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1. 发明申请

WO2008083312A3 CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF 审中-公开
标题翻译：化学连接器和可清洁基板及其结合
公开(公告)号：WO2008083312A3
公开(公告)日：2010-01-14
申请号：PCT/US2007089100
申请日：2007-12-28
申请人： MEDAREX INC , SUFI BILAL , GUERLAVAIS VINCENT , CHEN LIANG , GANGWAR SANJEEV , ZHANG QIAN , PASSMORE DAVID B
发明人： SUFI BILAL , GUERLAVAIS VINCENT , CHEN LIANG , GANGWAR SANJEEV , ZHANG QIAN , PASSMORE DAVID B
IPC分类号： A61K47/48 , A61K49/00 , A61P35/00 , C07D403/14 , C07D487/04
CPC分类号： C07K5/06052 , A61K47/552 , A61K47/556 , A61K47/65 , A61K47/6809 , A61K47/6851 , A61K49/0002 , C07D403/14 , C07D487/04 , C07K5/06078 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/1008
摘要： The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
摘要翻译：本公开提供了药物 - 配体缀合物和药物可切割底物共轭物，其是有效的细胞毒素。本公开还涉及含有药物 - 配体缀合物的组合物以及使用它们的治疗方法。

2. 发明申请

WO2007051081B1 METHODS AND COMPOUNDS FOR PREPARING CC-1065 ANALOGS 审中-公开
标题翻译：制备CC-1065类似物的方法和化合物
公开(公告)号：WO2007051081B1
公开(公告)日：2007-07-19
申请号：PCT/US2006060050
申请日：2006-10-18
申请人： MEDAREX INC , GANGWAR SANJEEV , ZHANG QIAN
发明人： GANGWAR SANJEEV , ZHANG QIAN
IPC分类号： C07D209/60 , C07D403/12
CPC分类号： C07D209/60 , C07D403/12 , Y02P20/55
摘要： A method of forming a CBI CC- 1065 analog utilizes NH2 as a starting material, where R3 is H or alkyl and R6 is H, substituted or unsubstituted lower alkyl, cyano, or alkoxy. Intermediates (I) are used and are claimed.
摘要翻译：形成CBI CC-1065类似物的方法利用NH 2作为原料，其中R 3为H或烷基且R 6为H，取代或未取代的低级烷基，氰基或烷氧基。中间体（I）被使用并被要求保护。

3. 发明申请

WO2007051081A1 METHODS AND COMPOUNDS FOR PREPARING CC-1065 ANALOGS 审中-公开
标题翻译：制备CC-1065模拟物的方法和化合物
公开(公告)号：WO2007051081A1
公开(公告)日：2007-05-03
申请号：PCT/US2006060050
申请日：2006-10-18
申请人： MEDAREX INC , GANGWAR SANJEEV , ZHANG QIAN
发明人： GANGWAR SANJEEV , ZHANG QIAN
IPC分类号： C07D209/60 , C07D403/12
CPC分类号： C07D209/60 , C07D403/12 , Y02P20/55
摘要： A method of forming a CBI CC- 1065 analog utilizes NH2 as a starting material, where R3 is H or alkyl and R6 is H, substituted or unsubstituted lower alkyl, cyano, or alkoxy. Intermediates (I) are used and are claimed.
摘要翻译：形成CBI CC-1065类似物的方法利用NH 2作为起始原料，其中R3是H或烷基，R6是H，取代或未取代的低级烷基，氰基或烷氧基。中间体（I）被使用并被要求保护。

4. 发明申请

WO2008103693A3 CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF 审中-公开
标题翻译：具有单一氨基酸的化学连接体及其结合体
公开(公告)号：WO2008103693A3
公开(公告)日：2008-12-11
申请号：PCT/US2008054362
申请日：2008-02-20
申请人： MEDAREX INC , CHEN LIANG , GANGWAR SANJEEV , GUERLAVAIS VINCENT , LONBERG NILS , ZHANG QIAN
发明人： CHEN LIANG , GANGWAR SANJEEV , GUERLAVAIS VINCENT , LONBERG NILS , ZHANG QIAN
IPC分类号： C07D403/14 , A61K31/404 , A61K31/407 , A61P35/00 , C07D405/14 , C07D487/04 , C07K5/06
CPC分类号： C07D405/14 , A61K47/65 , A61K47/6889 , C07D403/14 , C07D487/04 , C07K1/13
摘要： The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
摘要翻译：本公开提供了药物 - 配体缀合物，其是有效的细胞毒素并且包括药物和配体之间的接头，其中接头具有单个氨基酸。本公开还涉及含有药物 - 配体缀合物的组合物以及使用它们的治疗方法。

5. 发明申请

WO2009054996A8 SYSTEMS AND METHODS FOR VIRAL THERAPY 审中-公开
公开(公告)号：WO2009054996A8
公开(公告)日：2009-11-05
申请号：PCT/US2008012061
申请日：2008-10-24
申请人： GENELUX CORP , SZALAY ALADAR A , YU YONG A , CHEN NANHAI , ZHANG QIAN , FRENTZEN ALEXA
发明人： YU YONG A , CHEN NANHAI , ZHANG QIAN , FRENTZEN ALEXA
IPC分类号： G01N33/50 , A61K48/00 , C12N7/00 , C12Q1/70
CPC分类号： G01N33/5011 , A61K35/768 , A61K38/45 , C07K14/005 , C12N7/00 , C12N2710/24122 , C12N2710/24132 , C12N2710/24161 , A61K2300/00
摘要： Diagnostic methods and compositions associated with viral therapy are provided. In particular, methods, compositions, and kits to measure markers and therapeutic indicator predictive of viral efficacy in antitumor therapy are provided. Therapeutic viruses and combinations and kits for use in the practicing the methods also are provided.

6. 发明申请

WO2007135529A2 AZABENZIMIDAZOLYL COMPOUNDS 审中-公开
标题翻译： AZABENZIMIDAZOLYL化合物
公开(公告)号：WO2007135529A2
公开(公告)日：2007-11-29
申请号：PCT/IB2007001293
申请日：2007-05-11
申请人： PFIZER PROD INC , BERKE HELEN , DUPLANTIER ALLEN JACOB , EFREMOV IVAN VIKTOROVICH , MCHARDY STANTON FURST , QIAN WEIMIN , ROGERS BRUCE NELSON , ZHAN LEI , ZHANG QIAN
发明人： BERKE HELEN , DUPLANTIER ALLEN JACOB , EFREMOV IVAN VIKTOROVICH , MCHARDY STANTON FURST , QIAN WEIMIN , ROGERS BRUCE NELSON , ZHAN LEI , ZHANG QIAN
CPC分类号： C07D471/04 , C07D471/14 , C07D471/18
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R 17 , R 2 , X 4 , X 9 , X 5 , X 6 , R 8 , X 2 , Y 1 and n are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译：公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有式（I）的结构：或其药学上可接受的盐，其中R 17，R 2，，X 4，X 9，X 5，X 6，R 8，，X 2，Y 1和n如本发明的详细描述中所定义。还公开了相应的药物组合物，治疗方法，合成方法和中间体。

7. 发明申请

WO2004079968A2 IMPROVED VERTICAL ROAMING IN WIRELESS NETWORKS THROUGH IMPROVED WIRELESS NETWORK CELL BOUNDARY DETECTION 审中-公开
标题翻译：通过改进的无线网络小区边界检测改善无线网络中的垂直漫游
公开(公告)号：WO2004079968A2
公开(公告)日：2004-09-16
申请号：PCT/US2004002501
申请日：2004-01-29
申请人： MICROSOFT CORP , GUO ZIHUA , ZHANG QIAN , YAO RICHARD , ZHU WENWU
发明人： GUO ZIHUA , ZHANG QIAN , YAO RICHARD , ZHU WENWU
IPC分类号： H04B7/212 , H04B7/26 , H04J3/16 , H04J7/00 , H04J11/00 , H04L20060101 , H04L12/28 , H04W36/14 , H04W36/30 , H04L
CPC分类号： H04W36/30 , H04B2201/70702
摘要： A system and method for improved vertical handoff between different types of wireless network. Network allocation vector occupation and packet collision probability are used as quality of service measures, enabling vertical handoffs to be delayed until actually beneficial to quality of service. Improved wireless network cell boundary detection in vertical handoff scenarios is achieved with a Fourier-based technique in conjunction with an adaptively determined minimum operating signal strength threshold. Improved wireless network cell boundary detection enables vertical handoffs from high quality of service networks to be delayed as long as possible. Together, practical wireless network quality of service measures and improved detection of wireless network cell boundaries in vertical handoff scenarios reduce the rate of unnecessary vertical handoff resulting in higher overall quality of service experienced by a mobile computing device roaming between wireless network types.
摘要翻译：一种用于改善不同类型无线网络之间的垂直切换的系统和方法。网络分配向量占用和分组冲突概率被用作服务质量度量，使得垂直切换被延迟，直到实际上有益于服务质量。利用基于傅里叶的技术结合自适应确定的最小操作信号强度阈值来实现垂直切换场景中改进的无线网孔单元边界检测。改进的无线网络小区边界检测能够使来自高质量服务网络的垂直切换尽可能延迟。总而言之，在垂直切换场景中实际的无线网络服务质量测量和无线网络小区边界的改进检测降低了不必要的垂直切换的速率，从而导致无线网络类型之间漫游的移动计算设备所经历的更高的整体服务质量。

8. 发明申请

WO2012142529A3 CLONAL STRAINS OF ATTENUATED VACCINIA VIRUSES AND METHODS OF USE THEREOF 审中-公开
标题翻译：减毒的痘苗病毒的克隆株及其使用方法
公开(公告)号：WO2012142529A3
公开(公告)日：2012-12-06
申请号：PCT/US2012033684
申请日：2012-04-13
申请人： GENELUX CORP , SZALAY ALADAR A , CHEN NANHAI GEORGE , YU YONG A , ZHANG QIAN
发明人： SZALAY ALADAR A , CHEN NANHAI GEORGE , YU YONG A , ZHANG QIAN
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K35/768 , C07K16/22 , C07K2317/622 , C12N2710/24121 , C12N2710/24132 , C12N2710/24143
摘要： Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations, Modified recombinant forms of the clonal strains also are provided. The clonal strains and virus preparations can be used for diagnostic and therapeutic methods, in particular for therapy and diagnosis or monitoring treatment of proliferative disorders, including neoplastic diseases, such as, but are not limited to, solid tumors and blood cancers.
摘要翻译：提供了痘苗病毒的克隆株。还提供了从病毒制备物中鉴定和分离减毒和溶瘤克隆株的方法，还提供了克隆株的修饰重组形式。克隆毒株和病毒制剂可用于诊断和治疗方法，特别是用于治疗和诊断或监测增生性病症的治疗，所述增殖性病症包括肿瘤性疾病，例如但不限于实体瘤和血液癌。

9. 发明申请

WO2008100292A8 MODIFIED VACCINIA VIRUS STRAINS FOR USE IN DIAGNOSTIC AND THERAPEUTIC METHODS 审中-公开
标题翻译：用于诊断和治疗方法的经修饰的痘苗病毒株
公开(公告)号：WO2008100292A8
公开(公告)日：2008-11-27
申请号：PCT/US2007022172
申请日：2007-10-16
申请人： GENELUX CORP , FRENTZEN ALEXA , CHEN NANHAI , ZHANG QIAN , YU YONG A , SZALAY ALADAR A
发明人： FRENTZEN ALEXA , CHEN NANHAI , ZHANG QIAN , YU YONG A , SZALAY ALADAR A
IPC分类号： A61K39/00
CPC分类号： C12N7/00 , A61K9/0019 , A61K31/282 , A61K31/4745 , A61K31/7068 , A61K33/24 , A61K35/76 , A61K38/1709 , A61K38/1793 , A61K38/20 , A61K38/204 , A61K38/36 , A61K38/484 , A61K39/12 , A61K39/285 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K48/0058 , A61K49/0008 , A61K49/0045 , A61K49/0047 , A61K49/0097 , A61K49/14 , A61K49/1896 , A61K2039/523 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/54 , C07K14/5412 , C07K14/7155 , C07K16/22 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/20 , C07K2319/60 , C07K2319/61 , C07K2319/74 , C12N15/86 , C12N2710/14171 , C12N2710/24121 , C12N2710/24122 , C12N2710/24132 , C12N2710/24141 , C12N2710/24143 , C12N2710/24162 , C12Q1/04 , G01N33/574 , G01N33/585
摘要： Modified or attenuated viruses and methods for preparing the modified viruses and modulating attenuation are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents. The viruses also can be used in diagnostic methods.
摘要翻译：提供了修饰或减毒病毒以及制备修饰病毒和调节减毒的方法。提供含有病毒的疫苗。这些病毒可用于治疗疾病的方法，如增殖性和炎性疾病，包括作为抗肿瘤剂。这些病毒也可以用于诊断方法。

10. 发明申请

WO2004077225A3 QUALITY OF SERVICE DIFFERENTIATION IN WIRELESS NETWORKS 审中-公开
标题翻译：无线网络中服务质量差异的质量
公开(公告)号：WO2004077225A3
公开(公告)日：2005-04-21
申请号：PCT/US2004002513
申请日：2004-01-29
申请人： MICROSOFT CORP , GUO ZIHUA , ZHU WENWU , ZHANG QIAN , ZHAO JUN
发明人： GUO ZIHUA , ZHU WENWU , ZHANG QIAN , ZHAO JUN
IPC分类号： H04L12/28 , H04L12/56 , H04W28/18 , H04W28/24 , H04W74/00 , H04W74/08 , H04Q7/24
CPC分类号： H04W74/0816 , H04W28/18 , H04W28/24 , H04W74/006 , H04W74/0833
摘要： A method provides differentiated quality of service (QoS) by providing adaptive updates to media access control (MAC) layer parameters on a distributed basis. The method includes calculating a failure probability for a transmission over the network, determining a target value for determining a contention window according to a mapped function of the failure probability, and altering the contention window according to a scaling function of the target value. The mapped function and the scaling can provide QoS differentiation. A wireless device ensures fairness in a wireless time slotted network and includes a network interface card (NIC), a network driver interface, a network monitor, a statistics engine, and an adaptive parameter engine for determining a target value for determining a contention window according to a mapped function of the one or more probabilities to enable an alteration of the contention window and provide new parameters for the MAC layer.
摘要翻译：一种方法通过在分布式的基础上提供媒体访问控制（MAC）层参数的适应性更新来提供差异化的服务质量（QoS）。该方法包括：计算网络传输的故障概率，根据故障概率的映射函数确定确定竞争窗口的目标值，并根据目标值的缩放函数改变争用窗口。映射函数和缩放可以提供QoS差异化。无线设备确保在无线时隙网络中的公平性，并且包括网络接口卡（NIC），网络驱动器接口，网络监视器，统计引擎和用于确定用于确定争用窗口的目标值的自适应参数引擎，涉及一个或多个概率的映射函数，以便能够改变争用窗口并为MAC层提供新的参数。

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