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    • 2. 发明申请
    • HUMAN CHEMOKINE HCC-1 POLYPEPTIDES TO IMPROVE STEM CELL TRANSPLANTATION
    • 人体肝癌HCC-1多肽改善干细胞移植
    • WO2005040209A1
    • 2005-05-06
    • PCT/EP2004/011691
    • 2004-10-16
    • IPF PHARMACEUTICALS GMBHRICHTER, RudolfHENSCHLER, ReinhardFORSSMANN, Wolf-Georg
    • RICHTER, RudolfHENSCHLER, ReinhardFORSSMANN, Wolf-Georg
    • C07K14/52
    • A61K49/0008A61K38/00C07K14/523
    • The invention discloses the human chemokine HCC-1, N-terminally truncated HCC-1 molecules and glycosylated HCC-1 which improve the homing of stem cells into the bone marrow during stem cell transplantation. It is also provided a procedure for producing the polypeptides by recombinant techniques or chemical synthesis and for producing antibodies against such polypeptide. Furthermore, it is disclosed the modification of the polypeptide by coupling of amino acid residues and/or chemical groups or deleting amino-acids generating potent derivatives of the polypeptide. Another aspect of the invention provides a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of various associated diseases. The invention concerns also the use of the HCC-1 molecules to increase engraftment of stem cells in the course of the stem cell transplantation performed in stem cell transplantation related diseases.
    • 本发明公开了干细胞移植期间人类趋化因子HCC-1,N-末端截短的HCC-1分子和糖基化的HCC-1,其改善干细胞归巢到骨髓中。 还提供了通过重组技术或化学合成生产多肽并产生针对这种多肽的抗体的方法。 此外,公开了通过偶联氨基酸残基和/或化学基团或删除产生多肽的有效衍生物的氨基酸来修饰多肽。 本发明的另一方面提供本发明的多肽和合适的药物载体的组合,用于提供治疗有效量的多肽用于治疗各种相关疾病。 本发明还涉及在干细胞移植相关疾病中进行的干细胞移植过程中使用HCC-1分子来增加干细胞的移植。