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1. 发明申请

WO2008035295A3 A MICRO-ACTUATOR DEVICE FOR THE USE IN A BIOCHIP OR BIOSYSTEM 审中-公开
标题翻译：用于生物化学或生物体系的微型致动器装置
公开(公告)号：WO2008035295A3
公开(公告)日：2009-02-05
申请号：PCT/IB2007053796
申请日：2007-09-19
申请人： KONINKL PHILIPS ELECTRONICS NV , GILLIES MURRAY F , DEN TOONDER JACOB M J , JOHNSON MARK T , PONJEE MARC W G
发明人： GILLIES MURRAY F , DEN TOONDER JACOB M J , JOHNSON MARK T , PONJEE MARC W G
IPC分类号： B81B3/00
CPC分类号： B81B3/0029 , B81B2201/036
摘要： The Invention concerns to a micro-actuator device for the use in biochip or bio-system. In order to achieve a micro-actuator device for the use as a micro pump in biosensors or bio-systems, or at least bio-chips, by which the actuation can be steered very precisely and effective, the solution is that the micro actuator consist of a photosensitive actuator element (1), which can be deformed from a reversal basic-form into an activated deformation form by photonic activation of a light source (3, 4, L1, L2) in order to generate with this controlled movement a defined flow in a gas or a liquid.
摘要翻译：本发明涉及用于生物芯片或生物系统的微致动器装置。为了实现微致动器装置，用作生物传感器或生物系统中的微泵，或至少可以非常精确和有效地转动致动的生物芯片，解决方案是微型致动器包括感光致动器元件（1），其可以通过光源（3,4，L1，L2）的光子激活而从反转基本形式变形为激活的变形形式，以便以该受控运动产生定义的在气体或液体中流动。

2. 发明申请

WO2009053870A3 DEVICE AND METHOD FOR THE MONITORING OF THE MOVEMENT OF CELLS 审中-公开
标题翻译：用于监测细胞运动的装置和方法
公开(公告)号：WO2009053870A3
公开(公告)日：2009-06-11
申请号：PCT/IB2008054195
申请日：2008-10-13
申请人： KONINKL PHILIPS ELECTRONICS NV , CATTANEO STEFANO , GILLIES MURRAY F , VULTO SIMONE I E , DE HOOG THOMAS J , MERKLE DENNIS , JOHNSON MARK T
发明人： CATTANEO STEFANO , GILLIES MURRAY F , VULTO SIMONE I E , DE HOOG THOMAS J , MERKLE DENNIS , JOHNSON MARK T
IPC分类号： C12M1/34 , G01N15/10 , G01N33/487 , G01N33/50
CPC分类号： B03C5/028 , G01N15/1031
摘要： The present invention relates to a device for the monitoring of very small movements of cells, in particular when undergoing chemotaxis. The invention makes use of various ways of electrical detection, like capacitance or impedance measurements. In this way the detection of the movement of cells can be done in situ, which accelerates the chemotaxis assay and increases the accuracy of the measurements. The device according to the present invention particularly comprises a stimulant gradient chamber (1) for providing a concentration gradient of a stimulant, said stimulant gradient chamber (1) having a cell inlet (12) for the inlet of cells (C), - an electrical sensor (2) placed in a measurement area for measuring an electrical parameter which changes in response to a movement of cells (C) in the surrounding of said sensor (2) and for generating a detection signal, and a signal evaluation unit (3) for evaluating said detection signal.
摘要翻译：本发明涉及用于监测细胞的非常小的运动的装置，特别是当经历趋化性时。本发明利用电检测的各种方式，如电容或阻抗测量。通过这种方式，细胞运动的检测可以在原位进行，这加速了趋化性测定并增加了测量的准确性。根据本发明的装置特别包括用于提供兴奋剂浓度梯度的兴奋剂梯度室（1），所述兴奋剂梯度室（1）具有用于细胞（C）入口的细胞入口（12）， - 电传感器（2），放置在测量区域中，用于测量响应于所述传感器（2）周围的单元（C）的移动而变化并且用于生成检测信号的电参数;以及信号评估单元（3 ）用于评估所述检测信号。

3. 发明申请

WO2006111879A3 OPTICALLY ADDRESSABLE BI-STABLE DISPLAY 审中-公开
标题翻译：可光寻址的双稳态显示
公开(公告)号：WO2006111879A3
公开(公告)日：2006-12-07
申请号：PCT/IB2006051058
申请日：2006-04-06
申请人： KONINKL PHILIPS ELECTRONICS NV , GILLIES MURRAY F , JOHNSON MARK T
发明人： GILLIES MURRAY F , JOHNSON MARK T
IPC分类号： G09G3/00 , G09G3/34
CPC分类号： G09G3/344 , G09G3/02 , G09G2360/141
摘要： An optically addressable bi-stable display module comprises a stack of a photoconductor and a bi-stable material which is sandwiched between a first electrode and a second electrode to obtain a display device. A light unit illuminates the display device. A light driver drives the light unit, and a data driver supplies a drive voltage between the first electrode and the second electrode. A controller controls the light driver and the data driver to obtain a sequence comprising at least a first phase and a second phase succeeding the first phase. The sequence comprises at least a first address phase (TA), and an erase phase (TR) and/or a hold phase (TO), and/or a second address phase (TA). The controller controls, during a transition (TU, TD) from the first phase to the second phase, (i) the data driver to change the drive voltage (VD) from one level to a next level, and (ii) the light driver to substantially coincidently switch off the light unit. In this approach an optical state of the display device is kept substantially unaltered during the transition (TU, TD).
摘要翻译：光寻址双稳态显示模块包括一个光电导体堆叠和双稳态材料，它夹在第一电极和第二电极之间以获得显示装置。灯单元照亮显示设备。光驱动器驱动灯单元，并且数据驱动器在第一电极和第二电极之间提供驱动电压。控制器控制光驱动器和数据驱动器以获得包括在第一阶段之后的至少第一阶段和第二阶段的序列。该序列至少包括第一地址相位（TA）和擦除相位（TR）和/或保持相位（TO）和/或第二寻址相位（TA）。在从第一阶段到第二阶段的转换（TU，TD）期间，控制器控制（i）将驱动电压（VD）从一个级别改变到下一级的数据驱动器，以及（ii）光驱动器以基本上一致地关闭灯单元。在该方法中，显示装置的光学状态在转换期间（TU，TD）基本上保持不变。

4. 发明申请

WO2008125927A3 MICROFLUIDIC SYSTEM WITH ACTUATORS 审中-公开
标题翻译：具有执行器的微流控系统
公开(公告)号：WO2008125927A3
公开(公告)日：2009-01-29
申请号：PCT/IB2007055104
申请日：2007-12-14
申请人： KONINKL PHILIPS ELECTRONICS NV , GILLIES MURRAY F , DEN TOONDER JACOB M J , PONJEE MARC W G , JOHNSON MARK T
发明人： GILLIES MURRAY F , DEN TOONDER JACOB M J , PONJEE MARC W G , JOHNSON MARK T
IPC分类号： F04B19/00 , B01L3/00
CPC分类号： B01F13/0059 , B01F13/0091 , B01L3/50273 , B01L3/502792 , B01L7/52 , B01L7/54 , B01L2300/0819 , B01L2300/089 , B01L2300/1822 , B01L2300/1827 , B01L2300/1872 , B01L2400/0484 , B01L2400/0633 , B01L2400/0688 , F04B19/006 , F04B19/24 , F04D33/00
摘要： The invention relates to microfluidic system (100), particularly a biosensor, for manipulating a sample in a sample chamber (1). The device comprises at least one actuator (10) that reversibly changes its spatial configuration if it is heated and/or cooled. The actuator (10) may particularly be arranged adjacent to an associated heating element (20) of a 5 heating array that is used to establish a predetermined spatial and/or temporal temperature profile in the sample chamber (1). The configuration change of the actuator (10) can be used to move the sample fluid or to control its passage through fluid channels. A plurality of actuators (10) may optionally be provided that undergo their configuration changes at different temperatures, particularly temperatures within a range that is passed during a 10 reaction like PCR.
摘要翻译：本发明涉及用于操纵样品室（1）中的样品的微流体系统（100），特别是生物传感器。该装置包括至少一个致动器（10），其如果被加热和/或冷却则可逆地改变其空间构造。致动器（10）可以特别地布置成与用于在样品室（1）中建立预定空间和/或时间温度分布的5个加热阵列的相关联的加热元件（20）相邻。致动器（10）的配置变化可用于移动样品流体或控制其通过流体通道。可以任选地提供多个致动器（10），其在不同温度，特别是在10反应期间通过的范围内的温度（如PCR）中进行其配置变化。

5. 发明申请

WO2008020374A3 AN ELECTRIC BASED MICRO-FLUIDIC DEVICE USING ACTIVE MATRIX PRINCIPLE 审中-公开
标题翻译：基于有源矩阵原理的电动微流体装置
公开(公告)号：WO2008020374A3
公开(公告)日：2008-04-24
申请号：PCT/IB2007053176
申请日：2007-08-10
申请人： KONINKL PHILIPS ELECTRONICS NV , JOHNSON MARK T , DEN TOONDER JACOB M J , GILLIES MURRAY F , FRENCH IAN , PONJEE MARC W G
发明人： JOHNSON MARK T , DEN TOONDER JACOB M J , GILLIES MURRAY F , FRENCH IAN , PONJEE MARC W G
IPC分类号： F04B19/00 , F04D33/00
CPC分类号： F04D33/00 , B01F13/0059 , B01F13/0091 , F04B19/006
摘要： The invention relates to an electric based micro-fluidic device using active matrix principle, for the use in medical and health and wellness products, in particular biochips or bio-systems. An electric based micro-fluidic device using active matrix principle, for the use in medical and health and wellness products, in particular biochips or bio-systems, wherein an 2-dimensional matrix array of poly MEMS actuators (PMA) (1) is arranged in a 2-dimenional system in which each single actuator is electrically/electronically steered independently from each other, in order to be able to generate a pattern of activation in the matrix.
摘要翻译：本发明涉及使用有源矩阵原理的电基微流体装置，用于医疗和健康以及健康产品，特别是生物芯片或生物系统。一种使用有源矩阵原理的基于电的微流体装置，用于医疗和健康以及健康产品，特别是生物芯片或生物系统，其中多MEMS致动器（PMA）（1）的二维矩阵阵列被布置在其中每个单个致动器彼此独立地电/电控制的二维系统中，以便能够在矩阵中产生激活模式。

6. 发明申请

WO2008020355A3 MOVING PARTICLE DISPLAY DEVICE 审中-公开
标题翻译：移动颗粒显示设备
公开(公告)号：WO2008020355A3
公开(公告)日：2008-04-17
申请号：PCT/IB2007053005
申请日：2007-07-30
申请人： KONINKL PHILIPS ELECTRONICS NV , JOHNSON MARK T , BUDZELAAR FRANCISCUS P M , GILLIES MURRAY F
发明人： JOHNSON MARK T , BUDZELAAR FRANCISCUS P M , GILLIES MURRAY F
IPC分类号： G02F1/167 , G09G3/34
CPC分类号： G02F1/167 , G02F1/134363 , G09G3/3446 , G09G2300/0434 , G09G2320/0252
摘要： A display device and a method for driving the display device is disclosed. The display device comprises drive circuitry (35) and a plurality of pixels (PIXl, PIX2, PIX3, PIX4, PIX5, PIX6) having movable charged particles (116). The drive circuitry is configured to apply control signals to the pixels to move the charged particles between first (110) and second (112) regions of each pixel in order to alter the optical appearance of each pixel. The method for each pixel comprises a pre-addressing stage (PRA) of moving the charged particles towards the boundary (114) between the first and second regions, and then an addressing stage (ADD) of moving the particles to one side or the other side of the boundary, in dependence on the desired optical appearance of the pixel.
摘要翻译：公开了一种用于驱动显示装置的显示装置和方法。显示装置包括具有可移动带电粒子（116）的驱动电路（35）和多个像素（PIX1，PIX2，PIX3，PIX4，PIX5，PIX6）。驱动电路被配置为向像素施加控制信号以将带电粒子移动到每个像素的第一（110）和第二（112）区域之间，以改变每个像素的光学外观。每个像素的方法包括将带电粒子移动到第一和第二区域之间的边界（114）的预寻址级（PRA），然后将粒子移动到一侧或另一侧的寻址级（ADD）边界，这取决于像素的期望的光学外观。

7. 发明申请

WO2009024901A2 SENSOR DEVICE 审中-公开
标题翻译：传感器装置
公开(公告)号：WO2009024901A2
公开(公告)日：2009-02-26
申请号：PCT/IB2008053248
申请日：2008-08-13
申请人： KONINKL PHILIPS ELECTRONICS NV , JOHNSON MARK T , STAPERT HENDRIK ROELOF , GILLIES MURRAY F , VOSSENAAR ERIK R
发明人： JOHNSON MARK T , STAPERT HENDRIK ROELOF , GILLIES MURRAY F , VOSSENAAR ERIK R
CPC分类号： G01N33/5438 , B01L3/50273 , B01L2300/0627 , B01L2300/14 , B01L2300/1805
摘要： The present invention provides a sensor device (10) for determining the presence and/or amount of target moieties (5) in a first, sample fluid (4). The sensor device (10) comprises fluid displacement means for controlled displacing the first, sample fluid(4)comprising the target moieties(5) and a second washing fluid (6). The sensor device (10) according to embodiments of the invention allows repeatedly washing and detecting the presence and/or amount of target moieties (7) bound to a sensor substrate surface (3). The present invention also provides a method for forming such sensor devices (10) and a method for determining the presence and/or amount of target moieties (5) in a first, sample fluid (4) using such sensor devices (10).
摘要翻译：本发明提供了用于确定第一样品流体（4）中的靶部分（5）的存在和/或量的传感器装置（10）。传感器装置（10）包括用于控制移位包括目标部分（5）的第一样品流体（4）和第二洗涤流体（6）的流体位移装置。根据本发明的实施例的传感器装置（10）允许反复清洗和检测结合到传感器衬底表面（3）的目标部分（7）的存在和/或数量。本发明还提供了用于形成这种传感器装置（10）的方法以及使用这种传感器装置（10）确定第一样品流体（4）中的靶部分（5）的存在和/或量的方法。

8. 发明申请

WO2008120135A2 A MICRO-FLUIDIC DEVICE BASED UPON ACTIVE MATRIX PRINCIPLES 审中-公开
标题翻译：基于有源矩阵原理的微流体设备
公开(公告)号：WO2008120135A2
公开(公告)日：2008-10-09
申请号：PCT/IB2008051102
申请日：2008-03-25
申请人： KONINKL PHILIPS ELECTRONICS NV , GILLIES MURRAY F , PONJEE MARC W G , JOHNSON MARK T
发明人： GILLIES MURRAY F , PONJEE MARC W G , JOHNSON MARK T
IPC分类号： B01L3/00 , G01F1/684 , G01F1/696 , G01F1/708 , G01P5/10 , G01P5/18
CPC分类号： B01L3/502715 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L2200/0673 , B01L2200/143 , B01L2200/147 , B01L2300/0819 , B01L2300/1827 , G01F1/6845 , G01F1/696 , G01F1/708 , G01P5/10 , G01P5/12 , G01P5/18
摘要： A micro-fluidic device (1) including a two-dimensional array of a plurality of components (2) for processing a fluid and/or for sensing properties of the fluid is suggested. Each component (2) is coupled to at least one control terminal (9,10) enabling an active matrix to change the state of each component individually. The components comprise at least one heater element (13). The active matrix includes a two-dimensional array of electronic components (12) realized in thin film technology. The active matrix provides a high versatility of the device. The thin film technology ensures a very cost efficient manufacturing also of large devices. In the micro-fluidic device the fluid flow can be detected.
摘要翻译：提出了包括用于处理流体和/或感测流体性质的多个组件（2）的二维阵列的微流体装置（1）。每个组件（2）耦合到至少一个控制终端（9,10），使得有源矩阵能够单独改变每个组件的状态。这些部件包括至少一个加热元件（13）。有源矩阵包括以薄膜技术实现的电子元件（12）的二维阵列。有源矩阵提供了高通用性的器件。薄膜技术确保了大型设备的高性价比制造。在微流体装置中，可以检测流体流动。

9. 发明申请

WO2006075289A2 OPTICALLY ADDRESSABLE DISPLAY 审中-公开
标题翻译：光学可寻址显示
公开(公告)号：WO2006075289A2
公开(公告)日：2006-07-20
申请号：PCT/IB2006050085
申请日：2006-01-10
申请人： KONINKL PHILIPS ELECTRONICS NV , GILLIES MURRAY F , JOHNSON MARK T
发明人： GILLIES MURRAY F , JOHNSON MARK T
CPC分类号： G09G3/3446 , G02F1/0126 , G02F1/167 , G02F1/3558 , G02F2202/12 , G09G2360/142
摘要： An optically addressable display comprises a pixels (Pi) which has a pixel volume (PVi) filled with a material (BMi) which comprises moveable charged particles (PAi). The pixel volume (PVi) comprises: a reservoir volume (RVi) in which particles are invisible to a viewer, and a display volume (DVi) in which particles are visible to the viewer. The pixel (Pi) comprises a second electrode (DEi; REi) and a third electrode (REi; DEi), both being associated with the pixel volume (PVi) to generate an in-plane electric field (EFi) in the pixel volume (PVi) to move the particles (PAi) between the reservoir volume (RVi) and the display volume (DVi). The pixel (Pi) further comprises a first electrode (BEi) which has a first surface area (SA1i) smaller than a pixel area (PIAi), and a photoconductor (PCi) arranged between the first electrode (BEi) and the third electrode (REi; DEi). The optically addressable display further comprises: a driver (DR) which supplies a first voltage (VIi) to the first electrode (BEi), and a second voltage (V2i) to the second electrode (DEi; REi). The third electrode (REi; DEi) is floating. A light source (LS) selectively illuminates the photoconductor (PCi).
摘要翻译：光学可寻址显示器包括具有填充有包含可移动带电粒子（PAi）的材料（BMi）的像素体积（PVi）的像素（Pi）。像素体积（PVi）包括：其中粒子对观看者不可见的储存体积（RVi）和其中粒子对观看者可见的显示体积（DVi）。像素（Pi）包括与像素体积（PVi）相关联的第二电极（DEi; REi）和第三电极（REi; DEi），以在像素体积中产生平面内电场（EFi） PVi）将粒子（PAi）在储存容积（RVi）和显示容积（DVi）之间移动。像素（Pi）还包括具有比像素区域（PIAi）小的第一表面积（SA1i）的第一电极（BEi），以及布置在第一电极（BEi）和第三电极（BEi）之间的光电导体（PCi） REi; DEi）。该光学可寻址显示器还包括：向第一电极（BEi）提供第一电压（VIi），向第二电极（DEi; REi）提供第二电压（V2i）的驱动器（DR）。第三电极（REi; DEi）是浮动的。光源（LS）选择性地照亮光电导体（PCi）。

10. 发明申请

WO2008035293A3 A MICRO-FLUIDIC DEVICE FOR THE USE IN BIOCHIPS OR BIOSYSTEMS 审中-公开
标题翻译：用于生物化学或生物制品的微流体装置
公开(公告)号：WO2008035293A3
公开(公告)日：2011-07-14
申请号：PCT/IB2007053792
申请日：2007-09-19
申请人： KONINKL PHILIPS ELECTRONICS NV , PONJEE MARC W G , DEN TOONDER JACOB M J , GILLIES MURRAY F , JOHNSON MARK T
发明人： PONJEE MARC W G , DEN TOONDER JACOB M J , GILLIES MURRAY F , JOHNSON MARK T
IPC分类号： B01L3/00 , F04D33/00
CPC分类号： F04D33/00 , B01L3/50273 , B01L2300/0819 , B01L2300/1822 , B01L2400/0484 , Y10T29/494
摘要： The Invention concerns to a micro-fluidic device for the use in biochip or bio- system, wherein an 2 dimensional matrix array of temperature sensitive po Iy-MEM actuators (1) is arranged in a 2 dimensional thermal processing array, in which each single temperature control element (6) or thermal element can be steered independently from each other, in order to be able to activate each single poly-MEM actuator (1).
摘要翻译：本发明涉及用于生物芯片或生物系统的微流体装置，其中将温度敏感的pIy-MEM致动器（1）的二维矩阵阵列布置在二维热处理阵列中，其中每个单个温度控制元件（6）或热元件可以彼此独立地转向，以便能够激活每个单个多MEM执行元件（1）。

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