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1. 发明申请

WO9640106A3 METHODS FOR CONTROLLING HIGHLY UNSATURATED FATTY ACID CONTENT IN VARIOUS TISSUES 审中-公开
标题翻译：控制不同组织中高度不饱和脂肪酸含量的方法
公开(公告)号：WO9640106A3
公开(公告)日：1997-03-13
申请号：PCT/US9608649
申请日：1996-06-03
申请人： MARTEK BIOSCIENCES CORP , KYLE DAVID J , LINSERT HENRY JR
发明人： KYLE DAVID J , LINSERT HENRY JR
IPC分类号： A61K31/20 , A61K31/202 , A61K31/23 , A61K36/02 , A61K36/06 , A61P7/00 , C12P7/64 , A61K35/70 , A61K35/80
CPC分类号： A61K35/68 , A61K31/202 , A61K36/02 , A61K36/06
摘要： A method of treating a neurological disorder comprises administering to a person affected from such a disorder a microbial oil comprising DHA, a microbial oil comprising ARA or a combination of DHA and ARA oils in an amount sufficient to elevate the levels of circulating DHA and/or ARA in the person's blood to at least normal levels.
摘要翻译：一种治疗神经障碍的方法包括向患有这种病症的人施用包含DHA的微生物油，包含ARA或DHA和ARA油的组合的微生物油，其量足以提高循环DHA和/或 ARA在人的血液中至少达到正常水平。

2. 发明申请

WO0149282A3 THERAPEUTIC PREPARATIONS OF HIGHLY UNSATURATED FATTY ACIDS 审中-公开
标题翻译：高度不饱和脂肪酸的治疗方法
公开(公告)号：WO0149282A3
公开(公告)日：2002-04-04
申请号：PCT/US0100507
申请日：2001-01-08
申请人： MARTEK BIOSCIENCES CORP , KYLE DAVID J
发明人： KYLE DAVID J
IPC分类号： A61K31/20 , A61K31/23 , A61K35/70 , A61K35/80 , A61P25/00 , A61P43/00
CPC分类号： A61K31/20 , A61K31/23
摘要： This invention provides a therapeutic composition comprising highly unsaturated fatty acids (HUFAs) in an amount and form sufficient to produce normal or supernormal levels of one or more of the respective HUFAs in one or more tissues of an individual in need thereof upon administration of the composition. Preferably, administration of this composition will raise the tissue level of one or more HUFA to over twice normal in a target tissue, more preferably, the tissue level of DHA is raised to over twice normal in the target tissue. Typically, the individual in need of the therapeutic composition is a mammal, especially a human, suffering from a disease selected from the group consisting of cystic fibrosis, multiple sclerosis, cerebral palsy, amyotrophic lateral sclerosis, phenylketonuria, and neurological disorders, including certain neurodegenerative diseases and psychiatric disorders. Preferably, the levels of one or more of the respective HUFAs, especially DHA, are normalized or supernormalized in membranes of the individual. In another preferred mode of this invention, the HUFAs in the therapeutic composition are in a readily absorbable form, such that the dose of HUFA required to achieve normal or supernormal levels in the individual is lower than the dose required for HUFA-containing triglycerides. For example, the HUFAs may be predominantely in the form of glycerol esters. Preferably at least 70% of the HUFAs are esterified to glycerol; more preferably, the HUFAs are predominantely in the form of diglycerides and/or monoglycerides.
摘要翻译：本发明提供包含高度不饱和脂肪酸（HUFA）的治疗组合物，其量和形式足以在施用组合物时产生有需要的个体的一个或多个组织中的一种或多种相应HUFA的正常或超常水平。优选地，该组合物的施用将使靶组织中的一种或多种HUFA的组织水平升高到正常的两倍以上，更优选地，目标组织中DHA的组织水平升高到正常的两倍以上。通常，需要治疗组合物的个体是患有选自囊性纤维化，多发性硬化，脑性麻痹，肌萎缩性侧索硬化，苯丙酮尿症和神经系统疾病（包括某些神经变性）的疾病的哺乳动物，特别是人疾病和精神疾病。优选地，各个HUFA，特别是DHA中的一种或多种的水平在个体的膜中被标准化或超正规化。在本发明的另一优选方式中，治疗组合物中的HUFA是易于吸收的形式，使得在个体中达到正常或超常量水平所需的HUFA剂量低于含有HUFA的甘油三酸酯所需的剂量。例如，HUFA可以主要以甘油酯的形式存在。优选地，至少70％的HUFA被酯化成甘油; 更优选地，HUFA主要是甘油二酯和/或甘油单酯的形式。

3. 发明申请

WO0181603A3 TROPHIC CONVERSION OF OBLIGATE PHOTOTROPHIC ALGAE THROUGH METABOLIC ENGINEERING 审中-公开
标题翻译：通过代谢工程进行的白藜芦醇的热转化
公开(公告)号：WO0181603A3
公开(公告)日：2002-05-23
申请号：PCT/US0112789
申请日：2001-04-20
申请人： MARTEK BIOSCIENCES CORP , APT KIRK E , ALLNUTT THOMAS F C , KYLE DAVID J , LIPPMEIER JAMES C
发明人： APT KIRK E , ALLNUTT THOMAS F C , KYLE DAVID J , LIPPMEIER JAMES C
IPC分类号： C12N15/09 , C12N1/12 , C12N1/13 , C12N15/65 , C12N15/79 , C12N15/82 , C12Q1/02 , C07K14/415 , C07K14/47
CPC分类号： C12N15/8209 , C12N1/12 , C12N15/65 , C12N15/79 , C12N15/8207 , Y10S435/946
摘要： Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically-derived energy. In this study it is shown that the microalga Phaeodaclylurn tricornutum can be engineered to import glucose and grow in the dark through the introduction of genes encoding glucose transporters. Both the human and Chlorella kessleri glucose transporters facilitated the uptake of glucose by P. tricornutum , allowing the cells to metabolize exogenous organic carbon and thrive, independent of light. This is the first successful trophic conversion of an obligate photoautotroph through metabolic engineering, and it demonstrates that methods of cell nourishment can be fundamentally altered with the introduction of a single gene. Since strains transformed with the glucose transport genes are able to grow non-photosynthetically, they can be exploited for the analysis of photosynthetic processes through mutant generation and characterization. Finally, this work also represents critical progress toward large-scale commercial exploitation of obligate phototrophic algae through the use of microbial fermentation technology, eliminating significant limitations resulting from light-dependent growth.
摘要翻译：大多数微藻是专性光自养体，其生长严格依赖于光合作用衍生能量的产生。在本研究中，显示微藻Phaeodaclylurn tricornutum可以通过引入编码葡萄糖转运蛋白的基因进行工程化以导入葡萄糖并在黑暗中生长。人和小球藻凯斯勒葡萄糖转运蛋白均促进了P的葡萄糖摄取。三角褐斑，允许细胞代谢外源有机碳，并且独立于光而茁壮成长。这是通过代谢工程首次成功地营养专一性自养型营养转化，并且表明通过引入单一基因可以从根本上改变细胞营养的方法。由于用葡萄糖转运基因转化的菌株能够非光合作用生长，因此可以通过突变体的产生和表征来开发光合作用的分析。最后，这项工作也是通过使用微生物发酵技术大规模商业开发专用光营养藻类的重要进展，消除了光依赖性生长造成的重大限制。

4. 发明申请

WO0054575A3 INFANT FORMULAS AND OTHER FOOD PRODUCTS CONTAINING PHOSPHOLIPIDS 审中-公开
标题翻译：婴儿配方食品和其他含磷脂的食品
公开(公告)号：WO0054575A3
公开(公告)日：2000-12-28
申请号：PCT/US0006755
申请日：2000-03-16
申请人： MARTEK BIOSCIENCES CORP , KYLE DAVID J , BECKER CLAUS C
发明人： KYLE DAVID J , BECKER CLAUS C
IPC分类号： A23D9/013 , A23J7/00 , A23L1/30 , A23L3/3553 , A23L1/29
CPC分类号： A23L3/3553 , A23D9/013 , A23J7/00 , A23L33/12
摘要： A food product containing mixed glycerides, including polyunsaturated fatty acid residues, highly unsaturated fatty acid residues, or a combination thereof, is stabilized by the addition of phospholipids. The addition of phospholipids to fat blends has been found to have an unexpected stabilizing effect on the fats contained in the blend. The phospholipids are preferably derived from vegetables, milk, microbes, or a combination thereof.
摘要翻译：包含多不饱和脂肪酸残基，高度不饱和脂肪酸残基或其组合的混合甘油酯的食品通过加入磷脂来稳定。已发现向脂肪混合物添加磷脂对混合物中所含的脂肪具有意想不到的稳定作用。磷脂优选来自蔬菜，牛奶，微生物或其组合。

5. 发明申请

WO2007117511A3 FEED FORMULATIONS CONTAINING DOCOSAHEXAENOIC ACID 审中-公开
标题翻译：含有DOCOSAHEXAENOIC酸的饲料配方
公开(公告)号：WO2007117511A3
公开(公告)日：2007-12-13
申请号：PCT/US2007008409
申请日：2007-04-03
申请人： ADVANCED BIONUTRITION CORP , KYLE DAVID J , PIECHOCKI JOHN , LAURIN EMILIE , RAKITSKY WALTER G
发明人： KYLE DAVID J , PIECHOCKI JOHN , LAURIN EMILIE , RAKITSKY WALTER G
IPC分类号： A61K8/97
CPC分类号： A61K36/02
摘要： The disclosure relates to an animal feed or feed ingredient containing from about 0.01% to 1.0% DHA, wherein all, or substantially all of the DHA comes from material that is of non-animal origin and the use of microbially-derived DHA at these low levels provides sufficient DHA for the optimal neurological development of the animal.
摘要翻译：本公开涉及含有约0.01％至1.0％DHA的动物饲料或饲料成分，其中所有或基本上所有的DHA来自非动物来源的材料，以及在这些低浓度下使用微生物来源的DHA 水平为动物的最佳神经发育提供了足够的DHA。

6. 发明申请

WO2006122299A2 FISH OIL IN STABILIZED FORM 审中-公开
标题翻译：鱼油在稳定的形式
公开(公告)号：WO2006122299A2
公开(公告)日：2006-11-16
申请号：PCT/US2006018398
申请日：2006-05-11
申请人： ADVANCED BIONUTRITION CORP , PIECHOCKI JOHN , KYLE DAVID J
发明人： PIECHOCKI JOHN , KYLE DAVID J
IPC分类号： A61K31/22 , A23L17/60
CPC分类号： A61K36/05 , A23L17/60 , A61K31/20 , A61K31/22 , A61K36/02 , A61K36/03 , A61K2300/00
摘要： A method of production and composition of a extremely stable fish oil blend and method of use of said blend. The instant invention provides phospholipid additives to fish oil or other long-chain polyunsaturated fatty acid in an admixture that enhances the stability of the final product. Most preferably said composition utilizes a crude extract of an algal producer of long-chain polyunsaturated acids containing soaps and phospholipids added to fish oil or other purified long-chain polyunsaturated fatty acid to provide a surprisingly stable product.
摘要翻译：非常稳定的鱼油混合物的生产方法和组合物以及所述共混物的使用方法。本发明提供了磷脂添加剂以鱼油或其它长链多不饱和脂肪酸的混合物，其增强了最终产品的稳定性。最优选地，所述组合物使用含有肥皂和磷脂的长链多不饱和酸的藻类生产者的粗提取物，其添加到鱼油或其它纯化的长链多不饱和脂肪酸中以提供令人惊奇的稳定产物。

7. 发明申请

WO2005079236A2 RNA-MEDIATED INTERFERENCE TO CONTROL DISEASE IN TERRESTRIAL AND AQUACULTURE ANIMALS 审中-公开
标题翻译： RNA介导的干扰对流感和水产动物的控制疾病
公开(公告)号：WO2005079236A2
公开(公告)日：2005-09-01
申请号：PCT/US2005003715
申请日：2005-02-04
申请人： ADVANCED BIONUTRITION CORP , KYLE DAVID J , DHAR ARUN K
发明人： KYLE DAVID J , DHAR ARUN K
IPC分类号： C12N15/11 , C12N15/113
CPC分类号： C12N15/111 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/32
摘要： The invention is directed to compositions (e.g., feeds, feed supplements, and therapeutic products) and methods for inhibiting an animal pathogen using RNA-interference technology.
摘要翻译：本发明涉及使用RNA干扰技术抑制动物病原体的组合物（例如饲料，饲料添加剂和治疗产品）和方法。

8. 发明申请

WO2004003143A3 VIRUSES AND VIRUS-LIKE PARTICLES FOR MULTIPLE ANTIGEN AND TARGET DISPLAY 审中-公开
标题翻译：用于多重抗原和靶标显示的病毒和病毒样颗粒
公开(公告)号：WO2004003143A3
公开(公告)日：2004-07-08
申请号：PCT/US0319855
申请日：2003-06-25
申请人： ALLNUTT F C THOMAS , KYLE DAVID J
发明人： ALLNUTT F C THOMAS , KYLE DAVID J
IPC分类号： A61K39/00 , A61K39/21 , A61K39/29 , C07K14/01 , C07K14/08 , C07K14/16 , C12N7/00 , C12N7/04 , A61K48/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K39/292 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/542 , C07K2319/00 , C12N7/00 , C12N2720/10023 , C12N2720/10043 , C12N2720/10061 , C12N2720/10062 , C12N2720/12023 , C12N2730/10122 , C12N2730/10134 , C12N2740/16034 , C12N2740/16061 , C12N2770/22022 , C12N2770/22023 , C12N2770/22043 , C12N2770/32043 , C12N2810/854
摘要： The present invention relates to the display of antigenic or allergenic components along with a tissue-targeting component on viruses or virus-like particles. Capsid protein genes are recombinantly modified to contain the specified components, then expressed within a host organism, such as yeasts, bacteria, or algae, and allowed to spontaneously form active virus particles or virus-like particles. The recombinant complexes (virus or virus-like particle) can then be purified or used in situ as a therapeutic tool for disease or allergy prevention. The expression of multivalent and multifunctional components to increase the immunogenicity of the recombinant complexes, especially on oral administration, is provided.
摘要翻译：本发明涉及在病毒或病毒样颗粒上显示抗原或变应原组分以及组织靶向组分。将衣壳蛋白基因重组修饰以包含特定组分，然后在宿主生物如酵母，细菌或藻类内表达，并允许自发形成活性病毒颗粒或病毒样颗粒。然后可以将重组复合物（病毒或病毒样颗粒）纯化或原位用作疾病或过敏预防的治疗工具。提供了多价和多功能组分的表达以提高重组复合物的免疫原性，尤其是口服给药。

9. 发明申请

WO03079810A8 MICROALGAL FEEDS CONTAINING ARACHIDONIC ACID AND THEIR PRODUCTION AND USE 审中-公开
标题翻译：含有ARACHIDONIC酸的微量饲料及其生产和使用
公开(公告)号：WO03079810A8
公开(公告)日：2004-11-04
申请号：PCT/US0307278
申请日：2003-03-19
申请人： ADVANCED BIONUTRITION CORP , KYLE DAVID J
发明人： KYLE DAVID J
IPC分类号： A23K1/00 , A23K1/16 , A23K1/18
CPC分类号： C11B1/10 , A23K10/12 , A23K10/16 , A23K20/158 , A23K50/80 , Y02A40/818 , Y10S426/805
摘要： An animal feed with a high level of arachidonic acid is produced from microalgae, and fed to aquatic animals grown in aquaculture. The arachidonic acid-rich microalgae are fed directly to the aquatic animals, or processed to produce an oil that can be used as a human nutritive supplement. The arachidonic acid-rich microalgae can be combined with long chain omega-3 fatty acids to provide a source of nutrition for humans and animals. The animal feed and nutritional supplements are free of animal byproducts.

10. 发明申请

WO02076391B1 MICROBIAL FEEDS FOR AQUACULTURE AND AGRICULTURE 审中-公开
标题翻译：农业和农业的微生物饲料
公开(公告)号：WO02076391B1
公开(公告)日：2004-04-08
申请号：PCT/US0208651
申请日：2002-03-22
申请人： ADVANCED BIONUTRITION , KYLE DAVID J
发明人： KYLE DAVID J
IPC分类号： A23K1/00 , A23K1/16 , A23K1/18 , A23L1/337 , A61K35/66 , A61K35/74 , A61K36/02 , A61K36/06 , A61K38/00 , A61K39/395 , A61K45/00 , A61P31/04 , A61P31/12 , C12N1/00 , C12N15/31 , C12P21/08 , A61K39/02
CPC分类号： A61K35/745 , A23K10/10 , A23K10/18 , A23K20/147 , A23K50/80 , A23L17/60 , A61K35/742 , A61K35/747 , A61K36/02 , A61K36/06
摘要： An animal feed contains microbial biomass comprising one or more proteins, antibodies, therapeutics, or a combination thereof, wherein said proteins and antibodies are non-native to the microbes of the biomass. The proteins can be therapeutic, bioactive, or nutritional proteins. A vaccine can be employed in bacteria to immunize an animal. Alternatively, an antimicrobial compound can be employed in bacteria.
摘要翻译：动物饲料含有包含一种或多种蛋白质，抗体，治疗剂或其组合的微生物生物质，其中所述蛋白质和抗体对生物质的微生物是非天然的。蛋白质可以是治疗性的，生物活性的或营养蛋白质。疫苗可用于细菌以免疫动物。或者，抗菌化合物可以用于细菌中。

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