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1. 发明申请

WO2017143130A1 STABILIZING METHODS FOR COATING SEEDS WITH BIOLOGICAL MATERIALS 审中-公开
标题翻译：用生物材料涂覆种子的稳定化方法
公开(公告)号：WO2017143130A1
公开(公告)日：2017-08-24
申请号：PCT/US2017/018280
申请日：2017-02-17
申请人： ADVANCED BIONUTRITION CORP.
发明人： REAP, James, J. , ACKERSON, Robert , TANG, Qiong , CANTOR, Stuart
IPC分类号： A01C1/06 , C09D105/00 , C09D7/12
CPC分类号： C09D105/00 , A01C1/06 , A01N63/00 , C09D7/40 , A01N25/10
摘要： The present invention provides a method for coating seeds with biological materials such as bacteria, fungi (e.g., yeasts and molds), parasites, recombinant vectors, and viruses. The method comprises (a) applying a moistening liquid to seeds to moisten seeds, wherein the moistening liquid comprises a moistening polymer, and (b) coating the moistened seeds with an effective amount of a dry composition, wherein the dry composition comprises biological materials, one or more disaccharides, one or more oligosaccharides, one or more polysaccharides, one or more carboxylic acid salts, and one or more hydrolyzed proteins. The coated seeds may have an initial water activity (Aw) below 0.4, and the microorganisms on the coated seeds have initial viability of at least 5 logs of colony forming units per gram of seeds (CFU/g seed). Also provided are coated seeds.
摘要翻译：本发明提供了用生物材料如细菌，真菌（例如酵母和霉菌），寄生虫，重组载体和病毒包衣种子的方法。该方法包括：（a）将润湿液施用于种子以润湿种子，其中润湿液包含润湿聚合物，和（b）用有效量的干燥组合物涂布润湿的种子，其中干燥组合物包含生物材料，一种或多种二糖，一种或多种低聚糖，一种或多种多糖，一种或多种羧酸盐和一种或多种水解蛋白。包衣的种子可以具有低于0.4的初始水分活度（Aw），并且包衣种子上的微生物具有每克种子（CFU / g种子）至少5个对数形成单位的起始活力。还提供了包衣种子。

2. 发明申请

WO2012021783A3 DRY STORAGE STABILIZING COMPOSITION FOR BIOLOGICAL MATERIALS 审中-公开
公开(公告)号：WO2012021783A3
公开(公告)日：2012-02-16
申请号：PCT/US2011/047547
申请日：2011-08-12
申请人： ADVANCED BIONUTRITION CORPORATION , HAREL, Moti , TANG, Qiong
发明人： HAREL, Moti , TANG, Qiong
IPC分类号： A23L3/40 , A23L3/3463 , C12N1/00 , C12N7/01
摘要： The present invention includes compositions and drying methods for preserving sensitive bioactive materials, such as peptides, proteins, hormones, nucleic acids, antibodies, drugs vaccines, yeast, bacteria (probiotic or otherwise), viruses and/or cell suspensions, in storage. The compositions include a carbohydrates component and a glass enhancer component, wherein the carbohydrate component includes a mixture of di-, oligo- and polysaccharides and the glass enhancer includes ions of organic acid and protein hydrolysates. The composition is prepared by dispersing all the solid components in a solution and then snap-frozen to form small beads, strings or droplets. The preferred drying method of the frozen beads, strings or droplets is initiated by a short purging and structure stabilizing step of the frozen particles under a vacuum pressure of less than 2000 mTORR and at a desired temperature. During the secondary and final drying step of the material a full vacuum pressure and elevated temperature are applied, to achieve a final desirable water activity of the dry material.

3. 发明申请

WO2010118188A3 PRODUCTION OF AN INTACT VIRUS IN A NON-HOST CELL SYSTEM USING A SECONDARY HOST VIRAL CONSTRUCT 审中-公开
标题翻译：使用二级主机病毒结构在非主机系统中产生致病病毒
公开(公告)号：WO2010118188A3
公开(公告)日：2011-03-17
申请号：PCT/US2010030314
申请日：2010-04-08
申请人： ADVANCED BIONUTRITION CORP , MACROGENICS INC , DHAR ARUN K , JOHNSON SYD , RAINEY JONAH
发明人： DHAR ARUN K , JOHNSON SYD , RAINEY JONAH
IPC分类号： C12N15/866 , C12N15/33 , C12N15/64
CPC分类号： C12N7/00 , A01K2227/101 , A01K2267/02 , C12N2710/14144 , C12N2770/16043 , C12N2770/24243 , C12N2770/32043 , C12N2830/60
摘要： The present invention relates to constructs and methods for the production of recombinant proteins, viruses, and viral vaccines in heterologous culture systems by expressing intact genes or viral genomes under the control of a pantropic promoter in a culture system that is not considered a host to the virus so produced. The promoter/viral genome constructs are inserted into a baculovirus and expressed in host cells that are acceptable for infection by the baculovirus.
摘要翻译：本发明涉及用于在异源培养系统中生产重组蛋白，病毒和病毒疫苗的构建体和方法，其通过在不被认为是宿主的培养系统中的泛素启动子的表达下表达完整的基因或病毒基因组病毒如此生产。将启动子/病毒基因组构建体插入杆状病毒中，并在宿主细胞中表达，其可被杆状病毒感染所接受。

4. 发明申请

WO2010111347A2 MICROENCAPSULATION OF BIOACTIVE SUBSTANCES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：生物活性物质的微观结构及其制备方法
公开(公告)号：WO2010111347A2
公开(公告)日：2010-09-30
申请号：PCT/US2010/028432
申请日：2010-03-24
申请人： ADVANCED BIONUTRITION CORPORATION , HAREL, Moti
发明人： HAREL, Moti
IPC分类号： A23P1/04 , A23L1/035 , A23L1/30 , A23L1/302 , A23L1/304
CPC分类号： A23L33/16 , A21D2/14 , A23L5/44 , A23L29/06 , A23L33/12 , A23L33/15 , A23L33/175 , A23P10/35 , A23V2002/00 , A23V2200/224 , A23V2250/702 , A23V2250/7106 , A23V2250/7142
摘要： The present invention relates to microparticles and methods of making such microparticles that protect a bioactive substance from heat, humidity and oxidation. A microparticle comprising a bioactive substance, an agglomerating agent, an emulsifier and solid fats is disclosed. A method to produce a microparticle comprising an agglomerated bioactive substance enrobed in a double layer of solid fats and emulsifier is also disclosed.
摘要翻译：本发明涉及微粒以及保护生物活性物质免受热，湿度和氧化的微粒的制造方法。公开了包含生物活性物质，附聚剂，乳化剂和固体脂肪的微粒。还公开了一种生产包含在双层固体脂肪和乳化剂中包埋的附聚生物活性物质的微粒的方法。

5. 发明申请

WO2007084500A3 CONTINUOUS SPRAY-CAPTURE PRODUCTION SYSTEM 审中-公开
标题翻译：连续喷雾生产系统
公开(公告)号：WO2007084500A3
公开(公告)日：2007-11-15
申请号：PCT/US2007001126
申请日：2007-01-16
申请人： ADVANCED BIONUTRITION CORP , PIECHOCKI JOHN , KYLE DAVID J
发明人： PIECHOCKI JOHN , KYLE DAVID J
IPC分类号： A01N43/04 , C08L3/00
CPC分类号： C08J3/03 , C08B37/0084 , C08J3/075 , C08J3/122 , C08J3/24 , C08J2303/02 , C08J2305/04 , C08L3/02 , C08L5/04
摘要： The disclosure relates to novel microencapsulation processes based on the use of high viscosity fluids (e.g., gelatinized starch and alginate), which are mixed and then sprayed using a much gentler hydraulic pressure and, preferably gas-based atomization into a crosslinking solution (e.g.. of calcium chloride). To improve the efficiency of the system, the process can be performed in a continuous mode rather than by a conventional batch process. This involves continuous or intermittent harvest of the microparticles collected in the capture vessel followed by amendment and recycling of the CaCl 2 solution and its redeployment into the capture vessel. The process allows production of microencapsulated probiotic bacteria without major losses in viability, thereby providing a useful and efficient new manufacturing method for the stabilization of probiotic bacteria prior to their introduction into functional foods.
摘要翻译：本公开涉及基于使用高粘度流体（例如糊化淀粉和藻酸盐）的新型微胶囊化方法，所述新型微胶囊化方法被混合，然后使用较轻的液压进行喷雾，并且优选基于气体雾化进入交联溶液（例如，的氯化钙）。为了提高系统的效率，该过程可以以连续模式而不是常规的批处理进行。这涉及收集在捕获容器中的微粒的连续或间歇收获，随后修复和回收CaCl 2 O 2溶液及其再次部署到捕获容器中。该方法允许生产微胶囊化的益生菌，而不会在生存力方面造成重大损失，从而为在益生菌引入功能性食品之前稳定益生菌提供了有用和高效的新的制造方法。

6. 发明申请

WO2005115341A3 MICROPARTICLES FOR ORAL DELIVERY 审中-公开
公开(公告)号：WO2005115341A3
公开(公告)日：2005-12-08
申请号：PCT/US2005/018797
申请日：2005-05-27
申请人： ADVANCED BIONUTRITION CORPORATION , HAREL, Mordechai
发明人： HAREL, Mordechai
IPC分类号： A61K9/16 , A61K38/00 , C07K14/00
摘要： The invention relates to particles suitable for oral administration of a composition to an animal. The particles comprise a substantially indigestible polymer matrix. In one embodiment, the matrix contains the composition and a lipid that is dissoluble in the animal. In another embodiment, the matrix is mixed with the composition and contained in a dissoluble coating. The lipid and coating can be ones which are preferentially dissoluble in one compartment of an animal than in another. For example, the particles can be made to preferentially release the composition in the intestines, rather than the stomach, of a mammal, a fish, or a crustacean. Examples of compounds which can be administered in such compositions include vitamins, fatty acids, oils, carotenoids, nutraceuticals, pharmaceuticals, live or dormant probiotic bacteria, hormones, nucleic acids, and proteins. The particles described herein have the further advantage that they can protect sensitive compounds from oxidation, taste or odor change, and other types of degradation.

7. 发明申请

WO2004036982A3 SHRIMP AND THE PRODUCTION THEREOF 审中-公开
标题翻译： SHRIMP及其生产
公开(公告)号：WO2004036982A3
公开(公告)日：2005-04-14
申请号：PCT/US0331518
申请日：2003-10-24
申请人： ADVANCED BIONUTRITION CORP , KYLE DAVID J , BULLIS ROBERT A
发明人： KYLE DAVID J , BULLIS ROBERT A
IPC分类号： A01K20060101 , A01K61/00 , A01K67/00 , A01K67/033 , A23K1/14 , A23K1/16 , A23K1/18
CPC分类号： A23K50/80 , A01K61/59 , A01K67/033 , A23K10/12 , A23K10/30 , A23K20/111 , A23K20/158 , A23K20/179 , A23L17/40 , Y02A40/824
摘要： This invention is directed to compositions comprising improved edible shrimp and other crustaceans. The shrimp or other crustaceans are enriched with one or more components that provide benefits, such as improved taste and/or appearance, or improved health benefits for humans consuming them. The invention also relates to methods of producing such shrimp and other crustaceans, and methods of making a feed to feed the shrimp and other crustaceans.
摘要翻译：本发明涉及包含改进的食用虾和其他甲壳类动物的组合物。虾或其他甲壳类动物富含一种或多种组分，其提供益处，例如改善的味道和/或外观，或改善对消费它们的人的健康益处。本发明还涉及生产这种虾和其他甲壳类动物的方法，以及制造饲料以供应虾和其他甲壳类动物的方法。

8. 发明申请

WO2016022532A1 ENCAPSULATION OF HYDROPHOBIC BIOLOGICALLY ACTIVE COMPOUNDS 审中-公开
标题翻译：疏水生物活性化合物的包埋
公开(公告)号：WO2016022532A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/043564
申请日：2015-08-04
申请人： ADVANCED BIONUTRITION CORPORATION
发明人： HAREL, Mordechai , KESHTMAND, Majid , KAMBALLAPALLY, Swetha , MORRISON-ROWE, Sara
IPC分类号： A23P1/04 , A23L1/00 , A23L1/30 , A61K9/48 , A61K47/26 , A61K47/42
CPC分类号： A61K9/5052 , A23K20/158 , A23K40/30 , A23L29/212 , A23L29/219 , A23L29/25 , A23L29/281 , A23L29/284 , A23L33/115 , A23P10/30 , A23V2002/00 , A61K9/1652 , A61K9/5073 , A61K9/5169 , A61K31/00 , A61K31/07 , A61K35/60
摘要： A composition comprising hydrophobic droplets coated by a shell and dispersed in a matrix and a consumable product comprising the composition are provided. The hydrophobic droplets comprise a hydrophobic compound, the shell comprises an irreversibly denatured protein, and the matrix comprises a protein, a starch, and a polysaccharide. Also provided are methods for preparing the composition and the consumable product.
摘要翻译：提供了包含由壳涂覆并分散在基质中的疏水性小滴和包含该组合物的消耗品的组合物。疏水性液滴包含疏水性化合物，所述壳包含不可逆变性的蛋白质，所述基质包含蛋白质，淀粉和多糖。还提供了制备组合物和消耗品的方法。

9. 发明申请

WO2015084594A1 COMPOSITION FOR ORAL DELIVERY OF BIOACTIVE AGENTS 审中-公开
标题翻译：用于口服递送生物剂的组合物
公开(公告)号：WO2015084594A1
公开(公告)日：2015-06-11
申请号：PCT/US2014/066510
申请日：2014-11-20
申请人： ADVANCED BIONUTRITION CORPORATION
发明人： HAREL, Moti , KAMBALAPALLY, Swetha
IPC分类号： A61K9/16 , A61K9/08 , A61K47/38 , A61K47/30
CPC分类号： A61K9/0053 , A01N25/28 , A01N43/16 , A61K9/1652 , A61K9/19 , A61K9/5026 , A61K9/5036 , A61K31/573 , A61K39/0275 , A61K39/107 , A61K39/35 , A61K47/36 , A61K47/44 , A61K2039/542 , A61K2039/552 , A61K2039/57 , A61K2039/575
摘要： A composition for oral administration of a bioactive agent to aquatic or terrestrial species includes particles each of which includes a bioactive agent dispersed in oil droplets, the oil droplets being dispersed in a matrix including an enteric coating polymer, wherein the particles each further include a mucoadhesive polymer. Methods of making and using the composition are also provided.
摘要翻译：用于口服给予水生或陆生物种的生物活性剂的组合物包括各自包括分散在油滴中的生物活性剂的颗粒，油滴分散在包含肠溶衣聚合物的基质中，其中颗粒各自还包括粘膜粘附聚合物。还提供了制备和使用该组合物的方法。

10. 发明申请

WO2013036745A3 IPNV-ISAV BIVALENT VACCINE USING A VIRUS-LIKE PARTICLE-BASED PLATFORM AND METHODS OF USING THE SAME 审中-公开
标题翻译：使用基于病毒颗粒的平台的IPNV-ISAV双重疫苗及其使用方法
公开(公告)号：WO2013036745A3
公开(公告)日：2013-05-02
申请号：PCT/US2012054125
申请日：2012-09-07
申请人： ADVANCED BIONUTRITION CORP , DHAR ARUN K
发明人： DHAR ARUN K
IPC分类号： C12N1/19 , A61K39/12 , C12N15/33 , C12N15/81
CPC分类号： A61K39/295 , A61K39/12 , A61K2039/523 , A61K2039/542 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C07K5/101 , C07K7/06 , C07K2319/00 , C12N7/00 , C12N2720/10023 , C12N2720/10034 , C12N2720/10044 , C12N2720/12023 , C12N2720/12034 , C12N2760/16034 , C12N2760/16043
摘要： The present invention provides bivalent oral vaccines against infectious pancreatic necrosis virus (IPNV) and infectious salmon anemia virus (ISAV). Yeast cells comprise an expression vector comprising (i) a polynucleotide sequence encoding a VP2 capsid protein of IPNV and (ii) a polynucleotide sequence encoding one or more antigenic epitopes of hemaglutinin of ISAV. The yeast cells express sub-viral particles (SVP) comprising a VP2 capsid protein of IPNV and one or more antigenic epitopes of hemaglutinin of ISAV. The yeast cells and SVP may be administered in an effective amount to increase the amount of antibodies against IPNV and ISAV in the fish, preferably Salmonidae. The yeast cells and SVP may be in the form of fish food for administering to the fish orally.
摘要翻译：本发明提供针对感染性胰腺坏死病毒（IPNV）和感染性鲑鱼贫血病毒（ISAV）的二价口服疫苗。酵母细胞包含表达载体，其包含（i）编码IPNV的VP2衣壳蛋白的多核苷酸序列和（ii）编码ISAV血凝素的一个或多个抗原表位的多核苷酸序列。酵母细胞表达包含IPNV的VP2衣壳蛋白和ISAV的血凝素的一个或多个抗原表位的亚病毒颗粒（SVP）。可以以有效量施用酵母细胞和SVP以增加鱼，优选鲑科的IPNV和ISAV抗体的量。酵母细胞和SVP可以是鱼类的形式，用于口服给鱼。

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