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1. 发明申请

WO2022096331A1 MACHINE LEARNED MOTION ESTIMATION AND COMPENSATION IN CT IMAGES 审中-公开
公开(公告)号：WO2022096331A1
公开(公告)日：2022-05-12
申请号：PCT/EP2021/079751
申请日：2021-10-27
申请人： KONINKLIJKE PHILIPS N.V.
发明人： SCHMITT, Holger , LOSSAU, Tanja , GRASS, Michael
IPC分类号： G06T11/00
摘要： Disclosed is a medical system (100) for processing computed tomography (CT) images (124, 132) comprising motion artifacts. The medical system (100) comprises a memory (110) storing machine executable instructions (120) and a machine learning framework (122) trained to receive a CT image (124, 132) comprising a motion artifact as an input and to provide one or more estimated motion vectors (128) of a motion causing the motion artifact in response as an output. The medical system (100) further comprises a processor (106) for controlling the medical system (100). Execution of the machine executable instructions (120) by the processor (106) causes the processor (106) to control the medical system (100) to receive an initial CT image (124) comprising an initial motion artifact and CT raw projection data (126) used for reconstructing the initial CT image (124), to determine an estimated motion vector field (128) of the motion causing the initial motion artifact using the output of the trained machine learning framework (122) in response to receiving the initial CT image (124) as input, and to reconstruct a motion corrected CT image (132) using the CT raw projection data (126) and the estimated motion vector field (128).

2. 发明申请

WO2018060529A1 APPARATUS FOR DETERMINING A FUNCTIONAL INDEX FOR STENOSIS ASSESSMENT 审中-公开
标题翻译：确定功能评估指标的装置
公开(公告)号：WO2018060529A1
公开(公告)日：2018-04-05
申请号：PCT/EP2017/075021
申请日：2017-10-02
申请人： KONINKLIJKE PHILIPS N.V.
发明人： HAASE, Christian , GRASS, Michael , VAN RENS, Bram, Antonius, Philomena , BULLENS, Roland, Wilhelmus, Maria , RONGEN, Peter, Maria, Johannes , VAN DER HORST, Arjen , FLORENT, Raoul , GAURIAU, Romane, Isabelle, Marie-Bernard , OLIVAN BESCOS, Javier , SCHMITT, Holger , AUVRAY, Vincent, Maurice, André
IPC分类号： A61B5/02 , A61B5/107 , A61B6/00 , A61B5/00 , A61B5/026 , A61B5/021 , G01N21/59
摘要： An apparatus for determining a functional index for stenosis assessment of a vessel is provided. The apparatus comprises an input interface (40) and a processing unit (50). The input interface is configured to obtain image data (30) representing a two-dimensional representation of a vessel (6). The processing unit (50) is configured to determine a course of the vessel (6) and a width (w1, w2) of the vessel along its course in the image data and is further configured to determine the functional index for stenosis assessment of the vessel based on the width of the vessel in the image data.
摘要翻译：提供了一种用于确定血管狭窄评估的功能指标的装置。该装置包括输入接口（40）和处理单元（50）。输入接口被配置为获得表示血管（6）的二维表示的图像数据（30）。处理单元（50）被配置为确定血管（6）的走向以及血管沿着其在图像数据中的路线的宽度（w1，w2），并且还被配置为确定血管（6）的狭窄评估的功能指数根据图像数据中血管的宽度设置血管。

3. 发明申请

WO2017001551A1 DEVICE AND METHOD FOR PROCESSING COMPUTER TOMOGRAPHY IMAGING DATA 审中-公开
标题翻译：用于处理计算机图像成像数据的装置和方法
公开(公告)号：WO2017001551A1
公开(公告)日：2017-01-05
申请号：PCT/EP2016/065286
申请日：2016-06-30
申请人： KONINKLIJKE PHILIPS N.V.
发明人： CAROLUS, Heike , KABUS, Sven , KLINDER, Tobias , SCHMITT, Holger
IPC分类号： G06T7/00 , G06T11/00
CPC分类号： G06T7/38 , G06T11/008 , G06T2207/10076 , G06T2207/30104 , G06T2211/404
摘要： The invention relates to a device for processing CT imaging data, comprising a processing unit, which is configured to receive a plurality of sets of CT imaging data recorded at different imaging positions and at different points in time. Furthermore, the processing device is configured to provide a plurality of auxiliary sets of CT imaging data, each auxiliary set of CT imaging data comprising processed image data allocated to spatial positions inside a respective spatial section of the object space, wherein a given one of the spatial sections contains those spatial positions which are covered by those sets of CT imaging data acquired at a respective one of the imaging positions, and to generate the processed image data for a given spatial position using those of the sets of CT imaging data acquired at the respective one of the imaging positions.
摘要翻译：本发明涉及一种用于处理CT成像数据的设备，包括处理单元，其被配置为接收记录在不同成像位置和不同时间点的多组CT成像数据。此外，处理装置被配置为提供多个CT成像数据的辅助组，每个辅助的CT成像数据组包括分配给对象空间的相应空间部分内的空间位置的经处理的图像数据，其中给定的一个空间部分包含这些空间位置，这些空间位置由在成像位置的相应一个处获取的那些CT成像数据组覆盖，并且使用在该位置处获取的CT成像数据集合来生成给定空间位置的处理图像数据相应的一个成像位置。

4. 发明申请

WO2016174010A1 FRACTIONAL FLOW RESERVE DETERMINATION 审中-公开
标题翻译：分流流量确定
公开(公告)号：WO2016174010A1
公开(公告)日：2016-11-03
申请号：PCT/EP2016/059248
申请日：2016-04-26
申请人： KONINKLIJKE PHILIPS N.V.
发明人： HANSIS, Eberhard Sebastian , SCHMITT, Holger , GRASS, Michael , SCHAEFER, Dirk , HOMANN, Hanno Heyke , KLINDER, Tobias , HAASE, Christian
IPC分类号： G06T17/20
CPC分类号： G06T17/20 , A61B5/004 , A61B5/02007 , A61B5/0285 , A61B5/1128 , G06T2210/41 , G16H50/50
摘要： The present invention relates to a device (1) for fractional flow reserve determination, the device (1) comprising: a model source (10) configured to provide a first three-dimensional model (3DM1) of a portion of an imaged vascular vessel tree (VVT) surrounding a stenosed vessel segment (SVS) and configured to provide a second three- dimensional model (3DM2) of a pressure wire insertable into the vascular vessel tree (VVT); and a processor (20) configured to calculate a first blood flow (Q1) through the stenosed vessel segment (SVS) with the pressure wire (PW) inserted into the vascular vessel tree (VVT) based on the first and the second three-dimensional model and to calculate a second blood flow (Q2) through the stenosed vessel segment (SVS) without the pressure wire (PW) inserted into the vascular vessel tree (VVT) based on the first three-dimensional model (3DM1) and to determine a first fractional flow reserve value (FFR1) to be measured with the pressure wire (PW) inserted into the vascular vessel tree (VVT) based on the first blood flow (Q1) and to determine a second fractional flow reserve value (FFR2) to be measured without the pressure wire (PW) inserted into the vascular vessel tree (VVT) based on the second blood flow (Q1).
摘要翻译：本发明涉及用于分数流储备确定的装置（1），装置（1）包括：模型源（10），被配置为提供成像血管血管树的一部分的第一三维模型（3DM1）（VVT），并且被配置为提供可插入到血管血管树（VVT）中的压力线的第二三维模型（3DM2）; 以及处理器（20），其被配置为基于所述第一和第二三维计算通过所述狭窄血管段（SVS）的第一血流（Q1），所述压力线（PW）插入所述血管血管树（VVT）模型，并且基于第一三维模型（3DM1）计算通过狭窄的血管段（SVS）的第二血流（Q2），而没有将压力线（PW）插入血管血管树（VVT）中，并且确定基于第一血流量（Q1），使用插入血管血管树（VVT）的压力线（PW）测量的第一分数流量储备值（FFR1），并确定第二分数流量储备值（FFR2）为基于第二血流量（Q1），没有插入血管血管树（VVT）中的压力线（PW）被测量。

5. 发明申请

WO2015185308A1 DEVICE AND METHOD FOR REGISTRATION OF TWO IMAGES 审中-公开
标题翻译：用于注册两个图像的设备和方法
公开(公告)号：WO2015185308A1
公开(公告)日：2015-12-10
申请号：PCT/EP2015/059711
申请日：2015-05-04
申请人： KONINKLIJKE PHILIPS N.V.
发明人： RUPPERTSHOFEN, Heike , KABUS, Sven , SCHMITT, Holger
IPC分类号： G06T7/00
CPC分类号： G06T7/33 , G06T2207/10072 , G06T2207/20101 , G06T2207/30004
摘要： The present invention relates to a device and method for registration of two images. To increase the accuracy of the registration the device comprises an input unit (126) for receiving one or more pairs of negative landmarks, which are indicated in the two images, a pair comprising two negative landmarks, one in each image, which structures are not identical and should not be aligned by the registration. Further, a registration unit (128) is provided for performing a registration of the two images by determining a transformation for transforming at least one of the images for registering it with the other image and determining a spacing measure of the distance between a first landmark in the transformed image and a second landmark in the other image, wherein the transformation is determined such that the spacing measure for a first landmark and a second landmark of at least one pair of negative landmarks is above a first distance threshold, whereby the negative landmarks are taken into account in the registration but are not aligned by the registration.
摘要翻译：本发明涉及一种用于登记两个图像的装置和方法。为了提高注册的准确性，该装置包括用于接收在两个图像中指示的一对或多对负地标对的输入单元（126），包括两个负的地标，每个图像中的一个，哪些结构不是相同，不应该通过注册来对齐。此外，提供了一种注册单元（128），用于通过确定用于变换用于将其登记的图像中的至少一个与其他图像进行变换的变换来执行两个图像的注册，并且确定第二地图之间的距离的间隔度量所述变换的图像和所述另一图像中的第二地标，其中所述变换被确定为使得至少一对负地标的第一地标和第二地标的间距测量高于第一距离阈值，由此所述负地标是在注册时考虑到，但不符合注册。

6. 发明申请

WO2015082576A1 LOCAL FFR ESTIMATION AND VISUALISATION FOR IMPROVED FUNCTIONAL STENOSIS ANALYSIS 审中-公开
标题翻译：局部FFR估计和可视化改进功能性STENOSIS分析
公开(公告)号：WO2015082576A1
公开(公告)日：2015-06-11
申请号：PCT/EP2014/076477
申请日：2014-12-04
申请人： KONINKLIJKE PHILIPS N.V.
发明人： NICKISCH, Hannes , GRASS, Michael , SCHMITT, Holger , TIMMER, Jan
IPC分类号： A61B5/00 , A61B5/02 , G06T7/00 , A61B5/026
CPC分类号： A61B6/507 , A61B5/02007 , A61B5/02028 , A61B5/026 , A61B5/742 , A61B6/032 , A61B6/4441 , A61B6/463 , A61B6/481 , A61B6/504 , A61B6/5217 , G06F19/00 , G06T7/0012 , G06T2207/10072 , G06T2207/10081 , G06T2207/10121 , G06T2207/20081 , G06T2207/30104 , G06T2207/30172 , G16H50/50
摘要： A system (IPS) and related method for fractional flow reserve, FFR, simulation. The simulation for a range of FFR values for a vasculature portion is based on a composite transfer function which is combined from a weighted sum of global effect transfer functions he, each representing a distinct physical effect that causes a pressure drop. The weights we are gotten from a previous training phase against pressure pi versus flow rate fi 5 sample measurements associated with respective vasculature geometries. The simulated range of FFR values is visualized in a graphics display (GD) as a function of pressure and flow rate values within respective intervals.
摘要翻译：一种系统（IPS）及相关方法，用于分数流量储备，FFR，模拟。用于脉管系统部分的FFR值范围的模拟基于复合传递函数，该复合传递函数从全局效应传递函数he的加权和组合而来，每个表示导致压降的不同物理效应。我们从以前的训练阶段获得的重量与压力pi相对于流速fi相关的5个样本测量结果相关联的脉管系统几何。 FFR值的模拟范围在图形显示（GD）中可视化，作为各个间隔内的压力和流量值的函数。

7. 发明申请

WO2015055599A2 REGISTRATION OF MEDICAL IMAGES 审中-公开
标题翻译：医学图像注册
公开(公告)号：WO2015055599A2
公开(公告)日：2015-04-23
申请号：PCT/EP2014/071934
申请日：2014-10-14
申请人： KONINKLIJKE PHILIPS N.V.
发明人： KABUS, Sven , RUPPERTSHOFEN, Heike , SCHMITT, Holger
IPC分类号： G06T7/00
CPC分类号： G06T7/0024 , A61B5/055 , A61B6/032 , A61B6/037 , A61B6/469 , A61B6/5247 , A61B8/00 , G01R33/4812 , G01R33/5608 , G06T3/0068 , G06T7/0012 , G06T7/11 , G06T7/30 , G06T2207/20012 , G06T2207/20092 , G06T2207/20104 , G06T2207/30004
摘要： The invention relates to a method and an image processing device (50) for the registration of two images(I 1 , I 2 ) that may for example be provided by a CT scanner (10) and/or an MRI scanner (20). According to one embodiment of the invention, the images are first globally registered (GR) with a given registration algorithm using a first parameter vector ( p 0 ). A user may then select a region of interest ROI, and a plurality of local registrations (LR1,... LRs,... LRn) are calculated for this ROI using the same registration algorithm but different parameter vectors( p 1 , p 2 , … p n ). The results of the local registrations (LR1,... LRs,... LRn) are displayed and the user can select the best local registration(s). In a final step, the selected local registration(s) (LRs) and the global registration (GR) may be merged. Additionally or alternatively, a parameter vector for a local registration in the ROI may be determined by an automatic analysis of the ROI.
摘要翻译：本发明涉及一种用于两个图像（I 1，I 2）的配准的方法和图像处理设备（50），该图像（I 1，I 2，...）可以例如由CT扫描仪（10）和/或MRI扫描仪（20）提供。根据本发明的一个实施例，图像首先利用第一参数矢量（ρ0）与给定的注册算法全局注册（GR）。然后，用户可以选择感兴趣区域ROI，并且使用相同的注册算法但是不同的参数向量（p 1 ，_{2 ，... _{n ）。显示本地注册（LR1，... LRs，... LRn）的结果，用户可以选择最佳本地注册。在最后一步中，所选的本地注册（LR）和全球注册（GR）可以合并。另外地或可选地，用于ROI中的本地注册的参数向量可以通过ROI的自动分析来确定。}}

8. 发明申请

WO2014167511A1 SHAPE SENSED ULTRASOUND PROBE FOR FRACTIONAL FLOW RESERVE SIMULATION 审中-公开
标题翻译：形状感应超声探头，用于分流流量保留模拟
公开(公告)号：WO2014167511A1
公开(公告)日：2014-10-16
申请号：PCT/IB2014/060559
申请日：2014-04-09
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS DEUTSCHLAND GMBH
发明人： KLINDER, Tobias , SCHMITT, Holger , GRASS, Michael
IPC分类号： A61B5/00 , A61B5/02 , A61B5/107 , A61B8/08 , A61B8/12 , A61B8/00 , A61B5/06
CPC分类号： A61B5/026 , A61B5/0066 , A61B5/0073 , A61B5/0084 , A61B5/02028 , A61B5/065 , A61B5/066 , A61B5/1076 , A61B5/4887 , A61B5/6852 , A61B8/085 , A61B8/0891 , A61B8/12 , A61B8/445 , A61B8/5276 , A61B2017/00084 , A61B2034/105 , A61B2034/2051 , A61B2034/2061 , A61B2090/3735 , A61B2090/3782 , A61B2560/0475 , G16H50/50
摘要： A medical system includes a medical instrument (102) configured for interventional deployment and a shape sensing system (104) mounted on or in the medical instrument and configured to measure a shape of the medical instrument during the interventional deployment. An imaging device (106) is mounted on or in the medical instrument and configured to image a lumen in which the imaging device is deployed. A registration module (140) is configured to register the shape of the medical instrument to an image of the lumen at a particular time to reconstruct a three-dimensional geometry of the lumen, accounting for motion.
摘要翻译：医疗系统包括被配置为用于介入部署的医疗器械（102）和安装在医疗器械上或其中的形状感测系统（104），并且被配置为在介入部署期间测量医疗器械的形状。成像装置（106）安装在医疗器械上或其中，并被配置成对其中部署成像装置的管腔进行成像。注册模块（140）被配置为在特定时间将医疗器械的形状注册到管腔的图像，以重建管腔的三维几何形状，从而考虑运动。

9. 发明申请

WO2023057189A1 DETERMINING VESSEL PARAMETERS 审中-公开
公开(公告)号：WO2023057189A1
公开(公告)日：2023-04-13
申请号：PCT/EP2022/075750
申请日：2022-09-16
申请人： KONINKLIJKE PHILIPS N.V.
发明人： FLORENT, Raoul , LEVRIER, Claire , ALEXANDRE, This , SCHMITT, Holger , VAN DER HORST, Arjen
IPC分类号： A61B6/00 , A61B6/481 , A61B6/486 , A61B6/504 , A61B6/507 , A61B6/5217
摘要： A system (100) for providing value of a transit velocity of an injected contrast agent bolus in a lumen, is provided. The system comprises one or more processors (120) configured to: receive X-ray angiographic image data comprising a temporal sequence of images representing a flow of the injected contrast agent bolus through a vessel tree comprising the lumen; generate a time-intensity curve for the vessel tree from the temporal sequence of images; calculate a transit time (TT) from the time-intensity curve; determine an estimate of the transit length (dT) of the lumen based on an analysis of an earlier X-ray image and a later X-ray image; and calculate the value of the transit velocity of the injected contrast agent bolus in the lumen based on a ratio of the estimated transit length (dT) to the calculated transit time (TT).

10. 发明申请

WO2018185298A1 FRACTIONAL FLOW RESERVE SIMULATION PARAMETER CUSTOMIZATION, CALIBRATION AND/OR TRAINING 审中-公开
公开(公告)号：WO2018185298A1
公开(公告)日：2018-10-11
申请号：PCT/EP2018/058885
申请日：2018-04-06
申请人： KONINKLIJKE PHILIPS N.V.
发明人： NICKISCH, Hannes , SCHMITT, Holger
IPC分类号： G16H50/30 , G16H50/50
CPC分类号： G16H50/30 , G16H50/50
摘要： A computing system (118) includes a computer readable storage medium (122) with computer executable instructions (124), including a including a biophysical simulator (126) with a segmentor (202) and a boundary condition determiner (206). The computing system further includes a processor (120) configured to execute the biophysical simulator to compute a fractional flow reserve index with cardiac imaging data and at least one of an adapted coronary tree segmentation and an adapted boundary condition.

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