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1. 发明申请

WO2004039978A2 HF-CHONDROOSTEOMODULIN, HERSTELLUNG UND VERWENDUNG ZUR BEHANDLUNG ODER DIAGNOSE VON KNOCHEN- UND KNORPELERKRANKUNGEN, FETTSUCHT SOWIE INFLAMMATORISCHER ERKRANKUNGEN UND HAUTERKRANKUNGEN 审中-公开
标题翻译： RF CHONDROOSTEOMODULIN，FOR骨和软骨病症，肥胖和炎性疾病和皮肤病的治疗或诊断生产和使用
公开(公告)号：WO2004039978A2
公开(公告)日：2004-05-13
申请号：PCT/EP2003/011799
申请日：2003-10-24
申请人： IPF PHARMACEUTICALS GMBH , MEDER, Wolfgang , WENDLAND, Martin , JOHN, Harald , RICHTER, Rudolf , MEYER, Markus , FORSSMANN, Wolf-Georg
发明人： MEDER, Wolfgang , WENDLAND, Martin , JOHN, Harald , RICHTER, Rudolf , MEYER, Markus , FORSSMANN, Wolf-Georg
IPC分类号： C12N15/12
CPC分类号： C07K14/705 , C07K14/47 , C07K14/51
摘要： Gegenstand der Erfindung sind das Polypeptid COM und seine Derivate, Verfahren zur Herstellung und Gewinnung in reiner oder partiell aufgereinigter Form aus Körperflüssigkeiten und Geweben, sowie seine Verwendung als Arzneimittel.
摘要翻译：本发明涉及所述多肽COM及其衍生物，一种用于产生和从体液和组织纯的或部分纯化的形式，以及其作为药物的用途中回收。

2. 发明申请

WO2002063305A2 HEMORPHINS AS ENDOGENOUS LIGANDS FOR HUMAN G-PROTEIN COUPLED BOMBESIN RECEPTOR SUBTYPE 3 (BRS-3) 审中-公开
标题翻译： HEMORPHINS作为人G蛋白偶联BOMBESIN受体亚型3（BRS-3）的内源性配体
公开(公告)号：WO2002063305A2
公开(公告)日：2002-08-15
申请号：PCT/EP2002/000978
申请日：2002-01-31
申请人： SOLVAY PHARMACEUTICALS GMBH , LAMMERICH, Hans-Peter , BUSMANN, Annette , KUTZLEB, Christian , WENDLAND, Martin , SEILER, Petra , BERGER, Claudia , EICKELMANN, Peter , MEYER, Markus , FORSSMANN, Wolf-Georg , MARONDE, Erik
发明人： LAMMERICH, Hans-Peter , BUSMANN, Annette , KUTZLEB, Christian , WENDLAND, Martin , SEILER, Petra , BERGER, Claudia , EICKELMANN, Peter , MEYER, Markus , FORSSMANN, Wolf-Georg , MARONDE, Erik
IPC分类号： G01N33/566
CPC分类号： G01N33/6863 , G01N33/57492 , G01N2333/70571
摘要： The present invention relates to the identification of a specific endogenous ligand for the human G-protein coupled receptor bombesin receptor subtype 3 (hereinafter referred to as BRS-3 receptor ("BRS-3"), and in particular the invention relates to the use of this receptor in drug discovery, preferably with respect to certain dysfunctions or diseases, and furthermore to the drugs that playa role in preventing, ameliorating or correcting said dysfunctions or diseases. In this context also described are BRS-3 polynucleotides, BRS-3 polypeptides encoded by them, and the use of such polynucleotides and polypeptides, and their production. The invention also relates to inhibiting or activating the action of such polynucleotides and polypeptides, to a vector containing said polynucleotides, a host cell containing such vector and transgenic animals where the BRS-3 gene is either overexpressed, misexpressed, underexpressed or suppressed (knock-out animals). The invention further relates to a method for screening compounds capable to act as an agonist or an antagonist of said G-protein coupled receptor BRS-3 or which modulate the activity of said G-protein coupled receptor BRS-3, and to an endogenous ligand of BRS-3 and the use of this ligand in the treating, preventing, ameliorating or correcting said dysfunctions or diseases related to the activities of BRS-3 in relation to its specific endogenous ligand.
摘要翻译：本发明涉及鉴定人G蛋白偶联受体铃蟾肽受体亚型3的特异性内源性配体（以下称为BRS-3受体（“BRS-3”），特别涉及使用在本发明中还描述了BRS-3多核苷酸，BRS-3多核苷酸，BRS-3多核苷酸，BRS-3多核苷酸，BRS-3多核苷酸，BRS-3多核苷酸本发明还涉及抑制或激活这种多核苷酸和多肽对含有所述多核苷酸的载体，含有这种载体的宿主细胞和转基因动物的作用，其中 BRS-3基因被过表达，错误表达，低表达或抑制（敲除动物）。本发明还涉及am 用于筛选能够作为所述G蛋白偶联受体BRS-3的激动剂或拮抗剂或调节所述G蛋白偶联受体BRS-3的活性的化合物的方法和BRS-3的内源性配体和使用此配体治疗，预防，改善或纠正与其特异性内源性配体相关的BRS-3活性相关的功能障碍或疾病。

3. 发明申请

WO2006110743A1 USE OF NATRIURETIC PEPTIDE FOR TREATING HEART FAILURE 审中-公开
标题翻译：用于治疗心脏衰竭的NATRIURETIC PEPTIDE的使用
公开(公告)号：WO2006110743A1
公开(公告)日：2006-10-19
申请号：PCT/US2006/013471
申请日：2006-04-07
申请人： CARDIOPEP PHARMA GMBH , MITROVIC, Veselin , LUSS, Hartmut , FORSSMANN, Wolf-Georg , MEYER, Markus , DOHLER, Klaus
发明人： MITROVIC, Veselin , LUSS, Hartmut , FORSSMANN, Wolf-Georg , MEYER, Markus , DOHLER, Klaus
IPC分类号： A61K38/00
CPC分类号： A61K38/2242 , A61K47/26
摘要： The present invention relates to the use of a natriurectic peptide, such as urodilatin, for treating a patient suffering from heart failure, such as acute decompensated heart failure. Preferably, a composition comprising an effective amount of urodilatin is intravenously administered to the patient continuously through a time period of at least 24 hours and up to 120 hours, preferably at least 48 hours.
摘要翻译：本发明涉及尿钠肽如尿d素用于治疗患有心力衰竭的患者，例如急性失代偿性心力衰竭。优选地，将包含有效量的尿布菌素的组合物在至少24小时和至多120小时，优选至少48小时的持续时间内静脉内施用于患者。

4. 发明申请

WO2006018174A1 INDOLE DERIVATIVES COMPRISING AN ACETYLENE GROUP AS PPAR ACTIVATORS 审中-公开
标题翻译：包含乙酰基团作为PPAR激活剂的单独衍生物
公开(公告)号：WO2006018174A1
公开(公告)日：2006-02-23
申请号：PCT/EP2005/008571
申请日：2005-08-08
申请人： F. HOFFMANN-LA ROCHE AG , ACKERMANN, Jean , AEBI, Johannes , BINGGELI, Alfred , GRETHER, Uwe , KUHN, Bernd , MAERKI, Hans-Peter , MEYER, Markus
发明人： ACKERMANN, Jean , AEBI, Johannes , BINGGELI, Alfred , GRETHER, Uwe , KUHN, Bernd , MAERKI, Hans-Peter , MEYER, Markus
IPC分类号： C07D209/08
CPC分类号： C07D209/08
摘要： This invention is concerned with compounds of the formula (I), wherein one of R 6 , R 7 , R 8 and R 9 is formula (II), and X, R 1 to R 12 , m, n and o are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
摘要翻译：本发明涉及式（I）化合物，其中R 6，R 7，R 8和R 8中的一个， 9是式（II），X，R 1至R 12，m，n和o如说明书中所定义，和药学上可接受的盐和/或其酯。本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防由PPARd和/或PPARα激动剂调节的疾病的用途。

5. 发明申请

WO2005053433A1 RICE-BASED FOOD COMPOSITIONS AND PROCESSES FOR THEIR PREPARATION 审中-公开
标题翻译：基于米饭的食品组合物及其制备方法
公开(公告)号：WO2005053433A1
公开(公告)日：2005-06-16
申请号：PCT/EP2004/012710
申请日：2004-11-10
申请人： DSM IP ASSETS B.V. , BÜHLER AG , BRUEMMER, Thomas , KLEEMANN, Nicole , MEYER, Markus , SCHWEIKERT, Loni
发明人： BRUEMMER, Thomas , KLEEMANN, Nicole , MEYER, Markus , SCHWEIKERT, Loni
IPC分类号： A23L1/168
CPC分类号： A23L33/15 , A23L7/143 , A23L7/196 , A23V2002/00 , A23V2250/5118 , A23V2250/706 , A23V2250/7042 , A23V2250/7046 , A23V2250/702 , A23V2250/7056
摘要： The invention relates to micronutrient- enriched reconstituted rice and to a process for the preparation thereof from comminuted rice matrix material; to mixtures of such enriched reconstituted rice with natural rice; and to a process for the preparation of reconstituted rice kernels from comminuted or broken rice.
摘要翻译：本发明涉及富含微量营养素的重组水稻及其制备方法，粉碎的米粉基质材料; 将这种富含重构的大米与天然水稻的混合物混合; 以及从粉碎或破碎的米制备重构的米粒的过程。

6. 发明申请

WO2004111020A1 ANILINE DERIVATIVES 审中-公开
标题翻译：苯胺衍生物
公开(公告)号：WO2004111020A1
公开(公告)日：2004-12-23
申请号：PCT/EP2004/005871
申请日：2004-06-01
申请人： F. HOFFMANN-LA ROCHE AG , ACKERMANN, Jean , AEBI, Johannes , BINGGELI, Alfred , GRETHER, Uwe , HIRTH, Georges , KUHN, Bernd , MAERKI, Hans-Peter , MEYER, Markus , MOHR, Peter , WRIGHT, Matthew, Blake
发明人： ACKERMANN, Jean , AEBI, Johannes , BINGGELI, Alfred , GRETHER, Uwe , HIRTH, Georges , KUHN, Bernd , MAERKI, Hans-Peter , MEYER, Markus , MOHR, Peter , WRIGHT, Matthew, Blake
IPC分类号： C07D263/32
CPC分类号： C07D277/28 , C07D263/32
摘要： This invention relates to compounds of the formula (I); wherein X, Y, R 1 to R 11 and n are as defined in the description, and all enantiomers; and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists. Examples of such diseases are diabetes, particularly non-insulin dependent diabetes mellitus, increased lipid and cholesterol levels, particularly low HDL-cholesterol; high LDL- cholesterol, or high triglyceride levels, atherosclerotic diseases, metabolic syndrome (syndrome X), elevated blood pressure, endothelial dysfunction, procoagulant state, dyslipidemia, polycystic ovary syndrome, inflammatory diseases such as rheumatoid arthritis, osteoarthritis, psoriasis and other skin disorder, and proliferative diseases.
摘要翻译：本发明涉及式（I）化合物：其中X，Y，R 1至R 11和n如说明书中所定义，且所有对映异构体; 及其药学上可接受的盐和/或酯。本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防由PPARδ和/或PPARα激动剂调节的疾病的用途。这些疾病的实例是糖尿病，特别是非胰岛素依赖性糖尿病，脂质和胆固醇水平升高，特别是低HDL-胆固醇; 高LDL-胆固醇或高甘油三酯水平，动脉粥样硬化疾病，代谢综合征（综合征X），升高的血压，内皮功能障碍，促凝血状态，血脂异常，多囊卵巢综合征，炎性疾病如类风湿性关节炎，骨关节炎，牛皮癣和其他皮肤病，和增殖性疾病。

7. 发明申请

WO2009062322A1 RICE-BASED FOOD COMPOSITIONS AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：基于米饭的食品组合物及其制备方法
公开(公告)号：WO2009062322A1
公开(公告)日：2009-05-22
申请号：PCT/CH2008/000430
申请日：2008-10-15
申请人： BÜHLER AG , SPÖRNDLI, Ceacilia , MEYER, Markus , ZAMPROGNA, Eliana
发明人： SPÖRNDLI, Ceacilia , MEYER, Markus , ZAMPROGNA, Eliana
IPC分类号： A23L1/168 , F26B3/08
CPC分类号： A23L7/135 , A23L7/101 , A23P30/20
摘要： (A) comminuting rice and/or broken rice to obtain a comminuted rice-based material; (B) hydrothermally-mechanically treating the comminuted rice-based material until a rice-based matrix material is obtained by at least partial gelatinization of the comminuted rice-based material; (C) forming the at least partially gelatinized rice-based matrix material by pressing and portioning in order to obtain rice-based food articles; and (D) drying the rice-based food articles. The drying step (D) comprises a water removal phase (WR) where water is removed from the food articles; and a water homogenization phase (WH) where the water concentration within the food articles is homogenized.
摘要翻译：（A）粉碎米饭和/或破碎的米饭，以获得粉碎的米类材料; （B）水解 - 机械处理粉碎的米基材料直到通过粉碎的米类材料的至少部分糊化获得米基基质材料; （C）通过压制和分割形成至少部分糊化的基于米的基质材料，以获得米类食品; 和（D）干燥稻米食品。干燥步骤（D）包括从食品中除去水的脱水阶段（WR）; 和水均质化阶段（WH），其中食品中的水分浓度均匀化。

8. 发明申请

WO2007028424A1 AMIDE DERIVATIVES AS PPAR ACTIVATORS 审中-公开
标题翻译：作为PPAR激活剂的酰胺衍生物
公开(公告)号：WO2007028424A1
公开(公告)日：2007-03-15
申请号：PCT/EP2006/001057
申请日：2006-02-07
申请人： F. HOFFMANN-LA ROCHE AG , ACKERMANN, Jean , AEBI, Johannes , BINGGELI, Alfred , GRETHER, Uwe , KUHN, Bernd , MAERKI, Hans-Peter , MEYER, Markus
发明人： ACKERMANN, Jean , AEBI, Johannes , BINGGELI, Alfred , GRETHER, Uwe , KUHN, Bernd , MAERKI, Hans-Peter , MEYER, Markus
IPC分类号： C07D239/28 , A61K31/505 , A61P3/00 , C07D213/80
CPC分类号： C07D213/73 , C07D239/26 , C07D239/28 , C07D239/42
摘要： This invention is concerned with compounds of the formula (I), wherein one of R 5 , R 6 and R 7 is formula (II) and R 1 to R 13 , X 1 , X 2 , m and n are defined in the description, and all pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
摘要翻译：本发明涉及式（I）化合物，其中R 5，R 6和R 7之一是式（II）和R 1至R 13，X 1，X 2，m和n在说明书中定义，及其所有药学上可接受的盐和/或酯。本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防由PPARd和/或PPARα激动剂调节的疾病的用途。

9. 发明申请

WO2007011532A1 SYSTEM AND METHOD FOR PROVISIONING A USER DEVICE 审中-公开
标题翻译：用于提供用户设备的系统和方法
公开(公告)号：WO2007011532A1
公开(公告)日：2007-01-25
申请号：PCT/US2006/026303
申请日：2006-07-06
申请人： YAHOO! INC. , MEYER, Markus , BOERRIES, Marco , BREUER, Matthias , SCHULZ, Torsten , SRINIVASAN, Venkatachary
发明人： MEYER, Markus , BOERRIES, Marco , BREUER, Matthias , SCHULZ, Torsten , SRINIVASAN, Venkatachary
IPC分类号： H04L29/08 , H04L29/06
CPC分类号： H04L67/303 , H04L67/1095 , H04L67/125 , H04L69/24
摘要： System and method for providing multiple entry points for connecting one or more user devices in a communication network are disclosed. The method includes providing a server for communicating with the one or more user devices, where the server includes a connected-data-set and the one or more user devices share portions of the connected-data-set, receiving from the user device a request for accessing the connected-data-set from one of the multiple entry points, determining attributes of the user device automatically, selecting a method of communication from a database of predetermined client devices using the attributes of the user device, and provisioning the user device in accordance with the method of communication.
摘要翻译：公开了用于提供用于连接通信网络中的一个或多个用户设备的多个入口点的系统和方法。该方法包括提供用于与一个或多个用户设备通信的服务器，其中服务器包括连接数据集，并且一个或多个用户设备共享连接数据集的部分，从用户设备接收请求用于从所述多个入口点之一访问所述连接数据集，自动确定所述用户设备的属性，使用所述用户设备的属性从预定客户端设备的数据库中选择通信方法，以及将所述用户设备提供给按照通信方式。

10. 发明申请

WO2006004882A1 METHOD AND DEVICE TO RECOVER DIAGNOSTIC AND THERAPEUTIC AGENTS 审中-公开
标题翻译：用于恢复诊断和治疗药物的方法和装置
公开(公告)号：WO2006004882A1
公开(公告)日：2006-01-12
申请号：PCT/US2005/023189
申请日：2005-06-29
申请人： UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE , LEWINTER, Martin, M. , DAUERMAN, Harold, L. , LUSTGARTEN, Daniel, L. , MEYER, Markus
发明人： LEWINTER, Martin, M. , DAUERMAN, Harold, L. , LUSTGARTEN, Daniel, L. , MEYER, Markus
IPC分类号： A61M1/36
CPC分类号： A61M1/3621 , A61M1/0058 , A61M1/3613 , A61M1/3615 , A61M2025/1052
摘要： The invention relates to a method and device for recovering therapeutic and diagnostic agents from the venous outflow of a tissue or organ. A method for recovering an agent includes inserting a catheter into a vascular outflow of a tissue or organ, occluding the flow of blood/fluid through the vascular outflow, and withdrawing blood/fluid in the vascular outflow into the catheter to recover at least a portion of the agent administered to the vascular inflow of the organ or tissue. Also provided is a device to capture an agent administered to a vascular inflow, the device having a catheter having an expandable occlusion device to occlude a flow of fluid through the vascular outflow, a pump operably coupled to the catheter for withdrawing from the vascular outflow at least a portion of the agent administered to a vascular inflow of the organ or tissue, and an automated controller in signal communication with the catheter to control the expandable occlusion device and the pump to withdraw at least a portion of the agent from the vascular outflow.
摘要翻译：本发明涉及从组织或器官的静脉流出中回收治疗和诊断药物的方法和装置。用于回收试剂的方法包括将导管插入组织或器官的血管流出物中，阻断通过血管流出物的血液/流体的流动，以及将血管流出物中的血液/流体抽出到导管中以回收至少一部分的给药剂给予器官或组织的血管流入。还提供了一种用于捕获施用于血管流入物的药剂的装置，所述装置具有导管，所述导管具有可扩张闭塞装置，以阻塞通过血管流出物的流体流动;泵，可操作地连接到导管，用于从血管流出物排出施用于器官或组织的血管流入物的药剂的至少一部分，以及与导管信号通信的自动化控制器，以控制可扩张闭塞装置和泵从血管流出物中抽出至少一部分药剂。

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