透至固定深度，而不需要用户的专门知识。该装置由嵌套在内壳和外壳内的注射器组成。在内壳和外壳之间形成细长的环形通道。壳体以滑动接合的方式接收注射器和同心壳体。在壳体的远端上的第一密封件通过形成在外壳中的端口形成与细长环形通道连通的可变长度通道。当将该装置应用于皮肤时，壳体和注射器朝向皮肤滑动，并且可变长度通道产生迫使皮肤凸起进入细长环形通道的真空。结果，皮肤被横跨内壳张紧，以形成基本上平坦的，拉紧的皮肤目标区域。与壳体上的止动件组合的皮肤的拉紧目标区域决定了注射器的插入深度。

9. 发明申请

WO2005048875A2 DELIVERY DEVICE AND METHOD OF DELIVERY 审中-公开
标题翻译：交付设备和交付方法
公开(公告)号：WO2005048875A2
公开(公告)日：2005-06-02
申请号：PCT/US2004/038345
申请日：2004-11-15
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , CHAN, Julian, V. , ATWOOD, Jeffrey, M.
发明人： PY, Daniel , CHAN, Julian, V. , ATWOOD, Jeffrey, M.
IPC分类号： A61F
CPC分类号： B05B11/007 , A61F9/0008 , A61M11/007 , A61M15/08 , A61M35/003 , A61M2210/0612 , B05B11/0043 , B05B11/0048 , B05B11/0056 , B05B11/0072 , B05B11/3004 , B05B11/3056 , B05B11/307 , B05B11/3074 , B05B11/3077
摘要： An ophthalmic delivery device includes a body defining a fluid reservoir and a pump in fluid communication with the reservoir. The delivery device also includes a nozzle that includes a dosage chamber for holding a dosage of fluid, a valve seat, and a valve cover. The valve cover extends about the valve seat and forms an interface therebetween and the valve seat includes an outlet aperture. The interface is in fluid communication with the outlet aperture and the dosage chamber, and at least part of the valve cover is movable between (i) a closed position with the valve cover engaging the valve seat to close the interface and form a fluid-tight seal therebetween, and (ii) an open position with at least part of the valve cover spaced away from the valve seat in response to fluid flowing through the outlet aperture at a pressure greater than a valve opening pressure to allow the passage of pressurized fluid therebetween. The valve seat and the valve cover are dimensioned to dispense the dosage of fluid through the interface at a velocity of equal to or less than 6 meters per second.
摘要翻译：眼科输送装置包括限定流体储存器的主体和与储存器流体连通的泵。输送装置还包括喷嘴，该喷嘴包括用于保持一定量的流体的剂量室，阀座和阀盖。阀盖围绕阀座延伸并且在它们之间形成界面，并且阀座包括出口孔。所述界面与所述出口孔和所述剂量室流体连通，并且所述阀盖的至少一部分可在（i）与所述阀盖接合所述阀座的关闭位置之间移动以关闭所述界面并形成流体密封密封在其间，和（ii）打开位置，其中阀盖的至少一部分响应于流体以大于阀打开压力的压力流过出口孔而与阀座间隔开，以允许加压流体在其间通过。阀座和阀盖的尺寸设计为以等于或小于6米/秒的速度通过界面分配流体的剂量。

10. 发明申请

WO2005014465A2 PISTON-TYPE DISPENSER WITH ONE-WAY VALVE FOR STORING AND DISPENSING METERED AMOUNTS OF SUBSTANCES 审中-公开
标题翻译：具有单向阀的活塞式分配器，用于储存和分配物质的计量单位
公开(公告)号：WO2005014465A2
公开(公告)日：2005-02-17
申请号：PCT/US2004/023023
申请日：2004-07-17
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , CHAN, Julian, V. , RODRIGUEZ, Giovanni
发明人： PY, Daniel , CHAN, Julian, V. , RODRIGUEZ, Giovanni
IPC分类号： B67D
CPC分类号： B65D35/28 , A45D34/04 , A45D2034/007 , A45D2200/055
摘要： A dispenser for dispensing a substance, such as a liquid lipstick or other product, has a body defining a variable-volume storage chamber for storing the product. A dispensing portion is connected with the body and defines a bore coupled in fluid communication with the storage chamber for receiving product therefrom, and an outlet aperture coupled in fluid communication with the bore. A piston is received within the bore, and a one-way valve is mounted on the dispensing portion for dispensing metered amounts of product therethrough. The one-way valve has an axially-extending valve seat, and an axially-extending visco-elastic valve cover seated on the valve seat and defining a normally-closed, axially-extending seam therebetween forming a fluid-tight seal between the valve cover and valve seat. The flexible valve cover is movable relative to the valve seat, and the seam is connectable in fluid communication with the outlet aperture to allow the passage of product through the seam and out of the dispenser. An actuator is drivingly connected to the piston for moving the piston within the bore and dispensing a predetermined amount of product within the bore through the outlet aperture.
摘要翻译：用于分配诸如液体口红或其他产品的物质的分配器具有限定用于存储产品的可变容积储存室的主体。分配部分与主体连接并且限定了与储存室流体连通以与其接收产品的孔，以及与孔流体连通的出口孔。活塞被容纳在孔内，并且单向阀安装在分配部分上，用于分配计量的产品通过其中。单向阀具有轴向延伸的阀座和位于阀座上的轴向延伸的粘弹性阀盖，并且在其间形成常闭的轴向延伸的接缝，在其之间形成流体密封的密封件和阀座。柔性阀盖可相对于阀座移动，并且接缝可与出口孔流体连通以允许产品通过接缝并从分配器中通过。致动器驱动地连接到活塞上，用于在孔内移动活塞并且通过出口孔在孔内分配预定量的产品。

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