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1. 发明申请

WO2010042638A3 HPMA - DOCETAXEL OR GEMCITABINE CONJUGATES AND USES THEREFORE 审中-公开
公开(公告)号：WO2010042638A3
公开(公告)日：2010-04-15
申请号：PCT/US2009/059869
申请日：2009-10-07
申请人： LEE, Young Bok , AHN, Chang Ho , KIM, Deog Joong , GHANDEHARI, Hamidreza , RAY, Abhijit , NAN, Anjan
发明人： LEE, Young Bok , AHN, Chang Ho , KIM, Deog Joong , GHANDEHARI, Hamidreza , RAY, Abhijit , NAN, Anjan
IPC分类号： A61K47/48 , A61P35/00
摘要： Disclosed are water-soluble compositions of gemcitabine and docetaxel formed by conjugating the gemcitabine or docetaxel to a water-soluble polymer such as N-2-hydroxypropyl methacrylamide (HPMA). Also disclosed are methods of using the compositions of the invention for the treatment of cancer.

2. 发明申请

WO2005061009A2 MICROPARTICLES FOR MICROARTERIAL IMAGING AND RADIOTHERAPY 审中-公开
标题翻译：微波成像和放射治疗的微量元素
公开(公告)号：WO2005061009A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/019337
申请日：2004-06-18
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , LINE, Bruce, R. , VAN ECHO, David, A. , KENNEDY, Andrew, S. , GHANDEHARI, Hamidreza , NAN, Anjan
发明人： LINE, Bruce, R. , VAN ECHO, David, A. , KENNEDY, Andrew, S. , GHANDEHARI, Hamidreza , NAN, Anjan
IPC分类号： A61K51/12
CPC分类号： A61K51/1255 , A61K51/065 , A61K51/1251 , A61K51/1268 , B82Y5/00
摘要： Microparticles comprising a core, at least one linking carrier on the core, and at least one radioactive therapeutic agent covalently bonded to the linking carrier. The radioactive therapeutic agent may be a radionuclide or a radiopharmaceutical. A method of radiation therapy of a patient by administering to the patient the microparticles. The treatment may be radiation therapy to treat cancer or a tumor. A kit for preparing a microparticle treatment and a method for using the kit to prepare a microparticle treatment dose. The microparticle treatment dose may be made at a location of administration or at a site proximate to the location of administration, such as a local radiopharmacy, laboratory, hospital or physician's office.
摘要翻译：包含芯的芯片，芯上的至少一个连接载体和共价键合到连接载体的至少一种放射性治疗剂。放射性治疗剂可以是放射性核素或放射性药物。一种通过向患者施用微粒而对患者进行放射治疗的方法。治疗可以是用于治疗癌症或肿瘤的放射治疗。用于制备微粒处理的试剂盒和使用该试剂盒来制备微粒处理剂量的方法。微粒治疗剂量可以在施用的位置或在接近施用位置的位置，例如局部放射性药物，实验室，医院或医师办公室进行。

3. 发明申请

WO2003066068A1 HPMA-POLYAMINE CONJUGATES AND USES THEREFORE 审中-公开
标题翻译： HPMA-聚氨酯结合物及其用途
公开(公告)号：WO2003066068A1
公开(公告)日：2003-08-14
申请号：PCT/US2003/002707
申请日：2003-01-31
申请人： INTRADIGM CORPORATION , GHANDEHARI, Hamidreza , WOODLE, Martin, C. , SCARIA, Puthupparampil, V. , NAN, Anjan
发明人： GHANDEHARI, Hamidreza , WOODLE, Martin, C. , SCARIA, Puthupparampil, V. , NAN, Anjan
IPC分类号： A61K31/74
CPC分类号： C07K5/021 , A61K31/74 , A61K47/58 , C07K5/1008 , C07K5/1027 , C12N15/87 , C12N2810/405
摘要： The inventions provide compositions and methods for nucleic acid delivery comprising HPMA conjugated to a polyamine. These compositions have the benefit of the steric hindrance of HPMA and the nucleic acid binding capability of a polyamine. Useful polyamines for this purpose include spermine, spermidine and their analogues, and DFMO. These polyamines have the ability not only to bind nucleic acids, but also have anti-cancer effects themselves. The compounds provided can also include ligand binding domains, such as vascular endothelial growth factors, somatostatin and somatostatin analogs, transferring, melanotropin, ApoE and ApoE peptides, von Willebrand's factor and von Willebrand's factor peptides, adenoviral fiber protein and adenoviral fiber protein peptides, PD 1 and PD 1 peptides, EGF and EGF peptides, RGD peptides, CCK peptides, antibody and antibody fragments, folate, pyridoxyl and sialyl-LewisX and chemical analogs. Methods for using these compositions to achieve a therapeutic effect, including for vaccination, are also provided.
摘要翻译：本发明提供了包含与多胺缀合的HPMA的核酸递送的组合物和方法。这些组合物具有HPMA的空间位阻和多胺的核酸结合能力的益处。有用的多胺用于此目的包括精胺，亚精胺及其类似物，以及DFMO。这些多胺不仅具有结合核酸的能力，而且还具有抗癌作用。所提供的化合物还可以包括配体结合域，例如血管内皮生长因子，生长抑素和生长抑素类似物，转移，黑素素，ApoE和ApoE肽，血管性血友病因子和血管性血友病因子肽，腺病毒纤维蛋白和腺病毒纤维蛋白肽，PD 1和PD 1肽，EGF和EGF肽，RGD肽，CCK肽，抗体和抗体片段，叶酸，吡哆醛和唾液酸-LXXX和化学类似物。还提供了使用这些组合物来实现治疗效果的方法，包括用于疫苗接种。

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