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    • 5. 发明申请
    • USE OF POLYETHYLENE OXIDE FOR UROGENITAL INFECTION INHIBITION
    • 使用聚乙烯氧化物进行尿毒症感染抑制
    • WO2006065309A1
    • 2006-06-22
    • PCT/US2005/034167
    • 2005-09-23
    • KIMBERLY-CLARK WORLDWIDE, INC.HUANG, LeiYANG, Shu-PingHUANG, Yanbin
    • HUANG, LeiYANG, Shu-PingHUANG, Yanbin
    • A61K31/75A61P15/02
    • A61K9/0034A61K9/0036A61K31/75A61K31/765
    • There is provided compositions and methods to inhibit the adherence of pathogenic microorganisms to cells. The composition includes water soluble PEO/PEG polymers which may be hydrophilic or amphiphilic block copolymers. One example of a suitable composition is polyethylene glycol or polyethylene oxide with a chemical formula of H-(OCH2CH2)n-OH. Another example of a suitable composition is amphiphilic block copolymer with a chemical formula PEOm-Xp-PEOn, where PEO is -(OCH2CH2)n-O and X is PPO(-(OCH2 CH2CH2)m-), or PLGA (poly(lactic-co-glycolic acid), or PMMA (polymethyl methacrylate), or PBO (polybutylene oxide). The pathogenic microorganism may be a bacterial, fungal, viral or trichomonial pathogen and the composition prevents adherence of the pathogenic microorganism in, for example, a urogenital tract of a mammal and aids in reducing malodor generation. The composition may be applied to vaginal health products like, for example, moisturizer, gel, jelly, cream, insert (tablet), ointment, foam. The composition may also be applied to a feminine hygiene product, like, for example, a tampon, feminine pad, feminine wipe or panty liners.
    • 提供了抑制致病微生物对细胞的粘附的组合物和方法。 该组合物包括可以是亲水性或两亲嵌段共聚物的水溶性PEO / PEG聚合物。 合适组合物的一个实例是具有化学式为H-(OCH 2 CH 2)n -OH的聚乙二醇或聚环氧乙烷。 合适组合物的另一个实例是具有化学式PEOm-Xp-PEOn的两亲性嵌段共聚物,其中PEO是 - (OCH 2 CH 2)n O,X是PPO( - (OCH 2 CH 2 CH 2)m - )或PLGA(聚(乳酸 - - 乙醇酸)或PMMA(聚甲基丙烯酸甲酯)或PBO(聚环氧丁烷),病原微生物可以是细菌,真菌,病毒或毛滴虫病原体,并且该组合物可防止病原微生物在例如泌尿生殖道 可以将组合物用于阴道保健品,例如保湿剂,凝胶剂,果冻,霜剂,插入物(片剂),软膏剂,泡沫剂。该组合物还可以应用于女性化妆品 卫生产品,例如棉塞,女性衬垫,女性擦拭物或内裤衬里。
    • 8. 发明申请
    • LATERAL FLOW DEVICE FOR THE DETECTION OF LARGE PATHOGENS
    • 用于检测大病因的侧流装置
    • WO2006041537A1
    • 2006-04-20
    • PCT/US2005/018630
    • 2005-05-25
    • KIMBERLY-CLARK WORLDWIDE, INC.WEI, NingYANG, Shu-Ping
    • WEI, NingYANG, Shu-Ping
    • G01N33/558
    • G01N33/558
    • There is provided a lateral flow assay device for detecting the presence or quantity of an analyte residing in a test sample where the lateral flow assay device has a porous membrane in communication with a conjugate pad and a wicking pad. The porous membrane has a detection zone where a test sample is applied and which has an immobilized first capture reagent configured to bind to at least a portion of the analyte and analyte-conjugate complexes to generate a detection signal. The control zone is located downstream from the detection zone on the porous membrane and has a second capture reagent immobilized within the control zone. The conjugate pad is located upstream from the detection zone, and has detection probes with specific binding members for the analyte. A buffer release zone is located upstream of the conjugate zone and provides for buffer addition to the device, the buffer serving to move the detection probes to the detection and control zones.
    • 提供了一种侧流测定装置,用于检测驻留在测试样品中的分析物的存在或数量,其中侧流测定装置具有与缀合垫和芯吸垫连通的多孔膜。 多孔膜具有检测区域,其中施加了测试样品,并且其具有被配置为结合至少一部分分析物和分析物 - 共轭复合物的固定化的第一捕获试剂以产生检测信号。 控制区位于多孔膜上的检测区的下游,并且具有固定在控制区内的第二捕获试剂。 缀合垫位于检测区的上游,并具有用于分析物的具有特异性结合构件的检测探针。 缓冲区释放区域位于共轭区域的上游,并提供缓冲区添加到设备,缓冲区用于将检测探针移动到检测和控制区域。
    • 9. 发明申请
    • MAGNETIC ENZYME DETECTION TECHNIQUES
    • 磁性酶检测技术
    • WO2006007009A1
    • 2006-01-19
    • PCT/US2005/014169
    • 2005-04-25
    • KIMBERLY-CLARK WORLDWIDE, INC.SONG, XuedongYANG, Shu-PingKAYLOR, Rosann, Marie, Matthews
    • SONG, XuedongYANG, Shu-PingKAYLOR, Rosann, Marie, Matthews
    • G01N33/543
    • G01N33/558C12Q1/04G01N33/543G01N33/54326G01N33/58G01N33/68
    • A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes reactive complexes to facilitate the detection of the enzyme or enzyme inhibitor. The reactive complexes include a substrate joined (e.g., covalently bonded, physically adsorbed, etc.) to a reporter and magnetic substance. In one embodiment, for example, a peptide, protein, or glycoprotein substrate is joined to a reporter (e.g., dyed latex particle) and magnetic particle. In this embodiment, the substrate provides a cleavage target for a proteolytic enzyme. Specifically, upon contacting the reactive complexes, the proteolytic enzyme cleaves the substrate and releases the reporter and/or magnetic particle. The signal exhibited by the released reporters may then be used to indicate the presence or quantity of an enzyme or enzyme inhibitor within the test sample.
    • 提供了用于检测酶或酶抑制剂的存在或数量的诊断测试试剂盒。 诊断试剂盒利用反应性配合物来促进酶或酶抑制剂的检测。 反应性配合物包括与报告物和磁性物质连接(例如共价键合,物理吸附等)的底物。 在一个实施方案中,例如,将肽,蛋白质或糖蛋白底物连接到报告物(例如,染色的胶乳颗粒)和磁性颗粒。 在该实施方案中,底物提供蛋白水解酶的切割靶。 具体地,当与反应性配合物接触时,蛋白水解酶切割底物并释放报告物和/或磁性颗粒。 由释放的记者展示的信号可以用于指示测试样品中酶或酶抑制剂的存在或数量。