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1. 发明申请

WO2012004723A1 EXAMINATION SYSTEM WITH SAMPLE INCUBATION 审中-公开
标题翻译：检验系统与样本孵化
公开(公告)号：WO2012004723A1
公开(公告)日：2012-01-12
申请号：PCT/IB2011/052945
申请日：2011-07-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HARDEMAN, Wilhelmina, Maria , EVERS, Toon, Hendrik , JANSEN, Theodorus, Petrus, Henricus, Gerardus
发明人： HARDEMAN, Wilhelmina, Maria , EVERS, Toon, Hendrik , JANSEN, Theodorus, Petrus, Henricus, Gerardus
IPC分类号： G01N33/53
CPC分类号： G01N21/75 , B01L3/502715 , B01L2200/027 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2400/0406 , B01L2400/0487 , G01N33/54366
摘要： The invention relates to a cartridge(10) and its use in an examination apparatus(100). A sample(1) can be introduced into an inlet(11) of the cartridge(10) and conducted through a channel(12) to a reaction chamber(13). In the reaction chamber(13), an examination of the sample takes place, for example by frustrated total internal reflection. An agent(21) is applied to the sample close to the inlet(11), wherein said agent(21) is preferably stored in a reservoir(16) at the inlet(11). In this way the filling time of the reaction chamber(13) is simultaneously used for the incubation of the sample with the agent(21). Moreover, the filling-course of the cartridge and/or the reaction chamber may preferably be determined and taken into account during the execution of the examination and/or the evaluation of the results.
摘要翻译：本发明涉及一种盒（10）及其在检查装置（100）中的应用。样品（1）可以被引入到药筒（10）的入口（11）中并且通过通道（12）传导到反应室（13）。在反应室（13）中，例如通过沮丧的全内反射来检查样品。将试剂（21）施加到靠近入口（11）的样品上，其中所述试剂（21）优选储存在入口（11）处的储存器（16）中。以这种方式，反应室（13）的填充时间同时用于样品与试剂（21）的孵育。此外，可以在执行检查和/或评估结果期间优选地确定和考虑盒和/或反应室的填充过程。

2. 发明申请

WO2007132366A2 MICROELECTRONIC SENSOR DEVICE FOR CONCENTRATION MEASUREMENTS 审中-公开
标题翻译：用于浓度测量的微电子传感器装置
公开(公告)号：WO2007132366A2
公开(公告)日：2007-11-22
申请号：PCT/IB2007/051505
申请日：2007-04-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , NIEUWENHUIS, Jeroen Hans , VAN ZON, Hans , KAHLMAN, Josephus Arnoldus Henricus Maria , VEEN, Jeroen , DE BOER, Bart Michiel , JANSEN, Theodorus Petrus Henricus Gerardus
发明人： NIEUWENHUIS, Jeroen Hans , VAN ZON, Hans , KAHLMAN, Josephus Arnoldus Henricus Maria , VEEN, Jeroen , DE BOER, Bart Michiel , JANSEN, Theodorus Petrus Henricus Gerardus
IPC分类号： G01N33/543 , G01N35/00
CPC分类号： G01R33/093 , B82Y25/00 , G01N27/745 , G01R33/1269
摘要： The invention relates to a method and a magnetic sensor device for the determination of the concentration of target particles (2) in a sample fluid, wherein the amount of the target particles (2) in a sensitive region (14) is observed by sampling measurement signals with associated sensor units (10a-10d). The target particles (2) may optionally be bound to binding sites (3) in the sensitive region, and a parametric binding curve, e.g. a Langmuir isotherm, may be fitted to the sampled measurement signals to determine the desired particle concentration in the sample. Moreover, parameters like the sampling rate and the size of the sensitive region (14) can be dynamically fitted during the ongoing sampling process to improve the signal-to-noise ratio. In another embodiment of the invention, single events corresponding to the movement of target particles into, out of, or within the sensitive region are detected and counted.
摘要翻译：本发明涉及一种用于确定样品流体中目标颗粒（2）的浓度的方法和磁传感器装置，其中通过采样测量观察敏感区域（14）中的目标颗粒（2）的量信号与相关联的传感器单元（10a-10d）。目标颗粒（2）可以任选地结合到敏感区域中的结合位点（3）和参数结合曲线，例如， Langmuir等温线可以适应于取样的测量信号，以确定样品中所需的颗粒浓度。此外，在正在进行的采样过程中，可以动态地拟合诸如采样率和敏感区域（14）的尺寸的参数，以提高信噪比。在本发明的另一个实施例中，检测并计数对应于目标颗粒移动到，移出或在敏感区域内的单个事件。

3. 发明申请

WO2007042959A2 MAGNETIC SENSOR DEVICE WITH DIFFERENT INTERNAL OPERATING FREQUENCIES 审中-公开
标题翻译：具有不同内部操作频率的磁传感器装置
公开(公告)号：WO2007042959A2
公开(公告)日：2007-04-19
申请号：PCT/IB2006/053561
申请日：2006-09-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KAHLMAN, Josephus Arnoldus Henricus Maria , VEEN, Jeroen , DE BOER, Bart Michiel , JANSEN, Theodorus Petrus Henricus Gerardus
发明人： KAHLMAN, Josephus Arnoldus Henricus Maria , VEEN, Jeroen , DE BOER, Bart Michiel , JANSEN, Theodorus Petrus Henricus Gerardus
CPC分类号： G01R33/09 , B82Y25/00 , G01N15/0656 , G01N27/745 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： The invention relates to a magnetic sensor device (10) comprising wires (11, 13) for the generation of a magnetic field with a first frequency f 1 a GMR sensor (12) operated with an input current of a second frequency f 2 , and a demodulator (26) operated at a third frequency f 3 . In order to avoid signal corruption by phase noise and to improve the signal-to-noise ratio, the first, second and third frequencies are derived by a supply unit (121) from a common reference frequency f ref . Said derivation may for example be achieved with the help of digital frequency dividers. Furthermore, phase detectors (PD1, PD2) may be used in a feedback control loop to assure predetermined relations between the phases of the three frequencies. In another embodiment of the invention, the phase and/or amplitude of a model signal, which is used to process a desired signal component in the output of the sensor, is tracked by an adaptation algorithm, for example a gradient descent.
摘要翻译：本发明涉及一种磁传感器装置（10），其包括用于产生具有第一频率f 1的磁场的导线（11,13），GMR传感器（12）用输入电流第二频率f 2 2和在第三频率f 3 3处操作的解调器（26）。为了避免相位噪声的信号损坏并提高信噪比，第一，第二和第三频率由供电单元（121）从公共参考频率f ref 。所述推导可以例如在数字分频器的帮助下实现。此外，相位检测器（PD1，PD2）可用于反馈控制回路中以确保三个频率的相位之间的预定关系。在本发明的另一个实施例中，用于处理传感器的输出中的期望信号分量的模型信号的相位和/或幅度由适应算法（例如梯度下降）来跟踪。

4. 发明申请

WO2007034358A3 SENSOR DEVICE WITH GENERATOR AND SENSOR CURRENT SOURCES 审中-公开
公开(公告)号：WO2007034358A3
公开(公告)日：2007-03-29
申请号：PCT/IB2006/053226
申请日：2006-09-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , DE BOER, Bart, Michiel , JANSEN, Theodorus, Petrus, Henricus, Gerardus
发明人： DE BOER, Bart, Michiel , JANSEN, Theodorus, Petrus, Henricus, Gerardus
IPC分类号： G01R33/12
摘要： The invention relates to a magnetic sensor device (10) comprising wires (11, 13) for the generation of a magnetic field and a magnetic sensor element (12), for example a GMR (12), for sensing changes of the generated magnetic field caused by magnetic particles (2). The wires (11, 13) and the magnetic sensor element (12) are supplied with alternating currents (I1, I2) of high frequencies fl and f2. Said frequencies are chosen such that their difference Δf = æf2-f1æ is low and lies in a range of thermal white noise above the 1/f noise of an amplifier (24) and below the 1/f noise of the GMR (12). In this way it is possible to use a high-frequency magnetic field while only low frequency signals have to be processed.

5. 发明申请

WO2011117780A1 INTERFERENCE REDUCTION IN MONITORING A VITAL PARAMETER OF A PATIENT 审中-公开
标题翻译：监测患者健康参数的干扰减少
公开(公告)号：WO2011117780A1
公开(公告)日：2011-09-29
申请号：PCT/IB2011/051100
申请日：2011-03-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VEEN, Jeroen , JANSEN, Theodorus, Petrus, Henricus, Gerardus , FOKKENROOD, Steven, Antonie, Willem
发明人： VEEN, Jeroen , JANSEN, Theodorus, Petrus, Henricus, Gerardus , FOKKENROOD, Steven, Antonie, Willem
IPC分类号： A61B5/1455
CPC分类号： A61B5/14552
摘要： The invention relates to a method of and device for monitoring a vital parameter of a patient by emitting light onto tissue of the patient with at least one light source (1, 2) and collecting light which is transmitted through the tissue and/or which is reflected from the tissue. The emitted light is multiplexed according to a predefined multiplexing scheme having a plurality of multiplexing channels, and the collected light is detected according to the predefined multiplexing scheme, resulting in a plurality of detection channels (16, 17, 18, 19). At least one of the multiplexing channels is arranged to be a dark multiplexing channel for which no light is emitted by the at least one light source (1, 2), resulting in a dark detection channel (19), and the signal of this dark detection channel (19) is used for generating a reference signal for reducing interference in the signal of at least one of the other detection channels (16, 17, 18). In this way a versatile and reliable possibility of monitoring a vital parameter of a patient with a high signal-to-interference ratio is provided.
摘要翻译：本发明涉及一种用于通过用至少一个光源（1,2）发射光到患者的组织上并且收集透过组织的光和/或通过组织透射的光而监测患者的生命参数的方法和装置从组织反射。发射光根据具有多个复用信道的预定复用方案进行多路复用，并且根据预定的复用方案检测收集的光，从而产生多个检测通道（16,17,18,19）。多路复用通道中的至少一个被配置为暗的多路复用通道，由该至少一个光源（1,2）不发射光，导致暗检测通道（19），并且该暗信号检测通道（19）用于产生用于减少至少一个其它检测通道（16,17,18）的信号中的干扰的参考信号。以这种方式，提供了用于监视具有高信号与干扰比的患者的重要参数的通用且可靠的可能性。

6. 发明申请

WO2007034408A2 MAGNETIC SENSOR SEVICE WITH FILTERING MEANS 审中-公开
标题翻译：带滤波器的磁性传感器设备
公开(公告)号：WO2007034408A2
公开(公告)日：2007-03-29
申请号：PCT/IB2006/053361
申请日：2006-09-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , DE BOER, Bart Michiel , JANSEN, Theodorus Petrus Henricus Gerardus
发明人： DE BOER, Bart Michiel , JANSEN, Theodorus Petrus Henricus Gerardus
CPC分类号： G01R33/12
摘要： The invention relates to a magnetic sensor device (10) comprising wires (11, 13) for the generation of a magnetic field with a first frequency fls a GMR sensor (12) operated with an input current of a second frequency f2, and an amplifier (26) for amplifying the output of the GMR sensor (12). A first filter (24) is used to prevent noise of the current source (23) from reaching the GMR sensor (12), and to prevent magnetic signals from the GMR sensor (12) from reaching the current source (23). Moreover, a second filter (25) is used to prevent the second frequency f2 from reaching the amplifier (26).
摘要翻译：本发明涉及一种磁传感器装置（10），其包括用于产生具有以第二频率f2的输入电流操作的GMR传感器（12）的第一频率的磁场的导线（11,13）和放大器（26），用于放大GMR传感器（12）的输出。第一滤波器（24）用于防止电流源（23）的噪声到达GMR传感器（12），并且防止来自GMR传感器（12）的磁信号到达电流源（23）。此外，第二滤波器（25）用于防止第二频率f2到达放大器（26）。

7. 发明申请

WO2011030318A1 SENSING SYSTEM FOR SENSING A SUBSTANCE IN A FLUID 审中-公开
标题翻译：用于感测流体中的物质的感测系统
公开(公告)号：WO2011030318A1
公开(公告)日：2011-03-17
申请号：PCT/IB2010/054106
申请日：2010-09-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KAHLMAN, Josephus Arnoldus Henricus Maria , JANSEN, Theodorus Petrus Henricus Gerardus , SCHLEIPEN, Johannes Joseph Hubertina Barbara
发明人： KAHLMAN, Josephus Arnoldus Henricus Maria , JANSEN, Theodorus Petrus Henricus Gerardus , SCHLEIPEN, Johannes Joseph Hubertina Barbara
IPC分类号： G01N21/86
CPC分类号： G01N21/8483
摘要： The invention relates to a sensing system for sensing a substance in a fluid. The sensing system comprises a sensing site (132) at which the substance is to be sensed and a reference site (131). A signal generation unit generates a sensing signal by sensing the sensing site (132) and a reference signal by sensing the reference site (131). The reference signal is used for normalizing the sensing signal, wherein the sensing site (132) and the reference site (131) are arranged such that a drift variation of the normalized sensing signal is within a noise variation of the normalized sensing signal. This improves the accuracy of the normalized sensing signal.
摘要翻译：本发明涉及用于感测流体中的物质的感测系统。感测系统包括感测部位（132），物体被检测到的感测部位（132）和参考部位（131）。信号生成单元通过感测检测位置（132）和感测参考位置（131）的参考信号来生成感测信号。参考信号用于归一化感测信号，其中感测位置（132）和参考位置（131）被布置成使得归一化感测信号的漂移变化在归一化感测信号的噪声变化之内。这提高了归一化感测信号的精度。

8. 发明申请

WO2007129262A1 MAGNETO-RESISTIVE SENSORS WITH IMPROVED OUTPUT SIGNAL CHARACTERISTICS 审中-公开
标题翻译：具有改进的输出信号特性的磁电阻传感器
公开(公告)号：WO2007129262A1
公开(公告)日：2007-11-15
申请号：PCT/IB2007/051637
申请日：2007-05-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JANSEN, Theodorus Petrus Henricus Gerardus , KAHLMAN, Josephus Arnoldus Henricus Maria
发明人： JANSEN, Theodorus Petrus Henricus Gerardus , KAHLMAN, Josephus Arnoldus Henricus Maria
IPC分类号： G01R33/09
CPC分类号： G01R33/093 , B82Y25/00 , G01R33/12 , G01R33/1269
摘要： The present invention provides a magnetoresistive sensor (20) comprising a stabilizing circuit for stabilizing an electrical output signal (U o ) of the magnetoresistive sensor (20) in order to correct for the contribution of an internal magnetic field generated by a magnetoresistive element (21) which is part of the sensor (20). The present invention furthermore provides a biochip comprising at least one such magnetoresistive sensor (20) and a method for stabilizing the electrical output signal (U o ) of a magnetoresistive sensor (20).
摘要翻译：本发明提供一种磁阻传感器（20），其包括用于稳定磁阻传感器（20）的电输出信号（U SUB）的稳定电路，以便校正内部磁场的贡献由作为传感器（20）的一部分的磁阻元件（21）产生。本发明还提供一种包括至少一个这样的磁阻传感器（20）的生物芯片和用于稳定磁阻传感器（20）的电输出信号（U sub）的方法。

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