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1. 发明申请

WO2012160520A1 APPARATUS FOR GENERATING ASSIGNMENTS BETWEEN IMAGE REGIONS OF AN IMAGE AND ELEMENT CLASSES 审中-公开
标题翻译：用于在图像和元素类的图像区域之间生成分配的装置
公开(公告)号：WO2012160520A1
公开(公告)日：2012-11-29
申请号：PCT/IB2012/052576
申请日：2012-05-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BLAFFERT, Thomas , RENISCH, Steffen , SCHWEIZER, Bernd , HU, Zhiqiang
发明人： BLAFFERT, Thomas , RENISCH, Steffen , SCHWEIZER, Bernd , HU, Zhiqiang
IPC分类号： G06T7/00
CPC分类号： G06T11/008 , G06T7/0012 , G06T7/11 , G06T7/155 , G06T7/174 , G06T2207/10088 , G06T2207/10104 , G06T2207/20152 , G06T2207/20221 , G06T2207/30004 , G06T2207/30061
摘要： The invention relates to an apparatus for generating assignments between image regions of an image of an object and element classes. The apparatus (1) comprises an assigning unit (13) for assigning element classes to image regions of an element image of the object, which is indicative of a distribution of the element classes, depending on region and/or boundary features, which are determined depending on image values of a provided object image and provided first preliminary assignments. Thus, the resulting element image with the assignments to the element classes is not necessarily based on the provided object image only, but can also be based on the provided preliminary assignments. If the quality of the assignments defined by the element image would be restricted due to restrictions of the provided object image, these restrictions of the provided image can therefore be compensated by the preliminary assignments such that the quality of the resulting element image can be improved.
摘要翻译：本发明涉及一种用于在对象和元素类的图像的图像区域之间生成分配的装置。所述装置（1）包括分配单元（13），用于根据所确定的区域和/或边界特征将元素类别分配给所述对象的元素图像的图像区域，所述图像区域指示所述元素类别的分布取决于提供的对象图像的图像值并提供第一初步分配。因此，具有对元素类的赋值的所得到的元素图像不一定仅基于所提供的对象图像，而是还可以基于所提供的初步分配。如果由于所提供的对象图像的限制而限制由元素图像定义的分配的质量，则可以通过初步分配来补偿所提供的图像的这些限制，使得可以提高所得到的元素图像的质量。

2. 发明申请

WO2012120422A1 MR SEGMENTATION USING NUCLEAR EMISSION DATA IN HYBRID NUCLEAR IMAGING/MR 审中-公开
标题翻译：在混合核成像中使用核排放数据的MR分段/ MR
公开(公告)号：WO2012120422A1
公开(公告)日：2012-09-13
申请号：PCT/IB2012/050998
申请日：2012-03-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HU, Zhiqiang , OJHA, Navdeep , TUNG, Chi-Hua
发明人： HU, Zhiqiang , OJHA, Navdeep , TUNG, Chi-Hua
IPC分类号： G01R33/48 , G01T1/29
CPC分类号： A61B5/0033 , G01R33/481 , G01R33/5608 , G01T1/1603
摘要： When generating a magnetic resonance (MR) attenuation map (39), an MR image is segmented to identify a patient's body outline, soft tissue structures, and ambiguous structures comprising bone and/or air. To distinguish between bone and air in the ambiguous structures, a nuclear emission image (e.g., PET) of the same patient or region of interest is segmented. The segmented functional image data is correlated to the segmented MR image data to distinguish between bone and air in the ambiguous structures. Appropriate radiation attenuation values are assigned respectively to identify air voxels and bone voxels in the segmented MR image, and an MR attenuation map is generated from the enhanced segmented MR image, in which ambiguity between air and bone has been resolved. The MR attenuation map is used to generate an attenuation-corrected nuclear image, which is displayed to a user.
摘要翻译：当产生磁共振（MR）衰减图（39）时，MR图像被分割以识别患者的身体轮廓，软组织结构以及包含骨和/或空气的不明确的结构。为了区分不明确结构中的骨骼和空气，将相同患者或感兴趣区域的核发射图像（例如PET）分割。分割的功能图像数据与分割的MR图像数据相关，以区分不明确结构中的骨骼和空气。分配适当的辐射衰减值以识别分段MR图像中的空气体素和骨体素，并且从增强的分段MR图像生成MR衰减图，其中空气和骨骼之间的模糊度已被解决。 MR衰减图用于产生被显示给用户的衰减校正的核图像。

3. 发明申请

WO2010097714A2 ATTENUATION CORRECTION OF MR COILS IN A HYBRID PET/MR SYSTEM 审中-公开
标题翻译：混合PET / MR系统中MR线圈的衰减校正
公开(公告)号：WO2010097714A2
公开(公告)日：2010-09-02
申请号：PCT/IB2010/050218
申请日：2010-01-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , PAL, Debashish , HU, Zhiqiang , TUNG, Chi-hua , GUO, Tianrui , KASTE, Jeffrey
发明人： PAL, Debashish , HU, Zhiqiang , TUNG, Chi-hua , GUO, Tianrui , KASTE, Jeffrey
IPC分类号： G01T1/164
CPC分类号： G01T1/1648 , A61B5/0035 , A61B5/055 , A61B6/032 , A61B6/037 , A61B6/12 , A61B6/4417 , A61B6/5205 , A61B6/5235 , A61B6/5247 , A61B6/5258 , A61B6/5294 , A61B6/58 , G01R33/481 , G01T1/1603
摘要： Nuclear image data generated by a multimodal imaging device, such as a combined position emission tomography (PET)/magnetic resonance (MR) scanner (12, 14), is attenuation-corrected with a combined patient-specific attenuation correction (AC) map and an AC map template (70) for an MR coil (72) that is present in both the nuclear and MR scanning procedures. A template library (46) contains templates for each of a plurality of MR coils and other accessories. Each template is generated on one of two manners. The coil may be imaged inside the PET scanner 14 with the transmission source 16 (e.g., Ge-68 or Cs-137). A transmission image 48 is reconstructed using the known algorithms and may be used as the AC template directly. Alternatively, the template can be generated by creating a global histogram of the transmission image and identifying segments of the coil or other accessory. An average linear attenuation coefficient (LAC) value is determined from the distribution of the histogram. The coil or other accessory is imaged using a high resolution CT scan, and the CT image is segmented and assigned the computed LAC values determined from the distribution of the histogram to create the AC map template for the coil.
摘要翻译：由多模式成像装置（例如组合位置发射断层扫描（PET）/磁共振（MR））扫描仪（12,14））产生的核图像数据用组合的患者特异性衰减校正（AC）图和用于MR线圈（72）的AC映射模板（70），其存在于核和MR扫描过程中。模板库（46）包含用于多个MR线圈和其他附件中的每一个的模板。每个模板都以两种方式之一生成。线圈可以利用透射源16（例如Ge-68或Cs-137）在PET扫描器14内成像。使用已知算法重构发送图像48，并且可以直接用作AC模板。或者，可以通过创建传输图像的全局直方图并识别线圈或其他附件的段来生成模板。根据直方图的分布确定平均线性衰减系数（LAC）值。使用高分辨率CT扫描对线圈或其他附件进行成像，并且对CT图像进行分割并分配从直方图的分布确定的计算的LAC值，以创建线圈的AC图谱模板。

4. 发明申请

WO2007100954A3 IMAGE RECONSTRUCTION USING DATA ORDERING 审中-公开
公开(公告)号：WO2007100954A3
公开(公告)日：2007-09-07
申请号：PCT/US2007/061595
申请日：2007-02-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , HU, Zhiqiang , WANG, Wenli , GAGNON, Daniel
发明人： HU, Zhiqiang , WANG, Wenli , GAGNON, Daniel
IPC分类号： G06T11/00
摘要： Methods, systems and apparatuses for processing data associated with nuclear medical imaging techniques are provided. Data is ordered in LUT's and memory structures. Articles of manufacture are provided for causing computers to carry out aspects of the invention. Data elements are ordered into a plurality of ordered data groups according to a spatial index order, and fetched and processed in the spatial index order. The data elements include sensitivity matrix elements, PET annihilation event data, and system and image matrix elements, the data grouped in orders corresponding to their processing. In one aspect geometric symmetry of a PET scanner FOV is used in ordering the data and processing. In one aspect a system matrix LUT comprises total number of system matrix elements equal to a total number of image matrix elements divided by a total number of possible third index values.

5. 发明申请

WO2007054843A1 PET IMAGING USING ANATOMIC LIST MODE MASK 审中-公开
标题翻译： PET成像使用解剖列表模式掩模
公开(公告)号：WO2007054843A1
公开(公告)日：2007-05-18
申请号：PCT/IB2006/053824
申请日：2006-10-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , GAGNON, Daniel , WANG, Wenli , HU, Zhiqiang
发明人： GAGNON, Daniel , WANG, Wenli , HU, Zhiqiang
IPC分类号： G01T1/29 , G06T11/00
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/1611 , G06T11/006 , G06T2211/424
摘要： A method and apparatus are provided for reconstructing list mode data acquired during a positron emission tomography scan of an object, the data including information indicative of a plurality of detected positron annihilation events. Detected events occurring in a region of interest are identified; the identified events are reconstructed using an iterative reconstruction technique which includes a ray tracing operation to generate volumetric data indicative of the region of interest, wherein the ray tracing operation traces only image matrix elements located in the region of interest; and a human readable image indicative of the volumetric data is generated. In another aspect an image mask and a projection mask are defined correlating to the region of interest; image matrix elements located in the region of interest are determined by applying the image mask; and detected events occurring in a region of interest are identified by applying the projection mask.
摘要翻译：提供了一种方法和装置，用于重构在对象的正电子发射断层摄影扫描期间获取的列表模式数据，该数据包括指示多个检测到的正电子湮灭事件的信息。确定在感兴趣区域发生的检测事件; 使用迭代重建技术来重建所识别的事件，所述迭代重建技术包括用于产生指示感兴趣区域的体积数据的光线跟踪操作，其中光线跟踪操作仅跟踪位于感兴趣区域中的图像矩阵元素; 并产生指示体积数据的人类可读取的图像。在另一方面，图像掩模和投影掩模被定义为与感兴趣区域相关; 通过应用图像掩模来确定位于感兴趣区域中的图像矩阵元素; 并且通过应用投影掩模来识别在感兴趣区域中发生的检测到的事件。

6. 发明申请

WO2010143082A1 TIME-OF-FLIGHT POSITRON EMISSION TOMOGRAPHY RECONSTRUCTION USING IMAGE CONTENT GENERATED EVENT-BY-EVENT BASED ON TIME-OF-FLIGHT INFORMATION 审中-公开
标题翻译：使用基于时间信息的图像内容生成事件的飞行时间位移重建图像重建
公开(公告)号：WO2010143082A1
公开(公告)日：2010-12-16
申请号：PCT/IB2010/051958
申请日：2010-05-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZHANG, Bin , HU, Zhiqiang , TUNG, Chi-Hua
发明人： ZHANG, Bin , HU, Zhiqiang , TUNG, Chi-Hua
IPC分类号： G06T11/00
CPC分类号： G06T11/005 , G06T2211/428
摘要： A method of processing a positron emission tomography (PET) imaging data set (30) acquired of a subject includes independently localizing each positron-electron annihilation event of the PET imaging data set based on time of flight (TOF) localization of the positron-electron annihilation event to form a generated image (34). The generated image may be displayed. The generated image is suitably used as the basis for an initial image of an iterative reconstruction (40) of the PET imaging data set (30) to produce a reconstructed image (42). A spatial contour (56) of an image of the subject in the PET imaging data set (30) is suitably delineated based on the generated image (34). A subject attenuation map (62) for use in PET image reconstruction (40) is suitably constructed based in part on the spatial contour (56).
摘要翻译：一种处理被摄体的正电子发射断层摄影（PET）成像数据集（30）的方法包括基于正电子 - 电子的飞行时间（TOF）定位来独立地定位PET成像数据集的每个正电子 - 电子湮灭事件湮灭事件以形成生成的图像（34）。可以显示生成的图像。生成的图像被适当地用作PET成像数据集（30）的迭代重建（40）的初始图像的基础，以产生重建图像（42）。基于所生成的图像适当地描绘PET成像数据组（30）中的对象的图像的空间轮廓（56）。用于PET图像重建（40）的被摄体衰减图（62）部分地基于空间轮廓（56）适当构造。

7. 发明申请

WO2007100954A2 IMAGE RECONSTRUCTION USING DATA ORDERING 审中-公开
标题翻译：使用数据订购的图像重构
公开(公告)号：WO2007100954A2
公开(公告)日：2007-09-07
申请号：PCT/US2007061595
申请日：2007-02-05
申请人： KONINKL PHILIPS ELECTRONICS NV , HU ZHIQIANG , WANG WENLI , GAGNON DANIEL
发明人： HU ZHIQIANG , WANG WENLI , GAGNON DANIEL
IPC分类号： G06T11/00
CPC分类号： G06K9/00362 , G06T11/006
摘要： Methods, systems and apparatuses for processing data associated with nuclear medical imaging techniques are provided. Data is ordered in LUT's and memory structures. Articles of manufacture are provided for causing computers to carry out aspects of the invention. Data elements are ordered into a plurality of ordered data groups according to a spatial index order, and fetched and processed in the spatial index order. The data elements include sensitivity matrix elements, PET annihilation event data, and system and image matrix elements, the data grouped in orders corresponding to their processing. In one aspect geometric symmetry of a PET scanner FOV is used in ordering the data and processing. In one aspect a system matrix LUT comprises total number of system matrix elements equal to a total number of image matrix elements divided by a total number of possible third index values.
摘要翻译：提供了用于处理与核医学成像技术相关联的数据的方法，系统和装置。数据在LUT和存储器结构中排序。提供制造用于使计算机执行本发明的方面。数据元素根据空间索引顺序排列成多个有序数据组，并以空间索引顺序取出并处理。数据元素包括灵敏度矩阵元素，PET湮灭事件数据，以及系统和图像矩阵元素，数据按与它们的处理相对应的顺序分组。在一个方面，PET扫描器FOV的几何对称性用于排序数据和处理。在一个方面，系统矩阵LUT包括等于图像矩阵元素的总数除以可能的第三索引值的总数的系统矩阵元素的总数。

8. 发明申请

WO2012160511A1 APPARATUS AND METHOD FOR GENERATING AN ATTENUATION CORRECTION MAP 审中-公开
标题翻译：用于产生衰减校正图的装置和方法
公开(公告)号：WO2012160511A1
公开(公告)日：2012-11-29
申请号：PCT/IB2012/052561
申请日：2012-05-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BLAFFERT, Thomas , RENISCH, Steffen , SCHWEIZER, Bernd , HU, Zhiqiang
发明人： BLAFFERT, Thomas , RENISCH, Steffen , SCHWEIZER, Bernd , HU, Zhiqiang
IPC分类号： G06T7/00 , G01R33/48
CPC分类号： G06T11/005 , G01R33/481 , G06T7/11 , G06T7/155 , G06T7/174 , G06T7/181 , G06T2207/10084 , G06T2207/10088 , G06T2207/10104 , G06T2207/20152 , G06T2207/20221 , G06T2207/30004 , G06T2207/30008 , G06T2207/30061
摘要： The invention relates to an apparatus for generating an attenuation correction map. An image providing unit (5, 6) provides an image of an object comprising different element classes and a segmentation unit (11) applies a segmentation to the image for generating a segmented image comprising image regions corresponding to the element classes. The segmentation is based on at least one of a watershed segmentation and a body contour segmentation based on a contiguous skin and fat layers in the image. A feature determination unit (12) determines features of at least one of a) the image regions and b) boundaries between the image regions depending on image values of the image and an assigning unit (13) assigns attenuation values to the image regions based on the determined features for generating the attenuation correction map. The performed image processing steps can allow for producing a high quality attenuation correction map, even if the initial image does not comprise image values related to the attenuation of radiation like a CT image.
摘要翻译：本发明涉及一种用于产生衰减校正图的装置。图像提供单元（5,6）提供包括不同元素类别的对象的图像，并且分割单元（11）对图像应用分割以生成包括对应于元素类别的图像区域的分割图像。分割基于基于图像中的连续皮肤和脂肪层的分水岭分割和身体轮廓分割中的至少一个。特征确定单元（12）确定a）图像区域和b）图像区域之间的边界中的至少一个的特征，取决于图像的图像值，并且分配单元（13）基于图像区域向图像区域分配衰减值确定的用于产生衰减校正图的特征。执行的图像处理步骤可以允许产生高质量的衰减校正图，即使初始图像不包括像CT图像的辐射衰减相关的图像值。

9. 发明申请

WO2010097714A3 ATTENUATION CORRECTION OF MR COILS IN A HYBRID PET/MR SYSTEM 审中-公开
标题翻译：混合PET / MR系统中MR线圈的衰减校正
公开(公告)号：WO2010097714A3
公开(公告)日：2011-08-11
申请号：PCT/IB2010050218
申请日：2010-01-18
申请人： KONINKL PHILIPS ELECTRONICS NV , PAL DEBASHISH , HU ZHIQIANG , TUNG CHI-HUA , GUO TIANRUI , KASTE JEFFREY
发明人： PAL DEBASHISH , HU ZHIQIANG , TUNG CHI-HUA , GUO TIANRUI , KASTE JEFFREY
IPC分类号： G01T1/16 , G01R33/48 , G01T1/164
CPC分类号： G01T1/1648 , A61B5/0035 , A61B5/055 , A61B6/032 , A61B6/037 , A61B6/12 , A61B6/4417 , A61B6/5205 , A61B6/5235 , A61B6/5247 , A61B6/5258 , A61B6/5294 , A61B6/58 , G01R33/481 , G01T1/1603
摘要： Nuclear image data generated by a multimodal imaging device, such as a combined position emission tomography (PET)/magnetic resonance (MR) scanner (12, 14), is attenuation-corrected with a combined patient-specific attenuation correction (AC) map and an AC map template (70) for an MR coil (72) that is present in both the nuclear and MR scanning procedures. A template library (46) contains templates for each of a plurality of MR coils and other accessories. Each template is generated on one of two manners. The coil may be imaged inside the PET scanner 14 with the transmission source 16 (e.g., Ge-68 or Cs-137). A transmission image 48 is reconstructed using the known algorithms and may be used as the AC template directly. Alternatively, the template can be generated by creating a global histogram of the transmission image and identifying segments of the coil or other accessory. An average linear attenuation coefficient (LAC) value is determined from the distribution of the histogram. The coil or other accessory is imaged using a high resolution CT scan, and the CT image is segmented and assigned the computed LAC values determined from the distribution of the histogram to create the AC map template for the coil.
摘要翻译：由多模式成像装置（例如组合位置发射断层扫描（PET）/磁共振（MR）扫描仪（12,14））生成的核图像数据用组合的患者特异性衰减校正（AC）图和用于MR线圈（72）的AC映射模板（70），其存在于核和MR扫描过程中。模板库（46）包含用于多个MR线圈和其他附件中的每一个的模板。每个模板都以两种方式之一生成。线圈可以利用透射源16（例如Ge-68或Cs-137）在PET扫描器14内成像。使用已知算法重构发送图像48，并且可以直接用作AC模板。或者，可以通过创建传输图像的全局直方图并识别线圈或其他附件的段来生成模板。根据直方图的分布确定平均线性衰减系数（LAC）值。使用高分辨率CT扫描对线圈或其他附件进行成像，并且对CT图像进行分割并分配从直方图的分布确定的计算的LAC值，以创建线圈的AC图谱模板。

10. 发明申请

WO2009138898A1 USING NON-ATTENUATION CORRECTED PET EMISSION IMAGES TO COMPENSATE FOR INCOMPLETE ANATOMIC IMAGES 审中-公开
标题翻译：使用非衰减校正的PET排放图像补偿不完整的解剖图像
公开(公告)号：WO2009138898A1
公开(公告)日：2009-11-19
申请号：PCT/IB2009/051825
申请日：2009-05-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , HU, Zhiqiang , GAGNON, Daniel , TUNG, Chia-Hua
发明人： HU, Zhiqiang , GAGNON, Daniel , TUNG, Chia-Hua
IPC分类号： G06T11/00
CPC分类号： G06T11/006 , G06T2211/424 , G06T2211/432
摘要： When compensating for truncated patient scan data acquired by a multi¬ modal PET/CT or PET/MR imaging system (14, 16), such as occurs when a patient is larger than a field of view for an anatomical imaging device, a segmented contour of a non- attenuation-corrected (NAC) PET image is used to identify a contour of the truncated region. An appropriate tissue type is used to fill in truncated regions of a truncated CT or MR image for the attenuation map. The corrected attenuation map is then used to generate an attenuation-corrected PET image of the patient or a region of interest. Alternatively, the system can be employed in PET/CT or PET/MR imaging scenarios where two modalities are performed sequentially (e.g., not simultaneously), and thus the contour derived from the PET scan can be compared to the CT or MR image to infer potential subject motion between the PET and CT or MR scans. Additionally, the system can be employed in PET imaging scenarios where the contour derived from the NAC PET image is used as emission boundary for scatter correction using single-scatter simulation, in which a tail-fitting procedure utilizes an emission boundary to define pure-scatter tails (e.g., in the absence of true coincidence events).
摘要翻译：当补偿由多模PET / CT或PET / MR成像系统（14,16）获取的截断的患者扫描数据时，例如当患者大于解剖成像装置的视野时发生，分段轮廓使用非衰减校正（NAC）PET图像来识别截断区域的轮廓。使用适当的组织类型来填充用于衰减图的截断的CT或MR图像的截断区域。然后校正的衰减图用于产生患者或感兴趣区域的衰减校正的PET图像。或者，该系统可以用于PET / CT或PET / MR成像场合，其中顺序执行两种模式（例如，不同时执行），因此可以将从PET扫描导出的轮廓与CT或MR图像进行比较以推断 PET和CT或MR扫描之间的潜在主体运动。此外，该系统可以用于PET成像场景，其中从NAC PET图像导出的轮廓用作使用单分散模拟的散射校正的发射边界，其中尾部拟合过程利用发射边界来定义纯散射尾巴（例如，没有真正的巧合事件）。

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