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1. 发明申请

WO1997040377A1 DEVICE FOR HIGHLY SENSITIVE MAGNETIC DETECTION OF ANALYTES 审中-公开
标题翻译：设备分析物的最大灵敏度的磁检测
公开(公告)号：WO1997040377A1
公开(公告)日：1997-10-30
申请号：PCT/DE1997000611
申请日：1997-03-26
申请人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITÄT BERLIN , KOCH, Hans , MATZ, Hartmut , KÖTITZ, Roman , DRUNG, Dietmar , TRAHMS, Lutz , WEITSCHIES, Werner , SEMMLER, Wolfhard
发明人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITÄT BERLIN
IPC分类号： G01N33/483
CPC分类号： G01N33/54333 , G01N35/0098 , Y10S505/846
摘要： This invention concerns a device for qualitative and/or quantitative detection of analytes, particularly in an also biological test sample, by means of ligand-receptor bonds with a magnetizing device for producing field at the site of the test sample and with a detection device for measuring magnetic properties of the test sample. This device is characterized by the fact that the magnetizing device (11', 11'') is arranged spacially with respect to the detection device (71, 8, 9, 10; 16; 20), such that the magnetic field produced by the magnetizing device (11', 11'') at the site which the test sample occupies during measurement is weakened by at least a factor of 10, preferably by a factor of 1000 or more, or by the fact that a switching device is provided which can turn off the magnetic field of the magnetizing device (11; 21) at the site of the test sample (12) for a pre-set period, particularly during the measurement phase of the detection device (71, 8, 9, 10; 16; 20). This permits new kinds of processes for magneto-relaxometric detection of analytes to be carried out or for detection of analytes by means of remanence measurement, routinely and economically in vitro or in vivo.
摘要翻译：一种用于一个特定的生物样品中定性和/或定量检测的分析物的通过的受体 - 配体键的方式与磁化设备装置，用于在测量样本的位置产生磁场，并用一个检测装置，用于测量所述测量样品的磁特性，其特征在于该磁化装置（11'; 11“）在空间上以这样的方式向所述检测装置（71，8，9，10; 16; 20）被布置为使得磁化装置（11”; 11'）在磁化位置产生在该测量过程中测量样品占用磁场，至少10倍，并且优选是由1000或更多倍衰减，或开关装置被提供，其用于在预定的时间周期，特别是在检测装置的测量阶段（71， 8，9，10; 16），所述磁化装置（11的磁场; 21）可以在测量样品（12）的位置开关。因此，对于分析物的检测magnetorelaxometric或用于通过剩磁的装置的检测分析物的新方法可以在体外或体内常规且廉价地进行。

2. 发明申请

WO1998022146A2 OPTICAL DIAGNOSTIC AGENTS FOR DIAGNOSIS OF NEURODEGENERATIVE DISEASES BY MEANS OF NEAR INFRA-RED RADIATION (NIR RADIATION) 审中-公开
标题翻译：神经退化性疾病诊断光学诊断手段的近红外（NIR辐射）
公开(公告)号：WO1998022146A2
公开(公告)日：1998-05-28
申请号：PCT/DE1997002559
申请日：1997-10-29
申请人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITÄT BERLIN , TURNER, Jonathan , DYRKS, Thomas , SEMMLER, Wolfhard , LICHA, Kai , RIEFKE, Björn
发明人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITÄT BERLIN
IPC分类号： A61K49/00
CPC分类号： A61K49/0052 , A61K49/0032 , A61K49/0054 , A61K49/0056 , C07H15/26 , C08B37/0075 , C09B23/086 , C09B56/16 , G01N33/52 , G01N33/6896 , G01N2800/28
摘要： The invention relates to compounds of formula (I): Fm(-A1) (-Bn) (-WO) wherein F is a colorant-signal molecule with a maximum absorption value ranging from 600 - 1200 nm; A is a beta -amyloid plaque binding biomolecule; B is a beta -amyloid plaque binding colorant; and W is a beta -amyloid plaque binding hydrophilic low-molecular structural element. The invention also describes the use of these compounds in in vivo and in vitro diagnosis of neurodegenerative diseases such as Alzheimer's disease by means of near infra-red radiation (NIR radiation) as a contrasting agent in fluorescence and transillumination diagnosis in the NIR range. Diagnostic agents containing said components are also disclosed.
摘要翻译：本发明涉及通式（I）的化合物：FM（-A1）（BN）（-where），其中，F是其具有在600至1200纳米范围内的至少一个吸收最大值的染料的信号分子; A是β-淀粉样斑块的生物分子的结合; B被β-淀粉样斑块的结合染料; W被β-淀粉样斑块的亲水性，低分子量结构元件的结合; 和使用这些化合物用于体内和在神经变性疾病如阿尔茨海默氏病的体外诊断的，由诊断近红外辐射包含如在NIR范围的荧光和透射的诊断造影剂（NIR辐射），手段以及这些化合物代理商。

3. 发明申请

WO1996017628A1 IN-VIVO DIAGNOSTIC PROCESS BY NEAR INFRARED RADIATION 审中-公开
标题翻译：体内诊断方法近红外辐射
公开(公告)号：WO1996017628A1
公开(公告)日：1996-06-13
申请号：PCT/DE1995001465
申请日：1995-10-10
申请人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITÄT BERLIN , LICHA, Kai , RIEFKE, Björn , SEMMLER, Wolfhard , SPECK, Ulrich , HILGER, Christoph-Stephan
发明人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITÄT BERLIN
IPC分类号： A61K49/00
CPC分类号： A61K49/0032 , A61K49/0017 , A61K49/0021 , A61K49/005 , C09B23/086 , C09B69/105
摘要： An in-vivo diagnostic process by near infrared radiation (near I.R. radiation) uses water-soluble dyes and their biomolecular addition products having certain photophysical and pharmacochemical properties as contrasting agents for fluorescence and transillumination diagnosis in the near infrared range. Also disclosed are new dyes and pharmaceuticals containing the same.
摘要翻译：本发明涉及一种使用近红外辐射使用的水溶性染料和具有一定光物理其生物分子加合物和pharmacochemical属性，如在NIR范围的荧光和透射的诊断造影剂，新的（NIR辐射）用于体内诊断的方法染料和含有它们的药物组合物。

4. 发明申请

WO1996004017A1 IRON-CONTAINING NANOPARTICLES WITH DOUBLE COATING AND THEIR USE IN DIAGNOSIS AND THERAPY 审中-公开
标题翻译：铁含有纳米颗粒的在诊断和治疗中双涂层及应用
公开(公告)号：WO1996004017A1
公开(公告)日：1996-02-15
申请号：PCT/DE1995000924
申请日：1995-07-10
申请人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITÄT BERLIN , KRESSE, Mayk , PFEFFERER, Detlev , LAWACZEK, Rüdiger , WAGNER, Susanne , EBERT, Wolfgang , ELSTE, Volker , SEMMLER, Wolfhard , TAUPITZ, Matthias , GAIDA, Josef , HERRMANN, Anja , JUKL, Monika , SWIDERSKI, Udo
发明人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITÄT BERLIN
IPC分类号： A61K49/00
CPC分类号： A61K9/5115 , A61K9/5094 , A61K9/5161 , A61K49/1863 , A61K49/1866 , B01J13/02 , B82Y5/00 , G01N2400/22 , G01N2446/20 , G01N2446/30
摘要： Modular iron-containing nanoparticles are disclosed, as well as their production and use in diagnosis and therapy. The nanoparticles are characterised in that they have an iron-containing core, a primary coat (synthetic polymer) and a secondary coat (target polymer), and optional auxiliary pharmaceutical substances, pharmaceuticals and/or adsorption mediators.
摘要翻译：本发明涉及模块化的含铁纳米颗粒，其制备和用途在诊断和治疗。本发明的纳米颗粒的特征在于它们是由含铁的核心，一个Primärcoat（聚合物的合成）和一个Sekundärcoat（目标聚合物）和任选的药物赋形剂，药物产品和/或Adsorptionsvermittlern存在。

5. 发明申请

WO1995012610A1 N-ALKYL PEPTIDE CHELATE FORMERS, THEIR METAL COMPLEXES WITH RADIONUCLIDES, PROCESSES FOR PRODUCING THEM AND RADIO-PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS 审中-公开
标题翻译： N-烷基PEPTIDCHELATBILDNER用放射性核素及其金属配合物的方法生产它们的和含RADIO药物组合物
公开(公告)号：WO1995012610A1
公开(公告)日：1995-05-11
申请号：PCT/DE1994001295
申请日：1994-10-27
申请人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITÄT BERLIN , SPIES, Hartmut , SCHULZE, Paul-Eberhard , NOLL, Bernd , NOLL, Steffi , DINKELBORG, Ludger
发明人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITÄT BERLIN
IPC分类号： C07K05/062
CPC分类号： C07D457/06 , A61K51/088 , C07D457/12 , C07J41/0072 , C07J51/00 , C07K5/06026 , C07K5/0806 , C07K5/0827 , C07K14/57536
摘要： The invention relates to N-alkyl peptide chelate formers, their metal complexes with radionuclides, processes for their production and radio-pharmaceutical compositions containing these compounds. The invention also relates to radio-pharmaceuticals containing these chelates in metal-complexed form, diagnostic kits in which the chelate may be present in non-complexed form and is complexed by the addition of either technetium or rhenium ions, and the use of such preparations for diagnostic and therapeutic purposes.
摘要翻译：本发明涉及N-烷基肽螯合剂，金属复合物与放射性核素，处理用于含有这些化合物和放射性药物组合物及其制备方法。本发明还涉及到在与金属的形状，所述的诊断试剂盒，其中，所述螯合可以存在于非络合形式，并通过加入锝或铼离子，并且还对这些制剂的应用或者络合络合含有这些螯合物的放射性药物用于诊断和治疗目的。

6. 发明申请

WO1994019352A1 MESO-TETRAPHENYL PORPHYRIN COMPLEX COMPOUNDS, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICALS CONTAINING THE SAME 审中-公开
标题翻译：细观卟啉配位化合物PROCESS FOR THEIR与药品含
公开(公告)号：WO1994019352A1
公开(公告)日：1994-09-01
申请号：PCT/DE1994000159
申请日：1994-02-11
申请人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITÄT BERLIN , MAIER, Franz, Karl , EBERT, Wolfgang , LEE-VAUPEL, Mary , GRIES, Heinz , CONRAD, Jürgen
发明人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITÄT BERLIN
IPC分类号： C07D487/22
CPC分类号： C07D487/22
摘要： Porphyrin complex compounds contain a meso-tetraphenyl porphyrin ligand having general formula (I), in which R , R and R have different meanings, an ion of an element having an atomic number from 21 to 32, equal to 38 or 39, from 42 to 51 or from 58 to 83, and if required one or several physiologically neutral cations of inorganic and/or organic bases, aminoacids or aminoacid amides. These compounds are valuable diagnostic agents.

7. 发明申请

WO1997012850A2 BIFUNCTIONAL, SULPHIDE-CONTAINING SULPHONAMIDE-CHELATING AGENTS OF XSNY TYPE FOR RADIOACTIVE ISOTOPES 审中-公开
标题翻译：双功能硫化物含磺酰胺型螯合剂XSNY FOR放射性同位素
公开(公告)号：WO1997012850A2
公开(公告)日：1997-04-10
申请号：PCT/DE1996001826
申请日：1996-09-19
申请人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITÄT BERLIN , DINKELBORG, Ludger , HILGER, Christoph, Stephan , KRAMP, Wolfgang , PLATZEK, Johannes , RADÜCHEL, Bernd , ERBER, Sebastian
发明人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITÄT BERLIN
IPC分类号： C07B59/00
CPC分类号： C07K14/57536 , A61K51/0478 , A61K51/0497 , A61K51/088 , A61K2123/00 , C07B59/004 , C07C323/67 , C07F13/005 , C07K5/081 , C07K5/1013 , C07K7/14 , C07K7/64
摘要： New compounds have the general formula (I): M - L, in which M stands for a radio-isotope of Tc or Re and L stands for a ligand having the general formula (II): B-CR R -(CR R )n=1,2-S-CHR -CHR -SO2-NH-CR R -(CR R )m=1,2-D, in which R , R , R , R , R , R , R , R , R and R may have various meanings and B and D stand for another group which is suitable for binding metal ions by coordination and for coupling to selectively enriching compounds. Coupling to selectively enriching compounds may alternatively also be mediated by R . These new compounds are useful for complexing technetium and rhenium and are used for medical diagnosis and therapy.
摘要翻译：本发明涉及通式（I）的新化合物：M - L，其中M为Tc或Re和L的放射性同位素是通式的配位体（II）：B-CR <1> [R <2> - （CR <3> [R <4>）N = 1,2-S-CHR <5> -CHR <6> -SO 2 -NH-CR <7> - [R <8> - （CR <9> - [R <10>）米 = 1,2-D，其中R <1>，R <2>，R <3>，R <4>，R <5> - [R <6> - [R <7> - [R <8>，R 站可以具有<9>和R <10>具有不同的含义和B和D为一个另一组是适合在一方面为金属离子的配位键，在另一方面，用于耦合到积累选择性的化合物。化合物的积聚选择性的耦合可以替换地也可为R <8>。用于络合锝和铼的新化合物，以及在医学诊断和治疗中使用。

9. 发明申请

WO1994022491A1 BIFUNCTIONAL CHELATORS AND THEIR USE IN RADIOPHARMACEUTICALS 审中-公开
标题翻译：双功能螯合剂及其在RADIOPHARMAZEUTIK应用
公开(公告)号：WO1994022491A1
公开(公告)日：1994-10-13
申请号：PCT/DE1994000369
申请日：1994-03-29
申请人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITÄT BERLIN , ERBER, Sebastian , DINKELBORG, Ludger , ROHLFS, Gerhard , SCHULZE, Paul-Eberhard , NOLL, Bernhard
发明人： INSTITUT FÜR DIAGNOSTIKFORSCHUNG GMBH AN DER FREIEN UNIVERSITÄT BERLIN
IPC分类号： A61K49/02
CPC分类号： A61K51/08 , A61K38/00 , C07F13/005 , C07K14/57536
摘要： New technetium and rhenium chelate compounds are disclosed, as well as a process for preparing the same, radiopharmaceuticals containing these compounds, conjugates of these compounds with substances which selectively accumulate in diseased tissues, in particular peptides and proteins, as well as the preparation of compositions containing these compounds and their use in radiodiagnostic examinations.

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