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1. 发明申请

WO2008127369A3 HYBRID PET/MR IMAGING SYSTEMS 审中-公开
标题翻译：混合PET / MR成像系统
公开(公告)号：WO2008127369A3
公开(公告)日：2009-03-19
申请号：PCT/US2007081457
申请日：2007-10-16
申请人： KONINKL PHILIPS ELECTRONICS NV , GAGNON DANIEL , MORICH MICHAEL A , BLAKELEY DOUGLAS M , ZAHN ROBERT L , NIEMAN KEVIN M
发明人： GAGNON DANIEL , MORICH MICHAEL A , BLAKELEY DOUGLAS M , ZAHN ROBERT L , NIEMAN KEVIN M
IPC分类号： G01R33/28 , G01R33/421 , G01R33/422 , G01R33/48
CPC分类号： G01R33/28 , G01R33/3875 , G01R33/421 , G01R33/422 , G01R33/481 , G01R33/4812
摘要： A hybrid imaging system includes a magnetic resonance scanner (10) and a second modality imaging system (12) such as PET or SPECT disposed in the same radio frequency isolation space (16). The second modality imaging system includes radiation detectors (68, 70, 70') configured to detect at least one of high energy particles and high energy photons. In some embodiments a retractable radio frequency screen (92) is selectively extendible into a gap between the magnetic resonance scanner and the second modality imaging system. In some embodiments shim coils (52) are disposed with the magnetic resonance scanner and are configured to compensate for distortion of the static magnetic field of the magnetic resonance scanner produced by proximity of the second modality imaging system.
摘要翻译：混合成像系统包括磁共振扫描器（10）和设置在同一射频隔离空间（16）中的诸如PET或SPECT的第二模态成像系统（12）。第二模态成像系统包括被配置为检测高能量粒子和高能量光子中的至少一个的辐射检测器（68,70,70'）。在一些实施例中，可伸缩射频屏（92）可选择地延伸到磁共振扫描仪和第二模态成像系统之间的间隙中。在一些实施例中，衬垫线圈（52）与磁共振扫描器一起设置并且被配置为补偿由第二模态成像系统接近产生的磁共振扫描器的静态磁场的变形。

2. 发明申请

WO2010041191A3 ENCLOSURE FOR HYGROSCOPIC SCINTILLATION CRYSTAL FOR NUCLEAR IMAGING 审中-公开
标题翻译：用于核成像的吸湿性闪烁晶体的外壳
公开(公告)号：WO2010041191A3
公开(公告)日：2010-11-04
申请号：PCT/IB2009054351
申请日：2009-10-05
申请人： KONINKL PHILIPS ELECTRONICS NV , GAGNON DANIEL
发明人： GAGNON DANIEL
IPC分类号： G01T1/20
CPC分类号： G01T1/2018 , Y10T29/49002
摘要： When employing hygroscopic scintillation crystals (32) in a nuclear detector (e.g., PET or SPECT), Silicon photomultiplier (SiPM) sensors (34) are coupled to each scintillation crystal (32) to improve scintillation event detection and reduce scatter. The crystals (32) and sensors (34) are hermetically sealed in a detector housing (50) using a sealant layer (51). Electrical contacts (60) from each sensor (34) extend through the sealant layer (51) or are bused together such that the bus extends through the sealant layer (51). In this manner, hygroscopic scintillation crystals (e.g., LaBr, NaI, etc.) are protected from humidity and light scatter is reduced by direct coupling of the sensors (34) and crystals (32).
摘要翻译：当在核探测器（例如PET或SPECT）中使用吸湿闪烁晶体（32）时，硅光电倍增器（SiPM）传感器（34）与每个闪烁晶体（32）耦合以改善闪烁事件检测并减少散射。使用密封剂层（51）将晶体（32）和传感器（34）气密密封在检测器外壳（50）中。来自每个传感器（34）的电触点（60）延伸穿过密封剂层（51）或者被汇集在一起，使得总线延伸穿过密封剂层（51）。以这种方式，吸湿闪烁晶体（例如LaBr，NaI等）被保护免于湿气，并且通过传感器（34）和晶体（32）的直接耦合来减少光散射。

3. 发明申请

WO2010032167A3 MR SEGMENTATION USING TRANSMISSION DATA IN HYBRID NUCLEAR/MR IMAGING 审中-公开
标题翻译：在混合核/ MR成像中使用传输数据的MR分段
公开(公告)号：WO2010032167A3
公开(公告)日：2011-04-21
申请号：PCT/IB2009053944
申请日：2009-09-09
申请人： KONINKL PHILIPS ELECTRONICS NV , GAGNON DANIEL , HU ZHIQUIANG
发明人： GAGNON DANIEL , HU ZHIQUIANG
IPC分类号： G06T7/00
CPC分类号： G01R33/481 , G01R33/5608 , G06T7/11 , G06T2207/10088 , G06T2207/10104 , G06T2207/30004
摘要： When correcting attenuation in a nuclear image (e.g., PET or SPECT), an MR-based attenuation correction (AC) map (16) is generated using MR image data (14) of a subject (60). The subject (60) is then placed in a nuclear imaging device with a radioactive point or line source (18, 18') from which transmission data is measured as the patient is imaged. In order to resolve ambiguity between air voxels and bone voxels in the MR-based AC map (16), estimated transmission data (24) is generated from the AC map and compared to the measured transmission data (22) from the point or line source. An error is iteratively calculated for the estimated and measured transmission data, and attenuation values of the AC map (16) are refined to minimize the error. The refined AC map (32) is used to correct attenuation in collected nuclear data (41) which is reconstructed into an attenuation corrected image (99) of the patient.
摘要翻译：当校正核图像（例如PET或SPECT）中的衰减时，使用对象（60）的MR图像数据（14）来生成基于MR的衰减校正（AC）图（16）。然后将受试者（60）放置在具有放射性点或线源（18,18'）的核成像装置中，当患者被成像时，将从该成像装置测量透射数据。为了解决基于MR的AC映射（16）中的空气体素和骨骼体素之间的模糊性，从AC映射产生估计的传输数据（24），并与来自点或线源的测量的传输数据（22）进行比较。对估计和测量的传输数据迭代地计算误差，并且AC图（16）的衰减值被改进以使误差最小化。精细AC图（32）用于校正收集的核数据（41）中的衰减，其被重建为患者的衰减校正图像（99）。

4. 发明申请

WO2007039841A2 METHOD AND SYSTEM FOR PET IMAGE RECONSTRUCTION USING A SURROGATE IMAGE 审中-公开
标题翻译：用图像重建PET图像的方法和系统
公开(公告)号：WO2007039841A2
公开(公告)日：2007-04-12
申请号：PCT/IB2006053287
申请日：2006-09-14
申请人： KONINKL PHILIPS ELECTRONICS NV , GAGNON DANIEL , WANG WENLI , HU ZHIQIANG
发明人： GAGNON DANIEL , WANG WENLI , HU ZHIQIANG
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/1611 , G06T11/006
摘要： A method and system for use in positron emission tomography, wherein a first processor element (234) is configured to reconstruct a plurality of positron annihilation events detected during a positron emission tomography scan using a list-based reconstruction technique to generate first volumetric data. A second reconstructor (226) is configured to reconstruct the plurality of events using a second reconstruction technique to generate second volumetric data for determining an error correction (228), the error correction applied to the first volumetric data to generate corrected volumetric data for generating a human-readable image (234). In one embodiment a multiplicative error correction is performed on the plurality of events, the first processor element (234) reconstructing the corrected plurality of events; and the second volumetric data error correction comprises an additive error correction.
摘要翻译：一种用于正电子发射断层摄影的方法和系统，其中第一处理器元件（234）被配置为使用基于列表的重建技术来重建在正电子发射断层摄影扫描期间检测到的多个正电子湮没事件以生成第一体积数据。第二重建器（226）被配置为使用第二重建技术来重建多个事件以生成用于确定错误校正的第二体数据（228），所述错误校正被应用于第一体数据以生成校正的体数据以用于生成人类可读的图像（234）。在一个实施例中，对多个事件执行乘性误差校正，第一处理器元件（234）重构校正后的多个事件; 并且第二体积数据误差校正包括附加误差校正。

5. 发明申请

WO2009125309A3 MODULAR MULTI-GEOMETRY PET SYSTEM 审中-公开
标题翻译：模块化多元几何PET系统
公开(公告)号：WO2009125309A3
公开(公告)日：2010-08-12
申请号：PCT/IB2009051190
申请日：2009-03-20
申请人： KONINKL PHILIPS ELECTRONICS NV , GAGNON DANIEL , MCKNIGHT DOUGLAS B
发明人： GAGNON DANIEL , MCKNIGHT DOUGLAS B
IPC分类号： G01T1/24
CPC分类号： G01T1/2985 , A61B6/037 , G01R33/481
摘要： When performing positron emission tomography (PET) scanning and image reconstruction, a primary PET system (10) with a primary PET detector array (12) is used to image a patient or subject, and a secondary PET detector array (14) is coupled to the system at specific input points to mitigate unnecessary duplication of system components. The primary system (10) provides PET data processing and reconstruction for the secondary array (14), in addition to the first array (12). An adjustable array (120) includes radially movable detectors (122) and stationary detectors (124) with different crystal resolutions. The movable detectors (122) are alternately positioned with the stationary detectors (124) at a first radius to form a large detector ring, or are positioned at a second, smaller radius without the stationary detectors (124) to form a small detector ring.
摘要翻译：当进行正电子发射断层扫描（PET）扫描和图像重建时，使用具有主要PET检测器阵列（12）的主要PET系统（10）对患者或受试者进行成像，并且将辅助PET检测器阵列（14）耦合到该系统在特定的输入点，以减轻不必要的系统组件重复。除了第一阵列（12）之外，主系统（10）还为次级阵列（14）提供PET数据处理和重建。可调节阵列（120）包括具有不同晶体分辨率的径向可移动探测器（122）和固定探测器（124）。移动检测器（122）与第一半径处的固定式检测器（124）交替定位以形成大的检测器环，或者定位在第二较小的半径处，而没有固定的检测器（124）以形成小的检测器环。

6. 发明申请

WO2009144607A3 GEOMETRICAL TRANSFORMATIONS PRESERVING LIST-MODE FORMAT 审中-公开
标题翻译：几何变换保存列表模式格式
公开(公告)号：WO2009144607A3
公开(公告)日：2010-05-06
申请号：PCT/IB2009051987
申请日：2009-05-13
申请人： KONINKL PHILIPS ELECTRONICS NV , GAGNON DANIEL , OLIVIER PATRICK , KHURD PARMESHWAR KISHORE
发明人： GAGNON DANIEL , OLIVIER PATRICK , KHURD PARMESHWAR KISHORE
IPC分类号： G01T1/164 , G06T11/00
CPC分类号： G01T1/1648 , A61B6/037 , G06T11/005
摘要： A diagnostic imaging device includes detector elements (16) for detecting ?- rays indicative of nuclear decay events. The detected ?-rays are used to produce lines of response (LORs) (46), which are time stamped (20) and stored in list mode. The LORs are reconstructed (34) into an image. An image analysis processor (38) analyzes the image for motion artifacts and iteratively adjusts an event transform processor (30) to transform selected LORs to minimize the motion artifacts. If the transformed LOR (50) does not correspond with a pair of detector elements (16), closest detector elements (52, 54) are determined. Candidate LORs (62) are created between the closest and neighboring detector elements. An event location (40) on an LOR (46) is determined from the time-of- flight (TOF) information and then transformed (47) to generate a transformed event location (48). The candidate LOR (62) which most nearly intersects the transformed event location (40) and the appropriately updated TOF information is selected for use in image reconstruction.
摘要翻译：诊断成像装置包括用于检测指示核衰变事件的γ射线的检测器元件（16）。检测到的γ射线用于产生响应列（LOR）（46），它们是时间戳的（20）并以列表模式存储。 LOR被重构（34）成为图像。图像分析处理器（38）分析运动伪影的图像并迭代地调整事件变换处理器（30）以变换所选择的LOR以最小化运动伪影。如果变换的LOR（50）不对应于一对检测器元件（16），则确定最近的检测器元件（52,54）。在最近和相邻的检测器元件之间创建候选LOR（62）。从飞行时间（TOF）信息确定LOR（46）上的事件位置（40），然后变换（47）以生成转换的事件位置（48）。选择与变换的事件位置（40）最接近相交的候选LOR（62）和适当更新的TOF信息用于图像重建。

7. 发明申请

WO2008096285A3 MOTION ESTIMATION IN TREATMENT PLANNING 审中-公开
标题翻译：治疗计划中的运动估计
公开(公告)号：WO2008096285A3
公开(公告)日：2008-12-04
申请号：PCT/IB2008050279
申请日：2008-01-25
申请人： KONINKL PHILIPS ELECTRONICS NV , BRINKS RALPH , MEYER CARSTEN , FISCHER ALEXANDER , GAGNON DANIEL , BUSCH MARC
发明人： BRINKS RALPH , MEYER CARSTEN , FISCHER ALEXANDER , GAGNON DANIEL , BUSCH MARC
IPC分类号： A61B6/03
CPC分类号： A61B6/032 , A61B5/055 , A61B5/721 , A61B5/7289 , A61B6/037 , A61B6/527 , A61N5/103 , A61N5/1037 , A61N5/1067 , A61N2005/1052
摘要： An apparatus includes a scanner (102, 104) and a scanning motion monitor (100). A motion modeler (116) uses data from the scanning motion monitor (100) and the scanner (102, 104) to generate a motion model which describes motion of a region of interest of an object. A treatment planner (112) uses image data from the scanner (102, 104) to establish a treatment plan for the object. A treatment device 114, which operates in conjunction with a treatment motion monitor (108), uses the motion model to compensate for motion of the object during application of the treatment.
摘要翻译：一种装置包括扫描器（102,104）和扫描运动监视器（100）。运动建模器（116）使用来自扫描运动监控器（100）和扫描器（102,104）的数据来生成描述对象的感兴趣区域的运动的运动模型。治疗计划器（112）使用来自扫描仪（102,104）的图像数据来建立对象的治疗计划。与治疗运动监测器（108）一起操作的治疗装置114使用运动模型来补偿施加治疗期间对象的运动。

8. 发明申请

WO2007046013A3 PATIENT SCAN TIME OPTIMIZATION FOR PET/SPECT IMAGING 审中-公开
标题翻译：患者扫描时间优化PET / SPECT成像
公开(公告)号：WO2007046013A3
公开(公告)日：2008-01-03
申请号：PCT/IB2006053317
申请日：2006-09-15
申请人： KONINKL PHILIPS ELECTRONICS NV , NARAYANAN MANOJ , BAKKER BART , GAGNON DANIEL , FISCHER ALEXANDER , SPIES LOTHAR
发明人： NARAYANAN MANOJ , BAKKER BART , GAGNON DANIEL , FISCHER ALEXANDER , SPIES LOTHAR
IPC分类号： A61B6/00 , G01T1/29
CPC分类号： A61B6/00 , A61B6/037
摘要： An imaging system (10) comprises a data device (30), which controls radiation data acquisition from a subject positioned in an examination region (18) for an examination. A rebinning processor (40) bins the acquired data periodically into a histogram (42). A transform (70) transforms the histogram (42) into individual independent or uncorrelated components, each component including a signal content and a noise content. A stopping determining device (52) compares an aspect of at least one selected component to a predetermined threshold (TH) and, based on the comparison, terminates the data acquisition.
摘要翻译：成像系统（10）包括数据装置（30），其控制从位于检查区域（18）中的被摄体进行检查的辐射数据采集。重组处理器（40）将获取的数据周期性地存储到直方图（42）中。变换（70）将直方图（42）变换为独立的或不相关的分量，每个分量包括信号内容和噪声内容。停止确定装置（52）将至少一个所选择的组件的方面与预定阈值（TH）进行比较，并且基于该比较，终止数据采集。

9. 发明申请

WO2009150565A2 REVERSE DATA RECONSTRUCTION FOR OPTIMAL TIME SAMPLING OF COUNTS IN PHYSIOLOGICAL LIST-MODE NUCLEAR IMAGING 审中-公开
标题翻译：反向数据重建在生理学列表核成像中的最佳时间采样
公开(公告)号：WO2009150565A2
公开(公告)日：2009-12-17
申请号：PCT/IB2009052290
申请日：2009-05-29
申请人： KONINKL PHILIPS ELECTRONICS NV , UNIV HOSPITALS MEDICAL GROUP I , GAGNON DANIEL , TIPNIS SAMEER , MUZIC RAYMOND
发明人： GAGNON DANIEL , TIPNIS SAMEER , MUZIC RAYMOND
IPC分类号： A61B6/03
CPC分类号： A61B6/507 , A61B6/037 , A61B6/486 , G06T11/006 , G06T2211/412
摘要： A diagnostic imaging device includes detector elements (16) for detecting ?-rays indicative of nuclear decay events. Pairs of concurrently detected ?-rays define lines of response (LORs) which are collected, time stamped, and compiled in list-mode. In tissue perfusion studies, it is beneficial to use the data that concurrently maximizes contrast and signal-to-noise ratio in the reconstructed images. Using the list-mode data, events in an adjustable temporal window (33) are reconstructed and the reconstructed images are analyzed to determine a figure of merit based on contrast and signal-to-noise properties of the image. By iteratively adjusting the temporal window, extending its start point (36) backwards in time, and repeating the reconstructing, analyzing, and adjusting steps, an image with an optimal figure of merit is obtained.
摘要翻译：诊断成像装置包括用于检测指示核衰变事件的γ射线的检测器元件（16）。成对的同时检测到的？数组定义了列表模式中收集，时间戳和编译的响应行（LOR）。在组织灌注研究中，使用同时最大化重建图像中的对比度和信噪比的数据是有益的。使用列表模式数据，重建可调节时间窗口（33）中的事件，并且分析重建图像以基于图像的对比度和信噪比特性确定品质因数。通过迭代调整时间窗口，及时地将其起点（36）向后延伸，并重复重建，分析和调整步骤，获得具有最佳品质因数的图像。

10. 发明申请

WO2007100954A2 IMAGE RECONSTRUCTION USING DATA ORDERING 审中-公开
标题翻译：使用数据订购的图像重构
公开(公告)号：WO2007100954A2
公开(公告)日：2007-09-07
申请号：PCT/US2007061595
申请日：2007-02-05
申请人： KONINKL PHILIPS ELECTRONICS NV , HU ZHIQIANG , WANG WENLI , GAGNON DANIEL
发明人： HU ZHIQIANG , WANG WENLI , GAGNON DANIEL
IPC分类号： G06T11/00
CPC分类号： G06K9/00362 , G06T11/006
摘要： Methods, systems and apparatuses for processing data associated with nuclear medical imaging techniques are provided. Data is ordered in LUT's and memory structures. Articles of manufacture are provided for causing computers to carry out aspects of the invention. Data elements are ordered into a plurality of ordered data groups according to a spatial index order, and fetched and processed in the spatial index order. The data elements include sensitivity matrix elements, PET annihilation event data, and system and image matrix elements, the data grouped in orders corresponding to their processing. In one aspect geometric symmetry of a PET scanner FOV is used in ordering the data and processing. In one aspect a system matrix LUT comprises total number of system matrix elements equal to a total number of image matrix elements divided by a total number of possible third index values.
摘要翻译：提供了用于处理与核医学成像技术相关联的数据的方法，系统和装置。数据在LUT和存储器结构中排序。提供制造用于使计算机执行本发明的方面。数据元素根据空间索引顺序排列成多个有序数据组，并以空间索引顺序取出并处理。数据元素包括灵敏度矩阵元素，PET湮灭事件数据，以及系统和图像矩阵元素，数据按与它们的处理相对应的顺序分组。在一个方面，PET扫描器FOV的几何对称性用于排序数据和处理。在一个方面，系统矩阵LUT包括等于图像矩阵元素的总数除以可能的第三索引值的总数的系统矩阵元素的总数。

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