会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明申请
    • PROCESS FOR PRODUCING 6(R)-[2-(8'(S)-2
    • 生产6(R) - [2-(8'(S)-2',2“ - 二甲基丁酰氧基-2'(S),6'(R) - 二甲基-1,2,6,7',8 ',8A'(R) - 六氢萘-2-基](S))乙基] -4(R) - 羟基-3,4,5,6-四氢-2H-吡喃-2-酮
    • WO2009013764A2
    • 2009-01-29
    • PCT/IN2008/000467
    • 2008-07-24
    • JUBILANT ORGANOSYS LIMITEDSINGH, HarnamDUBEY, Shailendra KumarGUPTA, NitinDUBEY, Sushil Kumar
    • SINGH, HarnamDUBEY, Shailendra KumarGUPTA, NitinDUBEY, Sushil Kumar
    • C07D309/30
    • Disclosed herein is an improved process for producing HMG-CoA reductase inhibitor, 6(R)-[2-(8 '(S)-2 ",2 ''-dimethylbutyryloxy-2'(S),6 '(R)-dimethyl- 1', 2', 6', 7', 8',8a'(R)-hexahydronaphthyl-r(S))ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H- pyran-2-one, the process comprising hydrolyzing (lS,3R,7S,8S,8aR)-8-{2-[(2R,4R)- 4-hydroxy-6-oxotetrahydro-2H-ρyran-2-yl]ethyl}-3,7-dimethyl-l,2,3,7,8,8a- hexahydronaphthalen-1-yl (2S)-2-methylbutanoate in presence of a base and antioxidant, lactonizing and selectively protecting the hydroxyl group of the resultant compound, followed by acylation with an acylating agent to obtain 6(R)-[2-(8'(S)- 2",2''-dimethylbutyryloxy-2 '(S),6 '(R)-dimethyl- 1',2',6',7',8',8a'(R)- hexahydronaphthyl-r(S))ethyl]-4(R)-substituted)-3,4,5,6-tetrahydro-2H-pyran-2-one and further deprotection to obtain 6(R)-[2-(8'(S)-2",2"-dimethylbutyryloxy- 2'(S),6'(R)-dimethyl-1',2',6',7',8',8a'(R)-hexahydronaphthyl-1'(S))ethyl]-4(R)- hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one.
    • 本文公开了用于制备HMG-CoA还原酶抑制剂6(R) - [2-(8'(S)-2“,2” - 二甲基丁酰氧基-2'( S),6'(R) - 二甲基-1',2',6',7',8',8a'(R) - 六氢萘基-r(S))乙基] -4(R) - 羟基-3 (1S,3R,7S,8S,8aR)-8- {2 - [(2R,4R)-4-羟基-6,7-二氢-5H-吡咯并[2,3-b] - 氧代四氢-2H-吡喃-2-基]乙基} -3,7-二甲基-1,2,3,7,8,8a-六氢萘-1-基(2S)-2-甲基丁酸酯和 得到6(R) - [2-(8'(S)-2',2“ - 二甲基丁酰氧基-2'(2',3”,4'-二叔丁基二甲基甲硅烷基)氨基甲酸酯),并将其与酰化剂酰化, (R) - 二甲基-1',2',6',7',8',8a'(R) - 六氢萘基-r(S))乙基] -4(R) - 取代的) - (S)-2“,2” - 二甲基丁酰氧基-2'(S)-2 - [(2R) (R) - 二甲基-1',2',6',7',8',8a'(R) - 六氢萘基-1'(S))乙基] -4(R) - 羟基-3' 4,5 ,6-四氢-2H-吡喃-2-酮
    • 7. 发明申请
    • SERIAL CLUSTERING
    • 串行集群
    • WO2007055757A2
    • 2007-05-18
    • PCT/US2006/029082
    • 2006-07-26
    • RIVERBED TECHNOLOGY, INC.WU, David Tze-SiGUPTA, NitinLY, Kand
    • WU, David Tze-SiGUPTA, NitinLY, Kand
    • H04J1/16
    • H04L47/12H04L47/10H04L47/125H04L69/16H04L69/162H04L69/165H04L69/32
    • SERIAL CLUSTERING ABSTRACT OF THE DISCLOSURE Serial clustering uses two or more network devices connected in series via a local and/or wide-area network to provide additional capacity when network traffic exceeds the processing capabilities of a single network device. When a first network device reaches its capacity limit, any excess network traffic beyond that limit is passed through the first network device unchanged. A network device connected in series with the first network device intercepts and will process the excess network traffic provided that it has sufficient processing capacity. Additional network devices can process remaining network traffic in a similar manner until all of the excess network traffic has been processed or until there are no more additional network devices. Network devices may use rules to determine how to handle network traffic. Rules may be based on the attributes of received network packets, attributes of the network device, or attributes of the network.
    • 串行集群摘要串行集群使用两个或多个通过本地和/或广域网串联连接的网络设备,以便在网络流量超过单个网络设备的处理能力时提供额外的容量。 当第一个网络设备达到其容量限制时,超出该限制的任何超量网络流量不变地通过第一个网络设备。 与第一网络设备串联连接的网络设备将拦截并处理多余的网络流量,前提是它具有足够的处理能力。 额外的网络设备可以以类似的方式处理剩余的网络流量,直到已经处理了所有超量的网络流量,或者直到没有更多的额外的网络设备。 网络设备可能会使用规则来确定如何处理网络流量。 规则可以基于接收的网络分组的属性,网络设备的属性或网络的属性。
    • 8. 发明申请
    • CONGESTION MANAGEMENT OVER LOSSY NETWORK CONNECTIONS
    • 通过丢失网络连接阻止管理
    • WO2007016311A2
    • 2007-02-08
    • PCT/US2006/029337
    • 2006-07-26
    • RIVERBED TECHNOLOGY, INC.MCCANNE, StevenGUPTA, Nitin
    • MCCANNE, StevenGUPTA, Nitin
    • G01R31/08
    • H04L47/10H04L1/0002H04L1/004H04L1/0057H04L1/1809H04L1/187H04L1/188H04L43/0835H04L43/0847H04L47/11H04L47/25H04L47/27
    • A network stack includes a packet loss analyzer that distinguishes between packet losses due to congestion and due to lossyness of network connections. The loss analyzer observes the packet loss patterns for comparison with a packet loss model. The packet loss model may be based on a Forward Error Correction (FEC) system. The loss analyzer determines if lost packets could have been recovered by a receiving network device, if FEC had been used. If the lost packets could have been corrected by FEC, the loss analyzer assumes that no network congestion exists and that the packet loss comes from the lossy aspects of the network, such as radio interference for wireless networks. If the loss analyzer determines that some of the lost packet could not have been recovered by the receiving network device, the loss analyzer assumes that network congestion causes these packet losses and reduces the data rate.
    • 网络堆栈包括分组丢失分析器,该分组丢失分析器区分由于拥塞和由于网络连接的有损性而导致的分组丢失。 损失分析仪观察包丢失模式,以便与丢包模型进行比较。 分组丢失模型可以基于前向纠错(FEC)系统。 如果FEC已被使用,丢失分析器确定丢失的数据包是否可能被接收网络设备恢复。 如果丢失的分组可以通过FEC纠正,则丢失分析仪假定没有网络拥塞存在,并且分组丢失来自网络的有损方面,例如无线网络的无线电干扰。 如果丢失分析仪确定某些丢失的数据包不能被接收网络设备恢复,则丢失分析仪会认为网络拥塞导致这些数据包丢失并降低数据速率。