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1. 发明申请

WO2012077004A2 WETNESS SENSOR FOR USE IN AN ABSORBENT ARTICLE 审中-公开
标题翻译：用于吸收物品的湿度传感器
公开(公告)号：WO2012077004A2
公开(公告)日：2012-06-14
申请号：PCT/IB2011/054837
申请日：2011-10-31
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , WEI, Ning , SONG, Xuedong
发明人： WEI, Ning , SONG, Xuedong
IPC分类号： A61F13/42 , A61F13/511 , A61F13/514 , A61F13/53 , A61L15/56
CPC分类号： A61L15/56 , A61F13/42 , A61F2013/422
摘要： A wetness sensor for an absorbent article that is formed from an ink is provided. The ink includes a proton-accepting chromogen and a proton-donating agent (or color developer). Prior to use, the ink is generally dry and in a protonated form so that it has a visible color. However, upon contact with bodily fluids {e.g., urine, fecal matter, mucus, menses, vaginal fluid, etc.), water in the fluid can lead to deprotonation of the chromogen, thereby resulting in a shift of the absorption maxima of the chromogen towards either the red {"bathochromic shift") or blue end of the spectrum ("hypsochromic shift"). To increase the rate of the color change during use, the present inventors have discovered that a specific type of proton-donating agent may be employed. More particularly, the proton- donating agent is an aliphatic carboxylic acid that is highly soluble in the bodily fluid (e.g., urine), and therefore results in a color change that is very rapid and may be detected within a relatively short period of time. The extent of the color change is also generally sufficient to provide a "real-time" indication of wetness on the absorbent article.
摘要翻译：提供由油墨形成的吸收性物品的湿度传感器。油墨包括质子接受色原子和质子供体剂（或显色剂）。在使用之前，油墨通常是干燥的并且是质子化形式，使得它具有可见的颜色。然而，当与体液（例如尿液，粪便，粘液，月经，阴道液等）接触时，液体中的水会导致色原因的去质子化，从而导致色原体的吸收最大值的偏移朝向红色（“红移”）或蓝光端（“色变”）。为了增加使用期间的颜色变化率，本发明人已经发现可以使用特定类型的质子递送剂。更具体地，质子供体剂是高度可溶于体液（例如尿液）的脂族羧酸，因此导致颜色变化非常快并且可以在相对短的时间内检测。颜色变化的程度通常也足以在吸收制品上提供湿度的“实时”指示。

2. 发明申请

WO2012023071A3 DEHYDRATION SENSORS WITH ION-RESPONSIVE AND CHARGED POLYMERIC SURFACTANTS 审中-公开
标题翻译：具有反应性和充电聚合物表面活性剂的脱水传感器
公开(公告)号：WO2012023071A3
公开(公告)日：2012-06-07
申请号：PCT/IB2011053313
申请日：2011-07-25
申请人： KIMBERLY CLARK CO , SONG XUEDONG , WEI NING , PHILLIPS RONNIE L
发明人： SONG XUEDONG , WEI NING , PHILLIPS RONNIE L
IPC分类号： G01N33/493 , G01N21/80 , G01N31/22 , G01N33/52
CPC分类号： G01N33/558 , A61F13/42 , A61F13/84 , A61F2013/00429 , A61F2013/0094 , A61F2013/00948 , A61F2013/15081 , A61F2013/15154 , A61F2013/8473
摘要： A lateral flow assay device for determining the relative ionic strength of urine is described. The device includes a buffering zone having a polyelectrolyte disposed therein, and an indicator zone having a pH indicator non-diffusively immobilized therein, the indicator zone being separate from the buffering zone and positioned adjacent to and in fluid communication with the buffering zone. A detection zone is part of the buffering zone, and has a buffering component comprising a weak polymeric acid and weak polymeric base with a pKa = 10-3, and a class of charged polymeric surfactants that are responsive to relative ion concentrations in a sample solution, and a charged pH indicator with a charge opposite to that of the charged polymeric surfactant. The charged polymeric surfactant is soluble in amounts of greater than or equal to about 1% by weight (= 1wt. % solute) in water and aqueous solutions of low ionic concentration of = 0.1 wt. % salts, but insoluble ( 0.1 wt. % salts. The present invention also describes absorbent articles incorporating such an assay device and methods of monitoring dehydration or testing ion strength of a urine sample using such a test format.
摘要翻译：描述了用于确定尿液的相对离子强度的侧流测定装置。该装置包括其中布置有聚电解质的缓冲区和具有非扩散固定在其中的pH指示剂的指示区，指示区与缓冲区分离并且定位成与缓冲区相邻并且与缓冲区流体连通。检测区是缓冲区的一部分，并且具有包含弱聚合酸和pKa = 10-3的弱聚合物碱的缓冲组分和对样品溶液中的相对离子浓度有反应的一类带电聚合物表面活性剂和带电荷的pH指示剂，其电荷与带电聚合物表面活性剂的电荷相反。带电的聚合物表面活性剂可溶于大约或等于约1重量％（= 1重量％溶质）的水和低离子浓度= 0.1重量％的水溶液。％盐，但不溶于（<1重量％溶质）在高离子浓度> 0.1重量％的水溶液中。％盐。本发明还描述了结合这种测定装置的吸收制品以及使用这种测试形式监测尿样的脱水或测试离子强度的方法。

3. 发明申请

WO2012023071A2 DEHYDRATION SENSORS WITH ION-RESPONSIVE AND CHARGED POLYMERIC SURFACTANTS 审中-公开
标题翻译：具有离子反应和带电聚合物表面活性剂的脱水传感器
公开(公告)号：WO2012023071A2
公开(公告)日：2012-02-23
申请号：PCT/IB2011/053313
申请日：2011-07-25
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , SONG, Xuedong , WEI, Ning , PHILLIPS, Ronnie, L.
发明人： SONG, Xuedong , WEI, Ning , PHILLIPS, Ronnie, L.
IPC分类号： G01N33/493 , G01N33/52 , G01N21/80 , G01N31/22
CPC分类号： G01N33/558 , A61F13/42 , A61F13/84 , A61F2013/00429 , A61F2013/0094 , A61F2013/00948 , A61F2013/15081 , A61F2013/15154 , A61F2013/8473
摘要： A lateral flow assay device for determining the relative ionic strength of urine is described. The device includes a buffering zone having a polyelectrolyte disposed therein, and an indicator zone having a pH indicator non-diffusively immobilized therein, the indicator zone being separate from the buffering zone and positioned adjacent to and in fluid communication with the buffering zone. A detection zone is part of the buffering zone, and has a buffering component comprising a weak polymeric acid and weak polymeric base with a pKa ≤ 10 -3 , and a class of charged polymeric surfactants that are responsive to relative ion concentrations in a sample solution, and a charged pH indicator with a charge opposite to that of the charged polymeric surfactant. The charged polymeric surfactant is soluble in amounts of greater than or equal to about 1% by weight (≥ 1wt. % solute) in water and aqueous solutions of low ionic concentration of ≤ 0.1 wt. % salts, but insoluble ( 0.1 wt. % salts. The present invention also describes absorbent articles incorporating such an assay device and methods of monitoring dehydration or testing ion strength of a urine sample using such a test format.
摘要翻译：描述了用于确定尿液的相对离子强度的侧流测定装置。该装置包括其中设置有聚电解质的缓冲区和具有非扩散固定在其中的指示剂区的指示剂区，指示剂区与缓冲区分开并且与缓冲区相邻并且与缓冲区流体连通。检测区是缓冲区的一部分，并且具有包含弱聚合酸和弱聚合物碱的缓冲组分，所述缓冲组分具有pKa≤10-3和一类带电聚合物表面活性剂，其对样品溶液中的相对离子浓度，以及与带电聚合物表面活性剂的电荷相反的带电荷pH指示剂。带电聚合物表面活性剂在水中的溶解度大于或等于约1重量％（≥1重量％溶质），并且低离子浓度的水溶液≤0.1重量％％的盐，但是在高离子浓度的水溶液中不溶（<1wt。％溶质） 0.1重量％％的盐。本发明还描述了包含这种测定装置的吸收制品和使用这种测试形式来监测尿样的脱水或测试离子强度的方法。

4. 发明申请

WO2010048484A2 OPTICAL SPECTRAL CONCENTRATOR, SENSORS AND OPTICAL ENERGY POWER SYSTEMS 审中-公开
标题翻译：光谱集中器，传感器和光学能量系统
公开(公告)号：WO2010048484A2
公开(公告)日：2010-04-29
申请号：PCT/US2009061795
申请日：2009-10-23
申请人： UNIV CALIFORNIA , YU PAUL KIT LAI , CHEN WINNIE VICTORIA WEI-NING
发明人： YU PAUL KIT LAI , CHEN WINNIE VICTORIA WEI-NING
IPC分类号： F24S23/00 , F24S23/30 , H01L31/042
CPC分类号： H01L31/055 , F24J2/08 , H01S5/041 , H01S5/50 , Y02B10/20 , Y02E10/52
摘要： Methods and devices of the invention perform an optical concentration by an expansion of usable spectral width of the incident energy. Preferred methods and devices of the invention concentrate optical energy by tuning it into a narrow spectral width to match the bandgap of another system component, such as an optical fiber, an optical sensor or a photovoltaic device that converts the optical energy. Embodiments of the invention include methods and devices for the spectral concentration of multi-wavelength light and subsequent transport of the concentrated output light.
摘要翻译：本发明的方法和装置通过扩大入射能量的可用光谱宽度来执行光学浓度。本发明的优选方法和装置通过将光能调谐到窄的光谱宽度来集中光能，以匹配另一个系统部件（例如光纤，光学传感器或转换光能的光伏装置）的带隙。本发明的实施例包括用于多波长光的光谱浓度以及随后输送集中的输出光的方法和设备。

5. 发明申请

WO2006065314A1 SAMPLE-EFFICIENT LATERAL FLOW IMMUNOASSAY 审中-公开
标题翻译：样本效率的横向流动免疫
公开(公告)号：WO2006065314A1
公开(公告)日：2006-06-22
申请号：PCT/US2005/034653
申请日：2005-09-28
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , KAYLOR, Rosann, Marie , WEI, Ning , CHIDEBELU-EZE, Chibueze , FEASTER, Shawn, Ray , CHRISTOPHER, Paul
发明人： KAYLOR, Rosann, Marie , WEI, Ning , CHIDEBELU-EZE, Chibueze , FEASTER, Shawn, Ray , CHRISTOPHER, Paul
IPC分类号： G01N33/543
CPC分类号： G01N33/558
摘要： There is provided a lateral flow assay device for detecting the presence or quantity of an analyte residing in a test sample where the lateral flow assay device has a porous membrane in communication with a conjugate pad and a wicking pad. The porous membrane has a detection zone which has an immobilized first capture reagent configured to bind to at least a portion of the analyte and analyte-conjugate complexes to generate a detection signal. A control zone may be located downstream from the detection zone on the porous membrane and has a second capture reagent immobilized within the control zone. The conjugate pad is located upstream from the detection zone, and has detection probes with specific binding members for the analyte. The sample is deposited between the control and detection zones. A buffer release zone is located upstream of the conjugate pad and provides for buffer addition to the device, the buffer serving to move the detection probes to the detection and control zones.
摘要翻译：提供了一种侧流测定装置，用于检测驻留在测试样品中的分析物的存在或数量，其中侧流测定装置具有与缀合垫和芯吸垫连通的多孔膜。多孔膜具有检测区，其具有被配置为结合至少一部分分析物和分析物 - 共轭复合物的固定的第一捕获试剂以产生检测信号。控制区可以位于多孔膜上的检测区的下游，并且具有固定在控制区内的第二捕获试剂。缀合垫位于检测区的上游，并具有用于分析物的具有特异性结合构件的检测探针。样品沉积在控制区和检测区之间。缓冲区释放区位于缀合垫的上游，并为缓冲器添加缓冲区，该缓冲器用于将检测探针移动到检测和控制区。

6. 发明申请

WO2005059162A2 MICROBIAL DETECTION AND QUANTIFICATION 审中-公开
公开(公告)号：WO2005059162A2
公开(公告)日：2005-06-30
申请号：PCT/US2004042461
申请日：2004-12-16
申请人： KIMBERLY CLARK CO , LYE JASON , MACDONALD JOHN GAVIN , MARTIN STEPHANIE , WEI NING
发明人： LYE JASON , MACDONALD JOHN GAVIN , MARTIN STEPHANIE , WEI NING
IPC分类号： C12Q1/04 , C12Q1/00
CPC分类号： C12Q1/04
摘要： Suitable dyes are used herein to indicate the presence of microbial contamination by spraying them onto surfaces in the form of an aqueous solution. The dye solution may also be allowed to dry, thus producing the dried residue of an aqueous solution. It's believed that these dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye.

7. 发明申请

WO2013038278A3 WETNESS INDICATOR HAVING VARIED HUES 审中-公开
公开(公告)号：WO2013038278A3
公开(公告)日：2013-03-21
申请号：PCT/IB2012/053943
申请日：2012-08-01
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , SONG, Xuedong , GOEDERS, Karen, Meloy , WEI, Ning
发明人： SONG, Xuedong , GOEDERS, Karen, Meloy , WEI, Ning
IPC分类号： G01N31/22 , G01N21/81
摘要： A wetness indicator material may be used on a substrate to form a wetness sensor. The sensor may show either the presence or absence of an aqueous- based fluid or water-containing medium, such as vaginal fluid or urine in a personal hygiene article. The wetness sensor may be incorporated into the article. The wetness indicator material includes a standard colorant that does not change color when wetted. The standard colorant increases the range of hues exhibited by the wetness indicator material.

8. 发明申请

WO2008070722A2 METHODS AND SYSTEMS FOR IDENTIFYING DEFECT TYPES ON A WAFER 审中-公开
标题翻译：用于识别晶片上缺陷类型的方法和系统
公开(公告)号：WO2008070722A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/086508
申请日：2007-12-05
申请人： KLA-TENCOR CORPORATION , SAITO, Jason , SHEN, Wei-Ning
发明人： SAITO, Jason , SHEN, Wei-Ning
IPC分类号： G01N21/88
CPC分类号： G01N21/9501
摘要： Various methods and systems for identifying defect types on a wafer are provided. One computer-implemented method for identifying defect types on a wafer includes acquiring output of an inspection system for defects detected on a wafer. The output is acquired by different combinations of illumination and collection channels of the inspection system. The method also includes identifying defect types of the defects based on the output acquired by a set of the different combinations. The set of the different combinations is selected based on the defect types to be identified on the wafer and a wafer type of the wafer such that a different set of the different combinations of the illumination and collection channels is used for identifying different defect types on different wafer types.
摘要翻译：提供了用于识别晶片上的缺陷类型的各种方法和系统。一种用于识别晶片上的缺陷类型的计算机实现的方法包括获取检测系统对晶片上检测到的缺陷的输出。输出通过检测系统的照明和采集通道的不同组合获得。该方法还包括基于由一组不同组合获得的输出来识别缺陷的缺陷类型。基于要在晶片上识别的缺陷类型和晶片类型的晶片来选择这组不同的组合，使得不同组合的照明和收集通道用于识别不同的不同类型的不同的缺陷类型晶圆类型。

9. 发明申请

WO2007070095A1 METERING TECHNIQUE FOR LATERAL FLOW ASSAY DEVICES 审中-公开
标题翻译：侧流测量装置的测量技术
公开(公告)号：WO2007070095A1
公开(公告)日：2007-06-21
申请号：PCT/US2006/024379
申请日：2006-06-21
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , TAKEUCHI, James, M. , SONG, Xuedong , YANG, Kaiyuan , WEI, Ning , FEASTER, Shawn, R.
发明人： TAKEUCHI, James, M. , SONG, Xuedong , YANG, Kaiyuan , WEI, Ning , FEASTER, Shawn, R.
IPC分类号： G01N33/543
CPC分类号： G01N33/558 , Y10S436/825 , Y10T436/107497 , Y10T436/108331 , Y10T436/25375 , Y10T436/25625
摘要： A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. A sample membrane is utilized having a collection region and a detection region, the collection region having a known saturation volume for the intended test sample. A barrier is defined between the collection region and the detection region. The collection region is saturated with the test sample having a volume of less than about 100 microliters so that a known volume of the test sample is contained in the collection region. The barrier is removed from between the collection region and detection region of the membrane and a diluent is supplied to the collection region of the membrane to facilitate flow of the test sample from the collection region to the detection region of the membrane.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的诊断方法和相关测试试剂盒。使用具有收集区域和检测区域的样品膜，所述收集区域具有用于预期测试样品的已知饱和体积。在收集区域和检测区域之间限定屏障。收集区域用体积小于约100微升的测试样品饱和，使得已知体积的测试样品被包含在收集区域中。从收集区域和膜的检测区域之间移除屏障，并且将稀释剂供应到膜的收集区域，以促进测试样品从收集区域流到膜的检测区域。

10. 发明申请

WO2006118622A1 METERING TECHNIQUE FOR LATERAL FLOW ASSAY DEVICES 审中-公开
标题翻译：侧流测量装置的测量技术
公开(公告)号：WO2006118622A1
公开(公告)日：2006-11-09
申请号：PCT/US2006/002251
申请日：2006-01-19
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , YANG, Kaiyuan , WEI, Ning , FEASTER, Shawn, Ray
发明人： YANG, Kaiyuan , WEI, Ning , FEASTER, Shawn, Ray
IPC分类号： G01N33/543 , A61K39/00
CPC分类号： G01N33/558 , G01N33/54366
摘要： A diagnostic test kit for detecting an analyte residing in a test sample is provided. The kit employs a lateral flow device that contains a membrane. A metering channel is formed in the membrane that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay. Such a metering channel is particularly effective for embodiments in which the test sample has a relatively low volume, such as less than about 100 microliters, in some embodiments less than about 25 microliters, and in some embodiments, less than about 10 microliters. For example, whole blood drops obtained from patients with a lancet from low-pain areas (due to reduced nerve endings than finger), such as the forearm, thigh, or other alternate sites, may have a volume of from about 0.1 to about 5 microliters. Despite their low volume, the present inventors have discovered that the blood drops may still be accurately analyzed for the presence of an analyte using lateral flow detection techniques.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的诊断测试试剂盒。该套件采用包含膜的侧向流动装置。在膜中形成计量通道，其能够在测定开始时将受控体积的测试样品输送到检测区。这样的计量通道对于其中测试样品具有相对较低的体积，例如小于约100微升，在一些实施方案中小于约25微升，并且在一些实施方案中小于约10微升的实施方案是特别有效的。例如，从患有低疼痛区域的刺血针（由于神经末梢比手指减少）的患者（例如前臂，大腿或其他替代部位）获得的全血滴可具有约0.1至约5的体积微升。尽管本发明人的体积小，但是本发明人已经发现，使用侧流检测技术仍然可以精确地分析血液滴定分析物的存在。

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