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    • 6. 发明申请
    • USE OF POLYETHYLENE OXIDE FOR UROGENITAL INFECTION INHIBITION
    • 使用聚乙烯氧化物进行尿毒症感染抑制
    • WO2006065309A1
    • 2006-06-22
    • PCT/US2005/034167
    • 2005-09-23
    • KIMBERLY-CLARK WORLDWIDE, INC.HUANG, LeiYANG, Shu-PingHUANG, Yanbin
    • HUANG, LeiYANG, Shu-PingHUANG, Yanbin
    • A61K31/75A61P15/02
    • A61K9/0034A61K9/0036A61K31/75A61K31/765
    • There is provided compositions and methods to inhibit the adherence of pathogenic microorganisms to cells. The composition includes water soluble PEO/PEG polymers which may be hydrophilic or amphiphilic block copolymers. One example of a suitable composition is polyethylene glycol or polyethylene oxide with a chemical formula of H-(OCH2CH2)n-OH. Another example of a suitable composition is amphiphilic block copolymer with a chemical formula PEOm-Xp-PEOn, where PEO is -(OCH2CH2)n-O and X is PPO(-(OCH2 CH2CH2)m-), or PLGA (poly(lactic-co-glycolic acid), or PMMA (polymethyl methacrylate), or PBO (polybutylene oxide). The pathogenic microorganism may be a bacterial, fungal, viral or trichomonial pathogen and the composition prevents adherence of the pathogenic microorganism in, for example, a urogenital tract of a mammal and aids in reducing malodor generation. The composition may be applied to vaginal health products like, for example, moisturizer, gel, jelly, cream, insert (tablet), ointment, foam. The composition may also be applied to a feminine hygiene product, like, for example, a tampon, feminine pad, feminine wipe or panty liners.
    • 提供了抑制致病微生物对细胞的粘附的组合物和方法。 该组合物包括可以是亲水性或两亲嵌段共聚物的水溶性PEO / PEG聚合物。 合适组合物的一个实例是具有化学式为H-(OCH 2 CH 2)n -OH的聚乙二醇或聚环氧乙烷。 合适组合物的另一个实例是具有化学式PEOm-Xp-PEOn的两亲性嵌段共聚物,其中PEO是 - (OCH 2 CH 2)n O,X是PPO( - (OCH 2 CH 2 CH 2)m - )或PLGA(聚(乳酸 - - 乙醇酸)或PMMA(聚甲基丙烯酸甲酯)或PBO(聚环氧丁烷),病原微生物可以是细菌,真菌,病毒或毛滴虫病原体,并且该组合物可防止病原微生物在例如泌尿生殖道 可以将组合物用于阴道保健品,例如保湿剂,凝胶剂,果冻,霜剂,插入物(片剂),软膏剂,泡沫剂。该组合物还可以应用于女性化妆品 卫生产品,例如棉塞,女性衬垫,女性擦拭物或内裤衬里。