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1. 发明申请

WO2010087976A2 ANTI-CANCER PROTEIN-PLATINUM CONJUGATES 审中-公开
标题翻译：抗癌蛋白 - 铂合金
公开(公告)号：WO2010087976A2
公开(公告)日：2010-08-05
申请号：PCT/US2010/000250
申请日：2010-01-29
申请人： IGF ONCOLOGY, LLC , MCTAVISH, Hugh
发明人： MCTAVISH, Hugh
IPC分类号： H01L21/324
CPC分类号： A61K47/64
摘要： The invention provides polypeptide-platinum conjugates comprising an anti¬ cancer platinum complex conjugated to polypeptides that bind relatively specifically to cancer cells, so as to direct the conjugates to cancer cells resulting in increased anti¬ cancer efficacy and decreased side-effects as compared to cisplatin and other conventional anti-cancer platinum complexes.
摘要翻译：本发明提供了多肽 - 铂共轭物，其包含缀合到与癌细胞相对特异性结合的多肽的抗癌铂络合物，以便与顺铂相比，将结合物引导至癌细胞，导致增加的抗癌功效和降低的副作用和其他常规的抗癌铂络合物。

2. 发明申请

WO2005041865A2 COMPOUNDS AND METHOD FOR TREATING CANCER 审中-公开
标题翻译：化合物和治疗癌症的方法
公开(公告)号：WO2005041865A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/034704
申请日：2004-10-21
申请人： IGF ONCOLOGY, LLC , MCTAVISH, Hugh
发明人： MCTAVISH, Hugh
IPC分类号： A61K
CPC分类号： A61K45/06 , A61K47/64 , C07K14/65
摘要： The present invention provides a method of treating cancer involving administering an insulin-like growth factor-1 receptor (IGF-1 receptor) agonist and an anti-cancer chemotherapeutic agent. Also provided are compounds for treating cancer comprising an IGF-1-receptor ligand coupled to an anti-cancer chemotherapeutic agent. Also provided are compounds for treating cancer comprising an insulin-receptor ligand coupled to an anti-cancer chemotherapeutic agent.
摘要翻译：本发明提供一种治疗癌症的方法，其涉及施用胰岛素样生长因子-1受体（IGF-1受体）激动剂和抗癌化学治疗剂。还提供了用于治疗癌症的化合物，其包含与抗癌化学治疗剂偶联的IGF-1-受体配体。还提供了用于治疗癌症的化合物，其包含与抗癌化学治疗剂偶联的胰岛素受体配体。

3. 发明申请

WO2006047214A3 TOXINS AND RADIONUCLIDES COUPLED TO IGF-1 RECEPTOR LIGANDS FOR TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2006047214A3
公开(公告)日：2006-05-04
申请号：PCT/US2005/037739
申请日：2005-10-21
申请人： IGF ONCOLOGY, LLC , MCTAVISH, Hugh
发明人： MCTAVISH, Hugh
IPC分类号： A61K38/30
摘要： The invention provides an insulin-like growth factor-1 (IGF-1) receptor ligand carrying a therapeutic radionuclide for treatment of cancer is provided. A method of treating cancer using the IGF-1 receptor ligand carrying a therapeutic radionuclide is also provided. An anti-cancer therapeutic agent containing an IGF-1 receptor ligand linked to a toxin is also provided, as are methods of using the toxin conjugates for treatment of cancer.

4. 发明申请

WO2018217669A1 AN INSULIN-LIKE GROWTH FACTOR-CHEMOTHERAPEPUTIC CONJUGATE FOR TREATING MYELODYSPLASTIC SYNDROME 审中-公开
公开(公告)号：WO2018217669A1
公开(公告)日：2018-11-29
申请号：PCT/US2018/033747
申请日：2018-05-21
申请人： IGF ONCOLOGY, LLC
发明人： MCTAVISH, Hugh , DUDEK, Arkadiusz, Z.
IPC分类号： A61K47/64 , A61K9/08 , A61K31/519 , A61P35/02
摘要： Provided are methods of treating myelodysplastic syndrome (MDS), oligoblastic acute myelogenous leukemia (O-AML), or chronic myelomonocytic leukemia (CMML) using 765IGF-MTX and other IGF-receptor-targeted agents, and formulations for delivering 765IGF-MTX and other IGF-receptor-targeted agents to patients. Also provided are pharmaceutical compositions for use in treating MDS, O-AML, and CMML.

5. 发明申请

WO2006133421A2 TENNIS BACKBOARD 审中-公开
标题翻译： TENNIS背板
公开(公告)号：WO2006133421A2
公开(公告)日：2006-12-14
申请号：PCT/US2006/022516
申请日：2006-06-08
申请人： STROKEMASTER BACKBOARD, LLC , MCTAVISH, Hugh
发明人： MCTAVISH, Hugh
IPC分类号： A63B69/00
CPC分类号： A63B69/38 , A63B69/0097 , A63B2071/026 , A63B2209/00 , A63B2210/50
摘要： The invention provides a new tennis backboard design. The backboard includes a firm backing layer underlying a soft deadening layer. The rebound of a tennis ball from the backboard is reduced as compared to rebound from a rigid hard-surface backboard. This allows a player to stand fairly close to the backboard, which reduces misses. The player can stand fairly close and hit balls hard against the backboard. Because the rebound is reduced, the ball simply bounces back softly and easily to the player, allowing the player to hit hard again from a fairly short distance. Thus, long rallies without missing are easily achieved. Since the bounce is reduced, the player can stand closer to the backboard, and therefore the backboard can be smaller than conventional backboards without the player missing the backboard. This allows the backboard to be light, portable, and easily stored. Because of the addition of a soft deadening layer, the firm backing layer of the backboard can also be thin and made of lighter and weaker material than a conventional backboard, reducing the weight of the backboard.
摘要翻译：本发明提供了一种新的网球背板设计。背板包括柔软的消音层下面的坚固背衬层。与刚性硬表面背板的回弹相比，网球从背板的反弹减少了。这样一来，玩家就可以靠近篮板，这样可以减少错误。玩家可以相当接近，并且撞击篮板。因为反弹减少，球轻轻地弹回到玩家身上，让玩家从相当短的距离再次击中。因此，很容易就能实现没有失误的长期集会。由于反弹减少，玩家可以靠近背板，因此背板可以比常规背板小，而玩家缺少背板。这样就可以使背板轻巧，便于携带，方便存放。由于添加了柔软的减震层，背板的坚固背衬层也可以比传统背板更薄，材质更轻，材质更薄，从而减轻了背板的重量。

6. 发明申请

WO2005118826A1 ETHANOL PRODUCTION FROM BIOLOGICAL WASTES 审中-公开
标题翻译：来自生物废物的乙醇生产
公开(公告)号：WO2005118826A1
公开(公告)日：2005-12-15
申请号：PCT/US2005/018691
申请日：2005-05-26
申请人： NOVUS ENERGY, LLC , OFFERMAN, John, D. , HOGEN, Delman, R. , LIGHTHART, Jeffrey, W. , MCTAVISH, Hugh
发明人： OFFERMAN, John, D. , HOGEN, Delman, R. , LIGHTHART, Jeffrey, W. , MCTAVISH, Hugh
IPC分类号： C12P5/02
CPC分类号： C02F3/346 , C02F11/04 , C07C27/22 , C07C29/1518 , C12M21/04 , C12M43/00 , C12P5/023 , C12P7/04 , C12P7/08 , Y02E50/16 , Y02E50/17 , Y02E50/32 , Y02E50/343 , Y02W10/23 , C07C31/04 , C07C31/12 , C07C31/125 , C07C31/10 , C07C31/08
摘要： The invention provides methods, apparatuses, and kits for producing ethanol and other alcohols. The methods involve fermenting organic material in a fermentation mixture to a biogas comprising methane; converting at least a portion of the biogas to synthesis gas comprising CO and H 2 ; and contacting at least a portion of the synthesis gas with a catalyst to produce alcohol. In some embodiments, a microorganism that reduces ferric iron to ferrous iron is included in the fermentation mixture to enhance the efficiency of the fermentation and the yield of alcohol. The invention also provides a method of producing alcohol involving fermenting organic material to a biogas comprising methane; removing sulfhydryls from the biogas; converting at least a portion of the biogas to synthesis gas comprising CO and H 2 ; contacting at least a portion of the synthesis gas with a sulfur-free catalyst to produce a substantially sulfur-free alcohol; and purifying the alcohol wherein the purified alcohol is substantially sulfur-free and comprises less than 5% methanol and at least 70% C 2 + alcohols by weight.
摘要翻译：本发明提供用于生产乙醇和其它醇的方法，装置和试剂盒。所述方法包括将发酵混合物中的有机材料发酵成包含甲烷的沼气; 将至少一部分沼气转化成包含CO和H 2的合成气; 并使至少一部分合成气与催化剂接触以产生醇。在一些实施方案中，将发酵混合物中包含将铁还原成二价铁的微生物，以提高发酵的效率和醇的产率。本发明还提供一种生产醇的方法，其涉及将有机材料发酵成包含甲烷的沼气; 从沼气中除去巯基; 将至少一部分沼气转化成包含CO和H 2的合成气; 使至少一部分合成气与无硫催化剂接触以产生基本上不含硫的醇; 并纯化醇，其中纯化的醇基本上是无硫的，并且包含按重量计小于5％的甲醇和至少70％的C2 +醇。

7. 发明申请

WO2008002538A2 BIO-RECYCLING OF CARBON DIOXIDE EMITTED FROM POWER PLANTS 审中-公开
标题翻译：从发电厂发出的二氧化碳的二氧化碳循环
公开(公告)号：WO2008002538A2
公开(公告)日：2008-01-03
申请号：PCT/US2007/014746
申请日：2007-06-26
申请人： NOVUS ENERGY, LLC , OFFERMAN, John, D. , MCTAVISH, Hugh
发明人： OFFERMAN, John, D. , MCTAVISH, Hugh
IPC分类号： C12P5/02
CPC分类号： C12P5/023 , Y02E50/17 , Y02E50/343
摘要： The invention provides a method to decrease emission of carbon dioxide from combustion of fossil fuels or other hydrocarbons and to enhance the efficiency of methane production from anaerobic biodigesters. The invention involves feeding carbon dioxide from the exhaust gas of hydrocarbon fuel combustion to an anaerobic biodigester where biomass is anaerobically fermented to produce methane. Carbon dioxide is an electron acceptor for anaerobic fermentation, and thus some of the carbon dioxide is reduced to methane, which can again be used for fuel. In this way, at least a portion of the exhaust gas CO2 is recycled to form fuel methane instead of being released into the atmosphere. Thus, the net CO2 emission from burning a given amount of fossil fuel is decreased. Adding carbon dioxide to an anaerobic fermentation also increases the efficiency and amount of methane production in the fermentation.
摘要翻译：本发明提供了一种降低二氧化碳从化石燃料或其他烃类燃烧中排放的方法，并且提高了厌氧生物消化剂产生甲烷的效率。本发明涉及将碳氢化合物燃料燃烧废气中的二氧化碳供给到厌氧生物消化器，其中生物质被厌氧发酵以产生甲烷。二氧化碳是用于厌氧发酵的电子受体，因此一些二氧化碳被还原成甲烷，这可再次用于燃料。以这种方式，废气CO 2的至少一部分被再循环以形成燃料甲烷，而不是释放到大气中。因此，燃烧给定量的化石燃料的二氧化碳净排放量减少。将二氧化碳添加到厌氧发酵中也增加了发酵中甲烷生产的效率和量。

8. 发明申请

WO2015106224A3 FUSION PROTEINS CONTAINING INSULIN-LIKE GROWTH FACTOR-1 AND EPIDERMAL GROWTH FACTOR AND VARIANTS THEREOF AND USES THEREOF 审中-公开
公开(公告)号：WO2015106224A3
公开(公告)日：2015-07-16
申请号：PCT/US2015/011066
申请日：2015-01-12
申请人： MCTAVISH, Hugh
发明人： MCTAVISH, Hugh
IPC分类号： A61K38/00 , A61K38/22 , A61K38/30 , C07K1/00 , C12P21/04
摘要： Fusion proteins comprising cytokines, particularly insulin- like growth factor- 1 (IGF-1) and variants thereof, epidermal growth factor (EGF), and other ligands to the EGF receptor, are provided. The fusion proteins further comprise SEQ ID NO: l or other segments having lysine, glutamic acid, or aspartic acid residues. Uses for the fusion proteins are also provided.

9. 发明申请

WO2009158028A2 INTEGREATED SYSTEMS FOR PRODUCING BIOGAS AND LIQUID FUEL FROM ALGAE 审中-公开
标题翻译：用于从ALGAE生产生物和液体燃料的集成系统
公开(公告)号：WO2009158028A2
公开(公告)日：2009-12-30
申请号：PCT/US2009/003828
申请日：2009-06-26
申请人： NOVUS ENERGY LLC , OFFERMAN, John, D. , MCTAVISH, Hugh
发明人： OFFERMAN, John, D. , MCTAVISH, Hugh
IPC分类号： C10J3/20 , C10K1/00 , C10G5/00
CPC分类号： C10J3/00 , C10G2/32 , C10J2300/0916 , C10J2300/1659 , C12M21/02 , C12M21/04 , C12M43/02 , C12M43/06 , C12M47/18 , Y02E50/343 , Y02P20/145
摘要： The embodiments of the invention provide methods and systems for making biogas by growth of aquatic plants followed by anaerobic digestion of organic material from the aquatic plants to biogas comprising methane and carbon dioxide. The biogas can be burned as a fuel or can optionally be further processed to produce a liquid fuel, typically alcohol or diesel, by a Fischer-Tropsch process. The biogas is converted to synthesis gas comprising CO and H 2 , and the synthesis gas is contacted with a catalyst to be converted to liquid fuels.
摘要翻译：本发明的实施方案提供了通过水生植物的生长制备沼气的方法和系统，然后将有机材料从水生植物厌氧消化至包含甲烷和二氧化碳的沼气。沼气可以作为燃料燃烧，或者可以任选地进一步加工以通过费 - 托方法生产液体燃料，通常为醇或柴油。将沼气转化为包含CO和H 2的合成气，并使合成气与催化剂接触以转化为液体燃料。

10. 发明申请

WO2008124055A1 NON-SPECIFIC DELAYED-TYPE HYPERSENSITIVITY RESPONSE TO TREAT HERPES SIMPLEX VIRUS INFECTION 审中-公开
标题翻译：非特异性延迟型超敏感性反应来治疗单纯疱疹病毒感染
公开(公告)号：WO2008124055A1
公开(公告)日：2008-10-16
申请号：PCT/US2008/004392
申请日：2008-04-04
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , MCTAVISH, Hugh , HORN, Thomas, Dag , JOHNSON, Sandra, Marchese
发明人： MCTAVISH, Hugh , HORN, Thomas, Dag , JOHNSON, Sandra, Marchese
IPC分类号： A61K31/08 , A61K31/13 , A61K39/245 , A61K39/395 , A61K39/12 , C12Q1/70 , G01N33/53
CPC分类号： A61K9/0019 , A61K31/04 , A61K31/047 , A61K31/08 , A61K31/122 , A61K31/13 , A61K31/4745 , A61K39/0002 , A61K39/165 , A61K2039/54 , A61K2039/545 , A61K2039/58 , C12N7/00 , C12N2760/18733
摘要： A method is presented for treating herpes simplex virus (HSV) infection comprising: (a) locally administering a substance that induces a delayed type hypersensitivity (DTH) response to a patient at a site of an HSV lesion to induce a DTH response at the site of the lesion during one or more outbreaks of the HSV infection.
摘要翻译：提供了一种用于治疗单纯疱疹病毒（HSV）感染的方法，包括：（a）在HSV病变部位局部施用引起对患者的延迟型超敏反应（DTH）反应的物质，以在该位点诱导DTH应答在一次或多次HSV感染爆发期间的病变。

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