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1. 发明申请

WO2014190027A1 METHODS, SYSTEMS, AND APPARATUS FOR IMAGING SPECTROSCOPY 审中-公开
标题翻译：用于成像光谱的方法，系统和装置
公开(公告)号：WO2014190027A1
公开(公告)日：2014-11-27
申请号：PCT/US2014/038930
申请日：2014-05-21
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , HUNTER, Ian W. , CHEN, Yi
发明人： HUNTER, Ian W. , CHEN, Yi
IPC分类号： G01J3/44
CPC分类号： A61B1/0638 , G01J3/0286 , G01J3/0291 , G01J3/1256 , G01J3/2823 , G01J3/45 , G01J3/453 , G01J3/4535
摘要： Imaging spectrometers can be used to generate hyperspectral images for medical diagnoses, contaminant detection, and food safety inspections, among other applications. An exemplary imaging spectrometer includes an integrated position sensing array that measures the relative positions of the interferometer components based on an interference pattern generated by illuminating the interferometer with a reference beam. Such an imaging spectrometer includes a processor that controls the interferometer component position by actuating a voice coil and several piezo-electric elements to align the components with respect to each other and to provide a desired optical path length mismatch between the interferometer arms. In some cases, the processor may use feedback and feed forward control, possibly based on the actuators transfer functions, for more precise positioning. The processor may also implement adaptive and recursive spectral sampling to reduce the image acquisition period.
摘要翻译：成像光谱仪可用于生成用于医疗诊断，污染物检测和食品安全检查的高光谱图像，以及其他应用。示例性成像光谱仪包括集成位置检测阵列，其基于通过用参考光束照射干涉仪产生的干涉图案来测量干涉仪部件的相对位置。这种成像光谱仪包括处理器，其通过致动音圈和若干压电元件来控制干涉仪组件位置，以使组件相对于彼此对准并且提供干涉仪臂之间期望的光程长度失配。在一些情况下，处理器可以使用反馈和前馈控制，可能基于致动器传递功能来进行更精确的定位。处理器还可以实现自适应和递归频谱采样以减少图像采集周期。

2. 发明申请

WO2015168177A1 MULTI-LINK MODULAR CONTINUUM ROBOTIC ENDOSCOPE SYSTEM 审中-公开
标题翻译：多连杆模型连续机器人内窥镜系统
公开(公告)号：WO2015168177A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028082
申请日：2015-04-28
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： HUNTER, Ian, W. , CHEN, Yi , LIANG, Jiahui
IPC分类号： A61B1/005
CPC分类号： A61B1/0055 , A61B1/00006 , A61B1/00045 , A61B1/00105 , A61B1/0016 , A61B1/005 , A61B1/0052 , A61B1/0057 , A61B1/008 , A61B1/018 , A61B1/04 , A61B1/31 , A61B5/067 , A61B6/12 , A61B6/487 , A61B2034/2053 , A61B2034/301 , A61B2090/064 , A61B2562/0261
摘要： Robotic endoscopes have the potential to help endoscopists position tools during procedures, to propel the endoscope to the desired position, to automate functions and to prevent perforations during procedures. Modular architecture for a continuum robotic endoscope with multiple bending segments along the length of the endoscope. Each of the segments is modular, containing a set of actuation motors that drive short cables in the continuum segments.
摘要翻译：机器人内窥镜在手术过程中有可能帮助内窥镜定位工具，将内窥镜推进到所需的位置，自动执行功能并防止手术过程中的穿孔。具有沿内窥镜长度的多个弯曲段的连续机器人内窥镜的模块化结构。每个段都是模块化的，包含一组驱动电机，驱动连续区段中的短电缆。

3. 发明申请

WO2017011752A1 SYSTEMS, APPARATUS, AND METHODS FOR SPECTRAL IMAGING 审中-公开
标题翻译：用于光谱成像的系统，装置和方法
公开(公告)号：WO2017011752A1
公开(公告)日：2017-01-19
申请号：PCT/US2016/042512
申请日：2016-07-15
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： CHEN, Yi , HUNTER, Ian W.
IPC分类号： G01J3/44 , G01J3/45 , A61B1/06
CPC分类号： G01J3/4535 , A61B1/00096 , A61B1/043 , A61B5/0075 , A61B5/0084 , G01J3/021 , G01J3/06 , G01J3/2823 , G01J2003/062 , G01J2003/069 , G02B7/182
摘要： A spectral imaging system includes an autocorrelator to generate different autocorrelations when the moving reflector in the autocorrelator is at different positions so as to reconstruct spectral images. The system also includes a position measurement system to measure the actual positions of the moving reflector when autocorrelations are taken. These actual locations, instead of the desired locations in conventional methods, are then used to reconstruct the spectral image. This approach can address the misalignment of the moving reflector from its desired location (due to external disturbances, slow actuator dynamics, and other factors) in conventional spectral imaging techniques and allow the development of high-resolution, high-stability, portable imaging spectrometers for the general public.
摘要翻译：光谱成像系统包括自相关器，用于当自相关器中的移动反射器处于不同位置时产生不同的自相关性，以便重建光谱图像。该系统还包括一个位置测量系统，用于在进行自相关时测量移动反射器的实际位置。然后将这些实际位置代替常规方法中的所需位置来重建光谱图像。这种方法可以解决传统光谱成像技术中移动反射器从其期望位置（由于外部干扰，慢致动器动力学和其他因素）的不对准，并且允许开发高分辨率，高稳定性便携式成像光谱仪广大市民。

4. 发明申请

WO2013063468A1 AMINO ACID DERIVATES FUNCTIONALIZED ON THE N- TERMINAL CAPABLE OF FORMING DRUG INCAPSULATING MICROSPHERES 审中-公开
标题翻译：功能化的N-端可能形成药物包封微生物的氨基酸衍生物
公开(公告)号：WO2013063468A1
公开(公告)日：2013-05-02
申请号：PCT/US2012/062222
申请日：2012-10-26
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： DONG, Yizhou , LOVE, Kevin, Thomas , LANGER, Robert, S. , ANDERSON, Daniel, Griffith , CHEN, Delai , CHEN, Yi , VEGAS, Arturo, Jose , ALABI, Akinleye , ZHANG, Yunlong
IPC分类号： C07D207/16 , C07D209/20 , C07D233/64 , C07D241/08 , C07D403/06 , C07D487/06 , C07C227/18 , C07C229/12 , C07C229/16 , C07C229/22 , C07C229/26 , C07C229/28 , A61K48/00 , C12N15/87
CPC分类号： A61K31/7105 , A61K31/711 , A61K47/22 , A61K2121/00 , C07C229/12 , C07C229/22 , C07C229/24 , C07C229/26 , C07C229/36 , C07C237/08 , C07C237/12 , C07C271/22 , C07C279/14 , C07C323/58 , C07D207/16 , C07D209/20 , C07D209/24 , C07D233/64 , C07D241/08 , C07D265/32 , C07D403/06 , C07D413/06 , C07D487/04 , C07D487/06 , C12N15/87 , C12N15/88 , C12Q1/025 , G01N33/15
摘要： Described herein are compounds and compositions that are characterized by the Markush formulae (I), (II), (III), (IV), (V), and (VI) underneath, where at least one terminal amino group is further functionalized by bearing a group of type (i), (ii) or (iii). Such compounds are obtained by reacting the terminal amino group with epoxides or acrylates bearing long chain hydrocarbon groups. The resulting amphiphilic molecules (named "APPLs" in the application) are deemed useful as drug delivery system including nucleotide delivery to cells. Formulae (i), (ii), and (iii) are:
摘要翻译：本文描述的是其下面具有马库什式（I），（II），（III），（IV），（V）和（VI））的特征的化合物和组合物，其中至少一个末端氨基进一步由具有（i），（ii）或（iii）类型的组。通过使末端氨基与具有长链烃基的环氧化物或丙烯酸酯反应来获得这些化合物。所得到的两亲分子（在本申请中命名为“APPL”）被认为可用作药物递送系统，包括向细胞递送核苷酸。式（ⅰ），（ⅱ）和（ⅲ）是：

5. 发明申请

WO2011028716A1 NONLINEAR SYSTEM IDENTIFICATION TECHNIQUE FOR TESTING THE EFFICACY OF SKIN CARE PRODUCTS 审中-公开
标题翻译：用于测试皮肤护理产品效能的非线性系统识别技术
公开(公告)号：WO2011028716A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/047342
申请日：2010-08-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , HUNTER, Ian, W. , CHEN, Yi , JONES, Lynette, A. , HOGAN, N., Catherine
发明人： HUNTER, Ian, W. , CHEN, Yi , JONES, Lynette, A. , HOGAN, N., Catherine
IPC分类号： A61B5/103
CPC分类号： A61B5/442 , A61B5/0048 , A61B5/0051 , A61B5/0053 , A61B5/0055 , A61B5/0057 , A61B5/441 , A61B5/6824 , A61B9/00
摘要： A method for testing the effect of a skin care product includes measuring a mechanical property of skin tissue using nonlinear stochastic system identification, applying the product to the skin, repeating the measurement of the mechanical property after the application of the product, and comparing the before and after measurements to quantify the effect of the product. Measuring the mechanical property of the skin can include placing a probe against a surface of the skin, perturbing the skin with the probe using a stochastic sequence, and measuring the response of the skin to the perturbation. Perturbing the skin can include indenting the skin with the probe, extending the skin with the probe, and sliding the probe across the skin surface. The mechanical property may be indicative of skin compliance, skin elasticity, skin stiffness, or skin damping. The mechanical property can be dependent on perturbation depth and may be measured at a plurality of anatomical locations.
摘要翻译：用于测试皮肤护理产品的效果的方法包括使用非线性随机系统识别来测量皮肤组织的机械性质，将产品施用于皮肤，重复产品施用后的机械性能的测量，并比较之前并经过测量以量化产品的影响。测量皮肤的机械性能可以包括将探针放置在皮肤表面上，使用随机序列用探针扰动皮肤，以及测量皮肤对扰动的反应。刺激皮肤可以包括使用探针压伤皮肤，用探头延伸皮肤，并将探头滑过皮肤表面。机械性能可以指示皮肤顺应性，皮肤弹性，皮肤刚度或皮肤阻滞。机械性能可以取决于扰动深度，并且可以在多个解剖位置处测量。

6. 发明申请

WO2012027581A2 TIP ACTUATED DISPOSABLE ENDOSCOPE 审中-公开
标题翻译：提示激活的一次性内窥镜
公开(公告)号：WO2012027581A2
公开(公告)日：2012-03-01
申请号：PCT/US2011/049167
申请日：2011-08-25
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , HUNTER, Ian, W. , CHEN, Yi , OLIVEIRA, Jillian, M.
发明人： HUNTER, Ian, W. , CHEN, Yi , OLIVEIRA, Jillian, M.
IPC分类号： A61B1/005
CPC分类号： A61B1/0016 , A61B1/0052 , A61B1/0055
摘要： The present invention relates to an endoscope having a motorized assembly to control the distal end of an endoscope. Preferred embodiments can include disposable and reusable components. The system reduces the force need to control the tip of the endoscope and thereby reduce the risk of perforation'.
摘要翻译：内窥镜技术领域本发明涉及具有控制内窥镜远端的机动组件的内窥镜。优选实施例可以包括一次性和可重复使用的部件。该系统减少了控制内窥镜尖端的力量，从而降低了穿孔的风险。“

7. 发明申请

WO2011084511A1 JET INJECTOR USE IN ORAL EVALUATION 审中-公开
标题翻译：喷射器用于口腔评估
公开(公告)号：WO2011084511A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/060562
申请日：2010-12-15
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , HUNTER, Ian, W. , CHEN, Yi , HOGAN, Catherine, N. , RUDDY, Bryan, P.
发明人： HUNTER, Ian, W. , CHEN, Yi , HOGAN, Catherine, N. , RUDDY, Bryan, P.
IPC分类号： A61C17/02 , A61M5/30 , A61C19/06
CPC分类号： A61C17/02 , A61C19/063
摘要： A tooth treatment device includes a detector that detects a marker of oral health and a fluid ejector that ejects fluid against teeth in response to the detected marker. The device can include a housing configured to be held on hand, the fluid ejector being positioned at an end of the housing. Further, the device can include a servo controller controlling pressure of ejected fluid in response to the detected marker and a sensed surface condition. The device may include a pressure sensor that senses pressure of the fluid in the ejector. Also included may be a distance sensor that senses distance of the ejector from a tissue surface. In some embodiments, the fluid ejector comprises a stationary magnet assembly providing a magnetic field and a coil assembly, slidably disposed with respect to the magnet assembly, the coil assembly driving ejection of the fluid jet.
摘要翻译：牙齿治疗装置包括检测口腔健康的标记物的检测器和响应于检测到的标记物将流体喷射抵靠牙齿的流体喷射器。该装置可以包括构造成手持的壳体，流体喷射器位于壳体的端部。此外，该装置可以包括伺服控制器，该伺服控制器响应于检测到的标记和感测到的表面状况来控制排出的流体的压力。该装置可以包括感测喷射器中的流体的压力的压力传感器。还包括可以感测喷射器与组织表面的距离的距离传感器。在一些实施例中，流体喷射器包括提供磁场的固定磁体组件和相对于磁体组件可滑动地设置的线圈组件，线圈组件驱动喷射流体射流。

8. 发明申请

WO2011028719A2 NONLINEAR SYSTEM IDENTIFICATION TECHNIQUES AND DEVICES FOR DISCOVERING DYNAMIC AND STATIC TISSUE PROPERTIES 审中-公开
标题翻译：用于发现动态和静态组织特性的非线性系统识别技术和装置
公开(公告)号：WO2011028719A2
公开(公告)日：2011-03-10
申请号：PCT/US2010/047348
申请日：2010-08-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , HUNTER, Ian, W. , CHEN, Yi
发明人： HUNTER, Ian, W. , CHEN, Yi
IPC分类号： A61B5/103 , A01G7/00 , G01N3/40
CPC分类号： A61B5/103 , A01G7/00 , A61B5/0048 , A61B5/0053 , A61B5/0055 , A61B5/0057 , A61B5/442 , A61B5/6824 , A61B9/00 , G01N3/24 , G01N3/40 , G01N2203/0069 , G01N2203/0218 , G01N2203/0246 , G01N2203/0278
摘要： A device for measuring a mechanical property of a tissue includes a probe configured to perturb the tissue with movement relative to a surface of the tissue, an actuator coupled to the probe to move the probe, a detector configured to measure a response of the tissue to the perturbation, and a controller coupled to the actuator and the detector. The controller drives the actuator using a stochastic sequence and determines the mechanical property of the tissue using the measured response received from the detector. The probe can be coupled to the tissue surface. The device can include a reference surface configured to contact the tissue surface. The probe may include a set of interchangeable heads, the set including a head for lateral movement of the probe and a head for perpendicular movement of the probe. The perturbation can include extension of the tissue with the probe or sliding the probe across the tissue surface and may also include indentation of the tissue with the probe. In some embodiments, the actuator includes a Lorentz force linear actuator. The mechanical property may be determined using non-linear stochastic system identification. The mechanical property may be indicative of, for example, tissue compliance and tissue elasticity. The device can further include a handle for manual application of the probe to the surface of the tissue and may include an accelerometer detecting an orientation of the probe. The device can be used to test skin tissue of an animal, plant tissue, such as fruit and vegetables, or any other biological tissue.
摘要翻译：用于测量组织的机械性质的设备包括：探针，其被配置为通过相对于组织的表面的运动来干扰组织;致动器，其耦合到探针以移动探针;探测器被配置测量组织对微扰的响应，以及耦合到致动器和检测器的控制器。控制器使用随机序列驱动致动器，并使用从检测器接收到的测量响应来确定组织的机械性质。探头可以连接到组织表面。该装置可以包括构造成接触组织表面的参考表面。探针可以包括一组可互换头部，该组包括用于探针横向移动的头部和用于垂直移动探针的头部。扰动可以包括用探针延伸组织或将探针滑过组织表面并且还可以包括用探针对组织进行压痕。在一些实施例中，致动器包括洛伦兹力线性致动器。机械性质可以使用非线性随机系统识别来确定。机械性质可以指示例如组织柔顺性和组织弹性。该装置可以进一步包括用于手动将探针施加到组织表面的手柄，并且可以包括检测探针取向的加速度计。该装置可用于测试动物的皮肤组织，植物组织如水果和蔬菜，或任何其他生物组织。

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