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1. 发明申请

WO2011048529A1 ANALYZING TOOL FOR AMPLIFICATION REACTIONS 审中-公开
标题翻译：分析反应分析工具
公开(公告)号：WO2011048529A1
公开(公告)日：2011-04-28
申请号：PCT/IB2010/054646
申请日：2010-10-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KAHLMAN, Josephus Arnoldus Henricus Maria , NIJSEN, Tamara Mathea Elisabeth , YIN, Bin
发明人： KAHLMAN, Josephus Arnoldus Henricus Maria , NIJSEN, Tamara Mathea Elisabeth , YIN, Bin
IPC分类号： G06F19/24
CPC分类号： G06F19/24
摘要： The invention relates to a method and apparatus for obtaining information from an amplification curve of a target nucleic acid sequence or sequences by defining at least one model function that describes the amplification curve and that contains at least one parameter that is related to a physical quantity that influences the signals recorded, fitting said model function to the amplification curve, and obtaining information with respect to said physical quantity by identifying the value of said parameter that results in the best fit of the model function.
摘要翻译：本发明涉及一种通过定义描述扩增曲线的至少一个模型函数并且包含与物理量相关的至少一个参数来从靶核酸序列或序列的扩增曲线获得信息的方法和装置，影响记录的信号，将所述模型函数拟合到放大曲线，并通过识别导致模型函数的最佳拟合的所述参数的值来获得关于所述物理量的信息。

2. 发明申请

WO2011073867A1 SUBSTANCE DETERMINING APPARATUS 审中-公开
标题翻译：物质确定装置
公开(公告)号：WO2011073867A1
公开(公告)日：2011-06-23
申请号：PCT/IB2010/055723
申请日：2010-12-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KAHLMAN, Josephus Arnoldus Henricus Maria , VAN ZON, Joannes Baptist Adrianus Dionisius , SCHLEIPEN, Johannes Joseph Hubertina Barbara , KLUNDER, Derk Jan Wilfred , EVERS, Toon Hendrik , VAN LIESHOUT, Ron Martinus Laurentius
发明人： KAHLMAN, Josephus Arnoldus Henricus Maria , VAN ZON, Joannes Baptist Adrianus Dionisius , SCHLEIPEN, Johannes Joseph Hubertina Barbara , KLUNDER, Derk Jan Wilfred , EVERS, Toon Hendrik , VAN LIESHOUT, Ron Martinus Laurentius
IPC分类号： G01N21/86
CPC分类号： B01L3/5027 , B01L2200/0605 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , G01N21/552 , G01N21/8483 , G01N33/54373
摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles attach the substance and bind to a binding surface (30), wherein a sensing signal is generated depending on the bound particles. Binding events indicating a binding of a particle on the binding surface (30) are determined from the generated sensing signal, and the substance within the fluid is determined based on the determined binding events. During a procedure of determining a substance within a fluid, particles may bind to the binding surface and may leave the binding surface. Therefore, during this procedure a number of binding events can be determined being much larger than the number of bound particles. The determination of the substance within the fluid can therefore be based on a very large amount of data, thereby increasing the accuracy of determining the substance within the fluid.
摘要翻译：本发明涉及一种用于确定流体内物质的物质确定装置。颗粒附着物质并结合到结合表面（30），其中根据结合的颗粒产生感测信号。根据产生的感测信号确定指示结合表面（30）上的颗粒结合的结合事件，并且基于所确定的结合事件确定流体内的物质。在确定流体内的物质的过程中，颗粒可能结合到结合表面并且可能离开结合表面。因此，在此过程中，可以确定许多结合事件比结合粒子的数量大得多。因此，流体内的物质的测定可以基于非常大量的数据，从而提高确定流体内物质的准确性。

3. 发明申请

WO2011036650A2 SENSOR DEVICE WITH IMAGING OPTICS 审中-公开
标题翻译：具有成像光学元件的传感器装置
公开(公告)号：WO2011036650A2
公开(公告)日：2011-03-31
申请号：PCT/IB2010/054328
申请日：2010-09-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KAHLMAN, Josephus Arnoldus Henricus Maria , VAN ZON, Joannes Baptist Adrianus Dionisius
发明人： KAHLMAN, Josephus Arnoldus Henricus Maria , VAN ZON, Joannes Baptist Adrianus Dionisius
CPC分类号： G01N21/552 , G01N21/648 , G02B21/367
摘要： The invention relates to a method and a sensor device (100) for detecting particles (MP) that are bound to the binding surface (12) of a carrier (11). The sensor device (100) comprises a microscope (50) for imaging bound particles (MP)onto an image sensor (53). In order to increase the spatial resolution of the microscope(50), a displacement unit (60,70,80) is provided that can displace the carrier (11) relative to the image sensor (53). The distance of a bound particle (MP) from the binding surface (12) and/or its lateraldisplacement in reaction to forces can thus be determine with high accuracy. This allows to discriminate specific bindings of large magnetic particles (MP) that are bound to the binding surface (12) via smaller target particles from nonspecific direct bindings.
摘要翻译：本发明涉及一种用于检测与载体（11）的结合表面（12）结合的粒子（MP）的方法和传感器装置（100）。传感器装置（100）包括用于将束缚粒子（MP）成像到图像传感器（53）上的显微镜（50）。为了增加显微镜（50）的空间分辨率，提供了可以使载体（11）相对于图像传感器（53）移位的移位单元（60,70,80）。因此，可以高准确度地确定结合表面（MP）与结合表面（12）和/或其对应力的后期位移的距离。这允许通过较小的目标颗粒与非特异性直接结合区分结合到结合表面（12）的大磁性颗粒（MP）的特异性结合。

4. 发明申请

WO2007129262A1 MAGNETO-RESISTIVE SENSORS WITH IMPROVED OUTPUT SIGNAL CHARACTERISTICS 审中-公开
标题翻译：具有改进的输出信号特性的磁电阻传感器
公开(公告)号：WO2007129262A1
公开(公告)日：2007-11-15
申请号：PCT/IB2007/051637
申请日：2007-05-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JANSEN, Theodorus Petrus Henricus Gerardus , KAHLMAN, Josephus Arnoldus Henricus Maria
发明人： JANSEN, Theodorus Petrus Henricus Gerardus , KAHLMAN, Josephus Arnoldus Henricus Maria
IPC分类号： G01R33/09
CPC分类号： G01R33/093 , B82Y25/00 , G01R33/12 , G01R33/1269
摘要： The present invention provides a magnetoresistive sensor (20) comprising a stabilizing circuit for stabilizing an electrical output signal (U o ) of the magnetoresistive sensor (20) in order to correct for the contribution of an internal magnetic field generated by a magnetoresistive element (21) which is part of the sensor (20). The present invention furthermore provides a biochip comprising at least one such magnetoresistive sensor (20) and a method for stabilizing the electrical output signal (U o ) of a magnetoresistive sensor (20).
摘要翻译：本发明提供一种磁阻传感器（20），其包括用于稳定磁阻传感器（20）的电输出信号（U SUB）的稳定电路，以便校正内部磁场的贡献由作为传感器（20）的一部分的磁阻元件（21）产生。本发明还提供一种包括至少一个这样的磁阻传感器（20）的生物芯片和用于稳定磁阻传感器（20）的电输出信号（U sub）的方法。

5. 发明申请

WO2012077065A1 A METHOD AND APPARATUS FOR DETERMINING A PARTIAL CARBON DIOXIDE PRESSURE ARTERIAL BLOOD 审中-公开
标题翻译：一种二氧化碳气压二氧化碳血液测定方法及装置
公开(公告)号：WO2012077065A1
公开(公告)日：2012-06-14
申请号：PCT/IB2011/055510
申请日：2011-12-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KAHLMAN, Josephus Arnoldus Henricus Maria , VEEN, Jeroen
发明人： KAHLMAN, Josephus Arnoldus Henricus Maria , VEEN, Jeroen
IPC分类号： A61B5/083 , A61B5/08 , A61B5/145 , A61B5/0205
CPC分类号： A61B5/0836 , A61B5/02055 , A61B5/082 , A61B5/14542 , A61B2010/0087 , A61M16/0045 , A61M16/101 , A61M16/12 , A61M16/202 , A61M2016/1025 , A61M2016/103 , A61M2230/005 , A61M2230/205 , A61M2230/208 , A61M2230/42
摘要： The partial carbon dioxide pressure in arterial blood of a subject is determined by: modulating at least one parameter of a subject, such, for example, the mutual concentration of gases supplied to the subject or the arterial blood temperature of the subject; deriving oxygen saturation of the arterial blood of said subject; and determining partial carbon dioxide pressure from said derived oxygen saturation.
摘要翻译：受试者的动脉血中的部分二氧化碳压力通过：调节受试者的至少一个参数，例如供应给对象的气体相互浓度或受试者的动脉血温; 导出所述受试者的动脉血的氧饱和度; 以及从所述导出的氧饱和度确定部分二氧化碳压力。

6. 发明申请

WO2008102218A1 A SENSOR DEVICE FOR AND A METHOD OF SENSING MAGNETIC PARTICLES 审中-公开
标题翻译：一种用于感测磁性颗粒的传感器装置和方法
公开(公告)号：WO2008102218A1
公开(公告)日：2008-08-28
申请号：PCT/IB2007/052449
申请日：2007-06-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN LANKVELT, Petrus Johannes Wilhelmus , NIEUWENHUIS, Jeroen Hans , IMMINK, Albert Hendrik Jan , KAHLMAN, Josephus Arnoldus Henricus Maria
发明人： VAN LANKVELT, Petrus Johannes Wilhelmus , NIEUWENHUIS, Jeroen Hans , IMMINK, Albert Hendrik Jan , KAHLMAN, Josephus Arnoldus Henricus Maria
IPC分类号： G01N33/543 , G01R33/06
CPC分类号： G01N33/54373 , B82Y25/00 , G01N27/745 , G01N33/54326 , G01R33/07 , G01R33/093 , G01R33/12 , G01R33/1269 , G01R33/1276
摘要： A sensor device (50) for sensing magnetic particles (15), the sensor device (50) comprising a substrate (25) and a sensing unit (11, 20) provided on and/or in and/or near the substrate (25) and being adapted for sensing a detection signal indicative of the presence of the magnetic particles (15), and a magnetic field control unit (30 to 34) provided off the substrate (25) and being adapted for generating a time-dependent magnetic field for interaction with the magnetic particles (15).
摘要翻译：一种用于感测磁性颗粒（15）的传感器装置（50），所述传感器装置（50）包括衬底（25）和设置在衬底（25）上和/或之中和/或附近的感测单元（11,20）适于感测表示磁性粒子（15）的存在的检测信号，以及设置在基板（25）之外的磁场控制部（30〜34），适于产生时间依赖性的磁场，与磁性颗粒（15）的相互作用。

7. 发明申请

WO2011036634A1 A BIOSENSOR SYSTEM FOR SINGLE PARTICLE DETECTION 审中-公开
标题翻译：一种用于单粒子检测的生物传感器系统
公开(公告)号：WO2011036634A1
公开(公告)日：2011-03-31
申请号：PCT/IB2010/054292
申请日：2010-09-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SCHLEIPEN, Johannes Joseph Hubertina Barbara , VAN ZON, Joannes Baptist Adrianus Dionisius , KLUNDER, Derk Jan Wilfred , EVERS, Toon Hendrik , KAHLMAN, Josephus Arnoldus Henricus Maria , VAN LIESHOUT, Ron Martinus Laurentius , OVSYANKO, Mikhail Mikhaylovich
发明人： SCHLEIPEN, Johannes Joseph Hubertina Barbara , VAN ZON, Joannes Baptist Adrianus Dionisius , KLUNDER, Derk Jan Wilfred , EVERS, Toon Hendrik , KAHLMAN, Josephus Arnoldus Henricus Maria , VAN LIESHOUT, Ron Martinus Laurentius , OVSYANKO, Mikhail Mikhaylovich
IPC分类号： G01R33/12 , G01N21/55
CPC分类号： G01N33/54373 , G01N15/10 , G01N15/1031 , G01N21/47 , G01N21/49 , G01N21/51 , G01N21/552 , G01N21/6458 , G01N27/72 , G01N33/54313 , G01N2015/0065 , G01N2201/12 , G01R33/1269
摘要： The present invention is related to a biosensor system for the detection of particles comprising: a biosensor cartridge comprising a sensor surface,a biosensor magnet assembly on one side of the cartridge for generating a magnetic field effective at the cartridge and the sensor surface, the first biosensor magnet assembly comprising at least two magnetic subunits separated by a gap, a first optical detection system for detecting the particles arranged at the same side of the cartridge as the magnet assembly, whereas the magnet assembly is designed in a way that the optical detection is accomplished through the gap of the magnet assembly.
摘要翻译：本发明涉及一种用于检测颗粒的生物传感器系统，包括：生物传感器盒，包括传感器表面，在盒的一侧上的生物传感器磁体组件，用于产生在盒和感测器表面有效的磁场;第一生物传感器磁体组件，其包括由间隙分开的至少两个磁性子单元，第一光学检测系统，用于检测与磁体组件位于盒的同一侧的颗粒，而磁体组件设计成使得光学检测是通过磁体组件的间隙完成。

8. 发明申请

WO2011030318A1 SENSING SYSTEM FOR SENSING A SUBSTANCE IN A FLUID 审中-公开
标题翻译：用于感测流体中的物质的感测系统
公开(公告)号：WO2011030318A1
公开(公告)日：2011-03-17
申请号：PCT/IB2010/054106
申请日：2010-09-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KAHLMAN, Josephus Arnoldus Henricus Maria , JANSEN, Theodorus Petrus Henricus Gerardus , SCHLEIPEN, Johannes Joseph Hubertina Barbara
发明人： KAHLMAN, Josephus Arnoldus Henricus Maria , JANSEN, Theodorus Petrus Henricus Gerardus , SCHLEIPEN, Johannes Joseph Hubertina Barbara
IPC分类号： G01N21/86
CPC分类号： G01N21/8483
摘要： The invention relates to a sensing system for sensing a substance in a fluid. The sensing system comprises a sensing site (132) at which the substance is to be sensed and a reference site (131). A signal generation unit generates a sensing signal by sensing the sensing site (132) and a reference signal by sensing the reference site (131). The reference signal is used for normalizing the sensing signal, wherein the sensing site (132) and the reference site (131) are arranged such that a drift variation of the normalized sensing signal is within a noise variation of the normalized sensing signal. This improves the accuracy of the normalized sensing signal.
摘要翻译：本发明涉及用于感测流体中的物质的感测系统。感测系统包括感测部位（132），物体被检测到的感测部位（132）和参考部位（131）。信号生成单元通过感测检测位置（132）和感测参考位置（131）的参考信号来生成感测信号。参考信号用于归一化感测信号，其中感测位置（132）和参考位置（131）被布置成使得归一化感测信号的漂移变化在归一化感测信号的噪声变化之内。这提高了归一化感测信号的精度。

9. 发明申请

WO2008044162A2 MAGNETIC SENSOR DEVICE WITH PAIRS OF DETECTION UNITS 审中-公开
标题翻译：具有检测单元对的磁传感器装置
公开(公告)号：WO2008044162A2
公开(公告)日：2008-04-17
申请号：PCT/IB2007/053944
申请日：2007-09-28
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DURIC, Haris , KAHLMAN, Josephus Arnoldus Henricus Maria , BLANKEN, Pieter, G.
发明人： DURIC, Haris , KAHLMAN, Josephus Arnoldus Henricus Maria , BLANKEN, Pieter, G.
CPC分类号： G01R33/093 , B82Y25/00 , G01R33/1269
摘要： The invention relates to a magnetic sensor device (100) with a primary and secondary detection unit (P, S), each of which comprises a magnetic sensor element and a magnetic field generator. In a preferred embodiment, the magnetic sensor elements are GMR elements (12, 22) with the same sensitive directions (D 12 , D 22 ), and the magnetic field generators are parallel wires (11, 21) which are supplied by an evaluation and control unit (40) with anti-parallel magnetic excitation currents. The magnetic excitation currents generate magnetic excitation fields (Bn, B2i) with opposite sense of rotation which in turn induce oppositely directed magnetic reaction fields (B' 11 , B' 21 ) in magnetized particles (1) provided in an investigation region (2). The magnetic reaction fields (B' 11 , B' 21 ) therefore have opposite effects on the GMR elements, yielding an increase in the difference (Δ) between the output signals of these elements. In a preferred embodiment, four detection units are arranged in a Wheatstone bridge.
摘要翻译：本发明涉及一种具有初级和次级检测单元（P，S）的磁性传感器装置（100），每个检测单元包括一个磁性传感器元件和一个磁场发生器。在优选实施例中，磁传感器元件是具有相同敏感方向（D 12，D 22）的GMR元件（12,22），并且磁场发生器是由评估和控制单元（40）由反并联磁激励电流提供的平行线（11,21）。磁激励电流产生具有相反旋转方向的磁激励场（Bn，B2i），这又引起相反方向的磁反应场（B'11，B'21）在调查区域（2）中设置的磁化颗粒（1）中。因此，磁反应场（B'11，B'21）对GMR元件具有相反的影响，从而导致输出信号这些元素。在优选实施例中，四个检测单元布置在惠斯通电桥中。

10. 发明申请

WO2007010455A3 SENSOR CHIP FOR A BIOSENSOR 审中-公开
公开(公告)号：WO2007010455A3
公开(公告)日：2007-01-25
申请号：PCT/IB2006/052383
申请日：2006-07-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KAHLMAN, Josephus Arnoldus Henricus Maria
发明人： KAHLMAN, Josephus Arnoldus Henricus Maria
IPC分类号： B01L3/00 , G01N15/06 , G01N33/543
摘要： The invention relates to a microchip (10) and a microfluidic biosensor (200) comprising such a microchip (10) as a sensor. The microchip (10) may particularly comprise coupling circuits on its sensitive side for generating and sensing magnetic fields. The circuits are connected by feedthrough connections (VIAs) to terminals (204) at the back side of the microchip (10) for external bonding. The front side of the sensor chip (10) can thus be kept freely accessible from a sample chamber (206). The back side of the sensor chip (10) may particularly be flip-chip bonded to a signal processing chip (20), which is connected to external circuits by a flex foil (202).

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