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1. 发明申请

WO2009077939A1 ADJUSTABLE LENS SYSTEM FOR REAL-TIME APPLICATIONS 审中-公开
标题翻译：可调镜头系统实时应用
公开(公告)号：WO2009077939A1
公开(公告)日：2009-06-25
申请号：PCT/IB2008/055205
申请日：2008-12-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SUIJVER, Jan, F. , HALL, Christopher, S. , FERNANDEZ, Anna, T. , KUIPER, Stein , SHI, Yan, S.
发明人： SUIJVER, Jan, F. , HALL, Christopher, S. , FERNANDEZ, Anna, T. , KUIPER, Stein , SHI, Yan, S.
IPC分类号： G02B3/14
CPC分类号： G02B3/14
摘要： An adjustable fluid type lens system is provided that allows e.g. ultrasound imaging through the lens during adjustment of the lens. The lens includes a container enclosing two immiscible fluids, e.g. water and oil, being in contact with each other at an interface. Incoming waves are then refracted at this interface. The shape of the interface, and thereby the refraction property, is adjustable by adjusting a voltage applied to the lens. The two fluids are selected such that they together exhibit a mechanical damping which is critical or near critical. A control circuit generates the electric voltage for adjusting the refraction from one value to another, the control circuit being arranged to change the electric voltage such that a rate of voltage change is limited to avoid oscillation of the interface, thereby adjusting refraction of incoming waves at the interface in a continuous manner. This makes it possible to use the lens while it is during adjustment from one refraction value to another, since the interface shape will at all time during the adjustment have a controlled shape. The voltage can be either a continuous voltage or a discrete stepwise (digital) voltage which is just controlled with respect to step size and temporal extension of the steps. The lens system has a number of applications e.g. within the medical field, e.g. for 'on the fly' high speed ultrasound imaging, or for ultrasound ablation applications where ablation can be performed during adjustment of the lens to follow a pre-defined trajectory.
摘要翻译：提供了一种可调节流体型透镜系统，超声波成像通过透镜在调整镜片期间。透镜包括容纳两个不混溶流体的容器，例如水和油在界面处彼此接触。然后在这个界面折射出来的波。通过调节施加到透镜上的电压来调节界面的形状以及由此的折射特性。选择两种流体使得它们一起显示出关键或近临界的机械阻尼。控制电路产生用于将折射率从一个值调整到另一个值的电压，控制电路被布置成改变电压，使得电压变化率被限制以避免界面的振荡，由此调节入射波的折射界面以连续的方式。这使得可以在从一个折射值到另一个折射值的调整期间使用透镜，因为在调节期间的所有时间的界面形状都具有受控的形状。电压可以是连续电压或离散的逐步（数字）电压，其仅仅相对于步长的步长和时间延长而被控制。透镜系统具有许多应用，例如，在医疗领域内。用于“飞行”高速超声成像，或用于超声消融应用，其中可以在镜片调整期间执行消融以遵循预定轨迹。

2. 发明申请

WO2008135896A1 METHODS AND APPARATUSES OF APERTURE CONTROL AND MULTIPLEXING WITH ADJUSTABLE FLUID LENSES 审中-公开
标题翻译：孔径控制和可调节流体镜的多路复用方法与装置
公开(公告)号：WO2008135896A1
公开(公告)日：2008-11-13
申请号：PCT/IB2008/051626
申请日：2008-04-28
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , FERNANDEZ, Anna, T. , HALL, Christopher, S. , SUIJVER, Jan, F.
发明人： FERNANDEZ, Anna, T. , HALL, Christopher, S. , SUIJVER, Jan, F.
IPC分类号： G10K11/30
CPC分类号： G10K11/30
摘要： An acoustic imaging system (1300) includes: an acoustic transducer (40); a plurality of variably-refracting acoustic lens elements (10) coupled to the acoustic transducer, a controller (1326) adapted to generate a plurality of control signals for electrodes (250, 260) of the variably-refracting acoustic lens elements (10); a multiplexer (1322) adapted to multiplex the control signals for the electrodes of the variably-refracting acoustic lens elements (10) to produce a multiplexed control signal; a decoder (1312) adapted to demultiplex the multiplexed control signal to produce the plurality of control signals for the electrodes (250, 260) of the variably-refracting acoustic lens elements (10); and a cable (1330) adapted to provide the multiplexed control signal from the multiplexer (1322) to the decoder (1312). The variably-refracting acoustic lens elements (10) are adapted, in response to control signals applied thereto, to adjust an effective aperture of the acoustic transducer (40) to have a selected aperture size.
摘要翻译：声学成像系统（1300）包括：声换能器（40）; 耦合到声换能器的多个可变折射声透镜元件（10），适于产生可变折射声透镜元件（10）的电极（250,260）的多个控制信号的控制器（1326）。多路复用器（1322），其适用于多路复用用于可变折射声透镜元件（10）的电极的控制信号以产生多路复用的控制信号; 解码器（1312），适于对多路复用控制信号进行解复用以产生用于可变折射声透镜元件（10）的电极（250,260）的多个控制信号; 以及适于将多路复用器（1322）的复用控制信号提供给解码器（1312）的电缆（1330）。响应于施加到其上的控制信号，可变折射声透镜元件（10）适于调节声换能器（40）的有效孔径以具有所选择的孔径尺寸。

3. 发明申请

WO2009027920A2 AN ULTRASOUND DEVICE FOR DETECTING PRESENCE OR ABSENCE OF CAVITATION EVENTS 审中-公开
标题翻译：用于检测存在或不存在空隙事件的超声波装置
公开(公告)号：WO2009027920A2
公开(公告)日：2009-03-05
申请号：PCT/IB2008/053397
申请日：2008-08-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HALL, Christopher, S. , FERNANDEZ, Anna, T. , SUIJVER, Jan, F.
发明人： HALL, Christopher, S. , FERNANDEZ, Anna, T. , SUIJVER, Jan, F.
IPC分类号： A61B6/12 , A61B17/22
CPC分类号： A61B17/22004 , A61B8/00 , A61B17/22029 , A61B17/225 , A61B2017/00106 , A61B2017/22009
摘要： This invention relates to an ultrasound device for detecting presence or absence of cavitation events. An ultrasound transducer receives emitted and reflected ultrasound waves from tissues within a specific target volume and the received ultrasound waves are subsequently converted into a detection signal. A control unit then processes the detected signal for determining whether a cavitation event is detected. A liquid lens having an adjustable focal point is placed in front of the ultrasound transducer such that the received ultrasound waves go through the liquid lens prior to be received by the ultrasound transducer. The lens is controlled by the control unit such that in response to a detection of a cavitation event the focal position of the lens is adjusted substantially closer to the spatial location of the detected cavitation event.
摘要翻译：本发明涉及用于检测气蚀事件的存在或不存在的超声波装置。超声波换能器从特定目标体积内的组织接收发射和反射的超声波，并且接收的超声波随后被转换成检测信号。控制单元然后处理检测到的信号，以确定是否检测到空化事件。具有可调焦点的液体透镜被放置在超声波换能器的前面，使得接收的超声波在被超声换能器接收之前通过液体透镜。透镜由控制单元控制，使得响应于空化事件的检测，透镜的焦点位置基本上更接近于检测到的气蚀事件的空间位置。

4. 发明申请

WO2009007900A2 ULTRASONIC ASSEMBLY WITH ADJUSTABLE FLUID LENS 审中-公开
标题翻译：超声波组件与可调节流体镜
公开(公告)号：WO2009007900A2
公开(公告)日：2009-01-15
申请号：PCT/IB2008/052716
申请日：2008-07-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HALL, Christopher, S. , FERNANDEZ, Anna, T. , SUIJVER, Jan, F.
发明人： HALL, Christopher, S. , FERNANDEZ, Anna, T. , SUIJVER, Jan, F.
IPC分类号： A61B17/22
CPC分类号： A61N7/022 , A61B2017/00243 , A61N2007/0056 , G10K11/30
摘要： An ultrasonic assembly suited for attachment to a catheter, e.g. for medical treatment. The ultrasonic assembly includes an adjustable ultrasonic focus mechanism arranged in connection with the ultrasonic transducer to adjust focus of ultrasonic waves generated by the transducer. The ultrasonic focus mechanism includes a fluid focus lens with at least two fluids separated by an interface such that ultrasonic waves are substantially reflected at the interface. At least two electrodes are arranged in connection with the fluid focus lens so as to allow adjustment of the interface shape, e.g. a curvature of the interface, when a voltage is applied to the electrodes. In preferred embodiments the electrodes are arranged so as to allow adjustment of the fluid focus lens in an elevation direction as well as in a radial direction. In simple embodiments with rotational symmetric geometry with the transducer positioned in the centre of the fluid focus lens, ultrasonic waves can be focused in an annular ring. This is e.g. suitable for ablative or coagulative necrotic treatment of human tissue, e.g. for atrial fibrillation treatment. In some embodiments, the assembly has a number of separate individually adjustable fluid focus lens compartments allowing a more detailed control of the ultrasonic focus pattern.
摘要翻译：适于附接到导管的超声波组件，例如用于治疗。超声波组件包括与超声波换能器连接布置的可调超声波聚焦机构，以调节由换能器产生的超声波的焦点。超声波聚焦机构包括流体聚焦透镜，其中至少两个流体被界面分开，使得超声波在界面处被大体上反射。至少两个电极被布置成与流体聚焦透镜相关联，以便允许调节界面形状，例如，当向电极施加电压时，界面的曲率。在优选实施例中，电极被布置成允许在高度方向以及径向方向上调整流体聚焦透镜。在具有旋转对称几何形状的简单实施例中，换能器定位在流体聚焦透镜的中心，超声波可以聚焦在环形环中。这是例如适用于人体组织的消融或凝血坏死治疗，例如用于心房颤动治疗。在一些实施例中，组件具有许多单独可单独调节的流体聚焦透镜隔室，允许对超声波聚焦图案进行更详细的控制。

5. 发明申请

WO2009001266A2 ACOUSTIC OFFSET FOR TRANSDUCER 审中-公开
标题翻译：声音偏移传感器
公开(公告)号：WO2009001266A2
公开(公告)日：2008-12-31
申请号：PCT/IB2008/052450
申请日：2008-06-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HALL, Christopher, S. , RAJU, Balasundar , AZEVEDO, Jose, M., I. , CHIN, Chien, T. , SHI, William, T.
发明人： HALL, Christopher, S. , RAJU, Balasundar , AZEVEDO, Jose, M., I. , CHIN, Chien, T. , SHI, William, T.
IPC分类号： A61B17/22 , A61N7/00
CPC分类号： A61B17/2251 , A61B2017/2253
摘要： The invention is related to a standoff comprising an acoustic coupling medium for use with an ultrasound transducer, comprising a first portion of tubular shape having a constant cross sectional area with an axis defining the direction of sound propagation and being adapted to be interfaced to the transducer, and a second portion of tapered shape being coaxial to the first portion. The second portion has a proximal end connected to the first, wherein the cross sectional area at a distal end of the second portion is smaller than the cross sectional area at the proximal end. The invention is further related to an envelope which is adapted to enclose the first and/or second portion of the standoff. The invention provides an improved acoustic standoff which is adapted for small and/or superficial structures.
摘要翻译：本发明涉及包括用于与超声换能器一起使用的声耦合介质的隔离件，其包括管状形状的第一部分，其具有恒定的横截面积，轴线限定声音传播的方向，并且适于与换能器和与第一部分同轴的锥形形状的第二部分。第二部分具有连接到第一部分的近端，其中第二部分的远端处的横截面面积小于近端处的横截面面积。本发明还涉及一种适于包围支架的第一和/或第二部分的外壳。本发明提供了一种适于小型和/或表面结构的改进的隔音。

6. 发明申请

WO2009063399A2 TISSUE TEMPERATURE INDICATING ELEMENT FOR ULTRASOUND THERAPY 审中-公开
标题翻译：组织温度指示超声治疗的元素
公开(公告)号：WO2009063399A2
公开(公告)日：2009-05-22
申请号：PCT/IB2008/054718
申请日：2008-11-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HALL, Christopher, S. , KURT, Ralph
发明人： HALL, Christopher, S. , KURT, Ralph
IPC分类号： A61N7/02 , G01K11/16
CPC分类号： A61N7/02 , A61B2017/00084 , C09K19/38 , C09K19/408 , C09K19/52 , G01K11/16 , G01K11/165
摘要： The present invention relates to a hydrogel-containing temperature indicating element for use in ultrasound therapy. The temperature indicating element of the present invention and the therapeutic device and method making use of the same enable in some embodiments an automated adaptation of the power output as a function of the tissue temperature, avoiding therefore overheating or burning of the skin.
摘要翻译：本发明涉及一种用于超声治疗的含水凝胶温度指示元件。本发明的温度指示元件和使用其的治疗装置和方法在一些实施例中能够根据组织温度自动调整功率输出，从而避免皮肤过热或燃烧。

7. 发明申请

WO2009001243A1 APPARATUS FOR CONTROLLED DELIVERY OF MOLECULES USING A CONTROLLED INJECTION SYSTEM 审中-公开
标题翻译：用控制注射系统控制输送分子的装置
公开(公告)号：WO2009001243A1
公开(公告)日：2008-12-31
申请号：PCT/IB2008/052373
申请日：2008-06-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HALL, Christopher, S. , RAJU, Balasundar, I. , CHIN, Chien, T. , SHI, William, T.
发明人： HALL, Christopher, S. , RAJU, Balasundar, I. , CHIN, Chien, T. , SHI, William, T.
IPC分类号： A61M37/00 , A61K41/00
CPC分类号： A61M37/0092 , A61K41/0033 , A61M5/16827
摘要： Apparatus for controlled delivery of molecules at a predetermined region of interest within a fluid- filled cavity or vessel by means of ultrasound activatable particles. Said apparatus comprises a system for locating the region of interest (1), a first injection system (4) for injecting said ultrasound activatable particles into said cavity or vessel, wherein said first injection system is adapted to adjust the flow rate of said ultrasound activatable particles and a second injection system (4) for injecting said molecules into said cavity or vessel, wherein said second injection system is adapted to adjust the flow rate of said molecules. The apparatus further comprises a delivery system (1) for delivering said molecules by activating the ultrasound activatable particles at the region of interest, a detection system for determining the delivery of the molecules at the region of interest and a controller (7) for controlling the first and second injection system and the delivery system in response to the detection system.
摘要翻译：用于通过超声可激活颗粒在流体填充的空腔或容器内的预定感兴趣区域处控制传递分子的装置。所述装置包括用于定位所述感兴趣区域（1）的系统，用于将所述超声可激活颗粒注入所述空腔或容器中的第一注射系统（4），其中所述第一注射系统适于调节所述超声可激活的颗粒和用于将所述分子注入所述空腔或容器中的第二注射系统（4），其中所述第二注射系统适于调节所述分子的流速。该装置还包括用于通过激活感兴趣区域上的超声可激活颗粒来递送所述分子的递送系统（1），用于确定感兴趣区域中分子递送的检测系统和用于控制第一和第二注射系统以及响应于检测系统的递送系统。

8. 发明申请

WO2007125500A2 METHOD AND APPARATUS FOR ELEVATION FOCUS CONTROL OF ACOUSTIC WAVES 审中-公开
标题翻译：用于高音重点控制声波的方法和装置
公开(公告)号：WO2007125500A2
公开(公告)日：2007-11-08
申请号：PCT/IB2007/051582
申请日：2007-04-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , HALL, Christopher, S. , CHIN, Chien, Ting , SUIJVER, Freek , HENDRIKS, Bernardus, H., W. , KUIPER, Stein
发明人： HALL, Christopher, S. , CHIN, Chien, Ting , SUIJVER, Freek , HENDRIKS, Bernardus, H., W. , KUIPER, Stein
CPC分类号： G10K11/30
摘要： An acoustic probe (100) includes an acoustic transducer (20) including a plurality of acoustic transducer elements arranged in a one-dimensional array; and a variably- refracting acoustic lens (10) coupled to the acoustic transducer. The variably-refracting acoustic lens has at least a pair of electrodes (150, 160) adapted to adjust the focus of the variably-refracting acoustic lens in response to a selected voltage applied across the electrodes. In one embodiment, the variably-refracting acoustic lens includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探针（100）包括声换能器（20），其包括以一维阵列排列的多个声换能器元件; 以及耦合到声换能器的可变折射声透镜（10）。可变折射声透镜具有至少一对电极（150,160），其适于响应于施加在电极上的选定电压来调节可变折射声透镜的焦点。在一个实施例中，可变折射声透镜包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

9. 发明申请

WO2009115967A2 METHOD FOR THE SYNTHESIS OF HOLLOW SPHERES 审中-公开
标题翻译：合成空心球的方法
公开(公告)号：WO2009115967A2
公开(公告)日：2009-09-24
申请号：PCT/IB2009/051052
申请日：2009-03-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BOHMER, Marcel, R. , CHLON, Caecilia, H., T. , SHI, William, T. , HALL, Christopher, S.
发明人： BOHMER, Marcel, R. , CHLON, Caecilia, H., T. , SHI, William, T. , HALL, Christopher, S.
IPC分类号： A61K49/22 , A61K41/00 , A61K9/51 , B01J13/12
CPC分类号： A61K49/223 , A61K9/5153 , A61K9/5192 , A61K41/0028 , A61K49/0002 , B01J13/125
摘要： The present invention relates to a method of synthesizing acoustically active biodegradable hollow spheres with a size below 1 micron. By using water soluble organic solvents and pegylated polymers, direct precipitation of these spheres is facilitated leading to a fast and convenient preparation route.
摘要翻译：本发明涉及一种合成尺寸小于1微米的声学活性生物可降解空心球的方法。通过使用水溶性有机溶剂和聚乙二醇化聚合物，这些球体的直接沉淀便于进行，从而导致快速和方便的制备途径。

10. 发明申请

WO2008090504A1 METHOD AND APPARATUS FOR ULTRASONIC DETECTION OF MOTION USING ADJUSTABLE FLUID LENSES 审中-公开
标题翻译：使用可调节流体镜检测运动的超声波检测方法和装置
公开(公告)号：WO2008090504A1
公开(公告)日：2008-07-31
申请号：PCT/IB2008/050194
申请日：2008-01-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , HALL, Christopher, S. , CHIN, Chien, Ying , SUIJVER, Jan, Frederik , HENDRIKS, Bernardus, Hendrikus, Wilhelmus , KUIPER, Stein
发明人： HALL, Christopher, S. , CHIN, Chien, Ying , SUIJVER, Jan, Frederik , HENDRIKS, Bernardus, Hendrikus, Wilhelmus , KUIPER, Stein
IPC分类号： A61B8/08
CPC分类号： G10K11/30 , A61B8/08 , A61B8/4281 , A61B8/488
摘要： A system (200) for detection of motion in a body includes an acoustic probe (242, 100), a motion detection processor (270), a variable voltage supply (290), and a controller (210). The acoustic probe (242, 100) includes an acoustic transducer (244, 20), and a variably-refracting acoustic lens (242, 10) coupled to the acoustic transducer. The variably-refracting acoustic lens has at least a pair of electrodes (150, 160a, 160b) adapted to adjust at least one characteristic of the variably-refracting acoustic lens in response to a selected voltage applied across the electrodes. The motion detection processor is coupled to the acoustic transducer and executes an algorithm to detect motion of an object in response to acoustic energy received by the acoustic transducer. The variable voltage supply applies selected voltages to the pair of electrodes. The controller controls the variable voltage supply to apply the selected voltages to the pair of electrodes.
摘要翻译：用于检测身体运动的系统（200）包括声探针（242,100），运动检测处理器（270），可变电压源（290）和控制器（210）。声探针（242,100）包括声换能器（244,20）和耦合到声换能器的可变折射声透镜（242,10）。所述可变折射声透镜具有至少一对电极（150,160a，160b），所述至少一对电极（150,160a，160b）响应于施加在所述电极上的选定电压而调节所述可变折射声透镜的至少一个特性。运动检测处理器耦合到声换能器并执行一种算法，以响应于由声换能器接收的声能来检测物体的运动。可变电压源将选定的电压施加到该对电极。控制器控制可变电压源以将所选择的电压施加到该对电极。

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