专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009072079A2 POLYMERIC DRUG CARRIER FOR IMAGE-GUIDED DELIVERY 审中-公开
标题翻译：用于图像引导递送的聚合物药物载体
公开(公告)号：WO2009072079A2
公开(公告)日：2009-06-11
申请号：PCT/IB2008/055098
申请日：2008-12-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LANGEREIS, Sander , GRUELL, Holger , MESSAGER, Léa, L., P. , PIKKEMAAT, Jeroen, A. , BURDINSKI, Dirk
发明人： LANGEREIS, Sander , GRUELL, Holger , MESSAGER, Léa, L., P. , PIKKEMAAT, Jeroen, A. , BURDINSKI, Dirk
IPC分类号： A61K41/00 , A61K49/00 , A61K49/18 , A61K9/00 , A61K9/127
CPC分类号： A61K41/0028 , A61K9/1273 , A61K49/1812
摘要： Described are Chemical Exchange-dependent Saturation Transfer (CEST) contrast agents for Magnetic Resonance Imaging (MRI) comprising a polymersome provided with a paramagnetic agent. The polymersome preferably comprises a polymeric shell enclosing a cavity, wherein the cavity comprises a pool of proton analytes, and wherein the shell allows diffusion of the proton analytes. The polymersome-based CEST MRI contrast agents are suitable as drug carriers useful in MRI-guided drug release.
摘要翻译：描述了用于磁共振成像（MRI）的化学交换依赖性饱和转移（CEST）造影剂，其包含提供有顺磁性试剂的聚合物囊泡。聚合物囊泡优选包含封闭空腔的聚合物壳，其中空腔包含质子分析物池，并且其中壳允许质子分析物扩散。聚合物基CEST MRI造影剂适合用作MRI引导药物释放的药物载体。

2. 发明申请

WO2010073184A1 MR IMAGING WITH CEST CONTRAST ENHANCEMENT 审中-公开
标题翻译：成像与CEST对比增强
公开(公告)号：WO2010073184A1
公开(公告)日：2010-07-01
申请号：PCT/IB2009/055760
申请日：2009-12-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , PIKKEMAAT, Jeroen, A. , LANGEREIS, Sander , GRUELL, Holger , BURDINSKI, Dirk , LAMERICHS, Rudolf, M., J., N. , KEUPP, Jochen
发明人： PIKKEMAAT, Jeroen, A. , LANGEREIS, Sander , GRUELL, Holger , BURDINSKI, Dirk , LAMERICHS, Rudolf, M., J., N. , KEUPP, Jochen
IPC分类号： G01R33/28
CPC分类号： G01R33/5601 , G01R33/5616
摘要： The invention relates to a method of MR imaging of at least a portion of a body of a patient placed in an examination volume of an MR device. The object of the invention is to improve CEST contrast enhanced imaging. The method of the invention comprises the following steps: a) saturation of nuclear magnetization of exchangeable protons of a CEST contrast agent administered to the patient by subjecting the portion of the body to at least one frequency-selective saturation RF pulse matched to the MR frequency of exchangeable protons of the CEST contrast agent, wherein the saturation period, i.e. the duration of the frequency-selective saturation RF pulse, is shorter than the time required for saturation to build up a full CEST contrast enhancement effect when starting from zero saturation; b) generating at least one MR signal of water protons of the body by subjecting the portion of the body to an MR imaging sequence comprising at least one RF pulse and switched magnetic field gradients; c) acquiring and sampling the at least one MR signal from the body; d) repeating steps a) to c) a number of times under variation of parameters of the MR imaging sequence, wherein MR signals are acquired and sampled during a saturation build-up period, i.e. before a steady state of the CEST effect is achieved; e) reconstructing a proton-density weighted, CEST contrast-enhanced MR image from the acquired and sampled MR signals
摘要翻译：本发明涉及放置在MR装置检查体积中的患者身体的至少一部分的MR成像方法。本发明的目的是改善CEST对比度增强成像。本发明的方法包括以下步骤：a）通过使身体的一部分经受与MR频率匹配的至少一个频率选择性饱和RF脉冲，使给予患者的CEST造影剂的可交换质子的核磁化饱和的CEST造影剂的可交换质子，其中饱和周期，即频率选择性饱和RF脉冲的持续时间比从零饱和开始时建立饱和CEST对比度增强效果所需的时间短; b）通过使身体的一部分经受包括至少一个RF脉冲和切换的磁场梯度的MR成像序列来产生身体的水质子的至少一个MR信号; c）从身体获取和采样至少一个MR信号; d）在MR成像序列的参数变化下重复步骤a）至c）多次，其中在饱和建立期间，即在实现CEST效应的稳定状态之前获取和采样MR信号; e）从获取和采样的MR信号重构质子密度加权的CEST对比度增强的MR图像

3. 发明申请

WO2009069051A2 NON-SPHERICAL CONTRAST AGENTS FOR CEST MRI BASED ON BULK MAGNETIC SUSCEPTIBILITY EFFECT 审中-公开
标题翻译：非球形对比剂基于大块磁性可靠性影响的CEST MRI
公开(公告)号：WO2009069051A2
公开(公告)日：2009-06-04
申请号：PCT/IB2008/054894
申请日：2008-11-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BURDINSKI, Dirk , LANGEREIS, Sander , PIKKEMAAT, Jeroen, A.
发明人： BURDINSKI, Dirk , LANGEREIS, Sander , PIKKEMAAT, Jeroen, A.
IPC分类号： A61K49/18
CPC分类号： A61K49/1812 , A61K49/1815
摘要： In magnetic resonance imaging (MRI) based on chemical exchange-dependent saturation transfer (CEST), a novel carrier for CEST contrast agents is provided. The carrier is non-spherical and comprises a semipermeable shell, wherein the shell comprises a paramagnetic compound. The shell encloses a cavitycomprising an MR analyte, wherein the semipermeable shell allows diffusion of the MR analyte. The CEST effect is based on the 5 bulk magnetic susceptibility effect caused by the anisotropy of the carrier. This leads to a versatile carrier that does not require interaction of the analyte with a paramgnetic chemical shift reagent.
摘要翻译：在基于化学交换依赖性饱和转移（CEST）的磁共振成像（MRI）中，提供了一种用于CEST造影剂的新载体。载体是非球形的并且包含半透性壳，其中壳包含顺磁性化合物。壳体包围一个包含MR分析物的空腔，其中半透膜允许MR分析物的扩散。 CEST效应基于由载体的各向异性引起的5体积磁化率效应。这导致通用载体，其不需要分析物与辅助化学位移试剂的相互作用。

4. 发明申请

WO2009060403A2 CEST MRI CONTRAST AGENTS BASED ON NON-SPHERICAL PARTICLES 审中-公开
标题翻译：基于非球形粒子的CEST MRI造影剂
公开(公告)号：WO2009060403A2
公开(公告)日：2009-05-14
申请号：PCT/IB2008/054630
申请日：2008-11-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LANGEREIS, Sander , BURDINSKI, Dirk , BEVERS, Edouard, M. , HACKENG, Tilman, M. , PIKKEMAAT, Jeroen, A.
发明人： LANGEREIS, Sander , BURDINSKI, Dirk , BEVERS, Edouard, M. , HACKENG, Tilman, M. , PIKKEMAAT, Jeroen, A.
IPC分类号： A61K49/18
CPC分类号： A61K49/1896
摘要： In magnetic resonance imaging (MRI) based on chemical exchange-dependent saturation transfer (CEST), a carrier for CEST contrast agents is provided which comprises a paramagnetic chemical shift reagent and a source of protons with which the chemical shift reagent can interact, so as to provide chemically shifted protons. It is desired for a CEST contrast agent to be non-spherical, so as to allow a bulk magnetic susceptibility effect of the poolofprotons within the agent to contribute to the CEST effect. Intrinsically non-spherical carriers are provided on the basis of erythrocyte ghosts.
摘要翻译：在基于化学交换依赖性饱和转移（CEST）的磁共振成像（MRI）中，提供了用于CEST造影剂的载体，其包含顺磁性化学位移试剂和质子源，化学位移试剂可以相互作用，从而提供化学位移的质子。希望CEST造影剂是非球形的，以便允许试剂内的池质体的大磁化率效应对CEST效应起作用。根据红细胞重影提供本质上非球形的载体。

5. 发明申请

WO2011001351A1 STIMULI-RESPONSIVE CARRIERS FOR MPI-GUIDED DRUG DELIVERY 审中-公开
标题翻译：用于MPI指导药物递送的刺激感染携带者
公开(公告)号：WO2011001351A1
公开(公告)日：2011-01-06
申请号：PCT/IB2010/052918
申请日：2010-06-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , BURDINSKI, Dirk , PIKKEMAAT, Jeroen, A. , SCHMITT, Bertrand , GRUELL, Holger , LANGEREIS, Sander
发明人： BURDINSKI, Dirk , PIKKEMAAT, Jeroen, A. , SCHMITT, Bertrand , GRUELL, Holger , LANGEREIS, Sander
IPC分类号： A61K9/00
CPC分类号： A61K9/0009
摘要： The present invention relates to a composition comprising a shell structure forming a cavity,wherein said shell structure comprises a drug and wherein said composition is associated with at least one contrast agent; wherein said shell structure is capable of releasing its contents into the exterior upon the application of an external stimulus and wherein said contrast agent comprises magnetic particles which are capable of being detected by Magnetic Particle Imaging (MPI), wherein at least more than 5% (w/w) of the magnetic particles comprised in said contrast agent have a magnetic moment of at least -18 m 2 A, 10 wherein said magnetic particles are preferably composed of Fe, Co, Ni, Zn or Mn or alloys thereof or oxides of any of these. The present invention further relates to the use of such a composition or a composition comprising a shell structure forming a cavity,wherein said shell structure comprises a drug and wherein said composition is associated with at least one contrast agent, wherein said contrast agent is capable of being detected by MPI and wherein said shell structure is capable of releasing its contents into the exterior upon the application of an external stimulus as a carrier for a controlled delivery of a drug, as well as to a method of data acquisition for the control ofa drug delivery process comprising the detection or localization via MPI of such compositions. In a further aspect the present invention relates to such compositions for treating a pathological condition, wherein the treatment comprises the release of the drug by the application of a stimulus.
摘要翻译：本发明涉及包含形成空腔的壳结构的组合物，其中所述壳结构包含药物，其中所述组合物与至少一种造影剂缔合; 其中所述壳结构能够在施加外部刺激时将其内容物释放到外部，并且其中所述造影剂包括能够通过磁性粒子成像（MPI）检测的磁性颗粒，其中至少大于5％ w / w）包含在所述造影剂中的磁性颗粒具有至少-18m 2 A，10的磁矩，其中所述磁性颗粒优选由Fe，Co，Ni，Zn或Mn组成或其合金或其合金或任何这些。本发明还涉及这种组合物或包含形成空腔的壳结构的组合物的用途，其中所述壳结构包含药物，并且其中所述组合物与至少一种造影剂缔合，其中所述造影剂能够由MPI检测，并且其中所述壳结构能够在施加外部刺激作为用于药物的受控递送的载体时将其内容物释放到外部，以及用于控制药物的数据采集方法递送过程包括通过这种组合物的MPI的检测或定位。在另一方面，本发明涉及用于治疗病理状况的这种组合物，其中所述治疗包括通过施用刺激物释放药物。

6. 发明申请

WO2010029469A1 DRUG CARRIER PROVIDING MRI CONTRAST ENHANCEMENT 审中-公开
标题翻译：药物载体提供MRI对比增强
公开(公告)号：WO2010029469A1
公开(公告)日：2010-03-18
申请号：PCT/IB2009/053836
申请日：2009-09-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , LANGEREIS, Sander , KEUPP, Jochen , GRUELL, Holger , BURDINSKI, Dirk , BEELEN, Danielle
发明人： LANGEREIS, Sander , KEUPP, Jochen , GRUELL, Holger , BURDINSKI, Dirk , BEELEN, Danielle
IPC分类号： A61K49/06 , A61K49/18 , A61K9/127
CPC分类号： A61K49/08 , A61K9/127 , A61K9/1271 , A61K9/1273 , A61K41/0028 , A61K49/10 , A61K49/12 , A61K49/1812
摘要： Described are drug carriers useful in magnetic resonance imaging (MRI)-guided drug release comprising a shell capable of releasing an enclosed biologically active agent as a result of a local stimulus, e.g. energy input, such as heat, wherein the shell encloses a 19 F MR contrast agent. Preferably, the carrier also acts as a contrast enhancement agent for MRI based on the principle of Chemical Exchange-dependent Saturation Transfer (CEST). To this end the shell encloses a cavity that comprises a paramagnetic chemical shift reagent, a pool of proton analytes, and the 19 F contrast agent, and wherein the shell allows diffusion of the proton analytes.
摘要翻译：描述了可用于磁共振成像（MRI）指导的药物释放的药物载体，其包含能够释放作为局部刺激的结果的封闭的生物活性剂的壳，例如，能量输入，例如热量，其中壳体包围19F MR造影剂。优选地，基于化学交换依赖性饱和转移（CEST）的原理，载体也用作MRI的对比度增强剂。为此，壳体包围包含顺磁化学位移试剂，质子分析物池和19F造影剂的空腔，并且其中壳允许质子分析物的扩散。

7. 发明申请

WO2008132666A1 T1 REDUCTION IN 19F MAGNETIC RESONANCE IMAGING (MRI) 审中-公开
标题翻译： 19F磁共振成像中的T1减少（MRI）
公开(公告)号：WO2008132666A1
公开(公告)日：2008-11-06
申请号：PCT/IB2008/051560
申请日：2008-04-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LAMERICHS, Rudolf, M., J., N. , BURDINSKI, Dirk , LANGEREIS, Sander , WEGH, Rene, T. , GRUELL, Holger
发明人： LAMERICHS, Rudolf, M., J., N. , BURDINSKI, Dirk , LANGEREIS, Sander , WEGH, Rene, T. , GRUELL, Holger
IPC分类号： A61K49/08 , A61K49/10 , A61K49/18 , C07C49/167 , C07C49/24 , C07C49/92 , C07F5/00 , A61B5/055
CPC分类号： C07C49/92 , A61K49/106 , A61K49/1818 , B82Y5/00 , G01R33/5601
摘要： Nanoparticles comprising paramagnetic complexes and use thereof are provided which are designed for the purpose of shortening the Tl relaxation time of fluorinated contrast agents in 19 F Magnetic Resonance Imaging. Preferably, the complexes are included in perfluorinated nanoparticle 19 F MRI contrast agents.
摘要翻译：提供包含顺磁性复合物的纳米颗粒及其用途，其被设计用于缩短氟化造影剂在19 F磁共振成像中的T1弛豫时间。优选地，所述复合物包括在全氟化纳米颗粒中的MRI造影剂。

8. 发明申请

WO2012007886A1 LIPID BILAYER CARRIER FOR DRUGS OR IMAGING AGENTS 审中-公开
标题翻译：用于药物或成像剂的LIPID BILAYER载体
公开(公告)号：WO2012007886A1
公开(公告)日：2012-01-19
申请号：PCT/IB2011/053047
申请日：2011-07-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LANGEREIS, Sander , GRUELL, Holger , DE SMET, Mariska , AUSSEMS-CUSTERS, Erica, Maria, Gerarda , LUB, Johan
发明人： LANGEREIS, Sander , GRUELL, Holger , DE SMET, Mariska , AUSSEMS-CUSTERS, Erica, Maria, Gerarda , LUB, Johan
IPC分类号： A61K9/127 , A61K31/704 , A61K41/00 , A61K49/18
CPC分类号： A61K9/127 , A61K31/704 , A61K41/0028 , A61K49/106 , A61K49/1812
摘要： Disclosed are carriers for drugs and/or MR imaging agents having a lipid bilayer shell comprising a phospholipid having two terminal alkyl chains, one being a short chain having a chain length of at most seven carbon atoms, the other being a long chain having a chain length of at least fifteen carbon atoms. The mixed long/short chain phospholipids serve to tune the release properties of the carrier. Preferred phospholipids are phosphatidylcholines.
摘要翻译：公开了具有脂质双层壳的药物和/或MR成像剂的载体，其包含具有两个末端烷基链的磷脂，一个是具有至多7个碳原子的链长的短链，另一个是具有链的长链长度至少十五个碳原子。混合的长/短链磷脂用于调节载体的释放性质。优选的磷脂是磷脂酰胆碱。

9. 发明申请

WO2011036619A2 TWO STEP ULTRASOUND PROTOCOL FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的两步超声波协议
公开(公告)号：WO2011036619A2
公开(公告)日：2011-03-31
申请号：PCT/IB2010/054232
申请日：2010-09-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , UNIVERSITE VICTOR SEGALEN BORDEAUX 2 , GRUELL, Holger , LANGEREIS, Sander , DE SMET, Mariska , MOONEN, Chrétien Theophilus Willibrordus , YUDINA, Anna , BOHMER, Marcel Rene
发明人： GRUELL, Holger , LANGEREIS, Sander , DE SMET, Mariska , MOONEN, Chrétien Theophilus Willibrordus , YUDINA, Anna , BOHMER, Marcel Rene
IPC分类号： A61K9/127
CPC分类号： A61K9/1271 , A61K9/0009 , A61K41/0028
摘要： Described is a method for the delivery of a bio-active molecule to a mammal comprising the steps of; (i) administering a Physiological Temperature Sensitive Carrier comprising a bio -active molecule; (ii) using a first ultrasound pulse so as to release the bio- active molecule from the temperature sensitive carrier, and (iii) using a second ultrasound pulse so as to facilitate sonoporation and subsequent intracellular uptake of the bio-active molecule, wherein step (iii) can be performed before, and/or after steps (i) to (ii). The method according to the invention is applicable to a broad range of bio-active molecules such as nucleotide based drugs (e.g. siRNA, mRNA, antisense, plasmid DNA) or small molecules that otherwise would not cross the cell membrane, including peptides and small proteins.
摘要翻译：描述了将生物活性分子递送至哺乳动物的方法，包括以下步骤：（i）施用包含生物活性分子的生理温度敏感载体; （ii）使用第一超声波脉冲以从所述温度敏感载体释放所述生物活性分子，和（iii）使用第二超声波脉冲，以促进所述生物活性分子的超声和随后的细胞内摄取，其中步骤（iii）可以在步骤（i）至（ii）之前和/或之后进行。根据本发明的方法适用于广泛的生物活性分子，例如基于核苷酸的药物（例如siRNA，mRNA，反义，质粒DNA）或否则不会穿过细胞膜的小分子，包括肽和小蛋白。

10. 发明申请

WO2010029500A1 CHELATING AMPHIPHILIC POLYMERS 审中-公开
标题翻译：吸引人气聚合物
公开(公告)号：WO2010029500A1
公开(公告)日：2010-03-18
申请号：PCT/IB2009/053921
申请日：2009-09-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , GRUELL, Holger , DE VRIES, Anke , LANGEREIS, Sander , LUB, Johan , AUSSEMS-CUSTERS, Erica, M., G.
发明人： GRUELL, Holger , DE VRIES, Anke , LANGEREIS, Sander , LUB, Johan , AUSSEMS-CUSTERS, Erica, M., G.
IPC分类号： A61K9/51 , A61K47/48 , A61K49/00
CPC分类号： C08G81/025 , A61K9/107 , A61K9/1075 , A61K9/1273 , A61K9/5146 , A61K49/0414 , A61K49/126 , A61K49/1806 , A61K49/1812 , A61K49/1818 , A61K51/06 , A61K51/065 , A61K51/1217 , A61K51/1237 , A61K51/1251
摘要： Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with 5 the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1 /T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.
摘要翻译：描述的是具有螯合部分的两亲性聚合物。两亲聚合物是包含亲水嵌段和疏水嵌段的嵌段共聚物，螯合部分连接到亲水嵌段的端基。所公开的聚合物能够自组装成结构如胶束和聚合物囊泡。使用与5个螯合部分配位络合物形式的合适金属，本发明的螯合两亲性聚合物适用于需要金属标记的各种成像技术，例如MRI（T 1 / T 2加权造影剂或CEST对比度药剂）SPECT，PET或光谱CT。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式