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    • 1. 发明申请
    • METHOD AND DEVICE FOR TERMINAL BATCH UPGRADING
    • 用于终端批量升级的方法和装置
    • WO2011150883A3
    • 2012-05-24
    • PCT/CN2011076199
    • 2011-06-23
    • HUAWEI DEVICE CO LTDWANG JINGHAN WEIDONG NIANZHU GUANGZE
    • WANG JINGHAN WEIDONG NIANZHU GUANGZE
    • H04L12/24H04L29/06H04L29/12
    • H04L41/082
    • The embodiments of the present invention disclose a method and device for terminal batch upgrading. The method includes: assigning different Internet Protocol (IP) addresses to different virtual network cards communicating with various terminals; binding respectively upgrade data packets, needing to be transmitted, with the various virtual network cards, or transmitting respectively maintenance IP address modification commands to the terminals communicating with the various virtual network cards, so that each terminal can modify its own maintenance IP address to a preset IP address separately, wherein the modified preset IP addresses of the various terminals are different; transmitting the upgrade data packets simultaneously to the various terminals via the different IP addresses of the various virtual network cards, so that the various terminals can fulfill the upgrading after receiving the upgrade data packets.
    • 本发明的实施例公开了一种用于终端批量升级的方法和装置。 该方法包括:向与各种终端通信的不同虚拟网卡分配不同的因特网协议(IP)地址; 绑定分别升级需要与各种虚拟网卡进行传输的数据包,或者分别向与各种虚拟网卡通信的终端发送维护IP地址修改命令,以便每个终端可以将其自己的维护IP地址修改为 预设IP地址,其中各个终端的修改的预设IP地址不同; 通过各种虚拟网卡的不同IP地址将升级数据包同时发送到各个终端,使得各种终端可以在接收到升级数据包之后实现升级。
    • 4. 发明申请
    • MICROFLUIDIC SYSTEM AND METHOD FOR ANALYSIS OF GENE EXPRESSION IN CELL-CONTAINING SAMPLES AND DETECTION OF DISEASE
    • 用于分析含细胞样本中基因表达的微流感系统和方法及疾病的检测
    • WO2007092713A3
    • 2008-12-18
    • PCT/US2007061352
    • 2007-01-31
    • UNIV PENNSYLVANIAZIOBER BARRY LBAU HAIM HMAUK MICHAEL GCHEN ZONGYUANWANG JING
    • ZIOBER BARRY LBAU HAIM HMAUK MICHAEL GCHEN ZONGYUANWANG JING
    • B01D11/04B01L3/00C12M1/30C12M3/00C12Q1/00G01N1/18G01N9/30G01N15/06G01N21/00G01N21/75G01N31/00G01N33/00G01N33/48G01N33/53G01N33/536G01N33/543G01N33/551G01N33/553
    • G01N33/574B01L3/502761B01L7/52B01L2200/0636B01L2200/0647B01L2300/0816B01L2300/0864B01L2300/1894B01L2400/043B01L2400/0487B01L2400/0677C12Q1/6886C12Q2600/158G01N33/54366G01N2333/70503G01N2800/52
    • Biomarkers for the detection of pre-cancer and cancer cells and a method for their detection at the point of care are disclosed. The system is comprised of an inexpensive, disposable microfluidic cassette for sample preparation; continuous-flow, magnetic-bead assisted cell sorting and cytometry; cell lysis; nucleic acid isolation and amplification, hybridization, quantification, and analysis. Typically, the disposable cassette will be used with a benchtop instrument platform that provides power, control and detection capabilities to the cassette. In one particular embodiment and application of the invention, the cell sorting is based on the selective binding of magnetic beads coated with an MCAP antibody to exfoliated precancerous and cancerous cells contained in saliva. The bead-labeled precancerous and cancerous cells are then separated from other saliva components using a magnetic field. Both labeled and unlabeled cells can be counted using integrated detectors of several types, including cell counters based on impedance measurements, and cytometers based on Coulter particle counter principles. The sorted sub-population of precancerous and cancerous cells are lysed, and the nucleic acids are isolated for gene assays and/or transcription profiling of the sorted sample subpopulation. In one embodiment of the invention, the cassette includes re verse- transcription polymerase chain reaction for nucleic acid detection and a hybridization array for gene identification. The devices, systems, modes of operation, and methods disclosed here are also applicable for cancer and other disease detection in other body fluids.
    • 公开了用于检测癌前和癌细胞的生物标志物及其在护理时检测的方法。 该系统由用于样品制备的廉价的一次性微流控盒组成; 连续流动,磁珠辅助细胞分选和细胞计数; 细胞裂解; 核酸分离和扩增,杂交,定量和分析。 通常,一次性盒式磁带将与台式仪器平台一起使用,该平台为磁带提供功率,控制和检测能力。 在本发明的一个具体实施方案和应用中,细胞分选基于用MCAP抗体包被的磁珠与包含在唾液中的脱落的癌前和癌细胞的选择性结合。 然后使用磁场将珠标记的癌前和癌细胞与其他唾液成分分离。 可以使用几种类型的集成检测器(包括基于阻抗测量的细胞计数器)和基于Coulter粒子计数器原理的细胞计数器来计数标记和未标记的细胞。 裂解癌前和癌细胞的分选亚群,分离核酸用于分选的样品亚群的基因测定和/或转录谱。 在本发明的一个实施方案中,盒包括用于核酸检测的转录聚合酶链反应和用于基因鉴定的杂交阵列。 本文公开的装置,系统,操作模式和方法也适用于其他体液中的癌症和其他疾病检测。
    • 6. 发明申请
    • HISTONE DEMETHYLASE INHIBITORS AND USES THEREOF FOR TREATMENT O F CANCER
    • HISTONE DEMETHYLASE抑制剂及其用于治疗的用途
    • WO2012071469A2
    • 2012-05-31
    • PCT/US2011061954
    • 2011-11-22
    • NEVADA CANCER INSTSHENZHEN GRADUATE SCHOOL OF PEKING UNIVERSITYZHANG HUIYE TAOQUAN JUNMINWANG JING
    • ZHANG HUIYE TAOQUAN JUNMINWANG JING
    • C07D403/02A61K31/496
    • C07D295/215A61K31/496C07D211/46C07D211/58C07D211/62
    • A compound of formula I: or a pharmaceutically acceptable salt, Ri is an optionally substituted heterocyclic group; R and R' are independently H, CH3, NO2, SO2N(CH3)2, SO2N((CH3)SO2), COOH, COOCH3, CO(N(CH3)), alkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl, heteroaryl, heterocycloalkyl, alkoxy, alkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aryloxycarbonyloxy, carboxylate, alkylcarbonyl, alkylaminocarbonyl, aralkylaminocarbonyl, alkenylaminocarbonyl, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, alkenylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylthiocarbonyl, trifluoromethyl, pentafluoroethyl, halogen, cyano, thio, amido, ether, ester, hydroxyl, hydroxyalkyl, saturated or unsaturated fatty acids, azido, phosphonamido, sulfonamido, lactam, phosphate, phosphonato, phosphinato, amino, acylamino, amidino, imino, guanidino, sulfhydryl, alkylthio, arylthio, thiocarboxylate, sulfates, alkylsulfinyl, sulfonato, sulfamoyl, sulfonamido, nitro, cyano, or azido; m and n are independently integers from 1 to 4; T, U, V, and Z are independently CH, N, or CR; L is NH, CH2, O, S, or SO2; X is N or CH; Y and Y' are independently O or S; and R3 is an optionally substituted aryl, heteroaryl, cycloalkyl, or heterocycloalkyl group.
    • 式I化合物或其药学上可接受的盐,R 1是任选取代的杂环基; R和R'独立地是H,CH 3,NO 2,SO 2 N(CH 3)2,SO 2 N((CH 3)SO 2),COOH,COOCH 3,CO(N(CH 3)),烷基,烯基,炔基,芳基,芳烷基,环烷基, 杂芳基,杂环烷基,烷氧基,烷基羰基氧基,芳基羰基氧基,烷氧基羰基氧基,芳氧基羰基氧基,羧酸酯,烷基羰基,烷基氨基羰基,芳烷基氨基羰基,烯基氨基羰基,烷基羰基,芳基羰基,芳烷基羰基,烯基羰基,烷氧羰基,氨基羰基,烷硫基羰基,三氟甲基,五氟乙基,卤素,氰基, 醚,酯,羟基,羟基烷基,饱和或不饱和脂肪酸,叠氮基,酰基氨基,亚磺酰氨基,内酰胺,磷酸酯,膦酰基,次膦酸酯基,氨基,酰氨基,脒基,亚氨基,胍基,巯基,烷硫基,芳硫基,硫代羧酸酯,硫酸酯,烷基亚磺酰基, 磺酸基,氨磺酰基,亚磺酰氨基,硝基,氰基或叠氮基; m和n独立地为1至4的整数; T,U,V和Z独立地为CH,N或CR; L是NH,CH 2,O,S或SO 2; X为N或CH; Y和Y'独立地为O或S; 并且R 3是任选取代的芳基,杂芳基,环烷基或杂环烷基。