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1. 发明申请

WO2009077939A1 ADJUSTABLE LENS SYSTEM FOR REAL-TIME APPLICATIONS 审中-公开
标题翻译：可调镜头系统实时应用
公开(公告)号：WO2009077939A1
公开(公告)日：2009-06-25
申请号：PCT/IB2008/055205
申请日：2008-12-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SUIJVER, Jan, F. , HALL, Christopher, S. , FERNANDEZ, Anna, T. , KUIPER, Stein , SHI, Yan, S.
发明人： SUIJVER, Jan, F. , HALL, Christopher, S. , FERNANDEZ, Anna, T. , KUIPER, Stein , SHI, Yan, S.
IPC分类号： G02B3/14
CPC分类号： G02B3/14
摘要： An adjustable fluid type lens system is provided that allows e.g. ultrasound imaging through the lens during adjustment of the lens. The lens includes a container enclosing two immiscible fluids, e.g. water and oil, being in contact with each other at an interface. Incoming waves are then refracted at this interface. The shape of the interface, and thereby the refraction property, is adjustable by adjusting a voltage applied to the lens. The two fluids are selected such that they together exhibit a mechanical damping which is critical or near critical. A control circuit generates the electric voltage for adjusting the refraction from one value to another, the control circuit being arranged to change the electric voltage such that a rate of voltage change is limited to avoid oscillation of the interface, thereby adjusting refraction of incoming waves at the interface in a continuous manner. This makes it possible to use the lens while it is during adjustment from one refraction value to another, since the interface shape will at all time during the adjustment have a controlled shape. The voltage can be either a continuous voltage or a discrete stepwise (digital) voltage which is just controlled with respect to step size and temporal extension of the steps. The lens system has a number of applications e.g. within the medical field, e.g. for 'on the fly' high speed ultrasound imaging, or for ultrasound ablation applications where ablation can be performed during adjustment of the lens to follow a pre-defined trajectory.
摘要翻译：提供了一种可调节流体型透镜系统，超声波成像通过透镜在调整镜片期间。透镜包括容纳两个不混溶流体的容器，例如水和油在界面处彼此接触。然后在这个界面折射出来的波。通过调节施加到透镜上的电压来调节界面的形状以及由此的折射特性。选择两种流体使得它们一起显示出关键或近临界的机械阻尼。控制电路产生用于将折射率从一个值调整到另一个值的电压，控制电路被布置成改变电压，使得电压变化率被限制以避免界面的振荡，由此调节入射波的折射界面以连续的方式。这使得可以在从一个折射值到另一个折射值的调整期间使用透镜，因为在调节期间的所有时间的界面形状都具有受控的形状。电压可以是连续电压或离散的逐步（数字）电压，其仅仅相对于步长的步长和时间延长而被控制。透镜系统具有许多应用，例如，在医疗领域内。用于“飞行”高速超声成像，或用于超声消融应用，其中可以在镜片调整期间执行消融以遵循预定轨迹。

2. 发明申请

WO2008135896A1 METHODS AND APPARATUSES OF APERTURE CONTROL AND MULTIPLEXING WITH ADJUSTABLE FLUID LENSES 审中-公开
标题翻译：孔径控制和可调节流体镜的多路复用方法与装置
公开(公告)号：WO2008135896A1
公开(公告)日：2008-11-13
申请号：PCT/IB2008/051626
申请日：2008-04-28
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , FERNANDEZ, Anna, T. , HALL, Christopher, S. , SUIJVER, Jan, F.
发明人： FERNANDEZ, Anna, T. , HALL, Christopher, S. , SUIJVER, Jan, F.
IPC分类号： G10K11/30
CPC分类号： G10K11/30
摘要： An acoustic imaging system (1300) includes: an acoustic transducer (40); a plurality of variably-refracting acoustic lens elements (10) coupled to the acoustic transducer, a controller (1326) adapted to generate a plurality of control signals for electrodes (250, 260) of the variably-refracting acoustic lens elements (10); a multiplexer (1322) adapted to multiplex the control signals for the electrodes of the variably-refracting acoustic lens elements (10) to produce a multiplexed control signal; a decoder (1312) adapted to demultiplex the multiplexed control signal to produce the plurality of control signals for the electrodes (250, 260) of the variably-refracting acoustic lens elements (10); and a cable (1330) adapted to provide the multiplexed control signal from the multiplexer (1322) to the decoder (1312). The variably-refracting acoustic lens elements (10) are adapted, in response to control signals applied thereto, to adjust an effective aperture of the acoustic transducer (40) to have a selected aperture size.
摘要翻译：声学成像系统（1300）包括：声换能器（40）; 耦合到声换能器的多个可变折射声透镜元件（10），适于产生可变折射声透镜元件（10）的电极（250,260）的多个控制信号的控制器（1326）。多路复用器（1322），其适用于多路复用用于可变折射声透镜元件（10）的电极的控制信号以产生多路复用的控制信号; 解码器（1312），适于对多路复用控制信号进行解复用以产生用于可变折射声透镜元件（10）的电极（250,260）的多个控制信号; 以及适于将多路复用器（1322）的复用控制信号提供给解码器（1312）的电缆（1330）。响应于施加到其上的控制信号，可变折射声透镜元件（10）适于调节声换能器（40）的有效孔径以具有所选择的孔径尺寸。

3. 发明申请

WO2009027920A2 AN ULTRASOUND DEVICE FOR DETECTING PRESENCE OR ABSENCE OF CAVITATION EVENTS 审中-公开
标题翻译：用于检测存在或不存在空隙事件的超声波装置
公开(公告)号：WO2009027920A2
公开(公告)日：2009-03-05
申请号：PCT/IB2008/053397
申请日：2008-08-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HALL, Christopher, S. , FERNANDEZ, Anna, T. , SUIJVER, Jan, F.
发明人： HALL, Christopher, S. , FERNANDEZ, Anna, T. , SUIJVER, Jan, F.
IPC分类号： A61B6/12 , A61B17/22
CPC分类号： A61B17/22004 , A61B8/00 , A61B17/22029 , A61B17/225 , A61B2017/00106 , A61B2017/22009
摘要： This invention relates to an ultrasound device for detecting presence or absence of cavitation events. An ultrasound transducer receives emitted and reflected ultrasound waves from tissues within a specific target volume and the received ultrasound waves are subsequently converted into a detection signal. A control unit then processes the detected signal for determining whether a cavitation event is detected. A liquid lens having an adjustable focal point is placed in front of the ultrasound transducer such that the received ultrasound waves go through the liquid lens prior to be received by the ultrasound transducer. The lens is controlled by the control unit such that in response to a detection of a cavitation event the focal position of the lens is adjusted substantially closer to the spatial location of the detected cavitation event.
摘要翻译：本发明涉及用于检测气蚀事件的存在或不存在的超声波装置。超声波换能器从特定目标体积内的组织接收发射和反射的超声波，并且接收的超声波随后被转换成检测信号。控制单元然后处理检测到的信号，以确定是否检测到空化事件。具有可调焦点的液体透镜被放置在超声波换能器的前面，使得接收的超声波在被超声换能器接收之前通过液体透镜。透镜由控制单元控制，使得响应于空化事件的检测，透镜的焦点位置基本上更接近于检测到的气蚀事件的空间位置。

4. 发明申请

WO2009007900A2 ULTRASONIC ASSEMBLY WITH ADJUSTABLE FLUID LENS 审中-公开
标题翻译：超声波组件与可调节流体镜
公开(公告)号：WO2009007900A2
公开(公告)日：2009-01-15
申请号：PCT/IB2008/052716
申请日：2008-07-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HALL, Christopher, S. , FERNANDEZ, Anna, T. , SUIJVER, Jan, F.
发明人： HALL, Christopher, S. , FERNANDEZ, Anna, T. , SUIJVER, Jan, F.
IPC分类号： A61B17/22
CPC分类号： A61N7/022 , A61B2017/00243 , A61N2007/0056 , G10K11/30
摘要： An ultrasonic assembly suited for attachment to a catheter, e.g. for medical treatment. The ultrasonic assembly includes an adjustable ultrasonic focus mechanism arranged in connection with the ultrasonic transducer to adjust focus of ultrasonic waves generated by the transducer. The ultrasonic focus mechanism includes a fluid focus lens with at least two fluids separated by an interface such that ultrasonic waves are substantially reflected at the interface. At least two electrodes are arranged in connection with the fluid focus lens so as to allow adjustment of the interface shape, e.g. a curvature of the interface, when a voltage is applied to the electrodes. In preferred embodiments the electrodes are arranged so as to allow adjustment of the fluid focus lens in an elevation direction as well as in a radial direction. In simple embodiments with rotational symmetric geometry with the transducer positioned in the centre of the fluid focus lens, ultrasonic waves can be focused in an annular ring. This is e.g. suitable for ablative or coagulative necrotic treatment of human tissue, e.g. for atrial fibrillation treatment. In some embodiments, the assembly has a number of separate individually adjustable fluid focus lens compartments allowing a more detailed control of the ultrasonic focus pattern.
摘要翻译：适于附接到导管的超声波组件，例如用于治疗。超声波组件包括与超声波换能器连接布置的可调超声波聚焦机构，以调节由换能器产生的超声波的焦点。超声波聚焦机构包括流体聚焦透镜，其中至少两个流体被界面分开，使得超声波在界面处被大体上反射。至少两个电极被布置成与流体聚焦透镜相关联，以便允许调节界面形状，例如，当向电极施加电压时，界面的曲率。在优选实施例中，电极被布置成允许在高度方向以及径向方向上调整流体聚焦透镜。在具有旋转对称几何形状的简单实施例中，换能器定位在流体聚焦透镜的中心，超声波可以聚焦在环形环中。这是例如适用于人体组织的消融或凝血坏死治疗，例如用于心房颤动治疗。在一些实施例中，组件具有许多单独可单独调节的流体聚焦透镜隔室，允许对超声波聚焦图案进行更详细的控制。

5. 发明申请

WO2010140069A1 VISUALIZATION APPARATUS 审中-公开
标题翻译：可视化装置
公开(公告)号：WO2010140069A1
公开(公告)日：2010-12-09
申请号：PCT/IB2010/051919
申请日：2010-05-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BARLEY, Maya, E. , DELADI, Szabolcs , HARKS, Godefridus, A. , SUIJVER, Jan, F. , MEGENS, Mischa
发明人： BARLEY, Maya, E. , DELADI, Szabolcs , HARKS, Godefridus, A. , SUIJVER, Jan, F. , MEGENS, Mischa
IPC分类号： A61B19/00 , A61B18/14
CPC分类号： A61B90/36 , A61B18/1492 , A61B34/20 , A61B2017/00106 , A61B2090/062 , A61B2090/065 , A61B2090/376 , G06F19/00
摘要： The invention relates to a visualization apparatus for visualizing aquality of applying energy to an object. The quality of applying energy at a location on the object (3) is visualized based on a) a provided image of the object and b) a provided quality value representing the quality of applying energy to the object at the location on the object (3), wherein a visual property assigning unit (9) assigns a visual property to the location depending on the quality value and a display(10) displays the provided image and the assigned visual property at the location on the object shown in the image.In general a person who applies energy to the object is focused on the location at which energy is applied. Since quality information is shown at the location on which the person is already focused, the quality dependent information can easily be absorbed by the person.
摘要翻译：本发明涉及一种可视化装置，用于将能量施加到物体上的可视化。基于a）所提供的对象图像和b）提供的质量值，表示在物体上的位置处对物体施加能量的质量（3），可视化对象（3）上的位置处的能量的质量），其中视觉特性分配单元（9）根据所述质量值向所述位置分配视觉特性，并且显示器（10）在所述图像中所示的对象上的位置处显示所提供的图像和所分配的视觉特性。将能量施加到物体的人一般集中在施加能量的位置上。由于质量信息显示在人已经聚焦的位置，所以质量依赖信息可以容易地被人吸收。

6. 发明申请

WO2010103423A2 CATHETER, APPARATUS, METHOD AND COMPUTER PROGRAM FOR APPLYING ENERGY TO AN OBJECT 审中-公开
标题翻译：用于将能量应用于物体的导管，设备，方法和计算机程序
公开(公告)号：WO2010103423A2
公开(公告)日：2010-09-16
申请号：PCT/IB2010/050886
申请日：2010-03-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WEEKAMP, Johannes, W. , DELADI, Szabolcs , BARLEY, Maya, E. , RADEMAKERS, Antonius, J., J. , SUIJVER, Jan, F.
发明人： WEEKAMP, Johannes, W. , DELADI, Szabolcs , BARLEY, Maya, E. , RADEMAKERS, Antonius, J., J. , SUIJVER, Jan, F.
IPC分类号： A61B18/14 , A61B8/12 , A61M25/10
CPC分类号： A61B8/4461 , A61B8/12 , A61B8/445 , A61B8/4472 , A61B18/1492 , A61B2018/00214 , A61B2018/00773 , A61B2018/1861 , A61B2090/3782 , A61M25/10
摘要： The present invention relates to a catheter for applying energy to an object. The catheter (5) has a longitudinal axis (7) and includes an energy applying unit (30) for applying energy to the object and a sensing unit (20) for sensing the object in a sensing direction (23). The sensing unit(20) is adapted to be rotatable with respect to the catheter (5) such that the angle (Î±) between the sensing direction (23) of the sensing unit (20) and the longitudinal axis (7) of the catheter (5) is adjustable. The sensing unit (20) can be adjusted during the application of energy to the object such that the sensing direction (23) of the sensing unit (20) points to the site to which the energy is applied, regardless of the angle that the catheter tip forms with the surface of the object at that site.
摘要翻译：本发明涉及一种用于向物体施加能量的导管。导管（5）具有纵向轴线（7）并且包括用于向物体施加能量的能量施加单元（30）和用于沿感测方向（23）感测物体的感测单元（20）。感测单元（20）适于相对于导管（5）旋转，使得感测单元（20）的感测方向（23）与纵向轴线（7）之间的角度（θcirc; 的导管（5）是可调节的。在向对象施加能量期间可以调节感测单元（20），使得感测单元（20）的感测方向（23）指向施加能量的位置，而不管导管尖端与该位置处的物体表面形成。

7. 发明申请

WO2009150593A1 APPARATUS FOR DETERMINING A PROPERTY OF AN OBJECT 审中-公开
标题翻译：用于确定对象的属性的装置
公开(公告)号：WO2009150593A1
公开(公告)日：2009-12-17
申请号：PCT/IB2009/052388
申请日：2009-06-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , THILWIND, Rachel, E. , SUIJVER, Jan, F. , DELADI, Szabolcs
发明人： THILWIND, Rachel, E. , SUIJVER, Jan, F. , DELADI, Szabolcs
IPC分类号： A61B5/00
CPC分类号： A61B8/12 , A61B5/0084 , A61B5/0095 , A61B6/12 , A61B6/4423 , A61B18/1492 , A61B2017/00106
摘要： The present invention relates to an apparatus for determining a property of an object (2), wherein the apparatus comprises a casing (31) comprising an inner region (33) for receiving an object influencing unit (3) for influencing the object (2) and an outer region (35) enclosing the inner region (33). The outer region (35) comprises a light transmission unit (36) for transmitting acoustic wave generating light to the object (2) for coupling the acoustic wave generating light into the object (2) for generating an acoustic wave within the object (2). Furthermore, the outer region (35) comprises an acoustic wave sensing element (37) for sensing the acoustic wave. The casing is preferentially a sheath surrounding the inner region (33), wherein preferentially in the wall of the sheath at least one cavity (39) defines the outer region (35).
摘要翻译：本发明涉及一种用于确定物体（2）的性质的装置，其中该装置包括一个壳体（31），该壳体包括用于接收用于影响物体（2）的物体影响单元（3）的内部区域（33）和封闭所述内部区域（33）的外部区域（35）。外部区域（35）包括用于将声波产生光传送到物体（2）的光传输单元（36），用于将声波产生光耦合到物体（2）中，用于在物体（2）内产生声波，。此外，外部区域（35）包括用于感测声波的声波感测元件（37）。壳体优选地是围绕内部区域（33）的护套，其中优选地在护套的壁中至少一个空腔（39）限定外部区域（35）。

8. 发明申请

WO2010082146A1 MONITORING APPARATUS FOR MONITORING AN ABLATION PROCEDURE 审中-公开
标题翻译：监测装置的监测程序
公开(公告)号：WO2010082146A1
公开(公告)日：2010-07-22
申请号：PCT/IB2010/050059
申请日：2010-01-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HARKS, Erik, A. , DELADI, Szabolcs , SUIJVER, Jan, F. , JANKOVIC, Ladislav , SHI, Yan, S. , RENSEN, Wouter, H., J. , BARLEY, Maya, E. , VAN DER VAART, Nijs, C.
发明人： HARKS, Erik, A. , DELADI, Szabolcs , SUIJVER, Jan, F. , JANKOVIC, Ladislav , SHI, Yan, S. , RENSEN, Wouter, H., J. , BARLEY, Maya, E. , VAN DER VAART, Nijs, C.
IPC分类号： A61B8/08 , A61B8/12 , A61B18/14
CPC分类号： A61B8/0858 , A61B8/12 , A61B8/445 , A61B8/486 , A61B18/02 , A61B18/1442 , A61B18/1492 , A61B18/18 , A61B18/20 , A61B2017/00106 , A61B2018/00577 , A61B2018/00738 , A61B2090/376 , A61B2090/3784 , A61B2218/002
摘要： The present invention relates to a monitoring apparatus(101) for monitoring an ablation procedure. The monitoring apparatus (101) comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object (4) that is ablated. The monitoring apparatus (101) further comprises an ablation depth determination unit (103) for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object (4) and for determining when the ablation has reached a desired progression.
摘要翻译：本发明涉及一种用于监测消融程序的监测装置（101）。监视装置（101）包括：超声信号提供单元，用于提供取决于被消融的物体（4）的接收回波序列的超声信号。监测装置（101）还包括用于根据所提供的超声信号确定消融深度的消融深度确定单元（103）。消融深度可以直接从超声信号确定，并且是执行消融过程的重要参数。例如，它可以用于确定对象（4）内的消融进展并确定消融何时达到期望的进程。

9. 发明申请

WO2009090588A1 APPARATUS, METHOD AND COMPUTER PROGRAM FOR APPLYING ENERGY TO AN OBJECT 审中-公开
标题翻译：用于将能量应用于对象的装置，方法和计算机程序
公开(公告)号：WO2009090588A1
公开(公告)日：2009-07-23
申请号：PCT/IB2009/050102
申请日：2009-01-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , THILWIND, Rachel, E. , SUIJVER, Jan, F. , DELADI, Szabolcs
发明人： THILWIND, Rachel, E. , SUIJVER, Jan, F. , DELADI, Szabolcs
IPC分类号： A61B5/00 , A61B18/00
CPC分类号： A61B18/1492 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/0095 , A61B18/02 , A61B18/24 , A61B2017/00057 , A61B2017/00106
摘要： The present invention relates to an apparatus for applying energy to an object. The invention relates further to a corresponding method and to a corresponding computer program. The apparatus comprises a catheter (3), which includes an energy applying unit (17, 18) for applying energy to the object (2) and a photoacoustic measurement unit (20, 21) for photo acoustically sensing the object (2). The photoacoustic measurement unit comprises preferentially a reflecting element (20), which is movable by an acoustic wave, wherein the apparatus comprises at least one optical fiber (21) located within the catheter (3) for guiding light to and/or from the movable reflecting element (20). The acoustic wave is preferentially measured by determining a phase shift of light reflected from the reflecting element (20), which moves, if the reflecting element is exposed to the acoustic wave.
摘要翻译：本发明涉及一种向物体施加能量的装置。本发明进一步涉及相应的方法和相应的计算机程序。该装置包括导管（3），其包括用于向物体（2）施加能量的能量施加单元（17,18）和用于光学感测物体（2）的光声测量单元（20,21）。光声测量单元优选地包括可由声波移动的反射元件（20），其中所述设备包括位于所述导管（3）内的至少一个光纤（21），用于将光导向和/或不移动反射元件（20）。如果反射元件暴露于声波，则通过确定从反射元件（20）反射的光的相移优先测量声波，所述相移将移动。

10. 发明申请

WO2008146212A1 HYDROGEL BASED SENSOR PROBE FOR DETECTING AN ENVIRONMENTAL STATE 审中-公开
标题翻译：用于检测环境状态的基于HYDROGEL的传感器探测器
公开(公告)号：WO2008146212A1
公开(公告)日：2008-12-04
申请号：PCT/IB2008/052019
申请日：2008-05-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus, H., W. , DELADI, Szabolcs , KURT, Ralph , SUIJVER, Jan, F.
发明人： HENDRIKS, Bernardus, H., W. , DELADI, Szabolcs , KURT, Ralph , SUIJVER, Jan, F.
IPC分类号： G01N21/77
CPC分类号： G01N21/7703 , A61B5/0084 , A61B5/14539 , G01N2021/772 , G01N2021/7723 , G01N2021/773 , G01N2021/7779
摘要： The invention relates to a sensor probe (100,110,120,130,140,150) for detecting an environmental state within a bodily lumen. The sensor probe (100,110,120,130,140,150) having an elongated body (9) comprises an optical guide (1) having an outcoupling surface (11),which is part of an end surface (3) of the elongated body (9), facing a reflective surface of an overhanging part (22,42,52,62), a photodetector which detects a property of light which is composed of light (32) in the optical guide (1) that is reflected from the outcoupling surface (11) of the optical guide (1) and of light (33) in the optical guide (1) that is reflected from the overhanging part (22,42,52,62), and a hydrogel material(2) of which a property changes when getting into contact with an environmental material and/or when detecting an environmental change, and which is provided between the end surface (3) of the elongated body (9)and the overhanging part (22,42,52,62). In this way a sensor probe (100,110,120,130,140,150) is provided that, because of its compactness, can be applied inside the bodily lumen for detecting and characterizing parameters that are vital indicators for the state of the human or animal body, and to which the hydrogel material (2) is responsive.
摘要翻译：本发明涉及一种用于检测体腔内的环境状态的传感器探针（100,110,120,130,140,150）。具有细长主体（9）的传感器探针（100,110,130,140,150）包括具有外耦合表面（11）的光导（1），该外耦合表面（11）是细长主体（9）的端表面（3）的一部分，面向反射表面突出部分（22,42,52,62）的光检测器，其检测由光导（1）中的光（32）组成的光的属性，所述光从光耦合表面（11）反射在导光体（1）中从突出部分（22,42,52,62）反射的导光体（1）和光（33）以及在接触时性质发生变化的水凝胶材料（2）和环境材料和/或当检测到环境变化时，并且设置在细长体（9）的端面（3）与伸出部分（22,42,52,62）之间。以这种方式，提供传感器探针（100,110,120,130,140,150），由于其紧凑性，可以在身体内部施加以检测和表征作为人或动物体状态的重要指标的参数，并且将水凝胶材料（2）有反应。

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