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1. 发明申请

WO2010057014A2 CAPTURING AND DELIVERING MOLECULES IN A MAMMAL 审中-公开
标题翻译：在哺乳动物中捕获和传递分子
公开(公告)号：WO2010057014A2
公开(公告)日：2010-05-20
申请号：PCT/US2009064419
申请日：2009-11-13
申请人： MAYO FOUNDATION , HOLMES DAVID R JR , SANDHU GURPREET S , SIMARI ROBERT D , SANDHU NICOLE P , HOLMES DAVID R III , HARBURN JONATHAN
发明人： HOLMES DAVID R JR , SANDHU GURPREET S , SIMARI ROBERT D , SANDHU NICOLE P , HOLMES DAVID R III , HARBURN JONATHAN
IPC分类号： G01N33/53 , G01N33/15 , G01N33/68
CPC分类号： G01N33/6896 , B01J20/26 , B01J20/268 , G01N33/54326 , G01N33/6854 , G01N33/84 , G01N33/948 , G01N33/9486 , G01N2333/475 , G01N2333/948 , G01N2430/00 , G01N2800/2821
摘要： This document relates to molecularly imprinted polymers for use in mammals. For example, methods and materials for capturing a molecule in the body of a mammal using a molecularly imprinted polymer are provided. In some cases methods for delivering a molecule using a molecularly imprinted polymer into the body of a mammal are provided. The methods provided can be used to target any molecule in the body of a mammal.
摘要翻译：该文献涉及用于哺乳动物的分子印迹聚合物。例如，提供了使用分子印记聚合物捕获哺乳动物体内分子的方法和材料。在一些情况下，提供了使用分子印记聚合物将分子递送到哺乳动物体内的方法。所提供的方法可用于靶向哺乳动物体内的任何分子。

2. 发明申请

WO2008105961A3 REDUCING CONTRAST AGENT-INDUCED TOXICITY 审中-公开
标题翻译：减少对比剂引起的毒性
公开(公告)号：WO2008105961A3
公开(公告)日：2009-02-19
申请号：PCT/US2007080979
申请日：2007-10-10
申请人： MAYO FOUNDATION , SANDHU GURPREET S , HOLMES DAVID R III , HOLMES DAVID R JR , SANDHU NICOLE P , SIMARI ROBERT D
发明人： SANDHU GURPREET S , HOLMES DAVID R III , HOLMES DAVID R JR , SANDHU NICOLE P , SIMARI ROBERT D
IPC分类号： A61B17/10 , A61B17/00 , A61B17/08 , A61F2/958
CPC分类号： A61K49/18 , A61B17/22031 , A61B2017/00876 , A61B2017/22035 , A61F2/01 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0071 , A61F2230/0076
摘要： This document provides methods and materials that can be used to reduce or prevent contrast agent-induced toxicity. For example, devices for capturing contrast agents from blood are provided.
摘要翻译：本文档提供了可用于减少或预防造影剂诱导的毒性的方法和材料。例如，提供用于从血液捕获造影剂的装置。

3. 发明申请

WO2009086071A2 SYSTEMS AND METHODS FOR MAGNETIC-ASSISTED THERAPEUTIC AGENT DELIVERY 审中-公开
标题翻译：用于磁性协助治疗剂递送的系统和方法
公开(公告)号：WO2009086071A2
公开(公告)日：2009-07-09
申请号：PCT/US2008087628
申请日：2008-12-19
申请人： MAYO FOUNDATION , SANDHU GURPREET S , HOLMES JR DAVID R , SIMARI ROBERT D , SANDHU NICOLE P , HOLMES III DAVID R
发明人： SANDHU GURPREET S , HOLMES JR DAVID R , SIMARI ROBERT D , SANDHU NICOLE P , HOLMES III DAVID R
IPC分类号： A61M37/00 , A61M5/00 , A61M35/00
CPC分类号： A61M37/00 , A61K9/5094 , A61N2/002 , A61N2/06
摘要： Systems and methods that provide magnetically-enhanced delivery of therapeutic agents to selected tissue are disclosed. The systems and methods involve the use of carrier devices and release devices and two different magnetic fields to move magnetic particles into selected tissue. Movement of the magnetic particles (and any associated therapeutic agent) into the tissue may be assisted by both magnetic attractive forces as well as magnetic repulsive forces.
摘要翻译：公开了向选定组织提供磁增强治疗剂递送的系统和方法。该系统和方法涉及使用载体装置和释放装置以及两个不同的磁场来将磁性颗粒移动到选定的组织中。磁性粒子（和任何相关治疗剂）向组织内的移动可以通过磁吸引力以及磁排斥力来辅助。

4. 发明申请

WO2006138612A3 MAGNETIC MEDICAL APPARATUS, KITS, AND METHODS 审中-公开
标题翻译：磁性医疗器械，套件和方法
公开(公告)号：WO2006138612A3
公开(公告)日：2009-04-30
申请号：PCT/US2006023571
申请日：2006-06-16
申请人： MAYO FOUNDATION , SANDHU GURPREET S , SIMARI ROBERT D , SANDHU NICOLE P , GULATI RAJIV
发明人： SANDHU GURPREET S , SIMARI ROBERT D , SANDHU NICOLE P , GULATI RAJIV
IPC分类号： A61N2/00 , A61B17/52 , A61N2/10
CPC分类号： A61F2/06 , A61F2/04 , A61F2/07 , A61F2/24 , A61F2/82 , A61F2/90 , A61F2/958 , A61F2210/0004 , A61F2210/009 , A61L27/28 , A61L27/54 , A61L27/56 , A61L27/58 , A61N1/05 , A61N1/375 , A61N2/06 , A61N2001/0585
摘要： Medical devices with surfaces on which viable biologic cells and/or other magnetic materials are magnetically attracted and retained are disclosed along with methods of magnetic coating. The medical devices may include skin layers or sleeves of non-magnetic binder containing magnetic particles, magnetic strands woven or knitted into a fabric structure, and fractured metallic coatings. The medical devices can be located in a carrier liquid containing high concentrations of magnetic cells before or after implantation. The carrier liquid with magnetic material may be contacted with the medical device in vitro or in vivo. In either case, the carrier liquid may have a concentration of magnetic material that is high enough to facilitate coating of the medical device within an acceptable period of time, e.g, several hours or less. Magnetization of medical devices before, during, and/or after implantation and apparatus for performing the same are disclosed. Degaussing of magnetic medical devices is also disclosed.
摘要翻译：公开了具有磁性吸引和保持活生物细胞和/或其它磁性材料的表面的医疗装置以及磁性涂层的方法。医疗装置可以包括含有磁性颗粒的非磁性粘合剂的表皮层或套筒，编织或针织成织物结构的磁性线，以及断裂的金属涂层。在植入之前或之后，医疗装置可以位于含有高浓度磁性细胞的载液中。具有磁性材料的载液可以在体外或体内与医疗装置接触。在任一种情况下，载液可以具有足够高的磁性材料的浓度，以便于在可接受的时间内（例如几个小时或更短）的时间内涂覆医疗装置。公开了在植入之前，期间和/或之后的医疗装置的磁化，以及用于执行它们的装置。还公开了磁性医疗装置的消磁。

5. 发明申请

WO2005056073A8 KITS, APPARATUS AND METHODS FOR MAGNETICALLY COATING MEDICAL DEVICES WITH LIVING CELLS 审中-公开
标题翻译：用于具有生命体的磁性涂敷医疗装置的工具，装置和方法
公开(公告)号：WO2005056073A8
公开(公告)日：2006-07-20
申请号：PCT/US2004040242
申请日：2004-12-02
申请人： MAYO FOUNDATION , SANDHU GURPREET S , SIMARI ROBERT D , SANDHU NICOLE P , GULATI RAJIV
发明人： SANDHU GURPREET S , SIMARI ROBERT D , SANDHU NICOLE P , GULATI RAJIV
IPC分类号： A61F2/06 , A61F2/24 , A61L27/38 , A61L27/50 , A61L29/14 , A61L29/16 , A61M25/00
CPC分类号： A61L27/50 , A61F2/06 , A61F2210/009 , A61L27/38 , A61L29/14 , A61L29/16 , A61L2300/606 , A61L2300/64
摘要： Medical devices with surfaces on which viable biologic cells are magnetically attracted and retained are disclosed along with methods of magnetic coating. The medical devices can be located in a carrier liquid containing high concentrations of magnetic cells before or after implantation. The carrier liquid with magnetic cells may be contact with the medical device in vitro or in vivo. In either case, the carrier liquid may have a concentration of magnetic cells that is high enough to facilitate coating of the medical device within an acceptable period of time, e.g., several hours or less. Magnetization of medical devices before, during, and/or after implantation and apparatus for performing the same are disclosed. Degaussing of magnetic medical devices is also disclosed.
摘要翻译：公开了具有磁力吸引和保留活生物细胞的表面的医疗装置以及磁性涂层的方法。在植入之前或之后，医疗装置可以位于含有高浓度磁性细胞的载液中。具有磁性细胞的载液可以在体外或体内与医疗装置接触。在任一情况下，载液可以具有足够高的磁性细胞浓度，以便于在可接受的时间内（例如数小时或更短）的时间内涂覆医疗装置。公开了在植入之前，期间和/或之后的医疗装置的磁化，以及用于执行它们的装置。还公开了磁性医疗装置的消磁。

6. 发明申请

WO2007084320A3 POROUS THREE DIMENSIONAL NEST SCAFFOLDING 审中-公开
标题翻译：多孔三维NEST SCAFFOLDING
公开(公告)号：WO2007084320A3
公开(公告)日：2008-10-30
申请号：PCT/US2007000707
申请日：2007-01-11
申请人： MAYO FOUNDATION , HOLMES DAVID R JR , SANDHU GURPREET S , SIMARI ROBERT D
发明人： HOLMES DAVID R JR , SANDHU GURPREET S , SIMARI ROBERT D
IPC分类号： A61L27/38 , A61L27/54 , A61L31/00 , A61L31/16
CPC分类号： A61L27/38 , A61L27/54 , A61L31/005 , A61L31/16 , A61L2300/00
摘要： The invention provides porous three dimensional scaffold structures that may be used to deliver a bioactive agent, such as cells, into a location within the body. In one example form, the porous three dimensional structure may be a stent. In another example form, the porous three dimensional structure may be a microscale or nanoscale device for the delivery of the bioactive agent. The scaffold may include a substrate and one or more nests connected to the substrate. The nest(s) extend away from the substrate to define an enclosed volume on the substrate within each nest. The nests have openings that extend from an outer surface of the nest to the enclosed volume within each nest. The scaffold includes a bioactive agent disposed within the enclosed volume of at least one nest on the substrate. The bioactive agent is delivered to the patient when the scaffold is located within the patient.
摘要翻译：本发明提供了可用于将生物活性剂（例如细胞）输送到体内的位置的多孔三维支架结构。在一个示例形式中，多孔三维结构可以是支架。在另一个示例形式中，多孔三维结构可以是用于递送生物活性剂的微尺度或纳米级装置。支架可以包括基底和连接到基底的一个或多个巢。嵌套从衬底延伸离开，以在每个嵌套内的衬底上限定封闭的体积。巢具有从巢的外表面延伸到每个窝内的封闭体积的开口。支架包括设置在衬底上的至少一个嵌套的封闭体积内的生物活性剂。当支架位于患者体内时，将生物活性剂递送至患者。

7. 发明申请

WO2011149913A3 MEDICAL DEVICES INCLUDING DUPLEX STAINLESS STEEL 审中-公开
标题翻译：包括双相不锈钢的医疗设备
公开(公告)号：WO2011149913A3
公开(公告)日：2012-04-05
申请号：PCT/US2011037707
申请日：2011-05-24
申请人： MAYO FOUNDATION , SANDHU GURPREET S , SIMARI ROBERT D , HOLMES DAVID R , DRAGOMIR DAESCU M DAN , PARAKKA ANTHONY P
发明人： SANDHU GURPREET S , SIMARI ROBERT D , HOLMES DAVID R , DRAGOMIR DAESCU M DAN , PARAKKA ANTHONY P
IPC分类号： A61F2/02 , A61F2/915 , A61L27/04 , A61L27/40
CPC分类号： A61F2/82 , A61F2/915 , A61F2230/0054 , A61L31/022 , A61L31/14
摘要： Medical devices, such as endoprostheses, and methods of making the devices are disclosed. The endoprostheses comprise a tubular member capable of maintaining patency of a bodily vessel. The tubular member includes a duplex stainless steel (e.g., 2205 stainless steel), which may be magnetized.
摘要翻译：公开了医疗装置，例如内用假体，以及制造装置的方法。内用假体包括能够保持身体血管通畅的管状构件。管状构件包括可被磁化的双相不锈钢（例如2205不锈钢）。

8. 发明申请

WO2007139799A3 DEVICES AND METHODS FOR CROSSING CHRONIC TOTAL OCCLUSIONS 审中-公开
标题翻译：用于交叉治疗慢性阻塞性疾病的装置和方法
公开(公告)号：WO2007139799A3
公开(公告)日：2008-10-16
申请号：PCT/US2007012214
申请日：2007-05-22
申请人： MAYO FOUNDATION , SANDHU GURPREET S , RIHAL CHARANJIT S
发明人： SANDHU GURPREET S , RIHAL CHARANJIT S
IPC分类号： A61M29/00
CPC分类号： A61B17/3207 , A61B2017/00858 , A61B2017/22094 , A61M25/0043 , A61M25/0662 , A61M29/00 , A61M2025/006
摘要： Devices and methods for crossing total chronic occlusions in body lumens which may involve guidewire assisted delivery of a device to traverse a chronic total occlusion (CTO) and create a passageway through the CTO for a treatment device. Some devices of the present invention may include an expandable sleeve that expands in response to temperature changes. In other devices, an expandable sleeve is provided in which interlocking sections are arranged such that they have a first, smaller diameter enabling insertion through a CTO. The expandable sleeve can assume a second, larger diameter by moving the interlocking cylindrical sections relative to each other. In other aspects, a guide catheter may include a friction-enhanced outer surface to assist in maintaining the guide catheter in a selected location during use. The friction-enhanced property may be provided using, e.g., materials with an increased coefficient of friction, adding features to an otherwise smooth surface, etc.
摘要翻译：用于穿过体腔内的全部慢性闭塞的装置和方法，其可以涉及导丝辅助递送装置以横穿慢性完全闭塞（CTO）并且通过用于治疗装置的CTO创建通道。本发明的一些装置可以包括响应于温度变化而膨胀的可膨胀套筒。在其它装置中，提供了一种可膨胀套筒，其中互锁部分布置成使得它们具有能够穿过CTO插入的第一较小直径。可膨胀套筒可以相对于彼此移动互锁的圆柱形部分而呈现第二较大的直径。在其他方面，引导导管可以包括摩擦增强的外表面，以在使用期间辅助将引导导管保持在选定的位置。可以使用例如具有增加的摩擦系数的材料，将特征添加到其它光滑表面等来提供摩擦增强特性。

9. 发明申请

WO2011028358A3 SYSTEM AND METHOD FOR DETECTING HEALING ADJACENT TO IMPLANTED MEDICAL DEVICE 审中-公开
标题翻译：用于检测植入医疗装置的健康相关的系统和方法
公开(公告)号：WO2011028358A3
公开(公告)日：2011-06-16
申请号：PCT/US2010044513
申请日：2010-08-05
申请人： MAYO FOUNDATION , SANDHU GURPREET S , RODRIGUEZ-PORCEL MARTIN G
发明人： SANDHU GURPREET S , RODRIGUEZ-PORCEL MARTIN G
IPC分类号： G01N33/48 , A61B5/00 , A61B8/08 , A61B8/12 , A61F2/82
CPC分类号： A61B8/12 , A61B5/0066 , A61B5/064 , A61B5/6852
摘要： A method of detecting healing adjacent to an implanted medical device can first include pre-treating a surface of the medical device prior to implantation, thereby defining a pre-treated surface of the medical device. Then, subsequent to implantation, a portion of the pre-treated surface that is not covered by endothelial tissue is detected by a detection device.
摘要翻译：检测植入医疗装置附近的愈合的方法可以首先包括在植入之前对医疗装置的表面进行预处理，从而限定医疗装置的预处理表面。然后，在植入后，通过检测装置检测未被内皮组织覆盖的一部分预处理表面。

10. 发明申请

WO2009089143A2 STENT ADVANCEMENT ASSISTANT AND LESION DILATOR WIRE 审中-公开
标题翻译： STENT ADVANCEMENT ASSISTANT和LESION DILATOR WIRE
公开(公告)号：WO2009089143A2
公开(公告)日：2009-07-16
申请号：PCT/US2009030094
申请日：2009-01-05
申请人： MAYO FOUNDATION , SANDHU GURPREET S , RIHAL CHARANJIT S , GULATI RAJIV , BRESNAHAN JOHN F
发明人： SANDHU GURPREET S , RIHAL CHARANJIT S , GULATI RAJIV , BRESNAHAN JOHN F
IPC分类号： A61M25/02 , A61M25/09 , A61M25/10
CPC分类号： A61M25/09 , A61F2/95 , A61F2250/0062 , A61M25/09041 , A61M2025/09133
摘要： Materials and methods for placement of catheters, stents, and other therapeutic or diagnostic devices in blood vessels.
摘要翻译：用于在血管中放置导管，支架和其他治疗或诊断设备的材料和方法。

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