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1. 发明申请

WO2010118205A3 PRODUCTION OF AN INTACT VIRUS IN A MAMMALIAN (NON-HOST) CELL SYSTEM USING A SECONDARY NON-HOST VIRAL CONSTRUCT 审中-公开
标题翻译：使用二次非死亡病毒结构在马萨诸塞（非主机）细胞系统中产生致病病毒
公开(公告)号：WO2010118205A3
公开(公告)日：2011-03-24
申请号：PCT/US2010030348
申请日：2010-04-08
申请人： ADVANCED BIONUTRITION CORP , DHAR ARUN K
发明人： DHAR ARUN K
IPC分类号： C12N15/866 , C12N15/51 , C12N15/64
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/14144 , C12N2770/16043 , C12N2770/24243 , C12N2770/32043 , C12N2800/50 , C12N2830/60
摘要： The present invention relates to constructs and methods for the production of recombinant proteins, viruses, and viral vaccines in heterologous culture systems by expressing intact genes or viral genomes under the control of a pantropic promoter in a culture system that is not considered a host to the virus so produced. The promoter/viral genome constructs are inserted into a baculovirus and expressed in mammalian non-host cells for the baculovirus.
摘要翻译：本发明涉及用于在异源培养系统中生产重组蛋白质，病毒和病毒疫苗的构建体和方法，其通过在不被认为是宿主的培养系统中的泛素启动子的表达下表达完整的基因或病毒基因组病毒如此生产。将启动子/病毒基因组构建体插入杆状病毒中，并在用于杆状病毒的哺乳动物非宿主细胞中表达。

2. 发明申请

WO2008140610A9 ANTIGENICITY OF INFECTIOUS PANCREATIC NECROSIS VIRUS VP2 SUB-VIRAL PARTICLES EXPRESSED IN YEAST 审中-公开
标题翻译：感染性胰腺炎病毒VP2亚历山大小肠病毒的抗生素
公开(公告)号：WO2008140610A9
公开(公告)日：2009-04-16
申请号：PCT/US2007087942
申请日：2007-12-18
申请人： ADVANCED BIONUTRITION CORP , DHAR ARUN K , BOWERS ROBERT M , ALLNUTT THOMAS F C
发明人： DHAR ARUN K , BOWERS ROBERT M , ALLNUTT THOMAS F C
IPC分类号： C12N15/40 , A61K39/12 , C12N7/04
CPC分类号： A61K39/12 , A61K2039/51 , A61K2039/5258 , A61K2039/542 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2720/10022 , C12N2720/10023 , C12N2720/10034

3. 发明申请

WO2007084499A8 DISEASE CONTROL IN SHRIMP 审中-公开
标题翻译：疾病控制在SHRIMP
公开(公告)号：WO2007084499A8
公开(公告)日：2008-01-31
申请号：PCT/US2007001125
申请日：2007-01-16
申请人： SAN DIEGO STATE UNIVERSITY , DHAR ARUN K
发明人： DHAR ARUN K
IPC分类号： C12Q1/70 , A61K39/12 , C12N7/00
CPC分类号： G01N33/68 , C07K14/43509 , C12N2710/18034 , G01N33/5008 , G01N33/502 , G01N33/569 , G01N2500/04

4. 发明申请

WO2010118188A3 PRODUCTION OF AN INTACT VIRUS IN A NON-HOST CELL SYSTEM USING A SECONDARY HOST VIRAL CONSTRUCT 审中-公开
标题翻译：使用二级主机病毒结构在非主机系统中产生致病病毒
公开(公告)号：WO2010118188A3
公开(公告)日：2011-03-17
申请号：PCT/US2010030314
申请日：2010-04-08
申请人： ADVANCED BIONUTRITION CORP , MACROGENICS INC , DHAR ARUN K , JOHNSON SYD , RAINEY JONAH
发明人： DHAR ARUN K , JOHNSON SYD , RAINEY JONAH
IPC分类号： C12N15/866 , C12N15/33 , C12N15/64
CPC分类号： C12N7/00 , A01K2227/101 , A01K2267/02 , C12N2710/14144 , C12N2770/16043 , C12N2770/24243 , C12N2770/32043 , C12N2830/60
摘要： The present invention relates to constructs and methods for the production of recombinant proteins, viruses, and viral vaccines in heterologous culture systems by expressing intact genes or viral genomes under the control of a pantropic promoter in a culture system that is not considered a host to the virus so produced. The promoter/viral genome constructs are inserted into a baculovirus and expressed in host cells that are acceptable for infection by the baculovirus.
摘要翻译：本发明涉及用于在异源培养系统中生产重组蛋白，病毒和病毒疫苗的构建体和方法，其通过在不被认为是宿主的培养系统中的泛素启动子的表达下表达完整的基因或病毒基因组病毒如此生产。将启动子/病毒基因组构建体插入杆状病毒中，并在宿主细胞中表达，其可被杆状病毒感染所接受。

5. 发明申请

WO0034476A9 NUCLEIC ACID MOLECULES OF SHRIMP 审中-公开
标题翻译： SHRIMP的核酸分子
公开(公告)号：WO0034476A9
公开(公告)日：2002-08-22
申请号：PCT/US9929571
申请日：1999-12-10
申请人： TUFTS COLLEGE , ALCIVAR-WARREN ACACIA , XU ZHENKANG , DHAR ARUN K , FAN YONGJUN , MEEHAN DAWN , GARCIA DENISE K
发明人： ALCIVAR-WARREN ACACIA , XU ZHENKANG , DHAR ARUN K , FAN YONGJUN , MEEHAN DAWN , GARCIA DENISE K
IPC分类号： C07K14/435 , C12N15/12 , C07K16/18 , C12Q1/68
CPC分类号： C07K14/43509
摘要： Nucleic acid molecules which can be characterized as microsatellites of Penaeus monodon are described. Also described are nucleic acid molecules which can be characterized as microsatellites or ESTs of Litopenaeus vannemei. These nucleic acid molecules, the complements thereof, and molecules sharing nucleotide sequence similarity, including those sharing contiguous nucleotide sequence, and others described herein can be used to identify, map and characterize segments of the genome of various species of shrimp.
摘要翻译：描述了可以表征为对虾单体的微卫星的核酸分子。还描述了可以表征为微卫星或Litopenaeus vannemei的EST的核酸分子。这些核酸分子及其互补序列和共享核苷酸序列相似性的分子（包括共享连续核苷酸序列的分子）以及本文所述的其他核酸分子可用于鉴定，绘制和表征各种虾的基因组的片段。

6. 发明申请

WO2013036745A3 IPNV-ISAV BIVALENT VACCINE USING A VIRUS-LIKE PARTICLE-BASED PLATFORM AND METHODS OF USING THE SAME 审中-公开
标题翻译：使用基于病毒颗粒的平台的IPNV-ISAV双重疫苗及其使用方法
公开(公告)号：WO2013036745A3
公开(公告)日：2013-05-02
申请号：PCT/US2012054125
申请日：2012-09-07
申请人： ADVANCED BIONUTRITION CORP , DHAR ARUN K
发明人： DHAR ARUN K
IPC分类号： C12N1/19 , A61K39/12 , C12N15/33 , C12N15/81
CPC分类号： A61K39/295 , A61K39/12 , A61K2039/523 , A61K2039/542 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C07K5/101 , C07K7/06 , C07K2319/00 , C12N7/00 , C12N2720/10023 , C12N2720/10034 , C12N2720/10044 , C12N2720/12023 , C12N2720/12034 , C12N2760/16034 , C12N2760/16043
摘要： The present invention provides bivalent oral vaccines against infectious pancreatic necrosis virus (IPNV) and infectious salmon anemia virus (ISAV). Yeast cells comprise an expression vector comprising (i) a polynucleotide sequence encoding a VP2 capsid protein of IPNV and (ii) a polynucleotide sequence encoding one or more antigenic epitopes of hemaglutinin of ISAV. The yeast cells express sub-viral particles (SVP) comprising a VP2 capsid protein of IPNV and one or more antigenic epitopes of hemaglutinin of ISAV. The yeast cells and SVP may be administered in an effective amount to increase the amount of antibodies against IPNV and ISAV in the fish, preferably Salmonidae. The yeast cells and SVP may be in the form of fish food for administering to the fish orally.
摘要翻译：本发明提供针对感染性胰腺坏死病毒（IPNV）和感染性鲑鱼贫血病毒（ISAV）的二价口服疫苗。酵母细胞包含表达载体，其包含（i）编码IPNV的VP2衣壳蛋白的多核苷酸序列和（ii）编码ISAV血凝素的一个或多个抗原表位的多核苷酸序列。酵母细胞表达包含IPNV的VP2衣壳蛋白和ISAV的血凝素的一个或多个抗原表位的亚病毒颗粒（SVP）。可以以有效量施用酵母细胞和SVP以增加鱼，优选鲑科的IPNV和ISAV抗体的量。酵母细胞和SVP可以是鱼类的形式，用于口服给鱼。

7. 发明申请

WO2013026054A2 PRODUCTION OF INFECTIOUS RNA VIRUSES IN YEAST 审中-公开
标题翻译：酵母菌感染性RNA病毒的生产
公开(公告)号：WO2013026054A2
公开(公告)日：2013-02-21
申请号：PCT/US2012/051569
申请日：2012-08-20
申请人： AXELLA SOLUTIONS, LLC , DHAR, Arun, K. , BEDNARIK, Daniel
发明人： DHAR, Arun, K. , BEDNARIK, Daniel
IPC分类号： C12N7/00 , A61K39/12 , C12N15/83 , C12N1/19
CPC分类号： C12N15/86 , A61K39/12 , A61K39/125 , A61K2039/523 , A61K2039/5252 , A61K2039/5254 , C12N7/00 , C12N2760/18534 , C12N2770/16034 , C12N2770/16051 , C12N2770/24134 , C12N2770/24151 , Y02A50/386 , Y02A50/394
摘要： The method described herein provides a novel platform utilizing yeast as a biological non-host system to express and assemble whole viruses for use as attenuated or killed vaccines.
摘要翻译：本文描述的方法提供了利用酵母作为生物学非宿主系统来表达和组装整个病毒以用作减毒或杀死疫苗的新型平台。

8. 发明申请

WO2008140610A2 ANTIGENICITY OF INFECTIOUS PANCREATIC NECROSIS VIRUS VP2 SUB-VIRAL PARTICLES EXPRESSED IN YEAST 审中-公开
标题翻译：感染性胰腺炎病毒VP2亚历山大小肠病毒的抗生素
公开(公告)号：WO2008140610A2
公开(公告)日：2008-11-20
申请号：PCT/US2007/087942
申请日：2007-12-18
申请人： ADVANCED BIONUTRITION CORPORATION , DHAR, Arun, K. , BOWERS, Robert, M. , ALLNUTT, Thomas, F.C.
发明人： DHAR, Arun, K. , BOWERS, Robert, M. , ALLNUTT, Thomas, F.C.
IPC分类号： C12N15/40 , C12N7/04 , A61K39/12
CPC分类号： A61K39/12 , A61K2039/51 , A61K2039/5258 , A61K2039/542 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2720/10022 , C12N2720/10023 , C12N2720/10034
摘要： Infectious pancreatic necrosis virus (IPNV), the etiologic agent of infectious pancreatic necrosis in salmonid fish, causes significant losses to the aquaculture industry. The gene for the viral capsid protein (VP2) was cloned into a yeast expression vector and expressed in Saccharomyces cerevisae. Expression of the capsid gene in yeast resulted in formation of approximately 20 nanometer sub-viral particles composed solely of VP2 protein. Anti-PNV antibodies were detected in rainbow trout vaccinated either by injection of purified VP2- subviral particles (rVP2-SVP) or by feeding recombinant yeast expressing rVP2-SVP. Challenge of rVP2-SVP immunized trout with a heterologous IPNV strain and subsequent viral load determination showed that both injection and orally vaccinated fish had lower DPNV loads than naive or sham-vaccinated fish. This study demonstrates the ability of rVP2-SVPs to induce a specific immune response and the ability of immunized fish to reduce the viral load after an experimentally induced IPNV infection. The invention is not limited to IPNV, and is applicable to other similar viruses for which SVPs can be made and administered to fish.
摘要翻译：传染性胰腺坏死病毒（IPNV）是鲑鱼感染性胰腺坏死的病原体，对水产养殖业造成重大损失。将病毒衣壳蛋白（VP2）的基因克隆到酵母表达载体中并在酿酒酵母中表达。酵母中衣壳基因的表达导致形成仅由VP2蛋白组成的约20纳米亚病毒颗粒。通过注射纯化的VP2-亚病毒颗粒（rVP2-SVP）或通过饲喂表达rVP2-SVP的重组酵母，在虹鳟中检测到抗PNV抗体。用异源IPNV株进行rVP2-SVP免疫鳟鱼的挑战，随后的病毒载量测定表明，注射和口服接种的鱼都比初始或假手术的鱼具有更低的DPNV负荷。该研究证明rVP2-SVP诱导特异性免疫应答的能力以及免疫鱼在实验诱导的IPNV感染后降低病毒载量的能力。本发明不限于IPNV，适用于可以制造和施用SVP的其他类似病毒。

9. 发明申请

WO2005102041B1 CRUSTACEAN EXPRESSION VECTOR 审中-公开
标题翻译： CRUSTACEAN表达载体
公开(公告)号：WO2005102041B1
公开(公告)日：2006-11-09
申请号：PCT/US2005012979
申请日：2005-04-15
申请人： ADVANCED BIONUTRITION CORP , DHAR ARUN K , ALLNUTT THOMAS F C
发明人： DHAR ARUN K , ALLNUTT THOMAS F C
IPC分类号： A01K67/033 , C12N15/85
CPC分类号： A01K67/0338 , A01K2217/05 , A01K2227/70 , A01K2267/02 , A01K2267/0393 , C12N15/85 , C12N15/8509 , C12N2800/90 , C12N2830/60 , C12N2840/203
摘要： Methods and constructs for genetic manipulation of one or more of shrimp, shellfish, mollusks, and fish are disclosed. The nucleic acid construct includes a promoter and an internal ribosome entry site of an insect picornavirus, such as a cricket paralysis-like picornavirus. One or more open reading frames can be operably associated with one or both of the promoter and the internal ribosome entry site, and one or more proteins or protein subunits can be expressed upon introduction of the construct into a host cell, such as into a shrimp. Method for producing immortalized crustacean cell lines using enhancer elements derived from shrimp and/or shrimp viruses are also described.
摘要翻译：公开了用于对虾，贝类，软体动物和鱼中的一种或多种进行遗传操作的方法和构建体。核酸构建体包括昆虫微核糖核酸病毒的启动子和内部核糖体进入位点，如蟋蟀麻痹样小核糖核酸病毒。一个或多个开放阅读框可以与启动子和内部核糖体进入位点中的一个或两个可操作地相关联，并且可以在将构建体引入宿主细胞例如虾中时表达一个或多个蛋白质或蛋白质亚基。还描述了使用来源于虾和/或虾病毒的增强子元件生产永生化甲壳类动物细胞系的方法。

10. 发明申请

WO2005079236A3 RNA-MEDIATED INTERFERENCE TO CONTROL DISEASE IN TERRESTRIAL AND AQUACULTURE ANIMALS 审中-公开
公开(公告)号：WO2005079236A3
公开(公告)日：2005-09-01
申请号：PCT/US2005/003715
申请日：2005-02-04
申请人： ADVANCED BIONUTRITION CORPORATION , KYLE, David, J. , DHAR, Arun, K.
发明人： KYLE, David, J. , DHAR, Arun, K.
IPC分类号： C07H27/04
摘要： The invention is directed to compositions (e.g., feeds, feed supplements, and therapeutic products) and methods for inhibiting an animal pathogen using RNA-interference technology.

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